IMP

Process View

Mus musculus

17 genes annotated in mouse

pharyngeal system development

The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "pharyngeal system development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "pharyngeal system development" (in gray)

Name	Description	Probability	Func Analog Organism
Fgf8	fibroblast growth factor 8	0.998
Otx2	orthodenticle homolog 2 (Drosophila)	0.992
Pax2	paired box gene 2	0.985
Tbx1	T-box 1	0.969
Tbx3	T-box 3	0.948	Mouse
Eya1	eyes absent 1 homolog (Drosophila)	0.945
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.945
Shh	sonic hedgehog	0.937
Hoxa1	homeobox A1	0.922
Sox2	SRY-box containing gene 2	0.920
Emx2	empty spiracles homolog 2 (Drosophila)	0.919
Pitx2	paired-like homeodomain transcription factor 2	0.901
Hoxa13	homeobox A13	0.897
Rarg	retinoic acid receptor, gamma	0.886	Zebrafish
Nog	noggin	0.848
Foxg1	forkhead box G1	0.810
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.803
Gbx2	gastrulation brain homeobox 2	0.787
Emx1	empty spiracles homolog 1 (Drosophila)	0.757
Sox9	SRY-box containing gene 9	0.746
Lhx1	LIM homeobox protein 1	0.715	Mouse
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.712
Lhx3	LIM homeobox protein 3	0.707	Mouse
Hand2	heart and neural crest derivatives expressed transcript 2	0.674
Gata4	GATA binding protein 4	0.657	Mouse
Arhgef11	Rho guanine nucleotide exchange factor (GEF) 11	0.613
Fgfr2	fibroblast growth factor receptor 2	0.591
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.540
Chd7	chromodomain helicase DNA binding protein 7	0.511
Fgfr3	fibroblast growth factor receptor 3	0.484
Gli3	GLI-Kruppel family member GLI3	0.483
Pitx1	paired-like homeodomain transcription factor 1	0.426
Dlx2	distal-less homeobox 2	0.408
Dlx1	distal-less homeobox 1	0.396	Mouse
Lhx9	LIM homeobox protein 9	0.395	Mouse
Tgfbr2	transforming growth factor, beta receptor II	0.364	Mouse
Sall4	sal-like 4 (Drosophila)	0.353
Col2a1	collagen, type II, alpha 1	0.344
Gata6	GATA binding protein 6	0.338	Mouse
Dlx5	distal-less homeobox 5	0.337
Hes5	hairy and enhancer of split 5 (Drosophila)	0.310	Mouse
Prrx2	paired related homeobox 2	0.287
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.279
Rxra	retinoid X receptor alpha	0.264
Pou3f4	POU domain, class 3, transcription factor 4	0.263
Hoxd3	homeobox D3	0.253
Rara	retinoic acid receptor, alpha	0.249
Vegfa	vascular endothelial growth factor A	0.243
Fgf10	fibroblast growth factor 10	0.236
Otx1	orthodenticle homolog 1 (Drosophila)	0.236
Pou5f1	POU domain, class 5, transcription factor 1	0.232
Lmx1a	LIM homeobox transcription factor 1 alpha	0.225	Mouse
Smad6	MAD homolog 6 (Drosophila)	0.222
En1	engrailed 1	0.221
Nrp1	neuropilin 1	0.216
Creb1	cAMP responsive element binding protein 1	0.216
Acvr1	activin A receptor, type 1	0.214
Dnmt3a	DNA methyltransferase 3A	0.201
Gsc	goosecoid homeobox	0.197
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.185
Lhx5	LIM homeobox protein 5	0.182	Mouse
Sox3	SRY-box containing gene 3	0.170
Tlx3	T-cell leukemia, homeobox 3	0.165
Lmx1b	LIM homeobox transcription factor 1 beta	0.156	Mouse
Tcfap2a	transcription factor AP-2, alpha	0.148
Pax1	paired box gene 1	0.146
Wnt1	wingless-related MMTV integration site 1	0.140
Hand1	heart and neural crest derivatives expressed transcript 1	0.138
