IMP

Process View

Homo sapiens

19 genes annotated in human

renal tubule development

The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "renal tubule development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "renal tubule development" (in gray)

Name	Description	Probability	Func Analog Organism
FGFR2	fibroblast growth factor receptor 2	1.000
JAG1	jagged 1	0.990	Mouse
NOTCH1	notch 1	0.935	Mouse Fly
NOTCH3	notch 3	0.931	Fly
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.926	Fly
SMAD3	SMAD family member 3	0.924
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.904	Human
FSTL1	follistatin-like 1	0.881
VEGFA	vascular endothelial growth factor A	0.786	Mouse Fly
EGR3	early growth response 3	0.771	Human
FGF10	fibroblast growth factor 10	0.768	Human
COL4A2	collagen, type IV, alpha 2	0.717	Human
FGF1	fibroblast growth factor 1 (acidic)	0.716
NRP1	neuropilin 1	0.704
WNK4	WNK lysine deficient protein kinase 4	0.642
KLHL3	kelch-like 3 (Drosophila)	0.641
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.601
CUL3	cullin 3	0.567
PAX8	paired box 8	0.565
BMPR1A	bone morphogenetic protein receptor, type IA	0.564	Fly
INSR	insulin receptor	0.552
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.532
ENG	endoglin	0.521
MEIS1	Meis homeobox 1	0.504
COL4A4	collagen, type IV, alpha 4	0.461	Human Fly
EGR2	early growth response 2	0.455	Human
COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	0.447	Human
EGR1	early growth response 1	0.404	Human
MEIS2	Meis homeobox 2	0.400
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.371
SKIL	SKI-like oncogene	0.364
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.342
COL4A5	collagen, type IV, alpha 5	0.340	Human Fly
IFNAR1	interferon (alpha, beta and omega) receptor 1	0.336
JAK1	Janus kinase 1	0.332
HDAC4	histone deacetylase 4	0.322
TSC22D4	TSC22 domain family, member 4	0.321
NKX2-1	NK2 homeobox 1	0.251
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.242
FGF8	fibroblast growth factor 8 (androgen-induced)	0.233
DAPK1	death-associated protein kinase 1	0.214
MSN	moesin	0.212
SMAD9	SMAD family member 9	0.204
ADAM17	ADAM metallopeptidase domain 17	0.184
TIMP3	TIMP metallopeptidase inhibitor 3	0.180
COL4A1	collagen, type IV, alpha 1	0.178
FGFR1	fibroblast growth factor receptor 1	0.177
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.157
IL4R	interleukin 4 receptor	0.151
MEOX1	mesenchyme homeobox 1	0.136
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.133
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.127	Fly
THBS1	thrombospondin 1	0.124
COL4A6	collagen, type IV, alpha 6	0.123	Human Fly
IRF9	interferon regulatory factor 9	0.119
TGFB2	transforming growth factor, beta 2	0.117
NOTCH2	notch 2	0.116	Mouse Fly
TCF4	transcription factor 4	0.110	Fly
GLIS2	GLIS family zinc finger 2	0.100
RUNX1	runt-related transcription factor 1	0.097
WNT1	wingless-type MMTV integration site family, member 1	0.095	Human Mouse Fly
BMP7	bone morphogenetic protein 7	0.095
PRMT6	protein arginine methyltransferase 6	0.094
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.094
FGF3	fibroblast growth factor 3	0.092	Human
FGF18	fibroblast growth factor 18	0.091
JAG2	jagged 2	0.083
BCL2L1	BCL2-like 1	0.083
COL2A1	collagen, type II, alpha 1	0.082
SPTBN1	spectrin, beta, non-erythrocytic 1	0.080
PJA1	praja ring finger 1	0.075
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.073
MAGED2	melanoma antigen family D, 2	0.071
NID1	nidogen 1	0.064
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.062
COL7A1	collagen, type VII, alpha 1	0.062
PARVA	parvin, alpha	0.061
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.060	Fly
STAP2	signal transducing adaptor family member 2	0.060
EPAS1	endothelial PAS domain protein 1	0.058
LAPTM5	lysosomal protein transmembrane 5	0.054
FGF7	fibroblast growth factor 7	0.054	Human
