IMP

Process View

Homo sapiens

7 genes annotated in human

alpha beta t cell differentiation

The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "alpha beta t cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "alpha beta t cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.999
IL4R	interleukin 4 receptor	0.997	Mouse
LCK	lymphocyte-specific protein tyrosine kinase	0.996
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.994
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.911	Mouse
NCOR2	nuclear receptor corepressor 2	0.877
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.862
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.753
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.738
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.729
BIRC3	baculoviral IAP repeat containing 3	0.689
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.574
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.553
LIN9	lin-9 homolog (C. elegans)	0.443
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.329	Mouse
CD247	CD247 molecule	0.320
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.316
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.312
RXRA	retinoid X receptor, alpha	0.294
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.259
BCL3	B-cell CLL/lymphoma 3	0.238	Mouse
TRAF1	TNF receptor-associated factor 1	0.224
PPARA	peroxisome proliferator-activated receptor alpha	0.188
IL23A	interleukin 23, alpha subunit p19	0.181	Mouse
PML	promyelocytic leukemia	0.133
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.119
IL4	interleukin 4	0.110	Mouse
IL2RG	interleukin 2 receptor, gamma	0.103	Mouse
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.089
EP300	E1A binding protein p300	0.078
HDAC7	histone deacetylase 7	0.078
CTBP1	C-terminal binding protein 1	0.076
RUNX3	runt-related transcription factor 3	0.070
VAV1	vav 1 guanine nucleotide exchange factor	0.069
PDZD11	PDZ domain containing 11	0.065
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.064
SMAD4	SMAD family member 4	0.064
SPRR2A	small proline-rich protein 2A	0.057
MEOX1	mesenchyme homeobox 1	0.054
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.051	Mouse
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.050
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.046
LIN54	lin-54 homolog (C. elegans)	0.046
HDAC4	histone deacetylase 4	0.043
IL2RB	interleukin 2 receptor, beta	0.042
CSNK1G1	casein kinase 1, gamma 1	0.040
TNIP2	TNFAIP3 interacting protein 2	0.038
IL6R	interleukin 6 receptor	0.037
CCR7	chemokine (C-C motif) receptor 7	0.037
GRAP2	GRB2-related adaptor protein 2	0.033
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.032
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.030
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.030
IL7R	interleukin 7 receptor	0.030
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.030
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.028
TRAF3	TNF receptor-associated factor 3	0.028
HDAC9	histone deacetylase 9	0.028
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.027
TRAT1	T cell receptor associated transmembrane adaptor 1	0.026
PRKCE	protein kinase C, epsilon	0.026
PIAS1	protein inhibitor of activated STAT, 1	0.026
LAT	linker for activation of T cells	0.025
ICAM1	intercellular adhesion molecule 1	0.025
CD2	CD2 molecule	0.023
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.023
MED25	mediator complex subunit 25	0.022
TGFB3	transforming growth factor, beta 3	0.022
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.022
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.021
H2AFX	H2A histone family, member X	0.021
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.021
PLCG1	phospholipase C, gamma 1	0.021
BCL2L1	BCL2-like 1	0.020
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.020
TGFB1	transforming growth factor, beta 1	0.019
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.019
HDAC5	histone deacetylase 5	0.019
RBMX2	RNA binding motif protein, X-linked 2	0.019
TNIP1	TNFAIP3 interacting protein 1	0.018
RARA	retinoic acid receptor, alpha	0.018
IRF4	interferon regulatory factor 4	0.017	Mouse
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.017
E2F4	E2F transcription factor 4, p107/p130-binding	0.017
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.017
NLK	nemo-like kinase	0.017
ESR1	estrogen receptor 1	0.017
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.016
PLXND1	plexin D1	0.016
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.015
RB1	retinoblastoma 1	0.015
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.015
E2F1	E2F transcription factor 1	0.015
TRAF3IP3	TRAF3 interacting protein 3	0.015
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.014
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.014
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.013
CD7	CD7 molecule	0.013
CD6	CD6 molecule	0.013
SLA	Src-like-adaptor	0.013
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.012
HDAC3	histone deacetylase 3	0.012
IRF8	interferon regulatory factor 8	0.012
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.012
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.011
GATA4	GATA binding protein 4	0.011
KSR1	kinase suppressor of ras 1	0.011
ZNF148	zinc finger protein 148	0.011
ITK	IL2-inducible T-cell kinase	0.011	Mouse
GRB2	growth factor receptor-bound protein 2	0.010
TBX21	T-box 21	0.010	Human
ZHX1	zinc fingers and homeoboxes 1	0.010
HDAC10	histone deacetylase 10	0.010
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.010
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.010