Pou4f3	POU domain, class 4, transcription factor 3	0.136
Apc	adenomatosis polyposis coli	0.136
Tbx5	T-box 5	0.135	Mouse
Isl1	ISL1 transcription factor, LIM/homeodomain	0.135
Pax3	paired box gene 3	0.133
Scn5a	sodium channel, voltage-gated, type V, alpha	0.132
Uncx	UNC homeobox	0.132
Bmp4	bone morphogenetic protein 4	0.129
Sall3	sal-like 3 (Drosophila)	0.123
Hoxd13	homeobox D13	0.122
Pthlh	parathyroid hormone-like peptide	0.119
Lef1	lymphoid enhancer binding factor 1	0.119
Wnt3a	wingless-related MMTV integration site 3A	0.119
Fgfr1	fibroblast growth factor receptor 1	0.116
Ednra	endothelin receptor type A	0.111
Hoxa3	homeobox A3	0.111
Hes1	hairy and enhancer of split 1 (Drosophila)	0.109
Wt1	Wilms tumor 1 homolog	0.096
Gdnf	glial cell line derived neurotrophic factor	0.093
Shox2	short stature homeobox 2	0.093
Smad3	MAD homolog 3 (Drosophila)	0.091
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.089
Arid1b	AT rich interactive domain 1B (SWI-like)	0.088
Efna2	ephrin A2	0.087
Inha	inhibin alpha	0.081
T	brachyury	0.081	Mouse
Ece1	endothelin converting enzyme 1	0.080
Gata3	GATA binding protein 3	0.074
Chrd	chordin	0.073
Dlx6	distal-less homeobox 6	0.073	Mouse
Tgfbr1	transforming growth factor, beta receptor I	0.071
En2	engrailed 2	0.070
Insm1	insulinoma-associated 1	0.070
Dll4	delta-like 4 (Drosophila)	0.069
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.068
Foxc1	forkhead box C1	0.066
Nkx6-1	NK6 homeobox 1	0.065
Eng	endoglin	0.061
Fgf3	fibroblast growth factor 3	0.061
Kiss1	KiSS-1 metastasis-suppressor	0.060
Smarcc1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.059
Fgf15	fibroblast growth factor 15	0.059
Arx	aristaless related homeobox	0.057
Tbx2	T-box 2	0.057	Zebrafish Mouse
Gja5	gap junction protein, alpha 5	0.055
Gli2	GLI-Kruppel family member GLI2	0.055
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.055	Mouse
Trp63	transformation related protein 63	0.055
Prrx1	paired related homeobox 1	0.054
Zeb1	zinc finger E-box binding homeobox 1	0.053
Pten	phosphatase and tensin homolog	0.052
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.049
Dpf1	D4, zinc and double PHD fingers family 1	0.049
Alx3	aristaless-like homeobox 3	0.048
Pax6	paired box gene 6	0.045
Wnt9a	wingless-type MMTV integration site 9A	0.044	Zebrafish
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.042	Mouse
Pitx3	paired-like homeodomain transcription factor 3	0.042
Msx1	homeobox, msh-like 1	0.041
Nkx3-2	NK3 homeobox 2	0.041	Mouse
Arhgef12	Rho guanine nucleotide exchange factor (GEF) 12	0.041
Hmx1	H6 homeobox 1	0.040
Smad5	MAD homolog 5 (Drosophila)	0.040
Neurog2	neurogenin 2	0.040
Pax7	paired box gene 7	0.038
Tcl1	T-cell lymphoma breakpoint 1	0.037
Hmx3	H6 homeobox 3	0.035
Col22a1	collagen, type XXII, alpha 1	0.035
Wnt6	wingless-related MMTV integration site 6	0.035
Hoxd1	homeobox D1	0.035
Sharpin	SHANK-associated RH domain interacting protein	0.034
Foxf1a	forkhead box F1a	0.033
Cited1	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	0.033
Ar	androgen receptor	0.033
Ptf1a	pancreas specific transcription factor, 1a	0.033
Jag1	jagged 1	0.032
Myod1	myogenic differentiation 1	0.031
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.030
Sim2	single-minded homolog 2 (Drosophila)	0.030
Esr1	estrogen receptor 1 (alpha)	0.029
