The network for 'regulation of interleukin 10 secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of interleukin 10 secretion

Any process that modulates the frequency, rate or extent of interleukin-10 secretion.

Mus musculus
Name Description Probability Func Analog Organism
Aim2 absent in melanoma 2 0.986
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.984
Cd40 CD40 antigen 0.982
Igh immunoglobulin heavy chain complex 0.978
Traf6 TNF receptor-associated factor 6 0.978
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.969
Cdkn2d cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.967
Traf2 TNF receptor-associated factor 2 0.967
Tnf tumor necrosis factor 0.963
Psg21 pregnancy-specific glycoprotein 21 0.919
Col11a2 collagen, type XI, alpha 2 0.910
Akt1 thymoma viral proto-oncogene 1 0.882
Lta lymphotoxin A 0.875
Pdcd1 programmed cell death 1 0.871
Ifng interferon gamma 0.832
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.819
Gbp5 guanylate binding protein 5 0.752
Bcl3 B-cell leukemia/lymphoma 3 0.744
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.706
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.702
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.698
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.687
S1pr2 sphingosine-1-phosphate receptor 2 0.664
Fas Fas (TNF receptor superfamily member 6) 0.655
Cd28 CD28 antigen 0.654
Slc26a4 solute carrier family 26, member 4 0.604
Psg28 pregnancy-specific glycoprotein 28 0.595
Casp1 caspase 1 0.563
Cd80 CD80 antigen 0.560
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.558
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.541
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.529
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.507
Nos2 nitric oxide synthase 2, inducible 0.502
Tnfsf18 tumor necrosis factor (ligand) superfamily, member 18 0.475
Prl2b1 prolactin family 2, subfamily b, member 1 0.419
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.410
Zbp1 Z-DNA binding protein 1 0.400
Psg19 pregnancy specific glycoprotein 19 0.359
Il1r1 interleukin 1 receptor, type I 0.340
Prkcd protein kinase C, delta 0.336
Socs1 suppressor of cytokine signaling 1 0.331
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.316
Il4 interleukin 4 0.314
Ceacam11 carcinoembryonic antigen-related cell adhesion molecule 11 0.312
Blnk B-cell linker 0.299
Mapkapk2 MAP kinase-activated protein kinase 2 0.272
Nlrp3 NLR family, pyrin domain containing 3 0.268
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.261
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.259
Hbb-y hemoglobin Y, beta-like embryonic chain 0.256
Plxna1 plexin A1 0.241
Ccl4 chemokine (C-C motif) ligand 4 0.233
Mapkap1 mitogen-activated protein kinase associated protein 1 0.232
Sh2d2a SH2 domain protein 2A 0.230
Cd70 CD70 antigen 0.216
Akt2 thymoma viral proto-oncogene 2 0.210
Il12rb1 interleukin 12 receptor, beta 1 0.210
Ctsr cathepsin R 0.204
Dao D-amino acid oxidase 0.186
Btk Bruton agammaglobulinemia tyrosine kinase 0.183
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.181
Gzmb granzyme B 0.180
Mmp1a matrix metallopeptidase 1a (interstitial collagenase) 0.176
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.175
Itk IL2-inducible T-cell kinase 0.174
Gzmd granzyme D 0.173
Prl7a2 prolactin family 7, subfamily a, member 2 0.171
Aire autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) 0.168
Ccrl2 chemokine (C-C motif) receptor-like 2 0.161
Ldb3 LIM domain binding 3 0.157
Il22 interleukin 22 0.148
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.148
Ctsj cathepsin J 0.146
Icos inducible T-cell co-stimulator 0.145
Ceacam14 carcinoembryonic antigen-related cell adhesion molecule 14 0.144
Zc3h12a zinc finger CCCH type containing 12A 0.143
Cd40lg CD40 ligand 0.135
Robo3 roundabout homolog 3 (Drosophila) 0.133
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.129
Traf3 TNF receptor-associated factor 3 0.123
Ceacam13 carcinoembryonic antigen-related cell adhesion molecule 13 0.122
Traf1 TNF receptor-associated factor 1 0.121
Psg18 pregnancy specific glycoprotein 18 0.120
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.118
Tcrb T-cell receptor beta chain 0.117
Pdcd1lg2 programmed cell death 1 ligand 2 0.117
Prl3c1 prolactin family 3, subfamily c, member 1 0.115
Prl3b1 prolactin family 3, subfamily b, member 1 0.113
Ccr8 chemokine (C-C motif) receptor 8 0.109
Ptk6 PTK6 protein tyrosine kinase 6 0.108
Tpbpa trophoblast specific protein alpha 0.107
Rel reticuloendotheliosis oncogene 0.104
Prl8a8 prolactin family 8, subfamily a, member 81 0.101
Hbb-bh1 hemoglobin Z, beta-like embryonic chain 0.100
Lif leukemia inhibitory factor 0.099
Fpr3 formyl peptide receptor 3 0.098
Psg23 pregnancy-specific glycoprotein 23 0.097
Pou3f4 POU domain, class 3, transcription factor 4 0.096
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.096
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HLA-DRA major histocompatibility complex, class II, DR alpha 0.994
HLA-DMA major histocompatibility complex, class II, DM alpha 0.992
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.987
BTN3A3 butyrophilin, subfamily 3, member A3 0.983
HLA-DMB major histocompatibility complex, class II, DM beta 0.951
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.940
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.921
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.876
HLA-G major histocompatibility complex, class I, G 0.851
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.846
BTN3A2 butyrophilin, subfamily 3, member A2 0.786
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.773
PILRA paired immunoglobin-like type 2 receptor alpha 0.750
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.730
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.727
BTN3A1 butyrophilin, subfamily 3, member A1 0.507
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.465
SIGLEC7 sialic acid binding Ig-like lectin 7 0.437
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.383
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.364
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.358
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.352
CD80 CD80 molecule 0.340
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.336
NLRC4 NLR family, CARD domain containing 4 0.232
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.164
MEFV Mediterranean fever 0.154
HCP5 HLA complex P5 0.147
PTAFR platelet-activating factor receptor 0.111
NLRP3 NLR family, pyrin domain containing 3 0.110
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.108
BTN2A2 butyrophilin, subfamily 2, member A2 0.088
HK3 hexokinase 3 (white cell) 0.082
TRAF1 TNF receptor-associated factor 1 0.077
TREM1 triggering receptor expressed on myeloid cells 1 0.071
CCR1 chemokine (C-C motif) receptor 1 0.069
SNAP23 synaptosomal-associated protein, 23kDa 0.062
HLA-F major histocompatibility complex, class I, F 0.058
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.045
AOAH acyloxyacyl hydrolase (neutrophil) 0.043
CSK c-src tyrosine kinase 0.041
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.040
NUMB numb homolog (Drosophila) 0.037
NLRC5 NLR family, CARD domain containing 5 0.037
UBA7 ubiquitin-like modifier activating enzyme 7 0.036
CD86 CD86 molecule 0.032
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.032
CCDC115 coiled-coil domain containing 115 0.031
SIRPB1 signal-regulatory protein beta 1 0.031
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.031
CD33 CD33 molecule 0.031
CD40 CD40 molecule, TNF receptor superfamily member 5 0.031
ZNF71 zinc finger protein 71 0.030
SIGLEC9 sialic acid binding Ig-like lectin 9 0.029
CD300C CD300c molecule 0.028
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.027
NOD2 nucleotide-binding oligomerization domain containing 2 0.027
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.025
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 0.025
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3 0.025
BST2 bone marrow stromal cell antigen 2 0.024
DOCK7 dedicator of cytokinesis 7 0.024
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.023
SLC15A3 solute carrier family 15, member 3 0.023
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 0.023
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 0.022
CCL4 chemokine (C-C motif) ligand 4 0.021
TFF1 trefoil factor 1 0.021
RFX5 regulatory factor X, 5 (influences HLA class II expression) 0.021
CASP5 caspase 5, apoptosis-related cysteine peptidase 0.020
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) 0.020
NMT2 N-myristoyltransferase 2 0.020
APOL3 apolipoprotein L, 3 0.019
TLR8 toll-like receptor 8 0.019
CD72 CD72 molecule 0.019
EMR1 egf-like module containing, mucin-like, hormone receptor-like 1 0.019
LGALS9 lectin, galactoside-binding, soluble, 9 0.019
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 0.018
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.018
IRF8 interferon regulatory factor 8 0.018
FCAR Fc fragment of IgA, receptor for 0.018
APOL1 apolipoprotein L, 1 0.018
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.017
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.017
EXT2 exostosin 2 0.017
BTN2A1 butyrophilin, subfamily 2, member A1 0.017
CYTH4 cytohesin 4 0.017
FPR2 formyl peptide receptor 2 0.017
MARCH1 membrane-associated ring finger (C3HC4) 1 0.017
VHL von Hippel-Lindau tumor suppressor 0.017
PHF11 PHD finger protein 11 0.017
CD1D CD1d molecule 0.016
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.016
MS4A4A membrane-spanning 4-domains, subfamily A, member 4 0.016
AIM2 absent in melanoma 2 0.016
RIPK2 receptor-interacting serine-threonine kinase 2 0.016
SIGLEC5 sialic acid binding Ig-like lectin 5 0.016
ERAP2 endoplasmic reticulum aminopeptidase 2 0.015
AIF1 allograft inflammatory factor 1 0.015
ADPRH ADP-ribosylarginine hydrolase 0.015
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism