IMP

Process View

Homo sapiens

29 genes annotated in human

negative regulation of endothelial cell migration

Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of endothelial cell migration"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of endothelial cell migration" (in gray)

Name	Description	Probability	Func Analog Organism
FGFR2	fibroblast growth factor receptor 2	0.988
RARA	retinoic acid receptor, alpha	0.967
TGFB1	transforming growth factor, beta 1	0.930
TEK	TEK tyrosine kinase, endothelial	0.899
JAG1	jagged 1	0.845	Human
BMP2	bone morphogenetic protein 2	0.805
NOTCH1	notch 1	0.805
ENG	endoglin	0.757
NOTCH3	notch 3	0.624	Human
MED25	mediator complex subunit 25	0.596
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.496	Human
A2M	alpha-2-macroglobulin	0.488
FGA	fibrinogen alpha chain	0.488
FGF1	fibroblast growth factor 1 (acidic)	0.475	Human
TGFB3	transforming growth factor, beta 3	0.457
RXRA	retinoid X receptor, alpha	0.457	Human
FKBP1A	FK506 binding protein 1A, 12kDa	0.360
NCOA1	nuclear receptor coactivator 1	0.347
FGFR1	fibroblast growth factor receptor 1	0.342
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.277
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.250
MEF2C	myocyte enhancer factor 2C	0.216
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.193
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.182
NRP1	neuropilin 1	0.180
NOTCH2	notch 2	0.179	Human
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.179
FGF10	fibroblast growth factor 10	0.177	Human
PRKD2	protein kinase D2	0.170
FBLN1	fibulin 1	0.167
MEF2A	myocyte enhancer factor 2A	0.164
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.164
BMPR1B	bone morphogenetic protein receptor, type IB	0.153	Human
NCOR2	nuclear receptor corepressor 2	0.140
HP	haptoglobin	0.110
GDF5	growth differentiation factor 5	0.107	Human
SMAD7	SMAD family member 7	0.107
FSTL1	follistatin-like 1	0.097
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.096
DLL1	delta-like 1 (Drosophila)	0.093	Human
APOC1	apolipoprotein C-I	0.088
ACVR1	activin A receptor, type I	0.088	Human
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.075	Human
KLF6	Kruppel-like factor 6	0.075	Human
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.073
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.073
PRKG1	protein kinase, cGMP-dependent, type I	0.072
FAM46A	family with sequence similarity 46, member A	0.071
TGFBR1	transforming growth factor, beta receptor 1	0.067	Human
BMP4	bone morphogenetic protein 4	0.067
PPARG	peroxisome proliferator-activated receptor gamma	0.062
KLF4	Kruppel-like factor 4 (gut)	0.062
JAG2	jagged 2	0.060	Human
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.060
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.058
S100B	S100 calcium binding protein B	0.058
SKIL	SKI-like oncogene	0.057
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.055
MAPK7	mitogen-activated protein kinase 7	0.054
FOXP3	forkhead box P3	0.052
PROX1	prospero homeobox 1	0.051
HDAC4	histone deacetylase 4	0.051	Human
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.050
CARHSP1	calcium regulated heat stable protein 1, 24kDa	0.049
VEGFC	vascular endothelial growth factor C	0.045
VEGFA	vascular endothelial growth factor A	0.045
BCL6	B-cell CLL/lymphoma 6	0.044
ARHGEF40	Rho guanine nucleotide exchange factor (GEF) 40	0.044
FGF2	fibroblast growth factor 2 (basic)	0.043
SAMD4A	sterile alpha motif domain containing 4A	0.041
CAV1	caveolin 1, caveolae protein, 22kDa	0.040
LAMB1	laminin, beta 1	0.039
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.038
ZMYND11	zinc finger, MYND-type containing 11	0.038
FGF7	fibroblast growth factor 7	0.037	Human
FGFR3	fibroblast growth factor receptor 3	0.037
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.036
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.035
JUN	jun proto-oncogene	0.035
APP	amyloid beta (A4) precursor protein	0.034
THBS1	thrombospondin 1	0.034
FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	0.033
GFI1B	growth factor independent 1B transcription repressor	0.031
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.031
SREBF2	sterol regulatory element binding transcription factor 2	0.030