IL2RB	interleukin 2 receptor, beta	0.052
LBX1	ladybird homeobox 1	0.052
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.051
FGF4	fibroblast growth factor 4	0.051	Human
SMAD7	SMAD family member 7	0.051	Fly
TGFBR1	transforming growth factor, beta receptor 1	0.051
STAT1	signal transducer and activator of transcription 1, 91kDa	0.047
HOXA10	homeobox A10	0.047
HMGA2	high mobility group AT-hook 2	0.046
BBS4	Bardet-Biedl syndrome 4	0.046
CXXC5	CXXC finger protein 5	0.044
NCOR1	nuclear receptor corepressor 1	0.044
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.043	Fly
TAOK1	TAO kinase 1	0.042
IL12RB2	interleukin 12 receptor, beta 2	0.041
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.040
NCOR2	nuclear receptor corepressor 2	0.040
TP53BP2	tumor protein p53 binding protein, 2	0.039
DLL1	delta-like 1 (Drosophila)	0.039	Mouse
TMEM173	transmembrane protein 173	0.038
SFRP1	secreted frizzled-related protein 1	0.037
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.035
IER2	immediate early response 2	0.033
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.033
ZNF331	zinc finger protein 331	0.032
MDFI	MyoD family inhibitor	0.031
SOX1	SRY (sex determining region Y)-box 1	0.031
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.030
HOXB5	homeobox B5	0.030
FOXA2	forkhead box A2	0.030	Fly
HDAC9	histone deacetylase 9	0.029
HOXA11	homeobox A11	0.029	Mouse
CAPNS1	calpain, small subunit 1	0.029
SIM2	single-minded homolog 2 (Drosophila)	0.029
NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)	0.029
FGFR3	fibroblast growth factor receptor 3	0.028
HOXD13	homeobox D13	0.028
WNT7A	wingless-type MMTV integration site family, member 7A	0.028	Human
COL1A1	collagen, type I, alpha 1	0.027
BCL6	B-cell CLL/lymphoma 6	0.027
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.026
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.026
COIL	coilin	0.025
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.025
CLDN7	claudin 7	0.025
HNF1A	HNF1 homeobox A	0.025	Human
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.024
STC1	stanniocalcin 1	0.023
ACAA2	acetyl-CoA acyltransferase 2	0.023
CLDN4	claudin 4	0.023
PGR	progesterone receptor	0.023
HOXB9	homeobox B9	0.022
PDX1	pancreatic and duodenal homeobox 1	0.022
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.022
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.022
SNAI1	snail homolog 1 (Drosophila)	0.022	Fly
STAT2	signal transducer and activator of transcription 2, 113kDa	0.021	Human
CTTN	cortactin	0.021
SOCS1	suppressor of cytokine signaling 1	0.021
PAX2	paired box 2	0.021
INHBB	inhibin, beta B	0.020
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.020
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.020	Mouse
SLC3A2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	0.020
CD2BP2	CD2 (cytoplasmic tail) binding protein 2	0.019
MYOD1	myogenic differentiation 1	0.019
NOG	noggin	0.019	Mouse
SOX9	SRY (sex determining region Y)-box 9	0.019	Mouse
HOXB6	homeobox B6	0.019
PAX7	paired box 7	0.018
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.018
EYA2	eyes absent homolog 2 (Drosophila)	0.018
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.018
NEUROG2	neurogenin 2	0.018
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.018
TGFB3	transforming growth factor, beta 3	0.018
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.018
FAM46A	family with sequence similarity 46, member A	0.017
NFIB	nuclear factor I/B	0.017
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.017
OXSR1	oxidative-stress responsive 1	0.017
SMAD6	SMAD family member 6	0.017	Fly
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.017
HES2	hairy and enhancer of split 2 (Drosophila)	0.017
TP73	tumor protein p73	0.017
THBS2	thrombospondin 2	0.016
LMO4	LIM domain only 4	0.016
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.016
