The network for 'peripheral nervous system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

peripheral nervous system development

The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.

Mus musculus
Name Description Probability Func Analog Organism
Isl1 ISL1 transcription factor, LIM/homeodomain 0.996
Ret ret proto-oncogene 0.982
Ntf3 neurotrophin 3 0.977
Sox10 SRY-box containing gene 10 0.965
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.943
Pax6 paired box gene 6 0.943
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.941
Epha4 Eph receptor A4 0.925
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.901
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.837
Notch1 Notch gene homolog 1 (Drosophila) 0.833
Phox2b paired-like homeobox 2b 0.828
Egr2 early growth response 2 0.819
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.791
Neurod1 neurogenic differentiation 1 0.763
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.759
Nrg1 neuregulin 1 0.735
Otx2 orthodenticle homolog 2 (Drosophila) 0.705
Hoxa1 homeobox A1 0.692
Emx1 empty spiracles homolog 1 (Drosophila) 0.661
Sox2 SRY-box containing gene 2 0.659
Gbx2 gastrulation brain homeobox 2 0.643
Ptf1a pancreas specific transcription factor, 1a 0.641
Pitx2 paired-like homeodomain transcription factor 2 0.614
Pax3 paired box gene 3 0.598
Shh sonic hedgehog 0.580
Vegfa vascular endothelial growth factor A 0.567
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.566
Lhx1 LIM homeobox protein 1 0.566
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.556
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.547
Foxc2 forkhead box C2 0.547
Phox2a paired-like homeobox 2a 0.530
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.529
Gli3 GLI-Kruppel family member GLI3 0.515
Efnb2 ephrin B2 0.509
Fgfr2 fibroblast growth factor receptor 2 0.501
Tcf3 transcription factor 3 0.485
Wnt6 wingless-related MMTV integration site 6 0.480
Dab1 disabled homolog 1 (Drosophila) 0.476
Adam12 a disintegrin and metallopeptidase domain 12 (meltrin alpha) 0.450
Hoxa9 homeobox A9 0.448
Tcfap2a transcription factor AP-2, alpha 0.419
Hes1 hairy and enhancer of split 1 (Drosophila) 0.419
Emx2 empty spiracles homolog 2 (Drosophila) 0.415
Hoxb1 homeobox B1 0.412
Onecut1 one cut domain, family member 1 0.402
Lhx9 LIM homeobox protein 9 0.397
Hoxa10 homeobox A10 0.391
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.388
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.387
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.373
Nf1 neurofibromatosis 1 0.351
Emid2 EMI domain containing 2 0.349
Rara retinoic acid receptor, alpha 0.347
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.346
Atoh7 atonal homolog 7 (Drosophila) 0.344
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.338
Efna2 ephrin A2 0.333
Neurog2 neurogenin 2 0.321
Gata4 GATA binding protein 4 0.320
Hoxc4 homeobox C4 0.319
Prnp prion protein 0.316
Insm1 insulinoma-associated 1 0.313
Lhx3 LIM homeobox protein 3 0.308
Gata6 GATA binding protein 6 0.305
Gdnf glial cell line derived neurotrophic factor 0.304
Pbx1 pre B-cell leukemia transcription factor 1 0.300
Aplp2 amyloid beta (A4) precursor-like protein 2 0.295
Lamc1 laminin, gamma 1 0.290
Lhx5 LIM homeobox protein 5 0.289
Pou4f3 POU domain, class 4, transcription factor 3 0.285
Hoxb9 homeobox B9 0.275
Hes5 hairy and enhancer of split 5 (Drosophila) 0.270
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.265
App amyloid beta (A4) precursor protein 0.260
Pax2 paired box gene 2 0.260
Dll1 delta-like 1 (Drosophila) 0.252
Pax1 paired box gene 1 0.244
Tlx3 T-cell leukemia, homeobox 3 0.226
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.224
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.222
Foxd1 forkhead box D1 0.218
Chd7 chromodomain helicase DNA binding protein 7 0.213
Bdnf brain derived neurotrophic factor 0.211
Wt1 Wilms tumor 1 homolog 0.208
Prox1 prospero-related homeobox 1 0.207
En1 engrailed 1 0.206
Gsc goosecoid homeobox 0.198
Hand2 heart and neural crest derivatives expressed transcript 2 0.197
Hoxc5 homeobox C5 0.195
Nrp1 neuropilin 1 0.191
Pou3f3 POU domain, class 3, transcription factor 3 0.188
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.188
Nog noggin 0.187
Dcc deleted in colorectal carcinoma 0.181
Pou3f1 POU domain, class 3, transcription factor 1 0.176
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.175
Ebf3 early B-cell factor 3 0.175
Meis2 Meis homeobox 2 0.175
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
notch1a notch homolog 1a 0.985
eya1 eyes absent homolog 1 0.980
sox3 SRY-box containing gene 3 0.960
neurog1 neurogenin 1 0.953
pax2a paired box gene 2a 0.934
dla deltaA 0.932
cdh2 cadherin 2, neuronal 0.869
alcama activated leukocyte cell adhesion molecule a 0.784
foxi1 forkhead box I1 0.781
fgf3 fibroblast growth factor 3 0.775
gata3 GATA-binding protein 3 0.748
dlc deltaC 0.737
sox1a SRY-box containing gene 1a 0.714
cntn2 contactin 2 0.707
foxa2 forkhead box A2 0.624
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.622
slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 0.618
shha sonic hedgehog a 0.608
ascl1a achaete-scute complex-like 1a (Drosophila) 0.590
lhx5 LIM homeobox 5 0.579
dpysl3 dihydropyrimidinase-like 3 0.569
otpb orthopedia homolog b 0.563
tbx2b T-box 2b 0.552
fzd8a frizzled homolog 8a 0.532
pitx3 paired-like homeodomain transcription factor 3 0.516
her6 hairy-related 6 0.463
tyr tyrosinase 0.461
notch3 notch homolog 3 0.453
pax6a paired box gene 6a 0.434
fsta follistatin a 0.425
olig2 oligodendrocyte lineage transcription factor 2 0.382
sox2 SRY-box containing gene 2 0.378
fgf8a fibroblast growth factor 8 a 0.373
tp53 tumor protein p53 0.372
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.371
dbx1a developing brain homeobox 1a 0.370
efnb1 ephrin B1 0.366
neurod neurogenic differentiation 0.362
cxcr4b chemokine (C-X-C motif), receptor 4b 0.356
rx3 retinal homeobox gene 3 0.343
emx3 empty spiracles homeobox 3 0.326
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.318
bmp4 bone morphogenetic protein 4 0.309
fgf10a fibroblast growth factor 10a 0.302
barhl2 BarH-like 2 0.298
spry1 sprouty homolog 1 (Drosophila) 0.297
otx1a orthodenticle homolog 1a 0.291
foxp2 forkhead box P2 0.289
six3a sine oculis homeobox homolog 3a 0.283
foxa1 forkhead box A1 0.271
jag2 jagged 2 0.260
six3b sine oculis homeobox homolog 3b 0.256
sox10 SRY-box containing gene 10 0.253
tp63 tumor protein p63 0.248
sox19a SRY-box containing gene 19a 0.248
pcdh10b protocadherin 10b 0.240
kita kit receptor a 0.236
pax6b paired box gene 6b 0.235
dlb deltaB 0.233
coe2 coe2 0.226
atoh1b atonal homolog 1b 0.224
bhlhe22 basic helix-loop-helix family, member e22 0.214
six4b sine oculis homeobox homolog 4b 0.205
irx4b iroquois homeobox protein 4b 0.203
irx1b iroquois homeobox protein 1, b 0.201
crabp2a cellular retinoic acid binding protein 2, a 0.198
dpysl2b dihydropyrimidinase-like 2b 0.198
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.193
scn8aa sodium channel, voltage-gated, type VIII, alpha a 0.192
eng2a engrailed 2a 0.192
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.190
her8a hairy-related 8a 0.188
msi1 musashi homolog 1 (Drosophila) 0.186
pax8 paired box gene 8 0.179
atoh1a atonal homolog 1a 0.177
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.176
hmx3 homeo box (H6 family) 3 0.173
nkx2.1b NK2 homeobox 1b 0.168
dmbx1a diencephalon/mesencephalon homeobox 1a 0.168
prnprs3 prion protein, related sequence 3 0.167
appa amyloid beta (A4) precursor protein a 0.165
her3 hairy-related 3 0.164
tfe3b transcription factor binding to IGHM enhancer 3b 0.163
crb1 crumbs homolog 1 (Drosophila) 0.162
eng2b engrailed 2b 0.161
ndr2 nodal-related 2 0.160
foxi3a forkhead box I3a 0.160
gata4 GATA-binding protein 4 0.159
stm starmaker 0.158
wu:fv91b12 wu:fv91b12 0.155
zic6 zic family member 6 0.154
pou3f1 POU class 3 homeobox 1 0.151
nrg1 neuregulin 1 0.150
slc17a6b solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b 0.150
rarab retinoic acid receptor, alpha b 0.150
