IMP
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negative regulation of gene expression epigenetic
Any epigenetic process that stops, prevents or reduces the rate of gene expression.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of gene expression epigenetic"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| HDAC1 | histone deacetylase 1 | 0.999 | Human Fly | |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.952 | ||
| HDAC2 | histone deacetylase 2 | 0.943 | ||
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 0.933 | Yeast Mouse | |
| CBX5 | chromobox homolog 5 | 0.905 | Fly | |
| UHRF1 | ubiquitin-like with PHD and ring finger domains 1 | 0.835 | ||
| ACTL6A | actin-like 6A | 0.700 | ||
| RBBP4 | retinoblastoma binding protein 4 | 0.519 | Yeast Fly | |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | 0.496 | ||
| RB1 | retinoblastoma 1 | 0.459 | ||
| PCNA | proliferating cell nuclear antigen | 0.419 | ||
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.371 | ||
| YY1 | YY1 transcription factor | 0.368 | Fly | |
| SIN3A | SIN3 homolog A, transcription regulator (yeast) | 0.328 | ||
| MCM6 | minichromosome maintenance complex component 6 | 0.310 | ||
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.306 | ||
| HIST1H3B | histone cluster 1, H3b | 0.263 | ||
| MCM7 | minichromosome maintenance complex component 7 | 0.251 | Yeast | |
| HCFC1 | host cell factor C1 (VP16-accessory protein) | 0.169 | ||
| SUMO1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) | 0.167 | ||
| CHAF1A | chromatin assembly factor 1, subunit A (p150) | 0.161 | ||
| SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | 0.156 | ||
| NBN | nibrin | 0.149 | ||
| DAXX | death-domain associated protein | 0.146 | ||
| PARP1 | poly (ADP-ribose) polymerase 1 | 0.139 | ||
| TMPO | thymopoietin | 0.136 | ||
| EED | embryonic ectoderm development | 0.131 | Fly | |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | 0.130 | Yeast | |
| BMI1 | BMI1 polycomb ring finger oncogene | 0.128 | Fly | |
| THOC4 | THO complex 4 | 0.124 | ||
| MED15 | mediator complex subunit 15 | 0.120 | ||
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | 0.109 | ||
| MYC | v-myc myelocytomatosis viral oncogene homolog (avian) | 0.109 | ||
| UBE2B | ubiquitin-conjugating enzyme E2B (RAD6 homolog) | 0.107 | Yeast Mouse | |
| HIST1H2AI | histone cluster 1, H2ai | 0.104 | Yeast | |
| BCOR | BCL6 corepressor | 0.102 | ||
| WDR5 | WD repeat domain 5 | 0.100 | ||
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.099 | ||
| MRFAP1 | Morf4 family associated protein 1 | 0.094 | ||
| HDAC3 | histone deacetylase 3 | 0.093 | ||
| KAT5 | K(lysine) acetyltransferase 5 | 0.093 | Yeast | |
| BRCA1 | breast cancer 1, early onset | 0.090 | ||
| MCM2 | minichromosome maintenance complex component 2 | 0.089 | ||
| ESR1 | estrogen receptor 1 | 0.089 | ||
| HIST1H2AM | histone cluster 1, H2am | 0.089 | ||
| CBX8 | chromobox homolog 8 | 0.086 | ||
| SUMO2 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) | 0.081 | ||
| HIST1H3D | histone cluster 1, H3d | 0.078 | Yeast | |
| RING1 | ring finger protein 1 | 0.078 | Fly | |
| TP53 | tumor protein p53 | 0.074 | ||
| SUZ12 | suppressor of zeste 12 homolog (Drosophila) | 0.074 | ||
| CHD8 | chromodomain helicase DNA binding protein 8 | 0.074 | ||
| CDC6 | cell division cycle 6 homolog (S. cerevisiae) | 0.073 | ||
| PBRM1 | polybromo 1 | 0.071 | Fly | |
| HIST1H4D | histone cluster 1, H4d | 0.070 | Yeast | |
| HIST1H2BG | histone cluster 1, H2bg | 0.069 | ||
| ORC3 | origin recognition complex, subunit 3 | 0.068 | ||
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.067 | ||
| KDM1A | lysine (K)-specific demethylase 1A | 0.066 | ||
| CBX3 | chromobox homolog 3 | 0.065 | Fly | |
| RUVBL1 | RuvB-like 1 (E. coli) | 0.064 | ||
| UBE2I | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 0.060 | ||
| DICER1 | dicer 1, ribonuclease type III | 0.058 | ||
| RBBP7 | retinoblastoma binding protein 7 | 0.055 | Yeast Fly | |
| HIST1H3A | histone cluster 1, H3a | 0.055 | ||
| HIST1H2AB | histone cluster 1, H2ab | 0.054 | Yeast | |
| SP1 | Sp1 transcription factor | 0.052 | ||
| CBX1 | chromobox homolog 1 | 0.051 | Fly | |
| NCAPH | non-SMC condensin I complex, subunit H | 0.050 | ||
| RNF2 | ring finger protein 2 | 0.048 | Fly | |
| USP11 | ubiquitin specific peptidase 11 | 0.048 | ||
| HIST1H2AE | histone cluster 1, H2ae | 0.046 | Yeast | |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.045 | Fly | |
| POLE2 | polymerase (DNA directed), epsilon 2 (p59 subunit) | 0.044 | ||
| MTA1 | metastasis associated 1 | 0.044 | ||
| CDC7 | cell division cycle 7 homolog (S. cerevisiae) | 0.043 | Yeast | |
| CHAF1B | chromatin assembly factor 1, subunit B (p60) | 0.042 | ||
| MCM4 | minichromosome maintenance complex component 4 | 0.042 | ||
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.041 | ||
| CDC73 | cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 0.040 | ||
| SAP30 | Sin3A-associated protein, 30kDa | 0.040 | ||
| HIST2H3C | histone cluster 2, H3c | 0.040 | ||
| MSH6 | mutS homolog 6 (E. coli) | 0.039 | ||
| ADNP | activity-dependent neuroprotector homeobox | 0.039 | ||
| ING3 | inhibitor of growth family, member 3 | 0.037 | ||
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.037 | ||
| TRIM28 | tripartite motif containing 28 | 0.037 | ||
| MORF4L1 | mortality factor 4 like 1 | 0.036 | Fly | |
| ASF1B | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) | 0.035 | Yeast | |
| MCM5 | minichromosome maintenance complex component 5 | 0.035 | Yeast | |
| LEO1 | Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 0.034 | ||
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.033 | Fly | |
| EP300 | E1A binding protein p300 | 0.033 | ||
| TFDP1 | transcription factor Dp-1 | 0.033 | ||
| HIST1H2AJ | histone cluster 1, H2aj | 0.032 | Yeast | |
| H2AFZ | H2A histone family, member Z | 0.032 | Yeast | |
| HIST1H2AL | histone cluster 1, H2al | 0.032 | Yeast | |
| MCM10 | minichromosome maintenance complex component 10 | 0.032 | Fly | |
| MBD1 | methyl-CpG binding domain protein 1 | 0.032 | ||
| MORF4L2 | mortality factor 4 like 2 | 0.031 | Fly | |
| EZH2 | enhancer of zeste homolog 2 (Drosophila) | 0.031 | ||
| ORC6 | origin recognition complex, subunit 6 | 0.031 | ||
| MYST1 | MYST histone acetyltransferase 1 | 0.030 | ||
| HIST1H4B | histone cluster 1, H4b | 0.030 | Yeast | |
| UBE2A | ubiquitin-conjugating enzyme E2A (RAD6 homolog) | 0.029 | Yeast | |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.028 | Yeast Mouse | |
| RAD18 | RAD18 homolog (S. cerevisiae) | 0.028 | ||
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.028 | ||
| E2F3 | E2F transcription factor 3 | 0.028 | ||
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.027 | ||
| HIST1H2BJ | histone cluster 1, H2bj | 0.025 | ||
| POLD1 | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 0.025 | ||
| SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | 0.025 | ||
| ORC2 | origin recognition complex, subunit 2 | 0.024 | Yeast | |
| ENO1 | enolase 1, (alpha) | 0.024 | ||
| TRIM39 | tripartite motif containing 39 | 0.024 | Human | |
| EIF2C1 | eukaryotic translation initiation factor 2C, 1 | 0.023 | Fly | |
| POLE3 | polymerase (DNA directed), epsilon 3 (p17 subunit) | 0.023 | Yeast | |
| HIST1H4E | histone cluster 1, H4e | 0.023 | Yeast | |
| SSRP1 | structure specific recognition protein 1 | 0.023 | ||
| NCBP1 | nuclear cap binding protein subunit 1, 80kDa | 0.022 | ||
| MBD2 | methyl-CpG binding domain protein 2 | 0.022 | ||
| HIST1H4A | histone cluster 1, H4a | 0.022 | Yeast | |
| ORC1 | origin recognition complex, subunit 1 | 0.022 | ||
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | 0.022 | ||
| H2AFX | H2A histone family, member X | 0.022 | Yeast | |
| LRIF1 | ligand dependent nuclear receptor interacting factor 1 | 0.021 | ||
| KIAA0101 | KIAA0101 | 0.021 | ||
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | 0.021 | ||
| RTF1 | Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 0.021 | ||
| MTA3 | metastasis associated 1 family, member 3 | 0.021 | ||
| MLL | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) | 0.021 | Yeast | |
| NIPBL | Nipped-B homolog (Drosophila) | 0.021 | ||
| HIST1H4H | histone cluster 1, H4h | 0.021 | Yeast | |
| POGZ | pogo transposable element with ZNF domain | 0.020 | ||
| PCGF1 | polycomb group ring finger 1 | 0.020 | ||
| TRIM5 | tripartite motif containing 5 | 0.019 | Human | |
| C20orf20 | chromosome 20 open reading frame 20 | 0.019 | ||
| MRFAP1L1 | Morf4 family associated protein 1-like 1 | 0.019 | ||
| SKP1 | S-phase kinase-associated protein 1 | 0.019 | ||
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.019 | ||
| RANBP2 | RAN binding protein 2 | 0.019 | ||
| HIST1H2BM | histone cluster 1, H2bm | 0.019 | ||
| CBX7 | chromobox homolog 7 | 0.019 | ||
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.019 | ||
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.018 | Mouse | |
| ORC4 | origin recognition complex, subunit 4 | 0.018 | Yeast | |
| SFPQ | splicing factor proline/glutamine-rich | 0.018 | ||
| NONO | non-POU domain containing, octamer-binding | 0.018 | ||
| WDR61 | WD repeat domain 61 | 0.017 | ||
| SMC4 | structural maintenance of chromosomes 4 | 0.017 | ||
| ORC5 | origin recognition complex, subunit 5 | 0.017 | Yeast | |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.017 | ||
| HIST1H2AK | histone cluster 1, H2ak | 0.017 | Yeast | |
| CXXC1 | CXXC finger protein 1 | 0.017 | ||
| MTA2 | metastasis associated 1 family, member 2 | 0.017 | ||
| FOXD3 | forkhead box D3 | 0.017 | ||
| HIST1H4I | histone cluster 1, H4i | 0.016 | Yeast | |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) | 0.016 | ||
| SOX10 | SRY (sex determining region Y)-box 10 | 0.016 | ||
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | 0.016 | ||
| RYBP | RING1 and YY1 binding protein | 0.016 | ||
| NCAPG | non-SMC condensin I complex, subunit G | 0.016 | ||
| LBR | lamin B receptor | 0.016 | ||
| PTMA | prothymosin, alpha | 0.015 | ||
| HIST1H4F | histone cluster 1, H4f | 0.015 | Yeast | |
| RCOR1 | REST corepressor 1 | 0.015 | ||
| POLA2 | polymerase (DNA directed), alpha 2 (70kD subunit) | 0.015 | ||
| CDT1 | chromatin licensing and DNA replication factor 1 | 0.015 | ||
| MAGOH | mago-nashi homolog, proliferation-associated (Drosophila) | 0.015 | ||
| CSNK2A1 | casein kinase 2, alpha 1 polypeptide | 0.015 | ||
| CTR9 | Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 0.015 | Yeast | |
| PCGF2 | polycomb group ring finger 2 | 0.015 | Fly | |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.015 | Fly | |
| HIST1H2BB | histone cluster 1, H2bb | 0.014 | ||
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.014 | Fly | |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.014 | ||
| GATAD2B | GATA zinc finger domain containing 2B | 0.014 | ||
| ZBTB8A | zinc finger and BTB domain containing 8A | 0.014 | ||
| EIF2C2 | eukaryotic translation initiation factor 2C, 2 | 0.014 | Fly | |
| TYMS | thymidylate synthetase | 0.014 | ||
| UBE2D4 | ubiquitin-conjugating enzyme E2D 4 (putative) | 0.014 | ||
| PHF10 | PHD finger protein 10 | 0.014 | ||
| TRRAP | transformation/transcription domain-associated protein | 0.013 | ||
| RNF20 | ring finger protein 20 | 0.013 | ||
| MEN1 | multiple endocrine neoplasia I | 0.013 | ||
| THOC2 | THO complex 2 | 0.013 | ||
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.013 | ||
| CDYL | chromodomain protein, Y-like | 0.013 | ||
| WHSC1 | Wolf-Hirschhorn syndrome candidate 1 | 0.013 | ||
| PAX3 | paired box 3 | 0.013 | ||
| TRIM21 | tripartite motif containing 21 | 0.013 | Human | |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.013 | Human | |
| HIST1H2BN | histone cluster 1, H2bn | 0.012 | ||
| MECP2 | methyl CpG binding protein 2 (Rett syndrome) | 0.012 | Mouse | |
| PAXIP1 | PAX interacting (with transcription-activation domain) protein 1 | 0.012 | ||
| GATAD2A | GATA zinc finger domain containing 2A | 0.012 | ||
| HIST1H3G | histone cluster 1, H3g | 0.012 | ||
| APPL1 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 | 0.012 | ||
| RSF1 | remodeling and spacing factor 1 | 0.012 | ||
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 0.012 | ||
| MYBL2 | v-myb myeloblastosis viral oncogene homolog (avian)-like 2 | 0.012 | ||
| BPTF | bromodomain PHD finger transcription factor | 0.012 | ||
| HIST1H4J | histone cluster 1, H4j | 0.012 | Yeast | |
| RSBN1 | round spermatid basic protein 1 | 0.011 | ||
| HIST2H4A | histone cluster 2, H4a | 0.011 | ||
| SOX2 | SRY (sex determining region Y)-box 2 | 0.011 | ||
| HIST1H2BI | histone cluster 1, H2bi | 0.011 | ||
| BCL11B | B-cell CLL/lymphoma 11B (zinc finger protein) | 0.011 | ||
| ZNF512B | zinc finger protein 512B | 0.011 | ||
| TRIM34 | tripartite motif containing 34 | 0.011 | ||
| SET | SET nuclear oncogene | 0.011 | ||
| HIST1H2BO | histone cluster 1, H2bo | 0.011 | ||
| HIST1H2AG | histone cluster 1, H2ag | 0.011 | Yeast | |
| FLNA | filamin A, alpha | 0.011 | ||
| SP100 | SP100 nuclear antigen | 0.011 | ||
| MCM3 | minichromosome maintenance complex component 3 | 0.011 | Yeast | |
| CDC14B | CDC14 cell division cycle 14 homolog B (S. cerevisiae) | 0.011 | ||
| HIST4H4 | histone cluster 4, H4 | 0.011 | Yeast | |
| PCGF6 | polycomb group ring finger 6 | 0.011 | ||
| SMC2 | structural maintenance of chromosomes 2 | 0.011 | ||
| UBXN7 | UBX domain protein 7 | 0.011 | ||
| BUB3 | budding uninhibited by benzimidazoles 3 homolog (yeast) | 0.011 | ||
| ZNF263 | zinc finger protein 263 | 0.011 | ||
| DPY30 | dpy-30 homolog (C. elegans) | 0.011 | ||
| HIST1H3H | histone cluster 1, H3h | 0.011 | ||
| ILF2 | interleukin enhancer binding factor 2, 45kDa | 0.011 | ||
| MBD4 | methyl-CpG binding domain protein 4 | 0.010 | ||
| ACTR5 | ARP5 actin-related protein 5 homolog (yeast) | 0.010 | ||
| DTL | denticleless homolog (Drosophila) | 0.010 | ||
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.010 | ||
| PHF19 | PHD finger protein 19 | 0.010 | ||
| RNASEH2A | ribonuclease H2, subunit A | 0.010 |