IMP

Process View

Homo sapiens

37 genes annotated in human

Multi-species View

regulation of interleukin 6 production

GO:0032675

Any process that modulates the frequency, rate, or extent of interleukin-6 production.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of interleukin 6 production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of interleukin 6 production" (in gray)

Name	Description	Probability	Func Analog Organism
MYD88	myeloid differentiation primary response gene (88)	0.997	Mouse
IRAK2	interleukin-1 receptor-associated kinase 2	0.962	Human
IRAK1	interleukin-1 receptor-associated kinase 1	0.913	Human
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.808
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.707
MAP2K4	mitogen-activated protein kinase kinase 4	0.659
LAMP1	lysosomal-associated membrane protein 1	0.373
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.348	Mouse
BIRC3	baculoviral IAP repeat containing 3	0.339
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.337
JUN	jun proto-oncogene	0.251
TLR4	toll-like receptor 4	0.217
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.196
TRAF1	TNF receptor-associated factor 1	0.177
SMAD3	SMAD family member 3	0.160
ZC3H12A	zinc finger CCCH-type containing 12A	0.132
TRADD	TNFRSF1A-associated via death domain	0.128
CD14	CD14 molecule	0.119
ZNF496	zinc finger protein 496	0.114
ARRB2	arrestin, beta 2	0.114	Human Mouse
CPNE6	copine VI (neuronal)	0.105
IL1R1	interleukin 1 receptor, type I	0.099
PELI3	pellino homolog 3 (Drosophila)	0.087
IL10RA	interleukin 10 receptor, alpha	0.087
TRAF6	TNF receptor-associated factor 6	0.083	Mouse
TLR2	toll-like receptor 2	0.083
HSF1	heat shock transcription factor 1	0.079
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.077
IRAK3	interleukin-1 receptor-associated kinase 3	0.072
IL22RA1	interleukin 22 receptor, alpha 1	0.067
TICAM2	toll-like receptor adaptor molecule 2	0.063
UBASH3B	ubiquitin associated and SH3 domain containing B	0.060
PYDC2	pyrin domain containing 2	0.060
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.059
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.057
MAPK14	mitogen-activated protein kinase 14	0.055	Human
SETD8	SET domain containing (lysine methyltransferase) 8	0.055
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.055
AXL	AXL receptor tyrosine kinase	0.054
TRAF2	TNF receptor-associated factor 2	0.054
BIRC2	baculoviral IAP repeat containing 2	0.053
C19orf50	chromosome 19 open reading frame 50	0.051
MEFV	Mediterranean fever	0.047
IL22RA2	interleukin 22 receptor, alpha 2	0.046
TNF	tumor necrosis factor	0.045
GATA2	GATA binding protein 2	0.044
NLRC4	NLR family, CARD domain containing 4	0.044
TNIP1	TNFAIP3 interacting protein 1	0.043
LAPTM5	lysosomal protein transmembrane 5	0.042
SOCS3	suppressor of cytokine signaling 3	0.041
IRAK4	interleukin-1 receptor-associated kinase 4	0.038
TXN	thioredoxin	0.037
SOD2	superoxide dismutase 2, mitochondrial	0.037
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.036
CCL20	chemokine (C-C motif) ligand 20	0.035
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.035
MARK2	MAP/microtubule affinity-regulating kinase 2	0.035
FADD	Fas (TNFRSF6)-associated via death domain	0.034
GNMT	glycine N-methyltransferase	0.033
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.033
TOLLIP	toll interacting protein	0.030
TRIM21	tripartite motif containing 21	0.028
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.027
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.026
SH3KBP1	SH3-domain kinase binding protein 1	0.026
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.025	Rat
JAK1	Janus kinase 1	0.025
LMO2	LIM domain only 2 (rhombotin-like 1)	0.025
HSPB1	heat shock 27kDa protein 1	0.024
DUSP1	dual specificity phosphatase 1	0.022
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.022
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.021
SYK	spleen tyrosine kinase	0.021
ZC3H12C	zinc finger CCCH-type containing 12C	0.021	Human
CCR1	chemokine (C-C motif) receptor 1	0.021
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.020
BAG3	BCL2-associated athanogene 3	0.020
EPOR	erythropoietin receptor	0.020
BTK	Bruton agammaglobulinemia tyrosine kinase	0.020
HDAC9	histone deacetylase 9	0.020
SP1	Sp1 transcription factor	0.020
TRIM22	tripartite motif containing 22	0.019
TNIP2	TNFAIP3 interacting protein 2	0.019
LY86	lymphocyte antigen 86	0.019
ATF2	activating transcription factor 2	0.018
HSPA6	heat shock 70kDa protein 6 (HSP70B')	0.018
PLEK	pleckstrin	0.018
CXCL2	chemokine (C-X-C motif) ligand 2	0.018
HSPH1	heat shock 105kDa/110kDa protein 1	0.018
KIAA1712	KIAA1712	0.018
CFL1	cofilin 1 (non-muscle)	0.018
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.017
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.017
LIMK1	LIM domain kinase 1	0.017
C14orf43	chromosome 14 open reading frame 43	0.017
TRIM34	tripartite motif containing 34	0.017