Hoxa11	homeobox A11	0.029
Foxe1	forkhead box E1	0.029
Mesp1	mesoderm posterior 1	0.029
Tcf15	transcription factor 15	0.028
Hoxb13	homeobox B13	0.028
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.028
Nobox	NOBOX oogenesis homeobox	0.028
Axin2	axin2	0.027
Hoxa2	homeobox A2	0.027
Snai1	snail homolog 1 (Drosophila)	0.027
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.027
Mnx1	motor neuron and pancreas homeobox 1	0.027
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.026
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.026
Tal1	T-cell acute lymphocytic leukemia 1	0.026
Nodal	nodal	0.026
Wnt9b	wingless-type MMTV integration site 9B	0.025
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.025
Nkx2-1	NK2 homeobox 1	0.024	Mouse
Odf3	outer dense fiber of sperm tails 3	0.024
Barx1	BarH-like homeobox 1	0.024	Zebrafish
Rarb	retinoic acid receptor, beta	0.024
Fshr	follicle stimulating hormone receptor	0.024
Hoxd11	homeobox D11	0.023
Btbd17	BTB (POZ) domain containing 17	0.023
Bcl6	B-cell leukemia/lymphoma 6	0.023
Arid1a	AT rich interactive domain 1A (SWI-like)	0.023
Otp	orthopedia homolog (Drosophila)	0.023
Notch1	Notch gene homolog 1 (Drosophila)	0.023
Gpc3	glypican 3	0.022
Ankrd2	ankyrin repeat domain 2 (stretch responsive muscle)	0.022
Tlx2	T-cell leukemia, homeobox 2	0.022
Msx3	homeobox, msh-like 3	0.022
Hes3	hairy and enhancer of split 3 (Drosophila)	0.021	Mouse
Smad4	MAD homolog 4 (Drosophila)	0.020
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.020
Serpinh1	serine (or cysteine) peptidase inhibitor, clade H, member 1	0.020
Bdnf	brain derived neurotrophic factor	0.020
Hoxa4	homeobox A4	0.020
Hesx1	homeobox gene expressed in ES cells	0.019
Vax1	ventral anterior homeobox containing gene 1	0.019
Alx4	aristaless-like homeobox 4	0.019
Npas2	neuronal PAS domain protein 2	0.019
Chst8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	0.019
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.019
Ighmbp2	immunoglobulin mu binding protein 2	0.019
Tert	telomerase reverse transcriptase	0.018
Art5	ADP-ribosyltransferase 5	0.018
Xirp1	xin actin-binding repeat containing 1	0.018
Pou4f2	POU domain, class 4, transcription factor 2	0.018
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.018
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.017
Hoxb6	homeobox B6	0.017
Plxna1	plexin A1	0.017	Mouse
Zic2	zinc finger protein of the cerebellum 2	0.017
Wnt10b	wingless related MMTV integration site 10b	0.017
Ptk7	PTK7 protein tyrosine kinase 7	0.017
Nrk	Nik related kinase	0.017
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.017	Mouse
Foxi3	forkhead box I3	0.017
Nynrin	NYN domain and retroviral integrase containing	0.017
Twist2	twist homolog 2 (Drosophila)	0.017
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.017
Pou3f1	POU domain, class 3, transcription factor 1	0.017
Bmp5	bone morphogenetic protein 5	0.017
Plac1	placental specific protein 1	0.016
Smarcc2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.016
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.016
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.016
Gpr27	G protein-coupled receptor 27	0.016
Pofut1	protein O-fucosyltransferase 1	0.016
Wnt4	wingless-related MMTV integration site 4	0.016
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.015
