IMP

Process View

Mus musculus

12 genes annotated in mouse

Multi-species View

negative regulation of muscle contraction

GO:0045932

Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of muscle contraction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of muscle contraction" (in gray)

Name	Description	Probability	Func Analog Organism
Gucy1b3	guanylate cyclase 1, soluble, beta 3	0.968	Mouse
Cckbr	cholecystokinin B receptor	0.895
Pnpla2	patatin-like phospholipase domain containing 2	0.792
Kl	klotho	0.776
Nos1	nitric oxide synthase 1, neuronal	0.691
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.523
Adrb1	adrenergic receptor, beta 1	0.485	Mouse Rat
Hpca	hippocalcin	0.374
ND6	NADH dehydrogenase subunit 6	0.364
Gucy1a3	guanylate cyclase 1, soluble, alpha 3	0.356
Mb	myoglobin	0.339
Prkg1	protein kinase, cGMP-dependent, type I	0.325
Sparcl1	SPARC-like 1	0.307
Ppp1r9b	protein phosphatase 1, regulatory subunit 9B	0.269
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.266
Rgs4	regulator of G-protein signaling 4	0.263	Mouse
Il6	interleukin 6	0.260
Ednrb	endothelin receptor type B	0.255
Abcc9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	0.241
Sstr4	somatostatin receptor 4	0.238
Sstr1	somatostatin receptor 1	0.215
Bdkrb2	bradykinin receptor, beta 2	0.191
Drd2	dopamine receptor D2	0.186
Lag3	lymphocyte-activation gene 3	0.164
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.150
Prkaca	protein kinase, cAMP dependent, catalytic, alpha	0.126
Darc	Duffy blood group, chemokine receptor	0.123
Lama2	laminin, alpha 2	0.120
Nos3	nitric oxide synthase 3, endothelial cell	0.117
Ptafr	platelet-activating factor receptor	0.116
Sst	somatostatin	0.115
Tek	endothelial-specific receptor tyrosine kinase	0.114
Trpv1	transient receptor potential cation channel, subfamily V, member 1	0.098
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.098
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.093
Rho	rhodopsin	0.091
Kit	kit oncogene	0.089
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.089
Pparg	peroxisome proliferator activated receptor gamma	0.085
Gabrb2	gamma-aminobutyric acid (GABA) A receptor, subunit beta 2	0.084
Krt86	keratin 86	0.083
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.083
Clcnka	chloride channel Ka	0.080
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.078	Mouse
Shc3	src homology 2 domain-containing transforming protein C3	0.076
Vip	vasoactive intestinal polypeptide	0.076
Emcn	endomucin	0.073
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.071
Adrb3	adrenergic receptor, beta 3	0.070	Mouse
Fgf4	fibroblast growth factor 4	0.070
Kcne2	potassium voltage-gated channel, Isk-related subfamily, gene 2	0.070
Ccr1l1	chemokine (C-C motif) receptor 1-like 1	0.068
Kcnk3	potassium channel, subfamily K, member 3	0.065
Npy2r	neuropeptide Y receptor Y2	0.065
Cd247	CD247 antigen	0.064
Cacna1d	calcium channel, voltage-dependent, L type, alpha 1D subunit	0.064
Grm2	glutamate receptor, metabotropic 2	0.060
Plau	plasminogen activator, urokinase	0.060
Zfr2	zinc finger RNA binding protein 2	0.060
Pvalb	parvalbumin	0.059
Mrvi1	MRV integration site 1	0.057
Fbn1	fibrillin 1	0.056
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.055
Cnr1	cannabinoid receptor 1 (brain)	0.055
Slc12a1	solute carrier family 12, member 1	0.054
Mef2c	myocyte enhancer factor 2C	0.054
Galr2	galanin receptor 2	0.054
Ap1s2	adaptor-related protein complex 1, sigma 2 subunit	0.053
Ddah1	dimethylarginine dimethylaminohydrolase 1	0.053
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.053
Spock1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1	0.053
Nos2	nitric oxide synthase 2, inducible	0.052
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.051
Adrb2	adrenergic receptor, beta 2	0.048
Ren1	renin 1 structural	0.045
Adora2b	adenosine A2b receptor	0.045
Vamp2	vesicle-associated membrane protein 2	0.043
C5ar1	complement component 5a receptor 1	0.042
Hrh1	histamine receptor H1	0.041
Ptprb	protein tyrosine phosphatase, receptor type, B	0.038
Cox8b	cytochrome c oxidase, subunit VIIIb	0.038
Gjd2	gap junction protein, delta 2	0.037
Tac2	tachykinin 2	0.036
Sult4a1	sulfotransferase family 4A, member 1	0.034
Sdpr	serum deprivation response	0.033
Mtap1a	microtubule-associated protein 1 A	0.033
Pip4k2a	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	0.033
Gfap	glial fibrillary acidic protein	0.033
Kcna5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.033
Ldb2	LIM domain binding 2	0.033
Sncb	synuclein, beta	0.033
Kitl	kit ligand	0.032
Cdh11	cadherin 11	0.032
Tyrobp	TYRO protein tyrosine kinase binding protein	0.032
Cryaa	crystallin, alpha A	0.031
Eltd1	EGF, latrophilin seven transmembrane domain containing 1	0.031
Grk6	G protein-coupled receptor kinase 6	0.031
Pde6a	phosphodiesterase 6A, cGMP-specific, rod, alpha	0.030
Dmkn	dermokine	0.030
Crhr1	corticotropin releasing hormone receptor 1	0.030
Chrna6	cholinergic receptor, nicotinic, alpha polypeptide 6	0.029
Coro1a	coronin, actin binding protein 1A	0.029
Prkcb	protein kinase C, beta	0.029
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.029	Mouse
Grid1	glutamate receptor, ionotropic, delta 1	0.029
Bsn	bassoon	0.028
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.028
Acta1	actin, alpha 1, skeletal muscle	0.028
Tyr	tyrosinase	0.028
Cntn3	contactin 3	0.028
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.028
Npr3	natriuretic peptide receptor 3	0.028
Actn2	actinin alpha 2	0.028
Fosb	FBJ osteosarcoma oncogene B	0.027
Hcrt	hypocretin	0.027
Mbp	myelin basic protein	0.027
Kifc2	kinesin family member C2	0.026
Cfh	complement component factor h	0.026
Grm8	glutamate receptor, metabotropic 8	0.026
Cotl1	coactosin-like 1 (Dictyostelium)	0.026
Myom1	myomesin 1	0.025
Fam105a	family with sequence similarity 105, member A	0.025
Myh1	myosin, heavy polypeptide 1, skeletal muscle, adult	0.025
Hrc	histidine rich calcium binding protein	0.025
Itga8	integrin alpha 8	0.025
Kcnc1	potassium voltage gated channel, Shaw-related subfamily, member 1	0.025
Cer1	cerberus 1 homolog (Xenopus laevis)	0.025
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.024
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.024
Selp	selectin, platelet	0.024
Scn7a	sodium channel, voltage-gated, type VII, alpha	0.023
Pdgfb	platelet derived growth factor, B polypeptide	0.023
Tll1	tolloid-like	0.023
Rasa3	RAS p21 protein activator 3	0.023
Galnt6	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6	0.023
Elk1	ELK1, member of ETS oncogene family	0.023
Col4a3	collagen, type IV, alpha 3	0.023
Sirpa	signal-regulatory protein alpha	0.023
Nt5e	5' nucleotidase, ecto	0.023
Ppp1r3c	protein phosphatase 1, regulatory (inhibitor) subunit 3C	0.023
Nrgn	neurogranin	0.023
Chst2	carbohydrate sulfotransferase 2	0.022
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.022
Krtap5-1	keratin associated protein 5-1	0.022
Smad1	MAD homolog 1 (Drosophila)	0.022
Fpr3	formyl peptide receptor 3	0.022
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.022
Drd4	dopamine receptor D4	0.021
Gabrg3	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3	0.021
Armcx1	armadillo repeat containing, X-linked 1	0.021
Prkcc	protein kinase C, gamma	0.021
