IMP

Process View

Mus musculus

13 genes annotated in mouse

tumor necrosis factor mediated signaling pathway

A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "tumor necrosis factor mediated signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "tumor necrosis factor mediated signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Tnf	tumor necrosis factor	1.000
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	1.000
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.999
Igh	immunoglobulin heavy chain complex	0.995
Ifng	interferon gamma	0.948
Myd88	myeloid differentiation primary response gene 88	0.947
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.943
Lta	lymphotoxin A	0.935	Mouse
Cd19	CD19 antigen	0.897
Cd40	CD40 antigen	0.839	Mouse
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.835
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.803
Stat3	signal transducer and activator of transcription 3	0.742
Fas	Fas (TNF receptor superfamily member 6)	0.717	Mouse Rat
Krt8	keratin 8	0.717
Krt6a	keratin 6A	0.692	Mouse
Tlr4	toll-like receptor 4	0.674
Traf6	TNF receptor-associated factor 6	0.646	Mouse
Pkp1	plakophilin 1	0.618
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.609
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.496
Krt17	keratin 17	0.490	Mouse
Krt5	keratin 5	0.448	Mouse
Ikbkg	inhibitor of kappaB kinase gamma	0.429
Il1r1	interleukin 1 receptor, type I	0.419
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.410
Krt33b	keratin 33B	0.373	Mouse
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.312
Gbp5	guanylate binding protein 5	0.310
Ltb	lymphotoxin B	0.303
Krt19	keratin 19	0.292	Mouse
Krt18	keratin 18	0.273
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.266
Wnt10a	wingless related MMTV integration site 10a	0.238
Csf1	colony stimulating factor 1 (macrophage)	0.216
Il4	interleukin 4	0.215
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.209
Lyz2	lysozyme 2	0.206
Traf2	TNF receptor-associated factor 2	0.204	Human Mouse
Socs1	suppressor of cytokine signaling 1	0.195
Cd44	CD44 antigen	0.182
Sprr1a	small proline-rich protein 1A	0.169
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.168
Krt86	keratin 86	0.163	Mouse
Krtap8-1	keratin associated protein 8-1	0.160
Il10	interleukin 10	0.155
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.153
Psapl1	prosaposin-like 1	0.151
Prf1	perforin 1 (pore forming protein)	0.144
Il7	interleukin 7	0.142
Tff1	trefoil factor 1	0.130
Bcl3	B-cell leukemia/lymphoma 3	0.125
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.122
Icos	inducible T-cell co-stimulator	0.117
Il6	interleukin 6	0.117
Ccl2	chemokine (C-C motif) ligand 2	0.115
Ptgs2	prostaglandin-endoperoxide synthase 2	0.114
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.100
Birc3	baculoviral IAP repeat-containing 3	0.098
Bcl6	B-cell leukemia/lymphoma 6	0.097
Krt71	keratin 71	0.092	Mouse
Krt7	keratin 7	0.092	Mouse
Ticam1	toll-like receptor adaptor molecule 1	0.091
Syt8	synaptotagmin VIII	0.082
Krt27	keratin 27	0.082	Mouse
Ikbkb	inhibitor of kappaB kinase beta	0.082
Krtap3-1	keratin associated protein 3-1	0.080
Nlrp3	NLR family, pyrin domain containing 3	0.080
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.077
Krtap5-1	keratin associated protein 5-1	0.076
Krt33a	keratin 33A	0.075	Mouse
Il6st	interleukin 6 signal transducer	0.074
Il22	interleukin 22	0.074
Rnf31	ring finger protein 31	0.069
5430421N21Rik	RIKEN cDNA 5430421N21 gene	0.068
Tnfrsf18	tumor necrosis factor receptor superfamily, member 18	0.063
Krt84	keratin 84	0.061	Mouse
Nos2	nitric oxide synthase 2, inducible	0.059
Cxcr5	chemokine (C-X-C motif) receptor 5	0.058
Irak1	interleukin-1 receptor-associated kinase 1	0.058
Alox12e	arachidonate lipoxygenase, epidermal	0.057
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.057
Apoe	apolipoprotein E	0.055
Dlx3	distal-less homeobox 3	0.052
Slurp1	secreted Ly6/Plaur domain containing 1	0.050
Asprv1	aspartic peptidase, retroviral-like 1	0.048
Mavs	mitochondrial antiviral signaling protein	0.048
S100a3	S100 calcium binding protein A3	0.048
Asap1	ArfGAP with SH# domain, ankyrin repeat and PH domain1	0.048
Krt4	keratin 4	0.044	Mouse
Krt14	keratin 14	0.043	Mouse
Stat6	signal transducer and activator of transcription 6	0.043
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.041
Krt13	keratin 13	0.038
Lgals7	lectin, galactose binding, soluble 7	0.038
Il2	interleukin 2	0.038
Ccl4	chemokine (C-C motif) ligand 4	0.037
Cd40lg	CD40 ligand	0.037	Mouse
Casp14	caspase 14	0.036
Krt31	keratin 31	0.036	Mouse
Oxt	oxytocin	0.035
Serpinb5	serine (or cysteine) peptidase inhibitor, clade B, member 5	0.035
Alox8	arachidonate 8-lipoxygenase	0.034