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.145
fgfr4 fibroblast growth factor receptor 4 0.143
prkcz protein kinase C, zeta 0.141
fgf24 fibroblast growth factor 24 0.140
phox2a paired-like homeobox 2a 0.137
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Drosophila melanogaster
Name Description Probability Func Analog Organism
insc inscuteable 0.936
rpr reaper 0.904
aop anterior open 0.886
Ephrin CG1862 gene product from transcript CG1862-RA 0.864
baz bazooka 0.860
HLHmdelta E(spl) region transcript mdelta 0.850
HLHm7 E(spl) region transcript m7 0.773
rap retina aberrant in pattern 0.740
exd extradenticle 0.722
Su(H) Suppressor of Hairless 0.710
HLHmbeta E(spl) region transcript mbeta 0.659
wg wingless 0.658
argos CG4531 gene product from transcript CG4531-RA 0.637
scrib scribbled 0.623
smo smoothened 0.601
Jra Jun-related antigen 0.591
Ser Serrate 0.583
emc extra macrochaetae 0.553
l(2)gl lethal (2) giant larvae 0.543
Pten CG5671 gene product from transcript CG5671-RB 0.493
sens senseless 0.417
N Notch 0.411
sc scute 0.399
kuz kuzbanian 0.392
Nrt Neurotactin 0.381
rho rhomboid 0.367
ex expanded 0.360
SAK Sak kinase 0.335
eya eyes absent 0.324
hth homothorax 0.319
Ras85D Ras oncogene at 85D 0.317
stan starry night 0.315
dock dreadlocks 0.310
dpn deadpan 0.302
malpha E(spl) region transcript malpha 0.301
bib big brain 0.298
arr arrow 0.296
Mad Mothers against dpp 0.296
srp serpent 0.295
LIMK1 LIM-kinase1 0.294
E(spl) Enhancer of split 0.287
mys myospheroid 0.285
stai stathmin 0.280
pnt pointed 0.263
mbc myoblast city 0.260
G-oalpha47A G protein oalpha 47A 0.250
ase asense 0.249
HLHm3 E(spl) region transcript m3 0.248
ds dachsous 0.241
tws twins 0.241
eyg eyegone 0.229
Ten-m Tenascin major 0.228
HLHmgamma E(spl) region transcript mgamma 0.223
Akt1 CG4006 gene product from transcript CG4006-RA 0.218
bowl brother of odd with entrails limited 0.211
drl derailed 0.205
ro rough 0.204
LanB2 Laminin B2 0.196
Rac1 CG2248 gene product from transcript CG2248-RA 0.195
neur neuralized 0.194
hpo hippo 0.193
CtBP C-terminal Binding Protein 0.182
htl heartless 0.180
ac achaete 0.179
ttk tramtrack 0.175
l(3)82Fd CG32464 gene product from transcript CG32464-RR 0.174
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.171
Ice CG7788 gene product from transcript CG7788-RA 0.171
rl rolled 0.169
klu klumpfuss 0.167
ss spineless 0.165
gro groucho 0.159
pros prospero 0.155
fng fringe 0.154
sca scabrous 0.154
tsh teashirt 0.153
HGTX CG13475 gene product from transcript CG13475-RB 0.148
S6k RPS6-p70-protein kinase 0.145
CycJ Cyclin J 0.143
scb scab 0.137
amos absent MD neurons and olfactory sensilla 0.135
ovo CG6824 gene product from transcript CG6824-RE 0.135
svp seven up 0.130
chb chromosome bows 0.126
sqh spaghetti squash 0.126
CycA Cyclin A 0.123
edl ETS-domain lacking 0.122
B-H1 BarH1 0.122
numb CG3779 gene product from transcript CG3779-RB 0.120
HLHm5 E(spl) region transcript m5 0.118
Rheb CG1081 gene product from transcript CG1081-RA 0.118
tbce tubulin-specific chaperone E 0.115
Tl Toll 0.110
Syx7 Syntaxin 7 0.107
sktl skittles 0.103
Mpk2 CG5475 gene product from transcript CG5475-RB 0.102
B-H2 BarH2 0.102
frc fringe connection 0.100
Eph Eph receptor tyrosine kinase 0.097
retn retained 0.095
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Homo sapiens
Name Description Probability Func Analog Organism
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 1.000
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 1.000
EGFR epidermal growth factor receptor 0.998
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.991
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.988
NOTCH1 notch 1 0.987
EGR1 early growth response 1 0.986
JAG1 jagged 1 0.968
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.960
PAX3 paired box 3 0.942
POU5F1 POU class 5 homeobox 1 0.920
POU3F2 POU class 3 homeobox 2 0.919
CDK2 cyclin-dependent kinase 2 0.913
CAB39 calcium binding protein 39 0.907
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.740
