IMP

Process View

Mus musculus

9 genes annotated in mouse

midbrain hindbrain boundary development

The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "midbrain hindbrain boundary development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "midbrain hindbrain boundary development" (in gray)

Name	Description	Probability	Func Analog Organism
Pax2	paired box gene 2	1.000	Zebrafish
Otx2	orthodenticle homolog 2 (Drosophila)	1.000	Zebrafish
Shh	sonic hedgehog	1.000
Gli3	GLI-Kruppel family member GLI3	1.000
Fgf8	fibroblast growth factor 8	1.000
Otx1	orthodenticle homolog 1 (Drosophila)	1.000	Zebrafish
Fgfr2	fibroblast growth factor receptor 2	0.999
Rarg	retinoic acid receptor, gamma	0.999
En1	engrailed 1	0.999
Emx2	empty spiracles homolog 2 (Drosophila)	0.999
Lhx1	LIM homeobox protein 1	0.998
Fgfr1	fibroblast growth factor receptor 1	0.996
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.995
Nog	noggin	0.993
Smo	smoothened homolog (Drosophila)	0.988
Foxc1	forkhead box C1	0.986
Gbx2	gastrulation brain homeobox 2	0.985
Pax3	paired box gene 3	0.974
Bmp4	bone morphogenetic protein 4	0.971
Gli2	GLI-Kruppel family member GLI2	0.971
Ctnnb1	catenin (cadherin associated protein), beta 1	0.967
Wnt1	wingless-related MMTV integration site 1	0.959
Sox2	SRY-box containing gene 2	0.957
Lmx1a	LIM homeobox transcription factor 1 alpha	0.948
Wnt3a	wingless-related MMTV integration site 3A	0.943	Zebrafish Mouse
Lmx1b	LIM homeobox transcription factor 1 beta	0.941	Zebrafish
Pitx2	paired-like homeodomain transcription factor 2	0.938
Foxc2	forkhead box C2	0.924
Eya1	eyes absent 1 homolog (Drosophila)	0.914
Bmp7	bone morphogenetic protein 7	0.913
Msx1	homeobox, msh-like 1	0.897
Rarb	retinoic acid receptor, beta	0.890
Tbx1	T-box 1	0.890
Foxg1	forkhead box G1	0.887
Hoxd11	homeobox D11	0.874
Chd7	chromodomain helicase DNA binding protein 7	0.860
T	brachyury	0.857
Rnf2	ring finger protein 2	0.841
Msx2	homeobox, msh-like 2	0.841
Emx1	empty spiracles homolog 1 (Drosophila)	0.827
Sall4	sal-like 4 (Drosophila)	0.812
Pax6	paired box gene 6	0.811
Vangl2	vang-like 2 (van gogh, Drosophila)	0.788
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.786
Tcfap2a	transcription factor AP-2, alpha	0.786
Hoxa1	homeobox A1	0.776
Zeb1	zinc finger E-box binding homeobox 1	0.768
Dlx5	distal-less homeobox 5	0.753
Ldb1	LIM domain binding 1	0.699
Nodal	nodal	0.697
Sox11	SRY-box containing gene 11	0.691
Lef1	lymphoid enhancer binding factor 1	0.671
Tbx3	T-box 3	0.644
Hes1	hairy and enhancer of split 1 (Drosophila)	0.631
Fgf10	fibroblast growth factor 10	0.604
Rara	retinoic acid receptor, alpha	0.591
Gsc	goosecoid homeobox	0.589
Pax8	paired box gene 8	0.481
Hmx3	H6 homeobox 3	0.464
Isl1	ISL1 transcription factor, LIM/homeodomain	0.461
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.440
Chrd	chordin	0.429
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.428
Lrp6	low density lipoprotein receptor-related protein 6	0.392
Prrx2	paired related homeobox 2	0.369
Ptk7	PTK7 protein tyrosine kinase 7	0.355
Gdnf	glial cell line derived neurotrophic factor	0.355
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.342
Fgf3	fibroblast growth factor 3	0.340
Hoxa13	homeobox A13	0.312
Hoxa2	homeobox A2	0.299
Jag1	jagged 1	0.296
Lhx5	LIM homeobox protein 5	0.293
Fgf15	fibroblast growth factor 15	0.279
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.272
Hand1	heart and neural crest derivatives expressed transcript 1	0.268
Pou5f1	POU domain, class 5, transcription factor 1	0.244
