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Homo sapiens

28 genes annotated in human

collagen metabolic process

The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "collagen metabolic process"

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Name	Description	Probability	Func Analog Organism
COL1A1	collagen, type I, alpha 1	0.982
COL6A1	collagen, type VI, alpha 1	0.968
COL3A1	collagen, type III, alpha 1	0.905	Human
TEK	TEK tyrosine kinase, endothelial	0.863
COL6A2	collagen, type VI, alpha 2	0.780
BMPR1A	bone morphogenetic protein receptor, type IA	0.721
COL1A2	collagen, type I, alpha 2	0.704	Human
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.693
FLNA	filamin A, alpha	0.639
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.627	Mouse Rat
COL4A1	collagen, type IV, alpha 1	0.506
BMP1	bone morphogenetic protein 1	0.496
FGA	fibrinogen alpha chain	0.495
BGN	biglycan	0.472
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.451
COL4A2	collagen, type IV, alpha 2	0.416
CAV1	caveolin 1, caveolae protein, 22kDa	0.390
POSTN	periostin, osteoblast specific factor	0.384
COL5A2	collagen, type V, alpha 2	0.322	Human
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.303
COL5A1	collagen, type V, alpha 1	0.275
DDR2	discoidin domain receptor tyrosine kinase 2	0.262
TIMP1	TIMP metallopeptidase inhibitor 1	0.260
PCOLCE	procollagen C-endopeptidase enhancer	0.242
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.219
PXDN	peroxidasin homolog (Drosophila)	0.218
PCYT2	phosphate cytidylyltransferase 2, ethanolamine	0.199
TMBIM6	transmembrane BAX inhibitor motif containing 6	0.198
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.191
ALB	albumin	0.186
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.180
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.177
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.158	Human Mouse
FSTL1	follistatin-like 1	0.147
COL6A3	collagen, type VI, alpha 3	0.133
ANGPT2	angiopoietin 2	0.131	Human
ADAM12	ADAM metallopeptidase domain 12	0.130
THY1	Thy-1 cell surface antigen	0.128
SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	0.111	Mouse
THBS2	thrombospondin 2	0.103
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.103
MXRA5	matrix-remodelling associated 5	0.102
FBN1	fibrillin 1	0.102
CYR61	cysteine-rich, angiogenic inducer, 61	0.101
CD248	CD248 molecule, endosialin	0.097
THBS1	thrombospondin 1	0.094
LAMB1	laminin, beta 1	0.094
PDIA3	protein disulfide isomerase family A, member 3	0.091
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.089
LTBP2	latent transforming growth factor beta binding protein 2	0.086
FKBP10	FK506 binding protein 10, 65 kDa	0.082
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.081
FGG	fibrinogen gamma chain	0.078
WISP1	WNT1 inducible signaling pathway protein 1	0.078
CYTH1	cytohesin 1	0.077
LUM	lumican	0.072
MFAP2	microfibrillar-associated protein 2	0.071
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.071
TIMP2	TIMP metallopeptidase inhibitor 2	0.069
ANGPTL2	angiopoietin-like 2	0.068	Human
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.067	Human
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.063
GRB7	growth factor receptor-bound protein 7	0.063
PRSS3	protease, serine, 3	0.062
PLXDC1	plexin domain containing 1	0.060
CDCP1	CUB domain containing protein 1	0.060
PLOD1	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	0.057
FBLN2	fibulin 2	0.055
WNT2	wingless-type MMTV integration site family member 2	0.054	Human
S100B	S100 calcium binding protein B	0.054
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.053
NID2	nidogen 2 (osteonidogen)	0.053
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.053	Human
CD63	CD63 molecule	0.051
TMSB4X	thymosin beta 4, X-linked	0.051
HSPG2	heparan sulfate proteoglycan 2	0.051
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.050	Rat
EMILIN1	elastin microfibril interfacer 1	0.049
COMP	cartilage oligomeric matrix protein	0.048
IGFBP3	insulin-like growth factor binding protein 3	0.047
PRKCDBP	protein kinase C, delta binding protein	0.046
COL13A1	collagen, type XIII, alpha 1	0.046
SLC39A1	solute carrier family 39 (zinc transporter), member 1	0.046
C1S	complement component 1, s subcomponent	0.045
ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	0.043
PLEC	plectin	0.043
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.043
VCAN	versican	0.042
FGF18	fibroblast growth factor 18	0.042
COL11A1	collagen, type XI, alpha 1	0.042	Human
PTRF	polymerase I and transcript release factor	0.041
SDF4	stromal cell derived factor 4	0.041
LOXL2	lysyl oxidase-like 2	0.041
GLRX	glutaredoxin (thioltransferase)	0.040
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.040
LRRC15	leucine rich repeat containing 15	0.039
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.039
A2M	alpha-2-macroglobulin	0.038
COL14A1	collagen, type XIV, alpha 1	0.037
EHD2	EH-domain containing 2	0.037
ITGB5	integrin, beta 5	0.037	Human
INHBA	inhibin, beta A	0.037
C1R	complement component 1, r subcomponent	0.036
COL7A1	collagen, type VII, alpha 1	0.036
PDGFA	platelet-derived growth factor alpha polypeptide	0.034
CCL7	chemokine (C-C motif) ligand 7	0.034
COL5A3	collagen, type V, alpha 3	0.034	Human
CAV2	caveolin 2	0.033
FAP	fibroblast activation protein, alpha	0.032
COL10A1	collagen, type X, alpha 1	0.032
ITGB4	integrin, beta 4	0.031	Human
GLT8D2	glycosyltransferase 8 domain containing 2	0.031
PTEN	phosphatase and tensin homolog	0.031
TGFB1	transforming growth factor, beta 1	0.031
ECM1	extracellular matrix protein 1	0.031
PDPN	podoplanin	0.030
ACAN	aggrecan	0.030
MSC	musculin	0.030
LOXL1	lysyl oxidase-like 1	0.029
LOX	lysyl oxidase	0.029
SPON2	spondin 2, extracellular matrix protein	0.028
CD68	CD68 molecule	0.028
AEBP1	AE binding protein 1	0.028
MXRA8	matrix-remodelling associated 8	0.028
MMP19	matrix metallopeptidase 19	0.027	Human
UBE2J1	ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)	0.027
PLXND1	plexin D1	0.027
MYO10	myosin X	0.027
OSMR	oncostatin M receptor	0.026
DCN	decorin	0.026
NNMT	nicotinamide N-methyltransferase	0.026
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.025
HYAL1	hyaluronoglucosaminidase 1	0.025
LRRC17	leucine rich repeat containing 17	0.025
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.025	Rat
SFRP4	secreted frizzled-related protein 4	0.025
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.025
CCL11	chemokine (C-C motif) ligand 11	0.025
MRC2	mannose receptor, C type 2	0.025
FMOD	fibromodulin	0.025
BMP8A	bone morphogenetic protein 8a	0.024
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.024
SPHK1	sphingosine kinase 1	0.024
VEGFC	vascular endothelial growth factor C	0.024
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.023
ISLR	immunoglobulin superfamily containing leucine-rich repeat	0.023
AMBP	alpha-1-microglobulin/bikunin precursor	0.023
PRRX2	paired related homeobox 2	0.023
GLT25D1	glycosyltransferase 25 domain containing 1	0.023
MMP13	matrix metallopeptidase 13 (collagenase 3)	0.022
ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	0.022
CXCL9	chemokine (C-X-C motif) ligand 9	0.022
CSTA	cystatin A (stefin A)	0.022
TGFB3	transforming growth factor, beta 3	0.021
CXCL12	chemokine (C-X-C motif) ligand 12	0.021
OLFML2B	olfactomedin-like 2B	0.021
ITGA6	integrin, alpha 6	0.021
EGLN3	egl nine homolog 3 (C. elegans)	0.020
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.020	Human Mouse Rat
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.020
FLOT1	flotillin 1	0.020
BMP4	bone morphogenetic protein 4	0.020
PLAT	plasminogen activator, tissue	0.020
FCGRT	Fc fragment of IgG, receptor, transporter, alpha	0.020
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.020	Human
EGFL6	EGF-like-domain, multiple 6	0.020
FIS1	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)	0.020
COL16A1	collagen, type XVI, alpha 1	0.020
FBLN1	fibulin 1	0.019
PTK7	PTK7 protein tyrosine kinase 7	0.019
COL2A1	collagen, type II, alpha 1	0.019	Human
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.019
SDC2	syndecan 2	0.019
ANGPTL4	angiopoietin-like 4	0.019
LAMC2	laminin, gamma 2	0.019
F3	coagulation factor III (thromboplastin, tissue factor)	0.019
NRP1	neuropilin 1	0.019
FLNB	filamin B, beta	0.019
FGB	fibrinogen beta chain	0.018	Human
TNC	tenascin C	0.018	Human
CD81	CD81 molecule	0.018
GPNMB	glycoprotein (transmembrane) nmb	0.018
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.017
DPT	dermatopontin	0.017
STRA6	stimulated by retinoic acid gene 6 homolog (mouse)	0.017
C2	complement component 2	0.017
APOE	apolipoprotein E	0.017
PLG	plasminogen	0.017
GPR124	G protein-coupled receptor 124	0.017
EPHB2	EPH receptor B2	0.017
CSF3	colony stimulating factor 3 (granulocyte)	0.017
SYK	spleen tyrosine kinase	0.017
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.016
CD34	CD34 molecule	0.016
GGT5	gamma-glutamyltransferase 5	0.016
ADAM9	ADAM metallopeptidase domain 9	0.016
STC1	stanniocalcin 1	0.016
CST1	cystatin SN	0.016	Human
PLAUR	plasminogen activator, urokinase receptor	0.016
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.016
IL32	interleukin 32	0.016
LGMN	legumain	0.016
LRP1	low density lipoprotein receptor-related protein 1	0.016
EHMT2	euchromatic histone-lysine N-methyltransferase 2	0.016
LAMA4	laminin, alpha 4	0.015
RARRES2	retinoic acid receptor responder (tazarotene induced) 2	0.015
DIO2	deiodinase, iodothyronine, type II	0.015
DMWD	dystrophia myotonica, WD repeat containing	0.015
RANBP9	RAN binding protein 9	0.015
OLFML3	olfactomedin-like 3	0.015
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.015
FOXF2	forkhead box F2	0.015
VWF	von Willebrand factor	0.015
GAS1	growth arrest-specific 1	0.015
PROCR	protein C receptor, endothelial	0.014
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.014
PTHLH	parathyroid hormone-like hormone	0.014
FGF4	fibroblast growth factor 4	0.014
NBL1	neuroblastoma, suppression of tumorigenicity 1	0.014
ANXA5	annexin A5	0.014
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.014
NOG	noggin	0.014
WNT4	wingless-type MMTV integration site family, member 4	0.014
MFGE8	milk fat globule-EGF factor 8 protein	0.014
IGFBP4	insulin-like growth factor binding protein 4	0.014
ESM1	endothelial cell-specific molecule 1	0.014
CST4	cystatin S	0.014	Human
F2	coagulation factor II (thrombin)	0.014
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.014
CXCL10	chemokine (C-X-C motif) ligand 10	0.014
CLIC4	chloride intracellular channel 4	0.014
PLAU	plasminogen activator, urokinase	0.014
MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	0.014	Human
CD151	CD151 molecule (Raph blood group)	0.014
CCND2	cyclin D2	0.013
CHPF	chondroitin polymerizing factor	0.013
LAMB3	laminin, beta 3	0.013
FSTL3	follistatin-like 3 (secreted glycoprotein)	0.013
KCND2	potassium voltage-gated channel, Shal-related subfamily, member 2	0.013
PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	0.013	Worm
EGLN1	egl nine homolog 1 (C. elegans)	0.013
PRRX1	paired related homeobox 1	0.013
F2R	coagulation factor II (thrombin) receptor	0.013
PDCD1	programmed cell death 1	0.013
EPAS1	endothelial PAS domain protein 1	0.013
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.013	Mouse
ADAMTS7	ADAM metallopeptidase with thrombospondin type 1 motif, 7	0.013	Human
CTHRC1	collagen triple helix repeat containing 1	0.013
NOTCH3	notch 3	0.013
EXT2	exostosin 2	0.013
HTRA1	HtrA serine peptidase 1	0.013
TMEM158	transmembrane protein 158 (gene/pseudogene)	0.013
P2RX2	purinergic receptor P2X, ligand-gated ion channel, 2	0.013
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.013
VTN	vitronectin	0.013
DLC1	deleted in liver cancer 1	0.012
GREM1	gremlin 1	0.012
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.012
PDLIM4	PDZ and LIM domain 4	0.012
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.012
ZNF431	zinc finger protein 431	0.012
CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)	0.012
P4HA2	prolyl 4-hydroxylase, alpha polypeptide II	0.012
IL11	interleukin 11	0.012
ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.012
BDNF	brain-derived neurotrophic factor	0.012
PLTP	phospholipid transfer protein	0.012
CRELD2	cysteine-rich with EGF-like domains 2	0.012
SPP1	secreted phosphoprotein 1	0.012
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.012
CTSK	cathepsin K	0.012
CCL5	chemokine (C-C motif) ligand 5	0.012
WIF1	WNT inhibitory factor 1	0.012
TWIST1	twist homolog 1 (Drosophila)	0.012
TSPAN9	tetraspanin 9	0.011
CTSA	cathepsin A	0.011
NID1	nidogen 1	0.011
TMEM45A	transmembrane protein 45A	0.011
LRRC32	leucine rich repeat containing 32	0.011
ROR2	receptor tyrosine kinase-like orphan receptor 2	0.011
HMGA2	high mobility group AT-hook 2	0.011
GBP2	guanylate binding protein 2, interferon-inducible	0.011
BCAR1	breast cancer anti-estrogen resistance 1	0.011
CCL22	chemokine (C-C motif) ligand 22	0.011
WISP2	WNT1 inducible signaling pathway protein 2	0.011
UNC5B	unc-5 homolog B (C. elegans)	0.011
MOXD1	monooxygenase, DBH-like 1	0.011
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.011
APOA2	apolipoprotein A-II	0.011
ITGA11	integrin, alpha 11	0.011
VAV1	vav 1 guanine nucleotide exchange factor	0.011
DOCK7	dedicator of cytokinesis 7	0.011
SFRP2	secreted frizzled-related protein 2	0.011
GAS6	growth arrest-specific 6	0.011
UBD	ubiquitin D	0.011
ADAMTSL2	ADAMTS-like 2	0.011
PPIC	peptidylprolyl isomerase C (cyclophilin C)	0.011
CLDN1	claudin 1	0.011
GANAB	glucosidase, alpha; neutral AB	0.011
CCIN	calicin	0.011
C6orf62	chromosome 6 open reading frame 62	0.011
HRH1	histamine receptor H1	0.011
KIAA1644	KIAA1644	0.011
COL8A2	collagen, type VIII, alpha 2	0.011
TPSD1	tryptase delta 1	0.011
CCDC80	coiled-coil domain containing 80	0.011
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.011
IFNGR1	interferon gamma receptor 1	0.011
KIRREL	kin of IRRE like (Drosophila)	0.011
CFD	complement factor D (adipsin)	0.011
SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.011
MEP1A	meprin A, alpha (PABA peptide hydrolase)	0.011
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.011
SLIT3	slit homolog 3 (Drosophila)	0.011
CYTIP	cytohesin 1 interacting protein	0.011
LHFPL2	lipoma HMGIC fusion partner-like 2	0.010
MDFI	MyoD family inhibitor	0.010
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.010
S100A3	S100 calcium binding protein A3	0.010
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.010
NGF	nerve growth factor (beta polypeptide)	0.010
SHOX2	short stature homeobox 2	0.010
FST	follistatin	0.010
TTR	transthyretin	0.010
CHIT1	chitinase 1 (chitotriosidase)	0.010
GLI3	GLI family zinc finger 3	0.010
PYY	peptide YY	0.010
IGF1	insulin-like growth factor 1 (somatomedin C)	0.010
FMO1	flavin containing monooxygenase 1	0.010
HGFAC	HGF activator	0.010