IMP
Process View
positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway
Any process that increases the frequency, rate or extent of metanephric mesenchymal cell migration as a result of the series of molecular signals generated as a consequence of a platelet-derived growth factor receptor-beta binding to one of its physiological ligands.
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Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.999 | ||
| Kdr | kinase insert domain protein receptor | 0.994 | Mouse | |
| Vegfa | vascular endothelial growth factor A | 0.988 | ||
| Pdgfrb | platelet derived growth factor receptor, beta polypeptide | 0.981 | ||
| Tie1 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | 0.912 | ||
| Cdh5 | cadherin 5 | 0.882 | ||
| Tgfbr2 | transforming growth factor, beta receptor II | 0.872 | ||
| Smo | smoothened homolog (Drosophila) | 0.868 | ||
| Ptprb | protein tyrosine phosphatase, receptor type, B | 0.843 | ||
| Slc9a3r2 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 | 0.823 | ||
| Sox18 | SRY-box containing gene 18 | 0.788 | ||
| Eng | endoglin | 0.716 | ||
| Csf1 | colony stimulating factor 1 (macrophage) | 0.700 | ||
| Acvrl1 | activin A receptor, type II-like 1 | 0.610 | ||
| She | src homology 2 domain-containing transforming protein E | 0.537 | ||
| Col1a1 | collagen, type I, alpha 1 | 0.533 | ||
| Foxc2 | forkhead box C2 | 0.486 | ||
| Bmp4 | bone morphogenetic protein 4 | 0.477 | ||
| Esam | endothelial cell-specific adhesion molecule | 0.434 | ||
| Tek | endothelial-specific receptor tyrosine kinase | 0.421 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.421 | ||
| Pdgfb | platelet derived growth factor, B polypeptide | 0.391 | Human | |
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.378 | Mouse | |
| Tgfb1 | transforming growth factor, beta 1 | 0.365 | ||
| Tgfb2 | transforming growth factor, beta 2 | 0.363 | ||
| Flt1 | FMS-like tyrosine kinase 1 | 0.361 | Mouse | |
| Lepr | leptin receptor | 0.328 | ||
| Arap3 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 | 0.300 | ||
| Cldn5 | claudin 5 | 0.296 | ||
| Epas1 | endothelial PAS domain protein 1 | 0.273 | ||
| Kitl | kit ligand | 0.259 | ||
| Adcy4 | adenylate cyclase 4 | 0.240 | ||
| Fgfr1 | fibroblast growth factor receptor 1 | 0.239 | ||
| Aplnr | apelin receptor | 0.225 | ||
| Col4a2 | collagen, type IV, alpha 2 | 0.224 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.220 | ||
| Apoe | apolipoprotein E | 0.209 | ||
| Plxnd1 | plexin D1 | 0.208 | ||
| Meox2 | mesenchyme homeobox 2 | 0.193 | ||
| Hspg2 | perlecan (heparan sulfate proteoglycan 2) | 0.191 | ||
| Pecam1 | platelet/endothelial cell adhesion molecule 1 | 0.181 | ||
| Ldb2 | LIM domain binding 2 | 0.175 | ||
| Acvr1 | activin A receptor, type 1 | 0.160 | ||
| Rasip1 | Ras interacting protein 1 | 0.158 | ||
| Robo4 | roundabout homolog 4 (Drosophila) | 0.154 | ||
| Efnb2 | ephrin B2 | 0.152 | ||
| Egfl7 | EGF-like domain 7 | 0.152 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.142 | ||
| Lrp1 | low density lipoprotein receptor-related protein 1 | 0.136 | ||
| Emcn | endomucin | 0.136 | ||
| Ednrb | endothelin receptor type B | 0.125 | ||
| Prrx1 | paired related homeobox 1 | 0.117 | ||
| Pkd1 | polycystic kidney disease 1 homolog | 0.113 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.113 | ||
| Nid1 | nidogen 1 | 0.113 | ||
| Bmp2 | bone morphogenetic protein 2 | 0.104 | ||
| Sox17 | SRY-box containing gene 17 | 0.103 | ||
