The network for 'positive regulation of insulin receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of insulin receptor signaling pathway

Any process that increases the frequency, rate or extent of insulin receptor signaling.

Mus musculus
Name Description Probability Func Analog Organism
Lepr leptin receptor 1.000
Ghr growth hormone receptor 0.997
Irs2 insulin receptor substrate 2 0.991
Prlr prolactin receptor 0.968
Nos3 nitric oxide synthase 3, endothelial cell 0.963
Insr insulin receptor 0.950
Lep leptin 0.928
Egfr epidermal growth factor receptor 0.905
Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C 0.865
Csf1 colony stimulating factor 1 (macrophage) 0.855
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.841
Cav1 caveolin 1, caveolae protein 0.800
Apoe apolipoprotein E 0.791
Nos1 nitric oxide synthase 1, neuronal 0.748
Agtr1a angiotensin II receptor, type 1a 0.736
Esr1 estrogen receptor 1 (alpha) 0.733
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.706
Pparg peroxisome proliferator activated receptor gamma 0.680
Kiss1 KiSS-1 metastasis-suppressor 0.656
Grb10 growth factor receptor bound protein 10 0.613
Plg plasminogen 0.594
Serpina1b serine (or cysteine) preptidase inhibitor, clade A, member 1B 0.586
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.571
Fga fibrinogen alpha chain 0.547
Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.534
Ahsg alpha-2-HS-glycoprotein 0.524
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.522
Apoa1 apolipoprotein A-I 0.428
Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) 0.428
Ren1 renin 1 structural 0.423
Alb albumin 0.423
Ambp alpha 1 microglobulin/bikunin 0.402
Apoh apolipoprotein H 0.381
Prkce protein kinase C, epsilon 0.381
Apoc4 apolipoprotein C-IV 0.376
Akr1c6 aldo-keto reductase family 1, member C6 0.362
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.351
Npc1 Niemann Pick type C1 0.349
Itih4 inter alpha-trypsin inhibitor, heavy chain 4 0.303
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.302
Ins2 insulin II 0.297
Serpina1a serine (or cysteine) peptidase inhibitor, clade A, member 1A 0.293
Vdr vitamin D receptor 0.286
Thra thyroid hormone receptor alpha 0.280
Pzp pregnancy zone protein 0.278
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.266
Lrg1 leucine-rich alpha-2-glycoprotein 1 0.257
Lrp1 low density lipoprotein receptor-related protein 1 0.250
Crp C-reactive protein, pentraxin-related 0.244
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.239
Pah phenylalanine hydroxylase 0.231
Kng1 kininogen 1 0.224
Uox urate oxidase 0.217
Fgg fibrinogen gamma chain 0.213
Hpx hemopexin 0.210
F2 coagulation factor II 0.209
Jak2 Janus kinase 2 0.206
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.185
Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 0.184
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.176
Tgfb1 transforming growth factor, beta 1 0.172
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.172
Igf1r insulin-like growth factor I receptor 0.170
Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 0.167
Gc group specific component 0.166
Cbl Casitas B-lineage lymphoma 0.163
Ahr aryl-hydrocarbon receptor 0.160
F9 coagulation factor IX 0.159
Baat bile acid-Coenzyme A: amino acid N-acyltransferase 0.153
Serpina3c serine (or cysteine) peptidase inhibitor, clade A, member 3C 0.151
Ptk2 PTK2 protein tyrosine kinase 2 0.149
Cyp2d10 cytochrome P450, family 2, subfamily d, polypeptide 10 0.145
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.144
Apof apolipoprotein F 0.142
Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 0.140
Apoa5 apolipoprotein A-V 0.137
Tdo2 tryptophan 2,3-dioxygenase 0.135
Ep300 E1A binding protein p300 0.134
Serpind1 serine (or cysteine) peptidase inhibitor, clade D, member 1 0.133
Itga1 integrin alpha 1 0.132
Asb6 ankyrin repeat and SOCS box-containing 6 0.127
C9 complement component 9 0.126
Hnf4a hepatic nuclear factor 4, alpha 0.122
Itih3 inter-alpha trypsin inhibitor, heavy chain 3 0.121
Aldob aldolase B, fructose-bisphosphate 0.115
Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.114
Cyp2a12 cytochrome P450, family 2, subfamily a, polypeptide 12 0.108
Foxa2 forkhead box A2 0.108
Gcgr glucagon receptor 0.106
Cps1 carbamoyl-phosphate synthetase 1 0.102
C4b complement component 4B (Childo blood group) 0.100
Slc10a6 solute carrier family 10 (sodium/bile acid cotransporter family), member 6 0.098
Cfi complement component factor i 0.098
Cyp2d9 cytochrome P450, family 2, subfamily d, polypeptide 9 0.096
Esr2 estrogen receptor 2 (beta) 0.095
Il1r1 interleukin 1 receptor, type I 0.095
Hp haptoglobin 0.095
Adipoq adiponectin, C1Q and collagen domain containing 0.094
Jak3 Janus kinase 3 0.094
Fshr follicle stimulating hormone receptor 0.093
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Lk6 CG17342 gene product from transcript CG17342-RA 0.395
Lnk CG17367 gene product from transcript CG17367-RC 0.177
Hcf Host cell factor 0.164
chico CG5686 gene product from transcript CG5686-RB 0.114
bun bunched 0.061
dm diminutive 0.060
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.058
HLH106 Helix loop helix protein 106 0.050
S6k RPS6-p70-protein kinase 0.050
Pk61C Protein kinase 61C 0.043
InR Insulin-like receptor 0.036
p53 CG33336 gene product from transcript CG33336-RB 0.031
Akt1 CG4006 gene product from transcript CG4006-RA 0.025
Gef26 CG9491 gene product from transcript CG9491-RB 0.024
B4 CG9239 gene product from transcript CG9239-RA 0.022
chrb charybde 0.021
Mnt CG13316 gene product from transcript CG13316-RD 0.020
mei-P26 CG12218 gene product from transcript CG12218-RA 0.020
Ilp2 Insulin-like peptide 2 0.018
scyl scylla 0.016
mi minus 0.016
stwl stonewall 0.014
Ide Insulin degrading metalloproteinase 0.013
Smg6 CG6369 gene product from transcript CG6369-RA 0.013
pico CG11940 gene product from transcript CG11940-RA 0.012
path pathetic 0.011
Mrtf Myocardin-related transcription factor 0.011
tefu telomere fusion 0.011
hppy happyhour 0.011
dnc dunce 0.011
trx trithorax 0.010
MTF-1 Metal response element-binding Transcription Factor-1 0.010
RanBPM Ran-binding protein M 0.010
foxo forkhead box, sub-group O 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
INSR insulin receptor 0.975
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.874
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.329
GRB10 growth factor receptor-bound protein 10 0.319
GRB2 growth factor receptor-bound protein 2 0.308
IGF1R insulin-like growth factor 1 receptor 0.284
IRS2 insulin receptor substrate 2 0.252
EGFR epidermal growth factor receptor 0.162
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.114
JAK2 Janus kinase 2 0.088
ZNF71 zinc finger protein 71 0.074
BCAR1 breast cancer anti-estrogen resistance 1 0.063
ITGB1BP3 integrin beta 1 binding protein 3 0.052
PTK2 PTK2 protein tyrosine kinase 2 0.052
PLCG1 phospholipase C, gamma 1 0.049
IRS1 insulin receptor substrate 1 0.047
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.043
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.040
FYN FYN oncogene related to SRC, FGR, YES 0.039
IGF2R insulin-like growth factor 2 receptor 0.038
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.032
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.022
CREBBP CREB binding protein 0.022
SRCIN1 SRC kinase signaling inhibitor 1 0.021
EP300 E1A binding protein p300 0.020
STAT5B signal transducer and activator of transcription 5B 0.019
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.018
NUMB numb homolog (Drosophila) 0.017
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.017
PTPN21 protein tyrosine phosphatase, non-receptor type 21 0.014
GRB7 growth factor receptor-bound protein 7 0.014
YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.013
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.013
MUC1 mucin 1, cell surface associated 0.013
FAF1 Fas (TNFRSF6) associated factor 1 0.012
LNX1 ligand of numb-protein X 1 0.012
PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.012
CCDC115 coiled-coil domain containing 115 0.011
F11R F11 receptor 0.011
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.010
MET met proto-oncogene (hepatocyte growth factor receptor) 0.010
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism