IMP

Process View

Homo sapiens

12 genes annotated in human

neuron projection guidance

The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "neuron projection guidance"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "neuron projection guidance" (in gray)

Name	Description	Probability	Func Analog Organism
EGFR	epidermal growth factor receptor	0.953
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.937	Fly
PLCG1	phospholipase C, gamma 1	0.703
QKI	quaking homolog, KH domain RNA binding (mouse)	0.572	Worm
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.570	Fly
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.544	Fly
FLNA	filamin A, alpha	0.514	Fly
FYN	FYN oncogene related to SRC, FGR, YES	0.496	Fly
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.476	Fly
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.447	Mouse
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.357
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.355
GSK3B	glycogen synthase kinase 3 beta	0.331
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.323
SMAD2	SMAD family member 2	0.241
FGFR1	fibroblast growth factor receptor 1	0.230	Worm
APC	adenomatous polyposis coli	0.208	Fly
GRB7	growth factor receptor-bound protein 7	0.155
GRB2	growth factor receptor-bound protein 2	0.145
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.133
ZNF746	zinc finger protein 746	0.116
MAPK8	mitogen-activated protein kinase 8	0.112	Fly
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.109
FN1	fibronectin 1	0.103
IGF1R	insulin-like growth factor 1 receptor	0.094	Fly
SMAD3	SMAD family member 3	0.092
ATXN1	ataxin 1	0.091
HDAC1	histone deacetylase 1	0.087	Fly
TAL1	T-cell acute lymphocytic leukemia 1	0.080
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.080
SPTBN1	spectrin, beta, non-erythrocytic 1	0.080	Worm
ATN1	atrophin 1	0.077
JAG1	jagged 1	0.072
HDAC2	histone deacetylase 2	0.070	Fly
ATF2	activating transcription factor 2	0.064
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.060
CREBBP	CREB binding protein	0.056
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.055	Fly
TUBB3	tubulin, beta 3	0.054
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.054
DST	dystonin	0.051	Fly
BMI1	BMI1 polycomb ring finger oncogene	0.050	Fly
FGFR2	fibroblast growth factor receptor 2	0.048	Worm
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.040
RBPMS	RNA binding protein with multiple splicing	0.037
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.037
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.036	Worm
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.034	Mouse Worm Fly
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.034
PCBP1	poly(rC) binding protein 1	0.032
CBX8	chromobox homolog 8	0.031
TCF4	transcription factor 4	0.031
NRP1	neuropilin 1	0.031	Zebrafish Mouse Rat
APP	amyloid beta (A4) precursor protein	0.030	Mouse
PLEC	plectin	0.030	Fly
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.029
NCOR1	nuclear receptor corepressor 1	0.029
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.028	Fly
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.028	Fly
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.026
RING1	ring finger protein 1	0.026
MYO10	myosin X	0.025
ZNF512B	zinc finger protein 512B	0.025
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.024
BMP7	bone morphogenetic protein 7	0.023	Mouse
TCF12	transcription factor 12	0.023
LMO4	LIM domain only 4	0.023
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.023
TRIO	triple functional domain (PTPRF interacting)	0.022	Worm Fly
SOX11	SRY (sex determining region Y)-box 11	0.022
ITGB4	integrin, beta 4	0.022	Fly
USP11	ubiquitin specific peptidase 11	0.022
ARHGAP1	Rho GTPase activating protein 1	0.021
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.021
CTNND1	catenin (cadherin-associated protein), delta 1	0.021
PAX3	paired box 3	0.021
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.021
RNF2	ring finger protein 2	0.020
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.020
FKBP1A	FK506 binding protein 1A, 12kDa	0.020
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.020
GAB1	GRB2-associated binding protein 1	0.019
SMAD4	SMAD family member 4	0.019	Mouse Fly
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.019
JAG2	jagged 2	0.019
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.019
ACTB	actin, beta	0.019
ARRB1	arrestin, beta 1	0.018
CHD4	chromodomain helicase DNA binding protein 4	0.018
TUBB	tubulin, beta	0.018	Human
CLASP1	cytoplasmic linker associated protein 1	0.017	Fly
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.017
RHOXF2	Rhox homeobox family, member 2	0.017
LAMB1	laminin, beta 1	0.017
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.017
ERBB2IP	erbb2 interacting protein	0.017
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.016
TUBB2A	tubulin, beta 2A	0.016	Human
RANBP9	RAN binding protein 9	0.016
LCK	lymphocyte-specific protein tyrosine kinase	0.016	Fly
SOS1	son of sevenless homolog 1 (Drosophila)	0.016	Fly
C2orf65	chromosome 2 open reading frame 65	0.016
LRP1	low density lipoprotein receptor-related protein 1	0.015
TRRAP	transformation/transcription domain-associated protein	0.015
FHL2	four and a half LIM domains 2	0.015
AXIN1	axin 1	0.015
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.015
KIF1B	kinesin family member 1B	0.015	Fly
SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	0.015
NOTCH3	notch 3	0.015	Fly
GHR	growth hormone receptor	0.015
TNK2	tyrosine kinase, non-receptor, 2	0.014
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.014
SMO	smoothened homolog (Drosophila)	0.014	Zebrafish Rat
SGSM2	small G protein signaling modulator 2	0.014
TUBB2C	tubulin, beta 2C	0.014	Human
LAT	linker for activation of T cells	0.014
SYK	spleen tyrosine kinase	0.014
SLIT2	slit homolog 2 (Drosophila)	0.013
ARID1A	AT rich interactive domain 1A (SWI-like)	0.013
WDR5	WD repeat domain 5	0.013
CHD7	chromodomain helicase DNA binding protein 7	0.013	Fly
SEMA6D	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.013	Human Fly
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.013
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.013
ANK1	ankyrin 1, erythrocytic	0.013
DOCK1	dedicator of cytokinesis 1	0.013
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.013	Fly
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.013
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.013
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.013
JUN	jun proto-oncogene	0.013
MAP2K4	mitogen-activated protein kinase kinase 4	0.013
PCGF2	polycomb group ring finger 2	0.013	Fly
CSNK2B	casein kinase 2, beta polypeptide	0.013
AGRN	agrin	0.013	Rat
CBX6	chromobox homolog 6	0.013
FLNB	filamin B, beta	0.012	Fly
FGF1	fibroblast growth factor 1 (acidic)	0.012	Worm
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.012	Fly
PTCH1	patched 1	0.012	Fly
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.012
SORBS1	sorbin and SH3 domain containing 1	0.012
TUBA1C	tubulin, alpha 1c	0.012
ZMYND11	zinc finger, MYND-type containing 11	0.012
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.012
NCKAP1	NCK-associated protein 1	0.012
PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.012
EPS8	epidermal growth factor receptor pathway substrate 8	0.012
RIN1	Ras and Rab interactor 1	0.012
AKAP1	A kinase (PRKA) anchor protein 1	0.012
RBBP4	retinoblastoma binding protein 4	0.011
LAMA5	laminin, alpha 5	0.011	Fly
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.011
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.011
PAX6	paired box 6	0.011	Mouse
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.011
MEOX2	mesenchyme homeobox 2	0.011
IRS1	insulin receptor substrate 1	0.011
TGFB2	transforming growth factor, beta 2	0.011	Mouse Fly
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.011
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.011	Fly
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.011
ABI1	abl-interactor 1	0.011	Fly
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.011
MAPT	microtubule-associated protein tau	0.010
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.010
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.010
PFN1	profilin 1	0.010
POU3F2	POU class 3 homeobox 2	0.010	Fly
VEGFA	vascular endothelial growth factor A	0.010	Mouse
PSEN1	presenilin 1	0.010
GAS7	growth arrest-specific 7	0.010
TP53	tumor protein p53	0.010
ENG	endoglin	0.010
CHD8	chromodomain helicase DNA binding protein 8	0.010	Fly
CBX4	chromobox homolog 4	0.010