| Flt4 | FMS-like tyrosine kinase 4 | 0.099 | Mouse | |
| Hic1 | hypermethylated in cancer 1 | 0.098 | ||
| Podxl | podocalyxin-like | 0.097 | ||
| Ramp2 | receptor (calcitonin) activity modifying protein 2 | 0.096 | ||
| Shank3 | SH3/ankyrin domain gene 3 | 0.093 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.091 | ||
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.091 | ||
| Gli3 | GLI-Kruppel family member GLI3 | 0.089 | ||
| Vegfc | vascular endothelial growth factor C | 0.086 | ||
| Tgfb1i1 | transforming growth factor beta 1 induced transcript 1 | 0.086 | ||
| Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 0.085 | ||
| Ece1 | endothelin converting enzyme 1 | 0.083 | ||
| Foxc1 | forkhead box C1 | 0.082 | ||
| Nrp1 | neuropilin 1 | 0.081 | ||
| Gja4 | gap junction protein, alpha 4 | 0.078 | ||
| Pten | phosphatase and tensin homolog | 0.076 | ||
| Thbd | thrombomodulin | 0.072 | ||
| Trp53 | transformation related protein 53 | 0.072 | ||
| Sema6d | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D | 0.072 | ||
| S1pr3 | sphingosine-1-phosphate receptor 3 | 0.071 | ||
| Sox7 | SRY-box containing gene 7 | 0.069 | ||
| Stab1 | stabilin 1 | 0.068 | ||
| Tmem204 | transmembrane protein 204 | 0.067 | ||
| Icam2 | intercellular adhesion molecule 2 | 0.066 | ||
| Bcl6b | B-cell CLL/lymphoma 6, member B | 0.064 | ||
| Ednra | endothelin receptor type A | 0.062 | ||
| Col4a1 | collagen, type IV, alpha 1 | 0.062 | ||
| Lyz2 | lysozyme 2 | 0.060 | ||
| Apc | adenomatosis polyposis coli | 0.057 | ||
| Hlx | H2.0-like homeobox | 0.057 | ||
| Plvap | plasmalemma vesicle associated protein | 0.055 | ||
| Crim1 | cysteine rich transmembrane BMP regulator 1 (chordin like) | 0.053 | ||
| Fgd5 | FYVE, RhoGEF and PH domain containing 5 | 0.053 | ||
| Sox9 | SRY-box containing gene 9 | 0.050 | ||
| Ptch1 | patched homolog 1 | 0.049 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.048 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.048 | ||
| Cxcl12 | chemokine (C-X-C motif) ligand 12 | 0.047 | ||
| Tenc1 | tensin like C1 domain-containing phosphatase | 0.047 | ||
| Mmp2 | matrix metallopeptidase 2 | 0.046 | ||
| Mmrn2 | multimerin 2 | 0.045 | ||
| Cd93 | CD93 antigen | 0.045 | ||
| Ldlr | low density lipoprotein receptor | 0.044 | ||
| Gja1 | gap junction protein, alpha 1 | 0.043 | ||
| Bgn | biglycan | 0.043 | ||
| Eltd1 | EGF, latrophilin seven transmembrane domain containing 1 | 0.043 | ||
| Sorbs3 | sorbin and SH3 domain containing 3 | 0.042 | ||
| Ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 0.042 | ||
| Tyrobp | TYRO protein tyrosine kinase binding protein | 0.041 | ||
| Fbln1 | fibulin 1 | 0.041 | ||
| Mcam | melanoma cell adhesion molecule | 0.040 | ||
| Plcg1 | phospholipase C, gamma 1 | 0.040 | ||
| Lama4 | laminin, alpha 4 | 0.040 | ||
| Sdc3 | syndecan 3 | 0.039 | ||
| Ltbp3 | latent transforming growth factor beta binding protein 3 | 0.039 | ||
| Ltbp4 | latent transforming growth factor beta binding protein 4 | 0.038 | ||
| Itga3 | integrin alpha 3 | 0.038 | ||
| Esr1 | estrogen receptor 1 (alpha) | 0.038 | ||
| Rxra | retinoid X receptor alpha | 0.037 | ||
| Gucy1b3 | guanylate cyclase 1, soluble, beta 3 | 0.037 | ||
| Notch3 | Notch gene homolog 3 (Drosophila) | 0.036 | ||
| Cd97 | CD97 antigen | 0.035 | ||
| Src | Rous sarcoma oncogene | 0.035 | ||
| Col6a2 | collagen, type VI, alpha 2 | 0.034 | ||
| Fzd4 | frizzled homolog 4 (Drosophila) | 0.034 | ||