CDH5	cadherin 5, type 2 (vascular endothelium)	0.030
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.030
FNDC3B	fibronectin type III domain containing 3B	0.029
HDAC7	histone deacetylase 7	0.027	Human
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.027
PLXDC1	plexin domain containing 1	0.027
PPARA	peroxisome proliferator-activated receptor alpha	0.026
ZBTB16	zinc finger and BTB domain containing 16	0.026
DCN	decorin	0.026
SLIT2	slit homolog 2 (Drosophila)	0.026
DUSP1	dual specificity phosphatase 1	0.026
IGF2	insulin-like growth factor 2 (somatomedin A)	0.025
SNCG	synuclein, gamma (breast cancer-specific protein 1)	0.025
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.025
ASRGL1	asparaginase like 1	0.024
MARK2	MAP/microtubule affinity-regulating kinase 2	0.024
LCAT	lecithin-cholesterol acyltransferase	0.024
CTBP1	C-terminal binding protein 1	0.024
MAML1	mastermind-like 1 (Drosophila)	0.024
SMAD3	SMAD family member 3	0.024
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.023
ACVR2B	activin A receptor, type IIB	0.023
COL2A1	collagen, type II, alpha 1	0.023
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.023
IFI44	interferon-induced protein 44	0.023
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.023
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.022
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.022
LPA	lipoprotein, Lp(a)	0.022
INPP5K	inositol polyphosphate-5-phosphatase K	0.022
EGFL7	EGF-like-domain, multiple 7	0.021
PDGFC	platelet derived growth factor C	0.021
TRIB3	tribbles homolog 3 (Drosophila)	0.021
FGG	fibrinogen gamma chain	0.020
XIAP	X-linked inhibitor of apoptosis	0.019
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.019
NCOR1	nuclear receptor corepressor 1	0.019
ANGPT2	angiopoietin 2	0.019
FAF1	Fas (TNFRSF6) associated factor 1	0.019
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.019
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.019
RHOB	ras homolog gene family, member B	0.018
ZNF512B	zinc finger protein 512B	0.018
TIMP3	TIMP metallopeptidase inhibitor 3	0.018
RUNX1	runt-related transcription factor 1	0.018
ACVR1B	activin A receptor, type IB	0.018	Human
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.018
JUB	jub, ajuba homolog (Xenopus laevis)	0.018
TGFB2	transforming growth factor, beta 2	0.017	Human
LAMA4	laminin, alpha 4	0.017
NOTCH4	notch 4	0.017	Human
WWTR1	WW domain containing transcription regulator 1	0.017
SMAD6	SMAD family member 6	0.017
INHBB	inhibin, beta B	0.017
DPT	dermatopontin	0.017
NRP2	neuropilin 2	0.017
RBMS3	RNA binding motif, single stranded interacting protein 3	0.016
RASSF8	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	0.016
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.016
USP15	ubiquitin specific peptidase 15	0.016
IGFBP5	insulin-like growth factor binding protein 5	0.016
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.016
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.016
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	0.016
TAL1	T-cell acute lymphocytic leukemia 1	0.016
RARG	retinoic acid receptor, gamma	0.016
APOC3	apolipoprotein C-III	0.015
SP140L	SP140 nuclear body protein-like	0.015	Human
PTN	pleiotrophin	0.015
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.015
COL5A1	collagen, type V, alpha 1	0.015
EFNB2	ephrin-B2	0.015
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.015
CAV2	caveolin 2	0.015
BTN3A2	butyrophilin, subfamily 3, member A2	0.015
PLTP	phospholipid transfer protein	0.015
NOG	noggin	0.015
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.015
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.015
ITGA6	integrin, alpha 6	0.014
SFRP4	secreted frizzled-related protein 4	0.014
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.014
RERE	arginine-glutamic acid dipeptide (RE) repeats	0.014
CTGF	connective tissue growth factor	0.014
SPTBN1	spectrin, beta, non-erythrocytic 1	0.014
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.014
PDGFA	platelet-derived growth factor alpha polypeptide	0.014
TTR	transthyretin	0.014
SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.014
BTN3A1	butyrophilin, subfamily 3, member A1	0.014
IRS2	insulin receptor substrate 2	0.013