PXDN	peroxidasin homolog (Drosophila)	0.016
ZFYVE9	zinc finger, FYVE domain containing 9	0.016
TJP2	tight junction protein 2 (zona occludens 2)	0.016
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.016
GDNF	glial cell derived neurotrophic factor	0.016
EFNA1	ephrin-A1	0.016
HNF1B	HNF1 homeobox B	0.016
PGF	placental growth factor	0.015	Mouse
IRX4	iroquois homeobox 4	0.015
PCBD2	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	0.015
CLDN1	claudin 1	0.015
BAD	BCL2-associated agonist of cell death	0.015
MNX1	motor neuron and pancreas homeobox 1	0.015
SLC7A11	solute carrier family 7, (cationic amino acid transporter, y+ system) member 11	0.015
EFNB2	ephrin-B2	0.015
NOVA2	neuro-oncological ventral antigen 2	0.015
IRX5	iroquois homeobox 5	0.015
SIX2	SIX homeobox 2	0.015	Mouse
PIAS3	protein inhibitor of activated STAT, 3	0.015
WNT3	wingless-type MMTV integration site family, member 3	0.015	Human
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.015
MCAM	melanoma cell adhesion molecule	0.014
LIMS1	LIM and senescent cell antigen-like domains 1	0.014
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.014
COL5A1	collagen, type V, alpha 1	0.014
NKPD1	NTPase, KAP family P-loop domain containing 1	0.014
DLX4	distal-less homeobox 4	0.014
FOXC1	forkhead box C1	0.014
RAX	retina and anterior neural fold homeobox	0.014
ECEL1	endothelin converting enzyme-like 1	0.014
FZD8	frizzled homolog 8 (Drosophila)	0.014
DUSP6	dual specificity phosphatase 6	0.013
TEAD4	TEA domain family member 4	0.013
NOTCH2NL	notch 2 N-terminal like	0.013
COL16A1	collagen, type XVI, alpha 1	0.013
TINAGL1	tubulointerstitial nephritis antigen-like 1	0.013
MEF2A	myocyte enhancer factor 2A	0.013
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.013
HOXD11	homeobox D11	0.013	Mouse
RBPMS	RNA binding protein with multiple splicing	0.013
C5orf13	chromosome 5 open reading frame 13	0.012
FSCN2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	0.012
LHX1	LIM homeobox 1	0.012	Mouse
CSNK1E	casein kinase 1, epsilon	0.012
DGCR14	DiGeorge syndrome critical region gene 14	0.012
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.012
TBX5	T-box 5	0.012
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.012
IHH	Indian hedgehog	0.012
TBX2	T-box 2	0.012
MAML1	mastermind-like 1 (Drosophila)	0.012
AMOTL1	angiomotin like 1	0.012
FOXD3	forkhead box D3	0.012
CAPN1	calpain 1, (mu/I) large subunit	0.012
HBEGF	heparin-binding EGF-like growth factor	0.011
AQP5	aquaporin 5	0.011
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.011
HOXA9	homeobox A9	0.011
SDF4	stromal cell derived factor 4	0.011
MED28	mediator complex subunit 28	0.011
HMGA1	high mobility group AT-hook 1	0.011
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.011
VSX1	visual system homeobox 1	0.011
HOXB1	homeobox B1	0.011
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.011
FZD7	frizzled homolog 7 (Drosophila)	0.011
ZNF205	zinc finger protein 205	0.011
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.011
WNT5A	wingless-type MMTV integration site family, member 5A	0.011
PROX1	prospero homeobox 1	0.011
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.011
DNAJC1	DnaJ (Hsp40) homolog, subfamily C, member 1	0.011
EVC2	Ellis van Creveld syndrome 2	0.011
NPHP1	nephronophthisis 1 (juvenile)	0.011
OVOL1	ovo-like 1(Drosophila)	0.011
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.010
BBS1	Bardet-Biedl syndrome 1	0.010
NGFR	nerve growth factor receptor	0.010
ALX4	ALX homeobox 4	0.010
RSPO1	R-spondin homolog (Xenopus laevis)	0.010
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.010
LIFR	leukemia inhibitory factor receptor alpha	0.010
MAVS	mitochondrial antiviral signaling protein	0.010
EPHA8	EPH receptor A8	0.010
PARVB	parvin, beta	0.010
ZNF512B	zinc finger protein 512B	0.010
BTRC	beta-transducin repeat containing	0.010
PAX3	paired box 3	0.010