IMP

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Homo sapiens

3 genes annotated in human

striated muscle cell apoptotic process

A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "striated muscle cell apoptotic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "striated muscle cell apoptotic process" (in gray)

Name	Description	Probability	Func Analog Organism
TBX5	T-box 5	0.918
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.843
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.752
IRS1	insulin receptor substrate 1	0.343
INSR	insulin receptor	0.341	Human
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.338
CAMK2B	calcium/calmodulin-dependent protein kinase II beta	0.335
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.293
GAB1	GRB2-associated binding protein 1	0.291
PAX8	paired box 8	0.282
EGFR	epidermal growth factor receptor	0.234
GATA4	GATA binding protein 4	0.231
DLG4	discs, large homolog 4 (Drosophila)	0.150
BLOC1S2	biogenesis of lysosomal organelles complex-1, subunit 2	0.144
GRB10	growth factor receptor-bound protein 10	0.140
SBF1	SET binding factor 1	0.135
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.124
FGFR1	fibroblast growth factor receptor 1	0.123
HSPA1A	heat shock 70kDa protein 1A	0.123
HSPA1B	heat shock 70kDa protein 1B	0.106
HTT	huntingtin	0.097
CARD11	caspase recruitment domain family, member 11	0.087
MAPK3	mitogen-activated protein kinase 3	0.086
SIRT3	sirtuin 3	0.082
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.081
GHR	growth hormone receptor	0.078
EPOR	erythropoietin receptor	0.077
NOG	noggin	0.075
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.071
PARVA	parvin, alpha	0.070
CAPZB	capping protein (actin filament) muscle Z-line, beta	0.070
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.068
IRS2	insulin receptor substrate 2	0.066
PARVB	parvin, beta	0.057
PTS	6-pyruvoyltetrahydropterin synthase	0.053
FUNDC2	FUN14 domain containing 2	0.050
IGF1R	insulin-like growth factor 1 receptor	0.049	Human
GRIA4	glutamate receptor, ionotrophic, AMPA 4	0.048
SH2B1	SH2B adaptor protein 1	0.047
HSPA4	heat shock 70kDa protein 4	0.046
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.045
LAT	linker for activation of T cells	0.045
C1orf93	chromosome 1 open reading frame 93	0.045
FHOD3	formin homology 2 domain containing 3	0.042
HSPB1	heat shock 27kDa protein 1	0.042
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.041
ILK	integrin-linked kinase	0.041	Rat
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.041
GNG5	guanine nucleotide binding protein (G protein), gamma 5	0.040
GAB2	GRB2-associated binding protein 2	0.039
PEA15	phosphoprotein enriched in astrocytes 15	0.035
C12orf4	chromosome 12 open reading frame 4	0.035
RHOA	ras homolog gene family, member A	0.034
PRKCE	protein kinase C, epsilon	0.033
HSF1	heat shock transcription factor 1	0.033
BAG1	BCL2-associated athanogene	0.032
IGSF21	immunoglobin superfamily, member 21	0.030
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.030
ZHX1	zinc fingers and homeoboxes 1	0.028
STAT5B	signal transducer and activator of transcription 5B	0.027
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.027
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.025
NCF2	neutrophil cytosolic factor 2	0.025
SESN2	sestrin 2	0.025
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.024
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.023
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.022
JAK3	Janus kinase 3	0.022
TRPV6	transient receptor potential cation channel, subfamily V, member 6	0.022
OPTN	optineurin	0.022
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.022
SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	0.022
GSK3B	glycogen synthase kinase 3 beta	0.021
AIG1	androgen-induced 1	0.021
PDX1	pancreatic and duodenal homeobox 1	0.021
SIX6	SIX homeobox 6	0.020
GNG2	guanine nucleotide binding protein (G protein), gamma 2	0.020
RSU1	Ras suppressor protein 1	0.020
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.019
NSA2	NSA2 ribosome biogenesis homolog (S. cerevisiae)	0.019
NIPA2	non imprinted in Prader-Willi/Angelman syndrome 2	0.019
HIC1	hypermethylated in cancer 1	0.019
NEUROG3	neurogenin 3	0.019
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.018
CALCA	calcitonin-related polypeptide alpha	0.018
DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4	0.018
SETDB1	SET domain, bifurcated 1	0.018
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.018
DUSP23	dual specificity phosphatase 23	0.018
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.018
ACTN1	actinin, alpha 1	0.018
IL12RB2	interleukin 12 receptor, beta 2	0.018
DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	0.017
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.017
MED31	mediator complex subunit 31	0.017
GABARAPL1	GABA(A) receptor-associated protein like 1	0.017
JAK2	Janus kinase 2	0.017	Rat
ZNF133	zinc finger protein 133	0.017
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.017
FOXL1	forkhead box L1	0.017
SIX3	SIX homeobox 3	0.016
NKX2-8	NK2 homeobox 8	0.016	Human
PABPC3	poly(A) binding protein, cytoplasmic 3	0.016
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.016
ARL15	ADP-ribosylation factor-like 15	0.016
PAX7	paired box 7	0.016
ALX3	ALX homeobox 3	0.016
GNB2	guanine nucleotide binding protein (G protein), beta polypeptide 2	0.016
RPL37	ribosomal protein L37	0.016
SLC6A11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.016
PRDM8	PR domain containing 8	0.015
LTK	leukocyte receptor tyrosine kinase	0.015
TPM4	tropomyosin 4	0.015
SMAD3	SMAD family member 3	0.015
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.015
KLC1	kinesin light chain 1	0.015
GATA5	GATA binding protein 5	0.015
AP2A2	adaptor-related protein complex 2, alpha 2 subunit	0.015
CMIP	c-Maf-inducing protein	0.015
SFRP5	secreted frizzled-related protein 5	0.015
HOXB7	homeobox B7	0.015
TBX1	T-box 1	0.015
HOXD11	homeobox D11	0.015
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.015
COL10A1	collagen, type X, alpha 1	0.015
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.015
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.014
FNDC1	fibronectin type III domain containing 1	0.014	Rat
CSRP1	cysteine and glycine-rich protein 1	0.014
POU3F3	POU class 3 homeobox 3	0.014
LIMS1	LIM and senescent cell antigen-like domains 1	0.014
PIAS4	protein inhibitor of activated STAT, 4	0.014
GNAS	GNAS complex locus	0.014
NKX2-2	NK2 homeobox 2	0.014	Human
DLG2	discs, large homolog 2 (Drosophila)	0.014
NKX2-1	NK2 homeobox 1	0.014	Human
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.014
SOX11	SRY (sex determining region Y)-box 11	0.014
DUSP3	dual specificity phosphatase 3	0.014
MNX1	motor neuron and pancreas homeobox 1	0.014
SDF4	stromal cell derived factor 4	0.013
DLX5	distal-less homeobox 5	0.013
GRB14	growth factor receptor-bound protein 14	0.013
BAG3	BCL2-associated athanogene 3	0.013	Mouse
RAD23A	RAD23 homolog A (S. cerevisiae)	0.013
TAF4	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	0.013
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.013
COL12A1	collagen, type XII, alpha 1	0.013
PAX5	paired box 5	0.013
MAPK1	mitogen-activated protein kinase 1	0.013
BAG2	BCL2-associated athanogene 2	0.013
DPH3	DPH3, KTI11 homolog (S. cerevisiae)	0.013
UBE2Z	ubiquitin-conjugating enzyme E2Z	0.013
COL3A1	collagen, type III, alpha 1	0.013
LMX1B	LIM homeobox transcription factor 1, beta	0.013
KCNC1	potassium voltage-gated channel, Shaw-related subfamily, member 1	0.013
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.013
POU4F3	POU class 4 homeobox 3	0.013
FAM127A	family with sequence similarity 127, member A	0.013