THRB	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	0.013
PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	0.013
MEGF11	multiple EGF-like-domains 11	0.013
SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.013
INHBA	inhibin, beta A	0.013
CHRD	chordin	0.013
ACAN	aggrecan	0.013
BGN	biglycan	0.013
BAIAP2	BAI1-associated protein 2	0.013
CLEC4G	C-type lectin domain family 4, member G	0.013
PLCG1	phospholipase C, gamma 1	0.013
EPHA3	EPH receptor A3	0.013
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.013
PARP12	poly (ADP-ribose) polymerase family, member 12	0.013
PTPRD	protein tyrosine phosphatase, receptor type, D	0.013	Human
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.013
CALD1	caldesmon 1	0.013
RECK	reversion-inducing-cysteine-rich protein with kazal motifs	0.013
DST	dystonin	0.013
ADAR	adenosine deaminase, RNA-specific	0.012
TRANK1	tetratricopeptide repeat and ankyrin repeat containing 1	0.012
XAF1	XIAP associated factor 1	0.012
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.012
FN1	fibronectin 1	0.012
SSPN	sarcospan (Kras oncogene-associated gene)	0.012
HDAC3	histone deacetylase 3	0.012
PCDH9	protocadherin 9	0.012
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.012
LTBP4	latent transforming growth factor beta binding protein 4	0.012
ERC1	ELKS/RAB6-interacting/CAST family member 1	0.012
CSNK2A2	casein kinase 2, alpha prime polypeptide	0.012
RND3	Rho family GTPase 3	0.012
APOM	apolipoprotein M	0.012
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.012
NMI	N-myc (and STAT) interactor	0.012
KIF1C	kinesin family member 1C	0.012
TGFBR3	transforming growth factor, beta receptor III	0.012
VCAN	versican	0.012
TNXB	tenascin XB	0.012
SFRP1	secreted frizzled-related protein 1	0.012
HR	hairless homolog (mouse)	0.012
PAK4	p21 protein (Cdc42/Rac)-activated kinase 4	0.012
AEBP1	AE binding protein 1	0.012
FRS2	fibroblast growth factor receptor substrate 2	0.012
NCOA3	nuclear receptor coactivator 3	0.012
DLL4	delta-like 4 (Drosophila)	0.012
KIF1B	kinesin family member 1B	0.012
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.011
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.011
S100A1	S100 calcium binding protein A1	0.011
SCRT1	scratch homolog 1, zinc finger protein (Drosophila)	0.011
CPNE6	copine VI (neuronal)	0.011
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.011
SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	0.011
ELK1	ELK1, member of ETS oncogene family	0.011
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.011
LRP1	low density lipoprotein receptor-related protein 1	0.011
DLC1	deleted in liver cancer 1	0.011
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.011
EMP1	epithelial membrane protein 1	0.011
GATAD1	GATA zinc finger domain containing 1	0.011
GATA2	GATA binding protein 2	0.011
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.011
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.011
RXRB	retinoid X receptor, beta	0.011	Human
SH3BP4	SH3-domain binding protein 4	0.011
PDE4DIP	phosphodiesterase 4D interacting protein	0.011
S1PR1	sphingosine-1-phosphate receptor 1	0.011
LAMA5	laminin, alpha 5	0.011
FILIP1L	filamin A interacting protein 1-like	0.011
SEPT4	septin 4	0.011
LOXL2	lysyl oxidase-like 2	0.011
OGN	osteoglycin	0.011
ALB	albumin	0.011
NR2F1	nuclear receptor subfamily 2, group F, member 1	0.010	Human
TGIF1	TGFB-induced factor homeobox 1	0.010
NFIB	nuclear factor I/B	0.010
PRRX1	paired related homeobox 1	0.010
KLF7	Kruppel-like factor 7 (ubiquitous)	0.010	Human
PTPRG	protein tyrosine phosphatase, receptor type, G	0.010
THRAP3	thyroid hormone receptor associated protein 3	0.010
TIAM1	T-cell lymphoma invasion and metastasis 1	0.010
TUBA1A	tubulin, alpha 1a	0.010
RAB3IL1	RAB3A interacting protein (rabin3)-like 1	0.010
GPC3	glypican 3	0.010
MLL4	myeloid/lymphoid or mixed-lineage leukemia 4	0.010
TBX2	T-box 2	0.010
NOS3	nitric oxide synthase 3 (endothelial cell)	0.010
FRZB	frizzled-related protein	0.010
COL18A1	collagen, type XVIII, alpha 1	0.010
PPFIBP1	PTPRF interacting protein, binding protein 1 (liprin beta 1)	0.010
RXRG	retinoid X receptor, gamma	0.010	Human
APOC2	apolipoprotein C-II	0.010
FZD7	frizzled homolog 7 (Drosophila)	0.010