En2	engrailed 2	0.239	Zebrafish Mouse
Efnb2	ephrin B2	0.236
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.227
Gli1	GLI-Kruppel family member GLI1	0.225
Fgfr3	fibroblast growth factor receptor 3	0.213
Prrx1	paired related homeobox 1	0.205
Hand2	heart and neural crest derivatives expressed transcript 2	0.200
Sox9	SRY-box containing gene 9	0.199
Lhx9	LIM homeobox protein 9	0.197
Twist2	twist homolog 2 (Drosophila)	0.189
Ptch1	patched homolog 1	0.180
Pou3f3	POU domain, class 3, transcription factor 3	0.175
Smad6	MAD homolog 6 (Drosophila)	0.168
Sox1	SRY-box containing gene 1	0.152
Neurog1	neurogenin 1	0.148
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.148
Tcfcp2l1	transcription factor CP2-like 1	0.146
Wt1	Wilms tumor 1 homolog	0.143
Nanog	Nanog homeobox	0.138
Tbx2	T-box 2	0.134
Efna4	ephrin A4	0.133
Hoxa3	homeobox A3	0.129
Alx4	aristaless-like homeobox 4	0.123
Gpc3	glypican 3	0.116
Gsk3b	glycogen synthase kinase 3 beta	0.115
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.110
Hoxd13	homeobox D13	0.106
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.106
Foxf1a	forkhead box F1a	0.103
Hoxd3	homeobox D3	0.103
Gas1	growth arrest specific 1	0.102
Hoxb2	homeobox B2	0.097
Kl	klotho	0.097
Uncx	UNC homeobox	0.097
Tgfb2	transforming growth factor, beta 2	0.096
Sox3	SRY-box containing gene 3	0.096
Wnt4	wingless-related MMTV integration site 4	0.091	Mouse
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.091
Jag2	jagged 2	0.090
Sall3	sal-like 3 (Drosophila)	0.089
Hoxa10	homeobox A10	0.085
Meox2	mesenchyme homeobox 2	0.084
Ret	ret proto-oncogene	0.080
Zic2	zinc finger protein of the cerebellum 2	0.079
Fzd10	frizzled homolog 10 (Drosophila)	0.078
Ctbp1	C-terminal binding protein 1	0.077
Pbx1	pre B-cell leukemia transcription factor 1	0.076
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.076
Bnc1	basonuclin 1	0.075
Axin1	axin 1	0.074
Hes5	hairy and enhancer of split 5 (Drosophila)	0.072	Mouse
Wnt10b	wingless related MMTV integration site 10b	0.072	Zebrafish Mouse
Hoxa4	homeobox A4	0.071
Emid2	EMI domain containing 2	0.067
Sall1	sal-like 1 (Drosophila)	0.066
Hmx1	H6 homeobox 1	0.064
Pou3f1	POU domain, class 3, transcription factor 1	0.063
Cdx1	caudal type homeobox 1	0.063
Hoxa11	homeobox A11	0.062
Vax1	ventral anterior homeobox containing gene 1	0.061
Gata3	GATA binding protein 3	0.060
Apaf1	apoptotic peptidase activating factor 1	0.060
Ssbp3	single-stranded DNA binding protein 3	0.057
Pitx1	paired-like homeodomain transcription factor 1	0.055
Hoxd9	homeobox D9	0.054
Tcfap2c	transcription factor AP-2, gamma	0.054
App	amyloid beta (A4) precursor protein	0.052
Hoxa5	homeobox A5	0.051
Ssbp2	single-stranded DNA binding protein 2	0.050	Mouse
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.048
Psen1	presenilin 1	0.047
Wnt6	wingless-related MMTV integration site 6	0.047	Mouse
Pick1	protein interacting with C kinase 1	0.046
Wnt2b	wingless related MMTV integration site 2b	0.045	Mouse
Zic3	zinc finger protein of the cerebellum 3	0.044
Tal1	T-cell acute lymphocytic leukemia 1	0.044
Hoxb6	homeobox B6	0.043
Efna2	ephrin A2	0.042
Dll1	delta-like 1 (Drosophila)	0.041
Tbx15	T-box 15	0.041
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.040
Wnt9a	wingless-type MMTV integration site 9A	0.040	Mouse
Clstn1	calsyntenin 1	0.040
Fzd8	frizzled homolog 8 (Drosophila)	0.039
Foxa2	forkhead box A2	0.038
Wnt3	wingless-related MMTV integration site 3	0.038	Mouse
Lhx2	LIM homeobox protein 2	0.037