ARRB1	arrestin, beta 1	0.017
LRP6	low density lipoprotein receptor-related protein 6	0.017
SLAMF1	signaling lymphocytic activation molecule family member 1	0.017
IRF7	interferon regulatory factor 7	0.017
TICAM1	toll-like receptor adaptor molecule 1	0.016	Mouse
SARM1	sterile alpha and TIR motif containing 1	0.016
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.016
PTAFR	platelet-activating factor receptor	0.016
DUSP9	dual specificity phosphatase 9	0.016
XPO7	exportin 7	0.016
STAT5A	signal transducer and activator of transcription 5A	0.016
TLR1	toll-like receptor 1	0.016	Human Mouse
MYH9	myosin, heavy chain 9, non-muscle	0.016
IL4R	interleukin 4 receptor	0.016
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.016
LDHB	lactate dehydrogenase B	0.016
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.015	Mouse
SPOP	speckle-type POZ protein	0.015
VNN2	vanin 2	0.015
TRAF3	TNF receptor-associated factor 3	0.015
CCL8	chemokine (C-C motif) ligand 8	0.015
ELF4	E74-like factor 4 (ets domain transcription factor)	0.015
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.015
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.015
IL8	interleukin 8	0.015
STAP2	signal transducing adaptor family member 2	0.015
PRMT2	protein arginine methyltransferase 2	0.014
IGSF6	immunoglobulin superfamily, member 6	0.014
LY96	lymphocyte antigen 96	0.014
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.014
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.014
PHC2	polyhomeotic homolog 2 (Drosophila)	0.014
FCAR	Fc fragment of IgA, receptor for	0.014
GTF2I	general transcription factor IIi	0.014
DOK3	docking protein 3	0.014
MAP2K7	mitogen-activated protein kinase kinase 7	0.014
BLNK	B-cell linker	0.014
RNASE6	ribonuclease, RNase A family, k6	0.014
FGF3	fibroblast growth factor 3	0.014
TRIB1	tribbles homolog 1 (Drosophila)	0.014
CYBB	cytochrome b-245, beta polypeptide	0.014
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.013
POU4F2	POU class 4 homeobox 2	0.013
C4BPA	complement component 4 binding protein, alpha	0.013
IRF8	interferon regulatory factor 8	0.013
DDR2	discoidin domain receptor tyrosine kinase 2	0.013
TLR7	toll-like receptor 7	0.013	Human Mouse
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.013
FZD1	frizzled homolog 1 (Drosophila)	0.012
IL10	interleukin 10	0.012
SAMHD1	SAM domain and HD domain 1	0.012
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.012
JAK2	Janus kinase 2	0.012
TREM1	triggering receptor expressed on myeloid cells 1	0.012
GJD2	gap junction protein, delta 2, 36kDa	0.012
BST1	bone marrow stromal cell antigen 1	0.012
C17orf62	chromosome 17 open reading frame 62	0.012
CAV1	caveolin 1, caveolae protein, 22kDa	0.012
CDX4	caudal type homeobox 4	0.012
HSPA8	heat shock 70kDa protein 8	0.012
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.012
TFEC	transcription factor EC	0.011
DDIT3	DNA-damage-inducible transcript 3	0.011
HDAC7	histone deacetylase 7	0.011
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.011
ESR2	estrogen receptor 2 (ER beta)	0.011
VSX1	visual system homeobox 1	0.011
IL19	interleukin 19	0.011	Human
CH25H	cholesterol 25-hydroxylase	0.011
TLR6	toll-like receptor 6	0.011	Human
IFIH1	interferon induced with helicase C domain 1	0.011
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.011
ANG	angiogenin, ribonuclease, RNase A family, 5	0.011
AQP9	aquaporin 9	0.011
KIAA1274	KIAA1274	0.011
MTA2	metastasis associated 1 family, member 2	0.011
CDK6	cyclin-dependent kinase 6	0.011
POU4F3	POU class 4 homeobox 3	0.011
SCGN	secretagogin, EF-hand calcium binding protein	0.011
ADRB2	adrenergic, beta-2-, receptor, surface	0.011
LHX5	LIM homeobox 5	0.011
IL20	interleukin 20	0.011	Human
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.011
STK4	serine/threonine kinase 4	0.011
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.011
MAVS	mitochondrial antiviral signaling protein	0.011
MAPK15	mitogen-activated protein kinase 15	0.011
IL2RA	interleukin 2 receptor, alpha	0.011
HOXD12	homeobox D12	0.011
IL13	interleukin 13	0.011
LRRN2	leucine rich repeat neuronal 2	0.011
SIGLEC5	sialic acid binding Ig-like lectin 5	0.011
CLEC7A	C-type lectin domain family 7, member A	0.010
CITED1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	0.010
KIF26A	kinesin family member 26A	0.010
PDX1	pancreatic and duodenal homeobox 1	0.010
TNFSF9	tumor necrosis factor (ligand) superfamily, member 9	0.010
POLR3D	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	0.010
C10orf46	chromosome 10 open reading frame 46	0.010
HMHA1	histocompatibility (minor) HA-1	0.010
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.010
CCL1	chemokine (C-C motif) ligand 1	0.010
PRKCD	protein kinase C, delta	0.010
GBP5	guanylate binding protein 5	0.010
TLR5	toll-like receptor 5	0.010	Human
CFLAR	CASP8 and FADD-like apoptosis regulator	0.010
MAX	MYC associated factor X	0.010
IFNB1	interferon, beta 1, fibroblast	0.010