Tm4sf1	transmembrane 4 superfamily member 1	0.021
Plat	plasminogen activator, tissue	0.021
Vav2	vav 2 oncogene	0.020
Mc1r	melanocortin 1 receptor	0.020
Cdh10	cadherin 10	0.020
Ucp1	uncoupling protein 1 (mitochondrial, proton carrier)	0.020
Nxph2	neurexophilin 2	0.020
Npy1r	neuropeptide Y receptor Y1	0.020
Fli1	Friend leukemia integration 1	0.020
4632428N05Rik	RIKEN cDNA 4632428N05 gene	0.019
Cplx3	complexin 3	0.019
Ptprm	protein tyrosine phosphatase, receptor type, M	0.019
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.019
Oprk1	opioid receptor, kappa 1	0.019
Tnnt3	troponin T3, skeletal, fast	0.019
Csf3	colony stimulating factor 3 (granulocyte)	0.018
Syn2	synapsin II	0.018
Ar	androgen receptor	0.018
Matn1	matrilin 1, cartilage matrix protein	0.018
Hbb-b1	hemoglobin, beta adult major chain	0.018
Twf2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.018
Vldlr	very low density lipoprotein receptor	0.018
Il18rap	interleukin 18 receptor accessory protein	0.018
Kcnk6	potassium inwardly-rectifying channel, subfamily K, member 6	0.018
Cul9	cullin 9	0.018
Fezf2	Fez family zinc finger 2	0.018
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.018
Adm	adrenomedullin	0.018
Prnp	prion protein	0.018
Gjb6	gap junction protein, beta 6	0.017
Tgfbr3	transforming growth factor, beta receptor III	0.017
Kcns2	K+ voltage-gated channel, subfamily S, 2	0.017
Trpc6	transient receptor potential cation channel, subfamily C, member 6	0.017
Plcb1	phospholipase C, beta 1	0.017
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.017
Dennd4b	DENN/MADD domain containing 4B	0.017
Gh	growth hormone	0.017
Tnfaip6	tumor necrosis factor alpha induced protein 6	0.017
Mpz	myelin protein zero	0.017
Pgf	placental growth factor	0.017
Ckmt2	creatine kinase, mitochondrial 2	0.017
Pcsk4	proprotein convertase subtilisin/kexin type 4	0.017
Gpr83	G protein-coupled receptor 83	0.016
Itgb3	integrin beta 3	0.016
Gpr37l1	G protein-coupled receptor 37-like 1	0.016
Ncf4	neutrophil cytosolic factor 4	0.016
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.016
Sgcb	sarcoglycan, beta (dystrophin-associated glycoprotein)	0.016
Rasal1	RAS protein activator like 1 (GAP1 like)	0.016
Npy5r	neuropeptide Y receptor Y5	0.016
Cyp21a1	cytochrome P450, family 21, subfamily a, polypeptide 1	0.016
Pde1b	phosphodiesterase 1B, Ca2+-calmodulin dependent	0.016
Mas1	MAS1 oncogene	0.016
F7	coagulation factor VII	0.016
Ccl22	chemokine (C-C motif) ligand 22	0.016
Npy6r	neuropeptide Y receptor Y6	0.016
Ncan	neurocan	0.016
Opn1sw	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	0.016
Mog	myelin oligodendrocyte glycoprotein	0.016
Tnnc2	troponin C2, fast	0.016
Rgs5	regulator of G-protein signaling 5	0.016	Mouse
Itgam	integrin alpha M	0.016
Ninj2	ninjurin 2	0.016
Pomc	pro-opiomelanocortin-alpha	0.015
Tspan2	tetraspanin 2	0.015
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.015
Edn3	endothelin 3	0.015
Rrh	retinal pigment epithelium derived rhodopsin homolog	0.015
Kcnj1	potassium inwardly-rectifying channel, subfamily J, member 1	0.015
Gab2	growth factor receptor bound protein 2-associated protein 2	0.015
Ogn	osteoglycin	0.015
Clec4d	C-type lectin domain family 4, member d	0.015
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.015
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.015
Tnni2	troponin I, skeletal, fast 2	0.014
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.014
Arrb2	arrestin, beta 2	0.014
Atp4a	ATPase, H+/K+ exchanging, gastric, alpha polypeptide	0.014	Mouse
Rp1	retinitis pigmentosa 1 (human)	0.014
Ankrd2	ankyrin repeat domain 2 (stretch responsive muscle)	0.014