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.033 | ||
| Tbx2 | T-box 2 | 0.033 | ||
| Ushbp1 | Usher syndrome 1C binding protein 1 | 0.033 | ||
| Cbl | Casitas B-lineage lymphoma | 0.031 | ||
| Vwf | Von Willebrand factor homolog | 0.030 | ||
| Ptprm | protein tyrosine phosphatase, receptor type, M | 0.030 | ||
| Jag1 | jagged 1 | 0.030 | ||
| Tgfbr3 | transforming growth factor, beta receptor III | 0.028 | ||
| Timp2 | tissue inhibitor of metalloproteinase 2 | 0.028 | ||
| Fgfr3 | fibroblast growth factor receptor 3 | 0.028 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.027 | ||
| Bmp7 | bone morphogenetic protein 7 | 0.027 | ||
| Ddr2 | discoidin domain receptor family, member 2 | 0.027 | ||
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.026 | ||
| Fbn1 | fibrillin 1 | 0.026 | ||
| Hey1 | hairy/enhancer-of-split related with YRPW motif 1 | 0.026 | ||
| Aebp1 | AE binding protein 1 | 0.025 | ||
| Wwtr1 | WW domain containing transcription regulator 1 | 0.025 | ||
| Cacna1c | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.025 | ||
| Vhl | von Hippel-Lindau tumor suppressor | 0.024 | ||
| Tspan9 | tetraspanin 9 | 0.024 | ||
| Hdac7 | histone deacetylase 7 | 0.022 | ||
| Apln | apelin | 0.022 | ||
| Il6st | interleukin 6 signal transducer | 0.021 | ||
| Apbb2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.021 | ||
| Efnb1 | ephrin B1 | 0.021 | ||
| Hspa12b | heat shock protein 12B | 0.021 | ||
| Cav1 | caveolin 1, caveolae protein | 0.021 | ||
| C1qb | complement component 1, q subcomponent, beta polypeptide | 0.021 | ||
| Ar | androgen receptor | 0.021 | ||
| Clec14a | C-type lectin domain family 14, member a | 0.020 | ||
| Lama5 | laminin, alpha 5 | 0.020 | ||
| Rgs5 | regulator of G-protein signaling 5 | 0.020 | ||
| Npr2 | natriuretic peptide receptor 2 | 0.020 | ||
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.019 | ||
| Ly86 | lymphocyte antigen 86 | 0.019 | ||
| Dnajb5 | DnaJ (Hsp40) homolog, subfamily B, member 5 | 0.018 | ||
| Fyn | Fyn proto-oncogene | 0.018 | ||
| Kit | kit oncogene | 0.018 | Mouse | |
| Sod3 | superoxide dismutase 3, extracellular | 0.018 | ||
| Bmpr2 | bone morphogenic protein receptor, type II (serine/threonine kinase) | 0.017 | ||
| Psen1 | presenilin 1 | 0.017 | ||
| Smad6 | MAD homolog 6 (Drosophila) | 0.017 | ||
| Gpr116 | G protein-coupled receptor 116 | 0.017 | ||
| Tnks1bp1 | tankyrase 1 binding protein 1 | 0.017 | ||
| C1qc | complement component 1, q subcomponent, C chain | 0.017 | ||
| Tcirg1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 | 0.017 | ||
| Fmnl3 | formin-like 3 | 0.017 | ||
| Gata2 | GATA binding protein 2 | 0.017 | ||
| C1qa | complement component 1, q subcomponent, alpha polypeptide | 0.017 | ||
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.016 | ||
| Arhgef15 | Rho guanine nucleotide exchange factor (GEF) 15 | 0.016 | ||
| Col6a1 | collagen, type VI, alpha 1 | 0.016 | ||
| Cd151 | CD151 antigen | 0.016 | ||
| Ghr | growth hormone receptor | 0.016 | ||
| Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | 0.016 | ||
| Abcc9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 0.016 | ||
| Rarb | retinoic acid receptor, beta | 0.016 | ||
| Rhoj | ras homolog gene family, member J | 0.015 | ||
| Tinagl1 | tubulointerstitial nephritis antigen-like 1 | 0.015 | ||
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.015 | ||
| Tgm2 | transglutaminase 2, C polypeptide | 0.015 | ||
| Kcnk3 | potassium channel, subfamily K, member 3 | 0.015 | ||
