IMP

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Mus musculus

20 genes annotated in mouse

Multi-species View

negative regulation of muscle tissue development

GO:1901862

Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of muscle tissue development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of muscle tissue development" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.994
Fgfr2	fibroblast growth factor receptor 2	0.948
Gli3	GLI-Kruppel family member GLI3	0.860
Pax3	paired box gene 3	0.784
Otx2	orthodenticle homolog 2 (Drosophila)	0.723
Pax6	paired box gene 6	0.693
Sox2	SRY-box containing gene 2	0.651	Mouse
Lef1	lymphoid enhancer binding factor 1	0.617
Msx1	homeobox, msh-like 1	0.599
Ctnnb1	catenin (cadherin associated protein), beta 1	0.557
Tbx3	T-box 3	0.551
Sox9	SRY-box containing gene 9	0.488	Mouse
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.426
Tcfap2a	transcription factor AP-2, alpha	0.312
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.259
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.221
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.218	Mouse
Trp53	transformation related protein 53	0.202
Msx2	homeobox, msh-like 2	0.183
Isl1	ISL1 transcription factor, LIM/homeodomain	0.174
Smo	smoothened homolog (Drosophila)	0.170
Hand1	heart and neural crest derivatives expressed transcript 1	0.156	Mouse
Gli2	GLI-Kruppel family member GLI2	0.154
Bmp4	bone morphogenetic protein 4	0.140	Human
Prrx1	paired related homeobox 1	0.136
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.136
Axin1	axin 1	0.126
Bmp7	bone morphogenetic protein 7	0.121
Runx2	runt related transcription factor 2	0.119
Lrp6	low density lipoprotein receptor-related protein 6	0.114
Fgfr1	fibroblast growth factor receptor 1	0.107
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.106	Mouse
Nos3	nitric oxide synthase 3, endothelial cell	0.105
Prrx2	paired related homeobox 2	0.104
Eya1	eyes absent 1 homolog (Drosophila)	0.102
Fgf8	fibroblast growth factor 8	0.093
Fgfr3	fibroblast growth factor receptor 3	0.093
Tgfb2	transforming growth factor, beta 2	0.092
Hes1	hairy and enhancer of split 1 (Drosophila)	0.090
Sox11	SRY-box containing gene 11	0.090	Mouse
Neurod1	neurogenic differentiation 1	0.088	Mouse
Hoxa5	homeobox A5	0.087
Pitx1	paired-like homeodomain transcription factor 1	0.087
Emx1	empty spiracles homolog 1 (Drosophila)	0.082
Lmx1b	LIM homeobox transcription factor 1 beta	0.080
Mecom	MDS1 and EVI1 complex locus	0.077
Meox2	mesenchyme homeobox 2	0.070
Twist2	twist homolog 2 (Drosophila)	0.069	Mouse
Kiss1	KiSS-1 metastasis-suppressor	0.066
Sox17	SRY-box containing gene 17	0.066	Mouse
Hes5	hairy and enhancer of split 5 (Drosophila)	0.065
Pitx2	paired-like homeodomain transcription factor 2	0.064
Tbx15	T-box 15	0.061
Nkx2-1	NK2 homeobox 1	0.061
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.059
Tbx5	T-box 5	0.058	Human
Gbx2	gastrulation brain homeobox 2	0.057
Neurog2	neurogenin 2	0.056	Mouse
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.056
Gas1	growth arrest specific 1	0.056
Hand2	heart and neural crest derivatives expressed transcript 2	0.055	Mouse
Smad6	MAD homolog 6 (Drosophila)	0.054
Hoxd11	homeobox D11	0.051
Pkd1	polycystic kidney disease 1 homolog	0.050
Per1	period homolog 1 (Drosophila)	0.050
Hdac1	histone deacetylase 1	0.047	Mouse
Foxa2	forkhead box A2	0.046
Sox3	SRY-box containing gene 3	0.045	Mouse
Sox18	SRY-box containing gene 18	0.045	Mouse
Pten	phosphatase and tensin homolog	0.044
Gsc	goosecoid homeobox	0.041
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.041
T	brachyury	0.041
Neurod4	neurogenic differentiation 4	0.041	Mouse
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.041
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.041
Hic1	hypermethylated in cancer 1	0.040
Eng	endoglin	0.039
Lep	leptin	0.038
Dlx6	distal-less homeobox 6	0.037
Tbx2	T-box 2	0.037
Raf1	v-raf-leukemia viral oncogene 1	0.036
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.036
Pthlh	parathyroid hormone-like peptide	0.036
Bmp2	bone morphogenetic protein 2	0.035	Human
Alx1	ALX homeobox 1	0.034
Lrp2	low density lipoprotein receptor-related protein 2	0.034	Mouse
Gja1	gap junction protein, alpha 1	0.033	Rat
Pdx1	pancreatic and duodenal homeobox 1	0.033
Hhex	hematopoietically expressed homeobox	0.032
Scn5a	sodium channel, voltage-gated, type V, alpha	0.031
Aplnr	apelin receptor	0.030
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.030
Gata1	GATA binding protein 1	0.029
Wnt3a	wingless-related MMTV integration site 3A	0.029
Dlx5	distal-less homeobox 5	0.029
Tal1	T-cell acute lymphocytic leukemia 1	0.028	Mouse
Alx4	aristaless-like homeobox 4	0.028
Pbx1	pre B-cell leukemia transcription factor 1	0.028
Ptch1	patched homolog 1	0.028
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.028
Braf	Braf transforming gene	0.028
Wfikkn2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.027
Cldn5	claudin 5	0.026
Apc	adenomatosis polyposis coli	0.026
Col1a1	collagen, type I, alpha 1	0.026
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.025
Hdac2	histone deacetylase 2	0.025
Plin1	perilipin 1	0.025
Hoxa10	homeobox A10	0.025
En1	engrailed 1	0.025
Fbn1	fibrillin 1	0.025
Fst	follistatin	0.025
Onecut1	one cut domain, family member 1	0.024
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.024
Zeb1	zinc finger E-box binding homeobox 1	0.023
Ptf1a	pancreas specific transcription factor, 1a	0.023	Mouse
Per2	period homolog 2 (Drosophila)	0.022
Pick1	protein interacting with C kinase 1	0.022
Bnc1	basonuclin 1	0.022
Col2a1	collagen, type II, alpha 1	0.022
Emx2	empty spiracles homolog 2 (Drosophila)	0.022
Pou4f2	POU domain, class 4, transcription factor 2	0.021
Pkdcc	protein kinase domain containing, cytoplasmic	0.021
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.021
She	src homology 2 domain-containing transforming protein E	0.020
Lhx5	LIM homeobox protein 5	0.020
Efna2	ephrin A2	0.020
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.020
Cdx2	caudal type homeobox 2	0.020
Cdh5	cadherin 5	0.020
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.020
Tcf21	transcription factor 21	0.020
Fgf10	fibroblast growth factor 10	0.020
Trp63	transformation related protein 63	0.019
Tcfap2c	transcription factor AP-2, gamma	0.019
Hoxd9	homeobox D9	0.019
Sox13	SRY-box containing gene 13	0.019
Pax9	paired box gene 9	0.019
Adcy4	adenylate cyclase 4	0.018
Pitx3	paired-like homeodomain transcription factor 3	0.018
Foxg1	forkhead box G1	0.018
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.018
Amhr2	anti-Mullerian hormone type 2 receptor	0.018
Matn3	matrilin 3	0.018
Agtr2	angiotensin II receptor, type 2	0.017
Bcl2	B-cell leukemia/lymphoma 2	0.017
Acvrl1	activin A receptor, type II-like 1	0.017
Srf	serum response factor	0.017
Dmpk	dystrophia myotonica-protein kinase	0.017
Ccnd1	cyclin D1	0.017
Hoxd12	homeobox D12	0.017	Fly
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.017
Pou3f3	POU domain, class 3, transcription factor 3	0.017
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.017	Mouse
Acan	aggrecan	0.017
Fgf4	fibroblast growth factor 4	0.017
Cry2	cryptochrome 2 (photolyase-like)	0.017
Hoxa13	homeobox A13	0.016
Hoxd4	homeobox D4	0.016
Nf1	neurofibromatosis 1	0.016
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.016
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.016
Wdr19	WD repeat domain 19	0.016
Icam2	intercellular adhesion molecule 2	0.016
Alx3	aristaless-like homeobox 3	0.016
Hoxd13	homeobox D13	0.016
Hoxc8	homeobox C8	0.015
Mdm2	transformed mouse 3T3 cell double minute 2	0.015
Hoxd10	homeobox D10	0.015