Bcor	BCL6 interacting corepressor	0.037
Foxf2	forkhead box F2	0.037
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.037
Sox4	SRY-box containing gene 4	0.036
Foxn1	forkhead box N1	0.036
Hoxa7	homeobox A7	0.035
Apc	adenomatosis polyposis coli	0.035
Rdh10	retinol dehydrogenase 10 (all-trans)	0.034
Foxb1	forkhead box B1	0.033
Hoxc9	homeobox C9	0.032
Hesx1	homeobox gene expressed in ES cells	0.032
Wnt11	wingless-related MMTV integration site 11	0.032	Mouse
Hoxd1	homeobox D1	0.031
Nkx6-1	NK6 homeobox 1	0.031
Axin2	axin2	0.031
Hoxb9	homeobox B9	0.031
Cbx3	chromobox homolog 3 (Drosophila HP1 gamma)	0.031
Tcf3	transcription factor 3	0.031
Des	desmin	0.031
Tbx6	T-box 6	0.030
Hoxc5	homeobox C5	0.030
Osr1	odd-skipped related 1 (Drosophila)	0.030
Acan	aggrecan	0.029
Fzd1	frizzled homolog 1 (Drosophila)	0.029
Vegfa	vascular endothelial growth factor A	0.029
Tead3	TEA domain family member 3	0.028
Wnt5a	wingless-related MMTV integration site 5A	0.028	Mouse
Gata6	GATA binding protein 6	0.027
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.027
Wls	wntless homolog (Drosophila)	0.026	Zebrafish
Bmper	BMP-binding endothelial regulator	0.026
Sim2	single-minded homolog 2 (Drosophila)	0.026
Fzd2	frizzled homolog 2 (Drosophila)	0.026
Pygo1	pygopus 1	0.025
Tcf15	transcription factor 15	0.025
Tcf21	transcription factor 21	0.025
Msi1	Musashi homolog 1(Drosophila)	0.025
Irx2	Iroquois related homeobox 2 (Drosophila)	0.024
Foxd3	forkhead box D3	0.024
Lhx3	LIM homeobox protein 3	0.024
Fgf4	fibroblast growth factor 4	0.024
Acvr1	activin A receptor, type 1	0.023
Foxd2	forkhead box D2	0.023
Nkx2-1	NK2 homeobox 1	0.023
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.023
Dlx6	distal-less homeobox 6	0.023
Slc27a3	solute carrier family 27 (fatty acid transporter), member 3	0.023
Fgf2	fibroblast growth factor 2	0.023
Crlf1	cytokine receptor-like factor 1	0.023
Foxh1	forkhead box H1	0.023
Grem1	gremlin 1	0.022
Hoxb4	homeobox B4	0.022
Neurog2	neurogenin 2	0.022
Sult5a1	sulfotransferase family 5A, member 1	0.022
Pax7	paired box gene 7	0.022
Tlx3	T-cell leukemia, homeobox 3	0.022
Tnni2	troponin I, skeletal, fast 2	0.022
Zic1	zinc finger protein of the cerebellum 1	0.022
Rspo1	R-spondin homolog (Xenopus laevis)	0.021
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.021
Porcn	porcupine homolog (Drosophila)	0.021
Celsr1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	0.021
Cbx8	chromobox homolog 8 (Drosophila Pc class)	0.020
Zfp503	zinc finger protein 503	0.020
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.020
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.020
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.020
Pofut1	protein O-fucosyltransferase 1	0.020
Col13a1	collagen, type XIII, alpha 1	0.019
Btbd17	BTB (POZ) domain containing 17	0.019
Krt15	keratin 15	0.019
Phox2a	paired-like homeobox 2a	0.019
Rybp	RING1 and YY1 binding protein	0.018
Dlg1	discs, large homolog 1 (Drosophila)	0.018
Sfrp2	secreted frizzled-related protein 2	0.017
Ntn3	netrin 3	0.017
Dlx1	distal-less homeobox 1	0.017
Pou3f2	POU domain, class 3, transcription factor 2	0.017
Fign	fidgetin	0.017
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.017
Dmbx1	diencephalon/mesencephalon homeobox 1	0.017
Trp63	transformation related protein 63	0.017
Ntf3	neurotrophin 3	0.017
Pou4f2	POU domain, class 4, transcription factor 2	0.017
Cbx2	chromobox homolog 2 (Drosophila Pc class)	0.017
Zbtb12	zinc finger and BTB domain containing 12	0.016
BC024139	cDNA sequence BC024139	0.016
Hoxd4	homeobox D4	0.016
Bmp2	bone morphogenetic protein 2	0.016
Pax9	paired box gene 9	0.016
Lrp4	low density lipoprotein receptor-related protein 4	0.016	Mouse
Foxa1	forkhead box A1	0.016
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.016
Zfp423	zinc finger protein 423	0.016
H1fx	H1 histone family, member X	0.016
Zfp771	zinc finger protein 771	0.016
Hoxb3	homeobox B3	0.016
Neurog3	neurogenin 3	0.016
Cdx2	caudal type homeobox 2	0.015
Hoxb13	homeobox B13	0.015
Mgat3	mannoside acetylglucosaminyltransferase 3	0.015
Eya4	eyes absent 4 homolog (Drosophila)	0.015
Slc18a3	solute carrier family 18 (vesicular monoamine), member 3	0.015
Twist1	twist homolog 1 (Drosophila)	0.015
Hoxc8	homeobox C8	0.015
Tgfa	transforming growth factor alpha	0.015
Tle6	transducin-like enhancer of split 6, homolog of Drosophila E(spl)	0.015
Ednra	endothelin receptor type A	0.015
Col4a3	collagen, type IV, alpha 3	0.015
Kdm1a	lysine (K)-specific demethylase 1A	0.014
Alx3	aristaless-like homeobox 3	0.014
Efnb1	ephrin B1	0.014
Sox7	SRY-box containing gene 7	0.014
Adra2b	adrenergic receptor, alpha 2b	0.014
Bcl2	B-cell leukemia/lymphoma 2	0.014
Irx4	Iroquois related homeobox 4 (Drosophila)	0.014
Nrtn	neurturin	0.014
Sema3b	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B	0.014
Cer1	cerberus 1 homolog (Xenopus laevis)	0.014
Gpr50	G-protein-coupled receptor 50	0.014
Ring1	ring finger protein 1	0.014
Agtr2	angiotensin II receptor, type 2	0.014
Pou4f3	POU domain, class 4, transcription factor 3	0.014
Tll2	tolloid-like 2	0.014
Il11	interleukin 11	0.014
Epha2	Eph receptor A2	0.014
Hmga2	high mobility group AT-hook 2	0.014
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.014
Zbtb16	zinc finger and BTB domain containing 16	0.014
Pvrl1	poliovirus receptor-related 1	0.013
Mnx1	motor neuron and pancreas homeobox 1	0.013	Mouse
Hoxd12	homeobox D12	0.013
Hs6st3	heparan sulfate 6-O-sulfotransferase 3	0.013
Fzd7	frizzled homolog 7 (Drosophila)	0.013
Lama1	laminin, alpha 1	0.013
Numb	numb gene homolog (Drosophila)	0.013
Bdnf	brain derived neurotrophic factor	0.013
Rxra	retinoid X receptor alpha	0.013
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.013
Igfbpl1	insulin-like growth factor binding protein-like 1	0.013
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.012
Gja3	gap junction protein, alpha 3	0.012
Fgf17	fibroblast growth factor 17	0.012	Mouse
Zfp358	zinc finger protein 358	0.012
Rem1	rad and gem related GTP binding protein 1	0.012
Lrp2	low density lipoprotein receptor-related protein 2	0.012	Mouse
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.012
Shox2	short stature homeobox 2	0.012
Lmo4	LIM domain only 4	0.012
Htt	huntingtin	0.012
Med16	mediator complex subunit 16	0.012
Nfe2l3	nuclear factor, erythroid derived 2, like 3	0.012
Shank1	SH3/ankyrin domain gene 1	0.011
Pou3f4	POU domain, class 3, transcription factor 4	0.011
Igf1r	insulin-like growth factor I receptor	0.011
Fzd6	frizzled homolog 6 (Drosophila)	0.011
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.011
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.011
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.011
Pcgf2	polycomb group ring finger 2	0.011
Pcdh12	protocadherin 12	0.011
Sp8	trans-acting transcription factor 8	0.011
Hoxb5	homeobox B5	0.011
Irx1	Iroquois related homeobox 1 (Drosophila)	0.011
Fgf5	fibroblast growth factor 5	0.010
Plag1	pleiomorphic adenoma gene 1	0.010
Hoxc4	homeobox C4	0.010
Vstm2b	V-set and transmembrane domain containing 2B	0.010