| Kifc3 | kinesin family member C3 | 0.015 | ||
| Sox13 | SRY-box containing gene 13 | 0.014 | ||
| Jup | junction plakoglobin | 0.014 | ||
| Dab2 | disabled homolog 2 (Drosophila) | 0.014 | ||
| Ret | ret proto-oncogene | 0.014 | ||
| Bmp6 | bone morphogenetic protein 6 | 0.014 | ||
| Lamc1 | laminin, gamma 1 | 0.014 | ||
| Cd34 | CD34 antigen | 0.014 | ||
| Lamb2 | laminin, beta 2 | 0.013 | ||
| Trim3 | tripartite motif-containing 3 | 0.013 | ||
| Leprel2 | leprecan-like 2 | 0.013 | ||
| Meox1 | mesenchyme homeobox 1 | 0.013 | ||
| S1pr1 | sphingosine-1-phosphate receptor 1 | 0.013 | ||
| Gpsm3 | G-protein signalling modulator 3 (AGS3-like, C. elegans) | 0.013 | ||
| Chrd | chordin | 0.013 | ||
| Rarg | retinoic acid receptor, gamma | 0.013 | ||
| Nf1 | neurofibromatosis 1 | 0.013 | ||
| Ptpn14 | protein tyrosine phosphatase, non-receptor type 14 | 0.012 | ||
| Gata6 | GATA binding protein 6 | 0.012 | ||
| Loxl1 | lysyl oxidase-like 1 | 0.012 | ||
| Elk3 | ELK3, member of ETS oncogene family | 0.012 | ||
| Ets1 | E26 avian leukemia oncogene 1, 5' domain | 0.012 | ||
| Mertk | c-mer proto-oncogene tyrosine kinase | 0.012 | ||
| St3gal2 | ST3 beta-galactoside alpha-2,3-sialyltransferase 2 | 0.012 | ||
| Cdc42ep1 | CDC42 effector protein (Rho GTPase binding) 1 | 0.012 | ||
| Akap2 | A kinase (PRKA) anchor protein 2 | 0.012 | ||
| Plxna1 | plexin A1 | 0.012 | ||
| Shh | sonic hedgehog | 0.012 | ||
| Pparg | peroxisome proliferator activated receptor gamma | 0.012 | ||
| Phldb1 | pleckstrin homology-like domain, family B, member 1 | 0.012 | ||
| Lmna | lamin A | 0.012 | ||
| Lamb1 | laminin B1 | 0.012 | ||
| Igfbp3 | insulin-like growth factor binding protein 3 | 0.012 | ||
| Lyz1 | lysozyme 1 | 0.012 | ||
| Klf2 | Kruppel-like factor 2 (lung) | 0.011 | ||
| Itpkb | inositol 1,4,5-trisphosphate 3-kinase B | 0.011 | ||
| S1pr2 | sphingosine-1-phosphate receptor 2 | 0.011 | ||
| BC013712 | cDNA sequence BC013712 | 0.011 | ||
| Card10 | caspase recruitment domain family, member 10 | 0.011 | ||
| Emp2 | epithelial membrane protein 2 | 0.011 | ||
| Sept4 | septin 4 | 0.011 | ||
| Phlda3 | pleckstrin homology-like domain, family A, member 3 | 0.011 | ||
| Runx2 | runt related transcription factor 2 | 0.011 | ||
| Aldh1a2 | aldehyde dehydrogenase family 1, subfamily A2 | 0.011 | ||
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.011 | ||
| Creb3l1 | cAMP responsive element binding protein 3-like 1 | 0.011 | ||
| Tln1 | talin 1 | 0.011 | ||
| Igfbp7 | insulin-like growth factor binding protein 7 | 0.011 | ||
| Col1a2 | collagen, type I, alpha 2 | 0.011 | ||
| Tnxb | tenascin XB | 0.011 | ||
| Itga5 | integrin alpha 5 (fibronectin receptor alpha) | 0.011 | ||
| Ptgs1 | prostaglandin-endoperoxide synthase 1 | 0.011 | ||
| X99384 | cDNA sequence X99384 | 0.011 | ||
| Selplg | selectin, platelet (p-selectin) ligand | 0.011 | ||
| Emr1 | EGF-like module containing, mucin-like, hormone receptor-like sequence 1 | 0.011 | ||
| Bmp1 | bone morphogenetic protein 1 | 0.011 | ||
| Pld4 | phospholipase D family, member 4 | 0.010 | ||
| Mrc2 | mannose receptor, C type 2 | 0.010 | ||
| Ppap2b | phosphatidic acid phosphatase type 2B | 0.010 | ||
| Sgpl1 | sphingosine phosphate lyase 1 | 0.010 | ||
| Myo1c | myosin IC | 0.010 | ||
| Jun | Jun oncogene | 0.010 | ||
| Gnaq | guanine nucleotide binding protein, alpha q polypeptide | 0.010 | ||
| Kcnj8 | potassium inwardly-rectifying channel, subfamily J, member 8 | 0.010 |