Ppef2	protein phosphatase, EF hand calcium-binding domain 2	0.014
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.014
Gabra2	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	0.014
Otog	otogelin	0.014
Kcnk4	potassium channel, subfamily K, member 4	0.014
Gnb4	guanine nucleotide binding protein (G protein), beta 4	0.014
Cacna1s	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.014
S100b	S100 protein, beta polypeptide, neural	0.014
Kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.014
Il12rb1	interleukin 12 receptor, beta 1	0.014
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.014
Gng2	guanine nucleotide binding protein (G protein), gamma 2	0.014
Ccl17	chemokine (C-C motif) ligand 17	0.014
Hsd3b4	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4	0.013
Col19a1	collagen, type XIX, alpha 1	0.013
Neurog3	neurogenin 3	0.013
Kcnab2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	0.013
Pcdh7	protocadherin 7	0.013
Cplx1	complexin 1	0.013
Matn3	matrilin 3	0.013
Expi	extracellular proteinase inhibitor	0.013
T	brachyury	0.013
Epas1	endothelial PAS domain protein 1	0.013
Plcg1	phospholipase C, gamma 1	0.013
Rasgrp1	RAS guanyl releasing protein 1	0.013
Scrg1	scrapie responsive gene 1	0.013
Ptgs1	prostaglandin-endoperoxide synthase 1	0.013
Mylpf	myosin light chain, phosphorylatable, fast skeletal muscle	0.013
Tmem47	transmembrane protein 47	0.013
Lrrk2	leucine-rich repeat kinase 2	0.012
Acr	acrosin prepropeptide	0.012
Nmbr	neuromedin B receptor	0.012
Gem	GTP binding protein (gene overexpressed in skeletal muscle)	0.012
Gpm6b	glycoprotein m6b	0.012
Nhedc2	Na+/H+ exchanger domain containing 2	0.012
Pitpnm1	phosphatidylinositol transfer protein, membrane-associated 1	0.012
Lmna	lamin A	0.012
Kctd12	potassium channel tetramerisation domain containing 12	0.012
Ldb3	LIM domain binding 3	0.012
Pla2g4a	phospholipase A2, group IVA (cytosolic, calcium-dependent)	0.012
Gpr98	G protein-coupled receptor 98	0.012
Kcnd1	potassium voltage-gated channel, Shal-related family, member 1	0.012
Pvrl3	poliovirus receptor-related 3	0.012
Trfr2	transferrin receptor 2	0.012
Kcnv1	potassium channel, subfamily V, member 1	0.012
Ank1	ankyrin 1, erythroid	0.011
Efna5	ephrin A5	0.011
Gcnt2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	0.011
Rbfox3	RNA binding protein, fox-1 homolog (C. elegans) 3	0.011
Afp	alpha fetoprotein	0.011
3110079O15Rik	RIKEN cDNA 3110079O15 gene	0.011
Gcgr	glucagon receptor	0.011
Vil1	villin 1	0.011
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.011
Nefh	neurofilament, heavy polypeptide	0.011
Plcz1	phospholipase C, zeta 1	0.011
Cd38	CD38 antigen	0.011
Adcyap1	adenylate cyclase activating polypeptide 1	0.011
Hoxc8	homeobox C8	0.011
Syt6	synaptotagmin VI	0.011
Coch	coagulation factor C homolog (Limulus polyphemus)	0.011
Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1	0.011
Chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)	0.011
Mt3	metallothionein 3	0.011
Tm6sf1	transmembrane 6 superfamily member 1	0.011
Edn1	endothelin 1	0.011
Kcnk2	potassium channel, subfamily K, member 2	0.010
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.010
Adcy8	adenylate cyclase 8	0.010
Crtac1	cartilage acidic protein 1	0.010
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.010
Kcnn1	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1	0.010
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.010
Rspo1	R-spondin homolog (Xenopus laevis)	0.010
Ppp1r1a	protein phosphatase 1, regulatory (inhibitor) subunit 1A	0.010
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.010
Cd40lg	CD40 ligand	0.010
Dlx6	distal-less homeobox 6	0.010