CAPN2	calpain 2, (m/II) large subunit	0.013
DAB1	disabled homolog 1 (Drosophila)	0.013
AKR1C3	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)	0.013
HSPB8	heat shock 22kDa protein 8	0.013
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.013
HOXD10	homeobox D10	0.013
CD151	CD151 molecule (Raph blood group)	0.013
KIR2DL1	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	0.013
HOXD9	homeobox D9	0.013
PABPC1	poly(A) binding protein, cytoplasmic 1	0.013
BHLHE23	basic helix-loop-helix family, member e23	0.013
HOXD1	homeobox D1	0.013
HOXD3	homeobox D3	0.013
APLP2	amyloid beta (A4) precursor-like protein 2	0.013
PSMD5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5	0.013
PRDM13	PR domain containing 13	0.013
FOXA2	forkhead box A2	0.013
RARA	retinoic acid receptor, alpha	0.013
EYA2	eyes absent homolog 2 (Drosophila)	0.013
ATP6V1B2	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	0.012
SFTPB	surfactant protein B	0.012
UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1	0.012
SSTR2	somatostatin receptor 2	0.012
CXCR5	chemokine (C-X-C motif) receptor 5	0.012
PFDN5	prefoldin subunit 5	0.012
TLX1	T-cell leukemia homeobox 1	0.012
CXCR1	chemokine (C-X-C motif) receptor 1	0.012	Rat
HOXB13	homeobox B13	0.012
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.012
KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.012
POU3F2	POU class 3 homeobox 2	0.012
FOXD3	forkhead box D3	0.012
PCDHB11	protocadherin beta 11	0.012
NGB	neuroglobin	0.012
RIC8A	resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)	0.012
FAM129A	family with sequence similarity 129, member A	0.012
TH	tyrosine hydroxylase	0.012
PAX4	paired box 4	0.012
PAX3	paired box 3	0.012
MSX1	msh homeobox 1	0.012
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.012
UPK3A	uroplakin 3A	0.012
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.012
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.012
RPS27L	ribosomal protein S27-like	0.012
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.012
LEFTY1	left-right determination factor 1	0.012
POSTN	periostin, osteoblast specific factor	0.012
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.012
FASTKD5	FAST kinase domains 5	0.012
COL8A1	collagen, type VIII, alpha 1	0.012
CAMTA2	calmodulin binding transcription activator 2	0.012
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.012
PITX2	paired-like homeodomain 2	0.012
FRS2	fibroblast growth factor receptor substrate 2	0.012
MYH6	myosin, heavy chain 6, cardiac muscle, alpha	0.012
CEL	carboxyl ester lipase (bile salt-stimulated lipase)	0.012
DIO3	deiodinase, iodothyronine, type III	0.012
HTRA3	HtrA serine peptidase 3	0.012
GPR50	G protein-coupled receptor 50	0.012
TRIM63	tripartite motif containing 63	0.012
DAZAP2	DAZ associated protein 2	0.012
NEUROG2	neurogenin 2	0.012
ANXA6	annexin A6	0.012
ARRB2	arrestin, beta 2	0.011
CDX2	caudal type homeobox 2	0.011
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.011
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.011
CTHRC1	collagen triple helix repeat containing 1	0.011
TCAP	titin-cap (telethonin)	0.011
C1QL1	complement component 1, q subcomponent-like 1	0.011
IHH	Indian hedgehog	0.011
KIF1C	kinesin family member 1C	0.011
ACVR2B	activin A receptor, type IIB	0.011
RAD52	RAD52 homolog (S. cerevisiae)	0.011
KLHL35	kelch-like 35 (Drosophila)	0.011
RBMXL2	RNA binding motif protein, X-linked-like 2	0.011
MYST1	MYST histone acetyltransferase 1	0.011
FOXD1	forkhead box D1	0.011
IDH3A	isocitrate dehydrogenase 3 (NAD+) alpha	0.011
BFSP1	beaded filament structural protein 1, filensin	0.011
FOXD2	forkhead box D2	0.011
HIP1	huntingtin interacting protein 1	0.011
BLOC1S3	biogenesis of lysosomal organelles complex-1, subunit 3	0.011
HP	haptoglobin	0.011
TCF15	transcription factor 15 (basic helix-loop-helix)	0.011
DLX4	distal-less homeobox 4	0.011
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.011
GLG1	golgi glycoprotein 1	0.011
EN2	engrailed homeobox 2	0.011
ZNRF4	zinc and ring finger 4	0.011
ACACA	acetyl-CoA carboxylase alpha	0.011
MYBPC3	myosin binding protein C, cardiac	0.011
S100B	S100 calcium binding protein B	0.011
FAM5C	family with sequence similarity 5, member C	0.011
DMRT1	doublesex and mab-3 related transcription factor 1	0.011
POU3F1	POU class 3 homeobox 1	0.011
NSF	N-ethylmaleimide-sensitive factor	0.011
OSTM1	osteopetrosis associated transmembrane protein 1	0.011
NRTN	neurturin	0.011
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.011
NEUROD2	neurogenic differentiation 2	0.011
HBE1	hemoglobin, epsilon 1	0.011
IRAK2	interleukin-1 receptor-associated kinase 2	0.011
TPO	thyroid peroxidase	0.011
WNT11	wingless-type MMTV integration site family, member 11	0.011
SOSTDC1	sclerostin domain containing 1	0.011
FGF3	fibroblast growth factor 3	0.011
WT1	Wilms tumor 1	0.011
HTR7	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	0.011
C15orf29	chromosome 15 open reading frame 29	0.011
SQSTM1	sequestosome 1	0.011
LPAR4	lysophosphatidic acid receptor 4	0.011
CKB	creatine kinase, brain	0.011
MXRA5	matrix-remodelling associated 5	0.011
GABRD	gamma-aminobutyric acid (GABA) A receptor, delta	0.011
ZNF212	zinc finger protein 212	0.011
CXCR2	chemokine (C-X-C motif) receptor 2	0.011	Rat
HOXD12	homeobox D12	0.011
SEMA3D	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	0.011
ONECUT2	one cut homeobox 2	0.011
CRH	corticotropin releasing hormone	0.011
CCDC92	coiled-coil domain containing 92	0.011
HSPA2	heat shock 70kDa protein 2	0.011
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.011
PTH	parathyroid hormone	0.011
POU1F1	POU class 1 homeobox 1	0.011
THEM4	thioesterase superfamily member 4	0.011
PYY	peptide YY	0.010
AKIRIN1	akirin 1	0.010
TRPM1	transient receptor potential cation channel, subfamily M, member 1	0.010
NOS1	nitric oxide synthase 1 (neuronal)	0.010
CAPNS1	calpain, small subunit 1	0.010
DCLK2	doublecortin-like kinase 2	0.010
MYOD1	myogenic differentiation 1	0.010
SIX1	SIX homeobox 1	0.010
C1orf61	chromosome 1 open reading frame 61	0.010
CDH5	cadherin 5, type 2 (vascular endothelium)	0.010
HMX2	H6 family homeobox 2	0.010
HOXB6	homeobox B6	0.010
SFRP2	secreted frizzled-related protein 2	0.010	Mouse
SSTR5	somatostatin receptor 5	0.010
SALL1	sal-like 1 (Drosophila)	0.010
PAX6	paired box 6	0.010
PCDHB8	protocadherin beta 8	0.010
C11orf66	chromosome 11 open reading frame 66	0.010
MN1	meningioma (disrupted in balanced translocation) 1	0.010
FZD10	frizzled homolog 10 (Drosophila)	0.010
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.010
C2orf55	chromosome 2 open reading frame 55	0.010
TMEM119	transmembrane protein 119	0.010
SLC34A1	solute carrier family 34 (sodium phosphate), member 1	0.010
DLG3	discs, large homolog 3 (Drosophila)	0.010
ATP6V1D	ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D	0.010
ALX1	ALX homeobox 1	0.010
ZNF746	zinc finger protein 746	0.010
FOXO3	forkhead box O3	0.010
HOXC11	homeobox C11	0.010
LEP	leptin	0.010
TLL2	tolloid-like 2	0.010
FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	0.010
ICAM4	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	0.010
PTCHD2	patched domain containing 2	0.010
MCHR1	melanin-concentrating hormone receptor 1	0.010
NOVA2	neuro-oncological ventral antigen 2	0.010
LHX5	LIM homeobox 5	0.010
KCNN3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	0.010
EVL	Enah/Vasp-like	0.010
HOXD8	homeobox D8	0.010
ACTR1A	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	0.010
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.010
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.010
HOXD13	homeobox D13	0.010
VAV3	vav 3 guanine nucleotide exchange factor	0.010
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.010