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.033
Cxcl13	chemokine (C-X-C motif) ligand 13	0.033
Krt35	keratin 35	0.033	Mouse
Casp1	caspase 1	0.031
S100a14	S100 calcium binding protein A14	0.031
Traf3	TNF receptor-associated factor 3	0.031
Has1	hyaluronan synthase1	0.030
Sult2b1	sulfotransferase family, cytosolic, 2B, member 1	0.029
Klk7	kallikrein related-peptidase 7 (chymotryptic, stratum corneum)	0.028
Krt72-ps	keratin 72, pseudogene	0.028	Mouse
Socs3	suppressor of cytokine signaling 3	0.028
Traf3ip2	TRAF3 interacting protein 2	0.026
Hr	hairless	0.026
Spp1	secreted phosphoprotein 1	0.025
Id2	inhibitor of DNA binding 2	0.025
Cdcp1	CUB domain containing protein 1	0.025
Krt77	keratin 77	0.025	Mouse
Krt32	keratin 32	0.025	Mouse
Foxp3	forkhead box P3	0.025
Ly6g6c	lymphocyte antigen 6 complex, locus G6C	0.024
Il1f5	interleukin 1 family, member 5 (delta)	0.024
Clic3	chloride intracellular channel 3	0.024
Krt34	keratin 34	0.023
Trp63	transformation related protein 63	0.023
Ikzf1	IKAROS family zinc finger 1	0.023
Eif1a	eukaryotic translation initiation factor 1A	0.022
Ppl	periplakin	0.022
Gm10229	predicted gene 10229	0.022
Fgf6	fibroblast growth factor 6	0.022
Krt1	keratin 1	0.022	Mouse
Mt4	metallothionein 4	0.022
Tacstd2	tumor-associated calcium signal transducer 2	0.022
Prkcd	protein kinase C, delta	0.021
Krt36	keratin 36	0.021	Mouse
Gp5	glycoprotein 5 (platelet)	0.021
Runx1	runt related transcription factor 1	0.021
Drd4	dopamine receptor D4	0.021
Trim29	tripartite motif-containing 29	0.021
Ltbr	lymphotoxin B receptor	0.020	Mouse
Cdsn	corneodesmosin	0.020
Klk6	kallikrein related-peptidase 6	0.020
Calm4	calmodulin 4	0.019
Btk	Bruton agammaglobulinemia tyrosine kinase	0.019
Krt85	keratin 85	0.019
Slc25a48	solute carrier family 25, member 48	0.019
H2-M9	histocompatibility 2, M region locus 9	0.019
Pparg	peroxisome proliferator activated receptor gamma	0.018
Padi3	peptidyl arginine deiminase, type III	0.018
Nsf	N-ethylmaleimide sensitive fusion protein	0.018
Krt75	keratin 75	0.018	Mouse
Rag1	recombination activating gene 1	0.018
Lce1i	late cornified envelope 1I	0.017
Eya2	eyes absent 2 homolog (Drosophila)	0.017
Krt15	keratin 15	0.017	Mouse
Cryaa	crystallin, alpha A	0.017
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.016
Gjb4	gap junction protein, beta 4	0.016
Card11	caspase recruitment domain family, member 11	0.016
Krtap12-1	keratin associated protein 12-1	0.016
Il4ra	interleukin 4 receptor, alpha	0.015
Cyld	cylindromatosis (turban tumor syndrome)	0.015
Amelx	amelogenin X chromosome	0.014
Hif1a	hypoxia inducible factor 1, alpha subunit	0.014
Krtap6-2	keratin associated protein 6-2	0.014
Jak2	Janus kinase 2	0.014	Human
Flii	flightless I homolog (Drosophila)	0.014
Casp8	caspase 8	0.014
2310014L17Rik	RIKEN cDNA 2310014L17 gene	0.014
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.014	Mouse
Rgs9	regulator of G-protein signaling 9	0.014
Ivl	involucrin	0.014
Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.014	Mouse
Mfi2	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	0.014
Fxyd3	FXYD domain-containing ion transport regulator 3	0.013
Tnip1	TNFAIP3 interacting protein 1	0.013
Anxa8	annexin A8	0.013
Il2ra	interleukin 2 receptor, alpha chain	0.013
Lce3c	late cornified envelope 3C	0.013
Muc1	mucin 1, transmembrane	0.013
Cstb	cystatin B	0.013
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.013
Omp	olfactory marker protein	0.013
Alox12b	arachidonate 12-lipoxygenase, 12R type	0.013
Eda	ectodysplasin-A	0.013
Elovl3	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	0.012
Traf1	TNF receptor-associated factor 1	0.012	Mouse
Itk	IL2-inducible T-cell kinase	0.012
Krtdap	keratinocyte differentiation associated protein	0.012
Prss32	protease, serine, 32	0.012
Il12rb2	interleukin 12 receptor, beta 2	0.012
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.012
Lama5	laminin, alpha 5	0.012
Ldlr	low density lipoprotein receptor	0.012
Rel	reticuloendotheliosis oncogene	0.012
Lad1	ladinin	0.012
Sypl2	synaptophysin-like 2	0.012
Mfn2	mitofusin 2	0.011
Ghrl	ghrelin	0.011
Lypd3	Ly6/Plaur domain containing 3	0.011
Tnfsf8	tumor necrosis factor (ligand) superfamily, member 8	0.011
Rab25	RAB25, member RAS oncogene family	0.011
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2	0.011
Reg3g	regenerating islet-derived 3 gamma	0.011
Col17a1	collagen, type XVII, alpha 1	0.011
Pou2af1	POU domain, class 2, associating factor 1	0.011
Wfdc12	WAP four-disulfide core domain 12	0.011
Tgm2	transglutaminase 2, C polypeptide	0.011
Trpm1	transient receptor potential cation channel, subfamily M, member 1	0.010
2310002J15Rik	RIKEN cDNA 2310002J15 gene	0.010
Gzmk	granzyme K	0.010
Barx2	BarH-like homeobox 2	0.010
Epha2	Eph receptor A2	0.010