Nanog	Nanog homeobox	0.015
Msi1	Musashi homolog 1(Drosophila)	0.015
Foxd2	forkhead box D2	0.015
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.015
Gata2	GATA binding protein 2	0.015	Mouse
Ntn3	netrin 3	0.015
Sox1	SRY-box containing gene 1	0.015
Fev	FEV (ETS oncogene family)	0.015
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.014	Mouse
Eomes	eomesodermin homolog (Xenopus laevis)	0.014	Mouse
Alx1	ALX homeobox 1	0.014
Foxb1	forkhead box B1	0.014
Pax8	paired box gene 8	0.014
Lamc1	laminin, gamma 1	0.014
Klf3	Kruppel-like factor 3 (basic)	0.014
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.014
Osr1	odd-skipped related 1 (Drosophila)	0.014
Vcl	vinculin	0.014
Rax	retina and anterior neural fold homeobox	0.014
Oprd1	opioid receptor, delta 1	0.014
Npr2	natriuretic peptide receptor 2	0.014
Grb10	growth factor receptor bound protein 10	0.014
Olig2	oligodendrocyte transcription factor 2	0.014
Rnf2	ring finger protein 2	0.014
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.013
Fzd8	frizzled homolog 8 (Drosophila)	0.013
Scube2	signal peptide, CUB domain, EGF-like 2	0.013
Hoxa10	homeobox A10	0.013
Barx2	BarH-like homeobox 2	0.013
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.013
Satb2	special AT-rich sequence binding protein 2	0.013
Bnc1	basonuclin 1	0.013
Wnt2b	wingless related MMTV integration site 2b	0.013
Hoxd12	homeobox D12	0.012
Cxcr4	chemokine (C-X-C motif) receptor 4	0.012
Pbx1	pre B-cell leukemia transcription factor 1	0.012
Xiap	X-linked inhibitor of apoptosis	0.012
Asb10	ankyrin repeat and SOCS box-containing 10	0.012
Cer1	cerberus 1 homolog (Xenopus laevis)	0.012
Zic1	zinc finger protein of the cerebellum 1	0.012
Dhh	desert hedgehog	0.012
Lhx4	LIM homeobox protein 4	0.012	Mouse
Sox11	SRY-box containing gene 11	0.012
Hoxb3	homeobox B3	0.012
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.012	Mouse
Cdh5	cadherin 5	0.012
Tcfcp2l1	transcription factor CP2-like 1	0.011
Dmrt3	doublesex and mab-3 related transcription factor 3	0.011
Tnfrsf25	tumor necrosis factor receptor superfamily, member 25	0.011
Neurog1	neurogenin 1	0.011
Cxadr	coxsackie virus and adenovirus receptor	0.011
Myog	myogenin	0.011
Htt	huntingtin	0.011
Fbn2	fibrillin 2	0.011
Nsd1	nuclear receptor-binding SET-domain protein 1	0.011
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.011
Dnmt3l	DNA (cytosine-5-)-methyltransferase 3-like	0.011
Col4a2	collagen, type IV, alpha 2	0.011
Hmga2	high mobility group AT-hook 2	0.011
Pnoc	prepronociceptin	0.011
Vangl2	vang-like 2 (van gogh, Drosophila)	0.011
Dnahc1	dynein, axonemal, heavy chain 1	0.011
Fgfrl1	fibroblast growth factor receptor-like 1	0.011
Tbx15	T-box 15	0.011	Mouse
Eln	elastin	0.011
Zic3	zinc finger protein of the cerebellum 3	0.011
Lhx6	LIM homeobox protein 6	0.011	Mouse
Zfpm2	zinc finger protein, multitype 2	0.010
Lama1	laminin, alpha 1	0.010
Hoxb4	homeobox B4	0.010
Gata1	GATA binding protein 1	0.010	Mouse
Myb	myeloblastosis oncogene	0.010
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.010
Ehmt1	euchromatic histone methyltransferase 1	0.010
Slc27a3	solute carrier family 27 (fatty acid transporter), member 3	0.010
Gli1	GLI-Kruppel family member GLI1	0.010
Pcdh12	protocadherin 12	0.010
Gdf11	growth differentiation factor 11	0.010
Hmx2	H6 homeobox 2	0.010