Fgf9	fibroblast growth factor 9	0.015
Sall4	sal-like 4 (Drosophila)	0.015
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.015
Npc1	Niemann Pick type C1	0.015
Notch2	Notch gene homolog 2 (Drosophila)	0.014
Fgf17	fibroblast growth factor 17	0.014
Hoxa4	homeobox A4	0.014
Sct	secretin	0.014
Sin3a	transcriptional regulator, SIN3A (yeast)	0.014
Rasip1	Ras interacting protein 1	0.014
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.014
Foxc1	forkhead box C1	0.014
Zfhx3	zinc finger homeobox 3	0.014
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.014
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.014
Irs3	insulin receptor substrate 3	0.014
Wnt1	wingless-related MMTV integration site 1	0.014
Irx3	Iroquois related homeobox 3 (Drosophila)	0.014
Gpr50	G-protein-coupled receptor 50	0.013
Csf1	colony stimulating factor 1 (macrophage)	0.013
Igf1	insulin-like growth factor 1	0.013
Tal2	T-cell acute lymphocytic leukemia 2	0.013	Mouse
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.013
Robo4	roundabout homolog 4 (Drosophila)	0.013
Meox1	mesenchyme homeobox 1	0.013
Tcf15	transcription factor 15	0.013	Mouse
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.013
Rim4	recombination induced mutation 4	0.013
Edar	ectodysplasin-A receptor	0.013
Sall3	sal-like 3 (Drosophila)	0.013
Foxf1a	forkhead box F1a	0.013
Hesx1	homeobox gene expressed in ES cells	0.013
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.013
Jup	junction plakoglobin	0.013
Snai1	snail homolog 1 (Drosophila)	0.012
Egfr	epidermal growth factor receptor	0.012
Edn3	endothelin 3	0.012
Disp1	dispatched homolog 1 (Drosophila)	0.012
Insm1	insulinoma-associated 1	0.012
Hoxb4	homeobox B4	0.012
Rara	retinoic acid receptor, alpha	0.012
Tcf7	transcription factor 7, T-cell specific	0.012	Mouse
Nrk	Nik related kinase	0.012
Nodal	nodal	0.012
Lhx9	LIM homeobox protein 9	0.012
Lpin1	lipin 1	0.012
Gja4	gap junction protein, alpha 4	0.012
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.012
Gsk3b	glycogen synthase kinase 3 beta	0.012	Mouse
Lrp5	low density lipoprotein receptor-related protein 5	0.012	Mouse
Ldlr	low density lipoprotein receptor	0.011
Neurog3	neurogenin 3	0.011	Mouse
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.011	Mouse
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.011	Mouse
Rfwd2	ring finger and WD repeat domain 2	0.011
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.011
Foxd1	forkhead box D1	0.011
Gata2	GATA binding protein 2	0.011
Dll4	delta-like 4 (Drosophila)	0.011
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.011
Nhlh1	nescient helix loop helix 1	0.011	Mouse
Sox7	SRY-box containing gene 7	0.011	Mouse
Chad	chondroadherin	0.011
Nhlh2	nescient helix loop helix 2	0.011	Mouse
Pofut1	protein O-fucosyltransferase 1	0.011
Gata4	GATA binding protein 4	0.011
Tgif2	TGFB-induced factor homeobox 2	0.011
Wnt6	wingless-related MMTV integration site 6	0.011
Efs	embryonal Fyn-associated substrate	0.011
Cer1	cerberus 1 homolog (Xenopus laevis)	0.011
Ryr2	ryanodine receptor 2, cardiac	0.011
Zfhx4	zinc finger homeodomain 4	0.011
Zic1	zinc finger protein of the cerebellum 1	0.011
Egfl7	EGF-like domain 7	0.011
Arx	aristaless related homeobox	0.011
Esam	endothelial cell-specific adhesion molecule	0.010	Mouse
Axin2	axin2	0.010
Cbfb	core binding factor beta	0.010
Fgf15	fibroblast growth factor 15	0.010
Ptprb	protein tyrosine phosphatase, receptor type, B	0.010
Smad3	MAD homolog 3 (Drosophila)	0.010
Kif3a	kinesin family member 3A	0.010
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.010
Wnt5a	wingless-related MMTV integration site 5A	0.010
Gnrh1	gonadotropin releasing hormone 1	0.010
En2	engrailed 2	0.010
Bmper	BMP-binding endothelial regulator	0.010
Cldn6	claudin 6	0.010
Hoxa6	homeobox A6	0.010
Hnf1b	HNF1 homeobox B	0.010
Id1	inhibitor of DNA binding 1	0.010