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.734
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.689
ARHGAP1 Rho GTPase activating protein 1 0.685
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.658
DTNA dystrobrevin, alpha 0.653
NOTCH3 notch 3 0.625
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.612
MEIS1 Meis homeobox 1 0.577
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.563
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.539
DMD dystrophin 0.537
IGF1R insulin-like growth factor 1 receptor 0.515
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.507
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.496
ZNF746 zinc finger protein 746 0.488
NCF1 neutrophil cytosolic factor 1 0.482
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.474
F11R F11 receptor 0.463
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.457
EP300 E1A binding protein p300 0.445
MEIS2 Meis homeobox 2 0.435
EFNA1 ephrin-A1 0.432
NLRC4 NLR family, CARD domain containing 4 0.425
TCF4 transcription factor 4 0.412
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.408
CCND1 cyclin D1 0.407
NAV1 neuron navigator 1 0.395
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.390
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.378
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.362
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.357
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.345
INADL InaD-like (Drosophila) 0.345
RARA retinoic acid receptor, alpha 0.338
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.325
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.322
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.316
EPHA7 EPH receptor A7 0.310
DLL1 delta-like 1 (Drosophila) 0.309
RIN1 Ras and Rab interactor 1 0.299
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.296
JAM3 junctional adhesion molecule 3 0.294
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.291
EFNA5 ephrin-A5 0.291
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 0.283
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.281
PRKCZ protein kinase C, zeta 0.281
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.279
APP amyloid beta (A4) precursor protein 0.279
NKX2-1 NK2 homeobox 1 0.278
INSR insulin receptor 0.277
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.277
JAG2 jagged 2 0.268
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.262
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.262
MED29 mediator complex subunit 29 0.250
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.247
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.237
JAK2 Janus kinase 2 0.232
HOXA9 homeobox A9 0.232
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.230
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.229
GRB10 growth factor receptor-bound protein 10 0.228
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.226
MAP2K1 mitogen-activated protein kinase kinase 1 0.225
PVRL3 poliovirus receptor-related 3 0.223
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.219
SOCS1 suppressor of cytokine signaling 1 0.216
ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 0.213
JAM2 junctional adhesion molecule 2 0.210
BARX1 BARX homeobox 1 0.209
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.208
NOTCH2 notch 2 0.204
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.200
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.197
SNRPG small nuclear ribonucleoprotein polypeptide G 0.197
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.195
HIPK2 homeodomain interacting protein kinase 2 0.190
SKP2 S-phase kinase-associated protein 2 (p45) 0.186
DEDD death effector domain containing 0.184
MYD88 myeloid differentiation primary response gene (88) 0.179
DLG4 discs, large homolog 4 (Drosophila) 0.177
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.176
CAV1 caveolin 1, caveolae protein, 22kDa 0.175
CCL14 chemokine (C-C motif) ligand 14 0.172
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism