The network for 'central nervous system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

central nervous system development

The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.

Danio rerio
Name Description Probability Func Analog Organism
sox2 SRY-box containing gene 2 1.000
eya1 eyes absent homolog 1 1.000
shha sonic hedgehog a 1.000
gata3 GATA-binding protein 3 1.000
gli2a GLI-Kruppel family member GLI2a 0.999
fgf3 fibroblast growth factor 3 0.999
olig2 oligodendrocyte lineage transcription factor 2 0.999
lhx1a LIM homeobox 1a 0.998
ascl1a achaete-scute complex-like 1a (Drosophila) 0.998
tbx1 T-box 1 0.998
egr2b early growth response 2b 0.997
otpb orthopedia homolog b 0.997
vdra vitamin D receptor a 0.996
six4b sine oculis homeobox homolog 4b 0.996
sox1a SRY-box containing gene 1a 0.996
dlb deltaB 0.995
shhb sonic hedgehog b 0.995
pax2a paired box gene 2a 0.995
tal1 T-cell acute lymphocytic leukemia 1 0.995
dld deltaD 0.995
bmp2b bone morphogenetic protein 2b 0.994
dla deltaA 0.994
gbx2 gastrulation brain homeo box 2 0.994
sox19a SRY-box containing gene 19a 0.993
otx1b orthodenticle homolog 1b 0.993
lef1 lymphocyte enhancer binding factor 1 0.993
ndr2 nodal-related 2 0.992
foxd3 forkhead box D3 0.992
her15.1 hairy and enhancer of split-related 15.1 0.991
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.991
hand2 heart and neural crest derivatives expressed transcript 2 0.990
epha4a eph receptor A4a 0.989
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.989
lhx5 LIM homeobox 5 0.989
spry4 sprouty (Drosophila) homolog 4 0.987
bdnf brain-derived neurotrophic factor 0.986
pax6a paired box gene 6a 0.985
ncam1b neural cell adhesion molecule 1b 0.985
meis2.1 myeloid ecotropic viral integration site 2.1 0.985
barhl2 BarH-like 2 0.984
isl1 islet1 0.983
sox3 SRY-box containing gene 3 0.982
pitx2 paired-like homeodomain transcription factor 2 0.982
rx3 retinal homeobox gene 3 0.981
hoxa3a homeo box A3a 0.980
six3b sine oculis homeobox homolog 3b 0.979
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.978
otx2 orthodenticle homolog 2 0.978
chd chordin 0.976
smo smoothened homolog (Drosophila) 0.975
robo2 roundabout homolog 2 0.974
meis3 myeloid ecotropic viral integration site 3 0.973
fabp7a fatty acid binding protein 7, brain, a 0.973
robo3 roundabout homolog 3 0.972
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.972
hdac1 histone deacetylase 1 0.971
pax3a paired box gene 3a 0.971
nr2f1a nuclear receptor subfamily 2, group F, member 1a 0.968
pax8 paired box gene 8 0.968
hnf1ba HNF1 homeobox Ba 0.968
hoxc4a homeo box C4a 0.966
barhl1.1 BarH-like 1.1 0.965
dlx5a distal-less homeobox gene 5a 0.964
rx2 retinal homeobox gene 2 0.964
zic4 zic family member 4 0.964
hoxb5b homeo box B5b 0.960
wnt1 wingless-type MMTV integration site family, member 1 0.959
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.959
six1b sine oculis homeobox homolog 1b 0.958
wnt8b wingless-type MMTV integration site family, member 8b 0.958
gdnf glial cell derived neurotrophic factor 0.956
tbx16 T-box gene 16 0.955
arx aristaless related homeobox 0.954
neo1 neogenin 1 0.953
mbp myelin basic protein 0.952
hmx3 homeo box (H6 family) 3 0.952
epb4.1l4 erythrocyte protein band 4.1-like 4 0.950
fezf2 FEZ family zinc finger 2 0.948
pax7a paired box gene 7a 0.947
foxa3 forkhead box A3 0.947
hhip hedgehog interacting protein 0.947
fzd7a frizzled homolog 7a 0.946
tp53 tumor protein p53 0.945
atoh1a atonal homolog 1a 0.945
cxcr4b chemokine (C-X-C motif), receptor 4b 0.944
dlx3b distal-less homeobox gene 3b 0.944
jag2 jagged 2 0.944
vcana versican a 0.943
her5 hairy-related 5 0.939
isl2a islet2a 0.939
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.939
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.937
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.936
pou3f1 POU class 3 homeobox 1 0.931
irx3a iroquois homeobox protein 3a 0.931
fzd8a frizzled homolog 8a 0.929
sall4 sal-like 4 (Drosophila) 0.928
tbx20 T-box 20 0.924
dbx1a developing brain homeobox 1a 0.923
robo1 roundabout homolog 1 0.922
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
dac dachshund 0.999
ato atonal 0.999
wg wingless 0.998
ci cubitus interruptus 0.998
Egfr Epidermal growth factor receptor 0.996
N Notch 0.994
ey eyeless 0.992
ena enabled 0.992
babo baboon 0.990
Ten-a Tenascin accessory 0.986
spi spitz 0.984
fru fruitless 0.983
kay kayak 0.980
lea leak 0.980
trio CG18214 gene product from transcript CG18214-RA 0.977
dock dreadlocks 0.977
robo roundabout 0.976
Rac1 CG2248 gene product from transcript CG2248-RA 0.976
slmb supernumerary limbs 0.972
argos CG4531 gene product from transcript CG4531-RA 0.971
drl derailed 0.971
Dscam Down syndrome cell adhesion molecule 0.970
sim single-minded 0.970
Ptpmeg CG1228 gene product from transcript CG1228-RD 0.966
fra frazzled 0.962
CycA Cyclin A 0.962
Sema-1a CG18405 gene product from transcript CG18405-RD 0.957
Fas2 Fasciclin 2 0.956
esg escargot 0.955
Ras85D Ras oncogene at 85D 0.955
sli slit 0.954
tkv thickveins 0.953
neur neuralized 0.951
E(spl) Enhancer of split 0.951
shi shibire 0.943
egh egghead 0.941
SoxN SoxNeuro 0.941
arm armadillo 0.935
hkb huckebein 0.932
opa odd paired 0.926
vvl ventral veins lacking 0.925
Src42A Src oncogene at 42A 0.922
oc ocelliless 0.911
eyg eyegone 0.906
Fmr1 CG6203 gene product from transcript CG6203-RC 0.906
pasha partner of drosha 0.894
mbc myoblast city 0.882
neb nebbish 0.877
sns sticks and stones 0.877
Ubx Ultrabithorax 0.876
grim CG4345 gene product from transcript CG4345-RA 0.875
Top2 Topoisomerase 2 0.874
Phm Peptidylglycine-alpha-hydroxylating monooxygenase 0.868
rg rugose 0.866
nej nejire 0.866
InR Insulin-like receptor 0.864
tll tailless 0.861
TBPH CG10327 gene product from transcript CG10327-RC 0.860
drpr draper 0.853
milt milton 0.851
arr arrow 0.849
Nedd4 CG42279 gene product from transcript CG42279-RJ 0.848
Ced-12 CG5336 gene product from transcript CG5336-RA 0.844
puc puckered 0.842
par-1 CG8201 gene product from transcript CG8201-RA 0.842
norpA no receptor potential A 0.842
slp1 sloppy paired 1 0.840
ttk tramtrack 0.837
Tm1 Tropomyosin 1 0.832
Mad Mothers against dpp 0.831
dsh dishevelled 0.824
Syx1A Syntaxin 1A 0.824
tutl turtle 0.822
bowl brother of odd with entrails limited 0.808
klu klumpfuss 0.807
robo3 CG5423 gene product from transcript CG5423-RA 0.804
CG2865 CG2865 gene product from transcript CG2865-RA 0.800
dpp decapentaplegic 0.798
rho rhomboid 0.794
sca scabrous 0.792
ptc patched 0.778
fng fringe 0.773
hbs hibris 0.768
Antp Antennapedia 0.767
stan starry night 0.762
HLHm7 E(spl) region transcript m7 0.760
sno strawberry notch 0.759
EcR Ecdysone receptor 0.756
tgo tango 0.754
spas spastin 0.751
Sema-2a CG4700 gene product from transcript CG4700-RC 0.744
rst roughest 0.743
Su(H) Suppressor of Hairless 0.741
ss spineless 0.741
ph-p polyhomeotic proximal 0.736
sev sevenless 0.735
HGTX CG13475 gene product from transcript CG13475-RB 0.734
nonA no on or off transient A 0.729
sle slender lobes 0.723
amos absent MD neurons and olfactory sensilla 0.722
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Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 0.998
TP53 tumor protein p53 0.997
ESR1 estrogen receptor 1 0.993
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.978
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.973
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.956
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.945
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.943
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.936
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.913
ATXN1 ataxin 1 0.887
NCOR1 nuclear receptor corepressor 1 0.886
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.855
MET met proto-oncogene (hepatocyte growth factor receptor) 0.838
FGFR2 fibroblast growth factor receptor 2 0.818
DAXX death-domain associated protein 0.806
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.787
APC adenomatous polyposis coli 0.712
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.669
CREBBP CREB binding protein 0.653
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.652
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.616
AR androgen receptor 0.608
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.600
PKM2 pyruvate kinase, muscle 0.590
HDAC1 histone deacetylase 1 0.586
MYOD1 myogenic differentiation 1 0.585
EP300 E1A binding protein p300 0.567
TAL1 T-cell acute lymphocytic leukemia 1 0.562
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.552
DRD2 dopamine receptor D2 0.545
ACTB actin, beta 0.525
RXRA retinoid X receptor, alpha 0.521
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.513
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.508
S100B S100 calcium binding protein B 0.497
FGFR1 fibroblast growth factor receptor 1 0.488
TP73 tumor protein p73 0.476
NCOR2 nuclear receptor corepressor 2 0.463
PDX1 pancreatic and duodenal homeobox 1 0.458
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.453
ITSN1 intersectin 1 (SH3 domain protein) 0.450
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.444
SP1 Sp1 transcription factor 0.438
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.433
POU3F2 POU class 3 homeobox 2 0.419
NOTCH1 notch 1 0.418
FGF1 fibroblast growth factor 1 (acidic) 0.414
FYN FYN oncogene related to SRC, FGR, YES 0.414
CRHR1 corticotropin releasing hormone receptor 1 0.409
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.400
PPARA peroxisome proliferator-activated receptor alpha 0.392
SORBS3 sorbin and SH3 domain containing 3 0.382
MPDZ multiple PDZ domain protein 0.372
SKI v-ski sarcoma viral oncogene homolog (avian) 0.363
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.359
LBX1 ladybird homeobox 1 0.357
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.353
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.345
EGR1 early growth response 1 0.344
HCFC1 host cell factor C1 (VP16-accessory protein) 0.335
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.328
NCOA2 nuclear receptor coactivator 2 0.327
PBX1 pre-B-cell leukemia homeobox 1 0.325
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.325
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.317
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.308
SFRP1 secreted frizzled-related protein 1 0.307
BCL2L1 BCL2-like 1 0.304
RUNX1 runt-related transcription factor 1 0.304
ZNF43 zinc finger protein 43 0.300
FGF3 fibroblast growth factor 3 0.297
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.295
EPAS1 endothelial PAS domain protein 1 0.293
ARID1A AT rich interactive domain 1A (SWI-like) 0.293
WNT1 wingless-type MMTV integration site family, member 1 0.292
JAG1 jagged 1 0.288
PEX14 peroxisomal biogenesis factor 14 0.287
FLNA filamin A, alpha 0.282
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.281
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.281
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.278
RBBP4 retinoblastoma binding protein 4 0.277
SMAD3 SMAD family member 3 0.272
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.271
SC4MOL sterol-C4-methyl oxidase-like 0.268
GSK3B glycogen synthase kinase 3 beta 0.264
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.261
SOX1 SRY (sex determining region Y)-box 1 0.257
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.257
NCOA1 nuclear receptor coactivator 1 0.255
IGF1R insulin-like growth factor 1 receptor 0.254
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.252
XIAP X-linked inhibitor of apoptosis 0.249
SMAD2 SMAD family member 2 0.247
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.247
APP amyloid beta (A4) precursor protein 0.246
VEGFA vascular endothelial growth factor A 0.243
PDIA3 protein disulfide isomerase family A, member 3 0.241
PFN1 profilin 1 0.238
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nfasc neurofascin 0.662
Grm7 glutamate receptor, metabotropic 7 0.655
Bcan brevican 0.638
Anxa2 annexin A2 0.621
Drd1a dopamine receptor D1A 0.605
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.604
Fgfr2 fibroblast growth factor receptor 2 0.593
Gad2 glutamate decarboxylase 2 0.587
Sirpa signal-regulatory protein alpha 0.584
Nrcam neuronal cell adhesion molecule 0.516
Notch3 Notch homolog 3 (Drosophila) 0.515
Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 0.510
Pdc phosducin 0.481
Rims1 regulating synaptic membrane exocytosis 1 0.479
S100a10 S100 calcium binding protein A10 0.466
Gria4 glutamate receptor, ionotrophic, AMPA 4 0.465
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 0.463
Ncan neurocan 0.459
Ahr aryl hydrocarbon receptor 0.456
Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide 0.442
Egr1 early growth response 1 0.441
Grik1 glutamate receptor, ionotropic, kainate 1 0.441
Kcnj9 potassium inwardly-rectifying channel, subfamily J, member 9 0.438
Adrb1 adrenergic, beta-1-, receptor 0.434
Lgals3 lectin, galactoside-binding, soluble, 3 0.431
Cd4 Cd4 molecule 0.430
Pnlip pancreatic lipase 0.421
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.421
Nrxn1 neurexin 1 0.418
Robo1 roundabout homolog 1 (Drosophila) 0.416
Id3 inhibitor of DNA binding 3 0.407
Atxn1 ataxin 1 0.403
Ptafr platelet-activating factor receptor 0.403
Epor erythropoietin receptor 0.401
Itgam integrin, alpha M 0.401
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.400
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.399
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.397
Hoxa2 homeo box A2 0.396
Chrna9 cholinergic receptor, nicotinic, alpha 9 0.393
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.387
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.384
Nr4a2 nuclear receptor subfamily 4, group A, member 2 0.381
Ednrb endothelin receptor type B 0.379
Syt4 synaptotagmin IV 0.379
Galr3 galanin receptor 3 0.377
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.372
Marcks myristoylated alanine rich protein kinase C substrate 0.369
Kcnt1 potassium channel, subfamily T, member 1 0.362
Crx cone-rod homeobox 0.361
Arpc1b actin related protein 2/3 complex, subunit 1B 0.356
Cckbr cholecystokinin B receptor 0.355
Kl Klotho 0.348
Add3 adducin 3 (gamma) 0.347
Adra2c adrenergic, alpha-2C-, receptor 0.346
Drd2 dopamine receptor D2 0.346
Slc32a1 solute carrier family 32 (GABA vesicular transporter), member 1 0.343
Dlg4 discs, large homolog 4 (Drosophila) 0.336
Calcrl calcitonin receptor-like 0.335
Sprr1al small proline-rich protein 1A-like 0.335
Cga glycoprotein hormones, alpha polypeptide 0.329
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.328
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 0.328
Sdc3 syndecan 3 0.327
Neurod1 neurogenic differentiation 1 0.326
Hoxa1 homeo box A1 0.325
Gabra3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 0.324
Cntn2 contactin 2 (axonal) 0.322
Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) 0.318
LOC246267 resection-induced TPI (rs11) 0.318
Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.317
Lzts1 leucine zipper, putative tumor suppressor 1 0.317
Cntn3 contactin 3 (plasmacytoma associated) 0.315
Cntfr ciliary neurotrophic factor receptor 0.311
Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.305
Myt1l myelin transcription factor 1-like 0.304
St18 suppression of tumorigenicity 18 0.304
Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.303
Camk4 calcium/calmodulin-dependent protein kinase IV 0.301
Gabra1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.301
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.301
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.300
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.297
Cebpe CCAAT/enhancer binding protein (C/EBP), epsilon 0.293
Slc6a1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1 0.292
Hapln1 hyaluronan and proteoglycan link protein 1 0.289
Ptprs protein tyrosine phosphatase, receptor type, S 0.288
Gas7 growth arrest specific 7 0.287
Tac1 tachykinin 1 0.286
Ube2d4 ubiquitin-conjugating enzyme E2D 4 0.286
Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 0.286
Ager advanced glycosylation end product-specific receptor 0.282
Krtap1-5 keratin associated protein 1-5 0.282
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.282
Rhoa ras homolog gene family, member A 0.280
Omp olfactory marker protein 0.275
Mog myelin oligodendrocyte glycoprotein 0.274
Nkx2-1 NK2 homeobox 1 0.274
Mc5r melanocortin 5 receptor 0.274
Nrg2 neuregulin 2 0.270
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism