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Homo sapiens

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fear response

GO:0042596

The response of an organism to a perceived external threat.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "fear response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "fear response" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2L1	BCL2-like 1	1.000
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.831
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.830
DLG4	discs, large homolog 4 (Drosophila)	0.684
BAX	BCL2-associated X protein	0.673
CRHR1	corticotropin releasing hormone receptor 1	0.667	Mouse
CRH	corticotropin releasing hormone	0.645	Rat
BAK1	BCL2-antagonist/killer 1	0.583
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.533
KIFC2	kinesin family member C2	0.525
ESR1	estrogen receptor 1	0.422
RPL18A	ribosomal protein L18a	0.380
AMBRA1	autophagy/beclin-1 regulator 1	0.351
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.342
MYLK2	myosin light chain kinase 2	0.315
PPP5C	protein phosphatase 5, catalytic subunit	0.297
ZNF784	zinc finger protein 784	0.278
HDAC4	histone deacetylase 4	0.277
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.254
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.215
UBXN2A	UBX domain protein 2A	0.212
LPL	lipoprotein lipase	0.206
VDAC2	voltage-dependent anion channel 2	0.183
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.167
BIK	BCL2-interacting killer (apoptosis-inducing)	0.158
PHLPP2	PH domain and leucine rich repeat protein phosphatase 2	0.155
BID	BH3 interacting domain death agonist	0.139
EIF2AK4	eukaryotic translation initiation factor 2 alpha kinase 4	0.134
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.126
HIPK2	homeodomain interacting protein kinase 2	0.116
CCKBR	cholecystokinin B receptor	0.104
EP300	E1A binding protein p300	0.101
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	0.099
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.089
DUSP23	dual specificity phosphatase 23	0.085
HDAC9	histone deacetylase 9	0.075
WDR20	WD repeat domain 20	0.074
PFN1	profilin 1	0.073
BBS10	Bardet-Biedl syndrome 10	0.072
RAI1	retinoic acid induced 1	0.068
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.067
DDX24	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	0.065
CYCS	cytochrome c, somatic	0.063
GSK3A	glycogen synthase kinase 3 alpha	0.061
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.061
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.060
DLAT	dihydrolipoamide S-acetyltransferase	0.058
FHL1	four and a half LIM domains 1	0.053
FDFT1	farnesyl-diphosphate farnesyltransferase 1	0.052
ASCC2	activating signal cointegrator 1 complex subunit 2	0.052
PGK1	phosphoglycerate kinase 1	0.052
VDAC1	voltage-dependent anion channel 1	0.050	Mouse
NLGN1	neuroligin 1	0.049
LDHA	lactate dehydrogenase A	0.049
BECN1	beclin 1, autophagy related	0.042
MAPK8	mitogen-activated protein kinase 8	0.041
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.040
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.040
NAF1	nuclear assembly factor 1 homolog (S. cerevisiae)	0.040
MEF2A	myocyte enhancer factor 2A	0.040
TP53BP2	tumor protein p53 binding protein, 2	0.039
CRMP1	collapsin response mediator protein 1	0.039
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.036
ACAT2	acetyl-CoA acetyltransferase 2	0.036
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.036
CYB5B	cytochrome b5 type B (outer mitochondrial membrane)	0.035
SMS	spermine synthase	0.034
AKAP13	A kinase (PRKA) anchor protein 13	0.034
UVRAG	UV radiation resistance associated gene	0.033
RAD23B	RAD23 homolog B (S. cerevisiae)	0.031
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.031
ZMYND11	zinc finger, MYND-type containing 11	0.031
DLG2	discs, large homolog 2 (Drosophila)	0.030
GGH	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	0.029
BAI1	brain-specific angiogenesis inhibitor 1	0.028
EEA1	early endosome antigen 1	0.028
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.028
FKBP8	FK506 binding protein 8, 38kDa	0.028
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	0.028
BBC3	BCL2 binding component 3	0.027
ACTL6B	actin-like 6B	0.027
NCOA1	nuclear receptor coactivator 1	0.027
HK1	hexokinase 1	0.027
NCKAP1	NCK-associated protein 1	0.027
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.026
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	0.026
CADM3	cell adhesion molecule 3	0.026
VPS33B	vacuolar protein sorting 33 homolog B (yeast)	0.026
DYNLL1	dynein, light chain, LC8-type 1	0.025
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.025
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.025
SOD1	superoxide dismutase 1, soluble	0.025
GRIA2	glutamate receptor, ionotropic, AMPA 2	0.025
DBN1	drebrin 1	0.025
EMX1	empty spiracles homeobox 1	0.025
MRPL20	mitochondrial ribosomal protein L20	0.024
PPID	peptidylprolyl isomerase D	0.024
PLXNA3	plexin A3	0.024
BTBD2	BTB (POZ) domain containing 2	0.024
RIBC2	RIB43A domain with coiled-coils 2	0.023
NIPSNAP1	nipsnap homolog 1 (C. elegans)	0.023
AFF2	AF4/FMR2 family, member 2	0.023
BCL2L2	BCL2-like 2	0.022
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.022
CA10	carbonic anhydrase X	0.022
RNF144B	ring finger protein 144B	0.022
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.022
ALDH9A1	aldehyde dehydrogenase 9 family, member A1	0.022
PPHLN1	periphilin 1	0.021
WDR48	WD repeat domain 48	0.021
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.021
KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.021
SPNS1	spinster homolog 1 (Drosophila)	0.021
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.021
INTS1	integrator complex subunit 1	0.021
CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.020
KCNJ9	potassium inwardly-rectifying channel, subfamily J, member 9	0.020
GRIA4	glutamate receptor, ionotrophic, AMPA 4	0.020
ASRGL1	asparaginase like 1	0.020
BLK	B lymphoid tyrosine kinase	0.020
MAP3K10	mitogen-activated protein kinase kinase kinase 10	0.020
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.020
GPR12	G protein-coupled receptor 12	0.020
PRDX3	peroxiredoxin 3	0.019
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.019
ACHE	acetylcholinesterase	0.019
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.019
GRIK1	glutamate receptor, ionotropic, kainate 1	0.019
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.018
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.018
DSCAML1	Down syndrome cell adhesion molecule like 1	0.018
PGAM1	phosphoglycerate mutase 1 (brain)	0.018
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.018
KCNJ4	potassium inwardly-rectifying channel, subfamily J, member 4	0.018
CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.018	Mouse
PICK1	protein interacting with PRKCA 1	0.018
POU4F2	POU class 4 homeobox 2	0.018
MAP2K7	mitogen-activated protein kinase kinase 7	0.018
ZNF331	zinc finger protein 331	0.018
CAMK2B	calcium/calmodulin-dependent protein kinase II beta	0.017
FEZF2	FEZ family zinc finger 2	0.017
FSTL4	follistatin-like 4	0.017
GPR6	G protein-coupled receptor 6	0.017
CACNG3	calcium channel, voltage-dependent, gamma subunit 3	0.017
PITPNM3	PITPNM family member 3	0.017
HSPA8	heat shock 70kDa protein 8	0.017
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.017
ACAD9	acyl-CoA dehydrogenase family, member 9	0.017
RIMS1	regulating synaptic membrane exocytosis 1	0.017
GLO1	glyoxalase I	0.016
GABRG3	gamma-aminobutyric acid (GABA) A receptor, gamma 3	0.016
UNC119	unc-119 homolog (C. elegans)	0.016
BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	0.016
CABP1	calcium binding protein 1	0.016
ATF2	activating transcription factor 2	0.016
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.016
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.016	Mouse
PTPRR	protein tyrosine phosphatase, receptor type, R	0.016
HPCAL4	hippocalcin like 4	0.015
DRD1	dopamine receptor D1	0.015	Mouse
CPNE6	copine VI (neuronal)	0.015
CITED1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	0.015
CACNG2	calcium channel, voltage-dependent, gamma subunit 2	0.015
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.015
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.015
ZNF746	zinc finger protein 746	0.015
GRIP1	glutamate receptor interacting protein 1	0.015
HRH3	histamine receptor H3	0.015
ZBTB4	zinc finger and BTB domain containing 4	0.015
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.015
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.015
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.014
SEZ6L	seizure related 6 homolog (mouse)-like	0.014
TBC1D17	TBC1 domain family, member 17	0.014
NELL1	NEL-like 1 (chicken)	0.014
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.014
AFG3L2	AFG3 ATPase family gene 3-like 2 (S. cerevisiae)	0.014
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.014
GRIN2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	0.014
POU4F1	POU class 4 homeobox 1	0.014
PRDM8	PR domain containing 8	0.014
NKX2-1	NK2 homeobox 1	0.014
UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	0.014
GRM5	glutamate receptor, metabotropic 5	0.014
SORCS3	sortilin-related VPS10 domain containing receptor 3	0.014
SCRT1	scratch homolog 1, zinc finger protein (Drosophila)	0.014
SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	0.014
GRM1	glutamate receptor, metabotropic 1	0.013
GRM6	glutamate receptor, metabotropic 6	0.013
IDH3A	isocitrate dehydrogenase 3 (NAD+) alpha	0.013
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.013
EBP	emopamil binding protein (sterol isomerase)	0.013
LY6H	lymphocyte antigen 6 complex, locus H	0.013
COPG2	coatomer protein complex, subunit gamma 2	0.013
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.013
SPTBN1	spectrin, beta, non-erythrocytic 1	0.013
FOXD3	forkhead box D3	0.013
PIN4	protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)	0.013
KCNK3	potassium channel, subfamily K, member 3	0.013
AES	amino-terminal enhancer of split	0.013
RIMS2	regulating synaptic membrane exocytosis 2	0.013
PRMT8	protein arginine methyltransferase 8	0.013
CDH8	cadherin 8, type 2	0.013
AKAP12	A kinase (PRKA) anchor protein 12	0.013
PGR	progesterone receptor	0.013
GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	0.013
MAP3K12	mitogen-activated protein kinase kinase kinase 12	0.013
SLITRK3	SLIT and NTRK-like family, member 3	0.013
RBMXL2	RNA binding motif protein, X-linked-like 2	0.013
FOXG1	forkhead box G1	0.013
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.012
CHN1	chimerin (chimaerin) 1	0.012
ADRA1D	adrenergic, alpha-1D-, receptor	0.012
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.012
OPRK1	opioid receptor, kappa 1	0.012
POU3F3	POU class 3 homeobox 3	0.012
C14orf43	chromosome 14 open reading frame 43	0.012
FGF12	fibroblast growth factor 12	0.012
EPHA5	EPH receptor A5	0.012
HCN4	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	0.012
NXPH2	neurexophilin 2	0.012
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.012
PCDH8	protocadherin 8	0.012
DAPK1	death-associated protein kinase 1	0.012
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A	0.012
KCNV1	potassium channel, subfamily V, member 1	0.012
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.012
HES1	hairy and enhancer of split 1, (Drosophila)	0.012
RPS14	ribosomal protein S14	0.012
ST8SIA3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	0.012
CRHBP	corticotropin releasing hormone binding protein	0.012
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.012
NPPC	natriuretic peptide C	0.012
ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.012
SIM1	single-minded homolog 1 (Drosophila)	0.012
PRDX4	peroxiredoxin 4	0.012
FAM123A	family with sequence similarity 123A	0.012
NOVA2	neuro-oncological ventral antigen 2	0.012
DCC	deleted in colorectal carcinoma	0.012
PTEN	phosphatase and tensin homolog	0.012
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.012
GPC5	glypican 5	0.012
GRIK3	glutamate receptor, ionotropic, kainate 3	0.012
RORB	RAR-related orphan receptor B	0.012
FAM5B	family with sequence similarity 5, member B	0.012
HS3ST2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	0.012
BRAP	BRCA1 associated protein	0.012
SLC6A5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.011
NKX2-2	NK2 homeobox 2	0.011
LRP2	low density lipoprotein receptor-related protein 2	0.011
AKT1S1	AKT1 substrate 1 (proline-rich)	0.011
GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3	0.011
SCNN1G	sodium channel, nonvoltage-gated 1, gamma	0.011
SPOCK3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	0.011
PDE4DIP	phosphodiesterase 4D interacting protein	0.011
FOXL1	forkhead box L1	0.011
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	0.011
FDPS	farnesyl diphosphate synthase	0.011
MYOD1	myogenic differentiation 1	0.011
PRMT2	protein arginine methyltransferase 2	0.011
PAX8	paired box 8	0.011
NCAN	neurocan	0.011
PSD	pleckstrin and Sec7 domain containing	0.011
ATP2B3	ATPase, Ca++ transporting, plasma membrane 3	0.011
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.011
EGLN1	egl nine homolog 1 (C. elegans)	0.011
GTF2I	general transcription factor IIi	0.011
NECAB2	N-terminal EF-hand calcium binding protein 2	0.011
YY1AP1	YY1 associated protein 1	0.011
DRD3	dopamine receptor D3	0.011
GRM3	glutamate receptor, metabotropic 3	0.011
LHB	luteinizing hormone beta polypeptide	0.011
PRDX1	peroxiredoxin 1	0.011
ADRB2	adrenergic, beta-2-, receptor, surface	0.011
TF	transferrin	0.011
IDI1	isopentenyl-diphosphate delta isomerase 1	0.011
MDH1	malate dehydrogenase 1, NAD (soluble)	0.011
CRHR2	corticotropin releasing hormone receptor 2	0.011
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.011
SLC6A11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.011
PABPC5	poly(A) binding protein, cytoplasmic 5	0.011
TMEM151B	transmembrane protein 151B	0.011
ARHGAP31	Rho GTPase activating protein 31	0.011
GABRA2	gamma-aminobutyric acid (GABA) A receptor, alpha 2	0.011
PTGER3	prostaglandin E receptor 3 (subtype EP3)	0.011
STAT5A	signal transducer and activator of transcription 5A	0.011
PIP4K2B	phosphatidylinositol-5-phosphate 4-kinase, type II, beta	0.011
GABRD	gamma-aminobutyric acid (GABA) A receptor, delta	0.011
CARHSP1	calcium regulated heat stable protein 1, 24kDa	0.011
CDH12	cadherin 12, type 2 (N-cadherin 2)	0.011
FH	fumarate hydratase	0.011
C2orf55	chromosome 2 open reading frame 55	0.010
TRPM3	transient receptor potential cation channel, subfamily M, member 3	0.010
USP12	ubiquitin specific peptidase 12	0.010
DLX5	distal-less homeobox 5	0.010
GABRA4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	0.010
CELF2	CUGBP, Elav-like family member 2	0.010
C10orf46	chromosome 10 open reading frame 46	0.010
GDF10	growth differentiation factor 10	0.010
RALYL	RALY RNA binding protein-like	0.010
PRPF40B	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	0.010
ATXN7	ataxin 7	0.010
ROBO2	roundabout, axon guidance receptor, homolog 2 (Drosophila)	0.010
SLC1A6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.010
GFAP	glial fibrillary acidic protein	0.010
HTR1D	5-hydroxytryptamine (serotonin) receptor 1D	0.010
ADAM11	ADAM metallopeptidase domain 11	0.010