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Danio rerio

21 genes annotated in zebrafish

negative regulation of canonical wnt signaling pathway

Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of canonical wnt signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of canonical wnt signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
wnt5b	wingless-type MMTV integration site family, member 5b	0.916	Human Zebrafish Mouse
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.737	Zebrafish
bmp4	bone morphogenetic protein 4	0.690
fzd5	frizzled homolog 5	0.559
wnt11r	wingless-type MMTV integration site family, member 11, related	0.498	Zebrafish Mouse
tbx1	T-box 1	0.465
frzb	frizzled-related protein	0.458	Human Zebrafish Mouse Rat
crb2a	crumbs homolog 2a	0.447	Zebrafish
gli1	GLI-Kruppel family member 1	0.393	Human
fzd7a	frizzled homolog 7a	0.364
pak1	p21/Cdc42/Rac1-activated kinase 1	0.336
LOC100000687	signal peptide, CUB and EGF-like domain-containing protein 3-like	0.317
fn1	fibronectin 1	0.302
wnt4a	wingless-type MMTV integration site family, member 4a	0.285	Zebrafish
cxcr4b	chemokine (C-X-C motif), receptor 4b	0.283
ephb4b	eph receptor B4b	0.252
wnt8a	wingless-type MMTV integration site family, member 8a	0.243
celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.229
smad9	MAD homolog 9 (Drosophila)	0.213
twist1a	twist1a	0.204
wnt1	wingless-type MMTV integration site family, member 1	0.201	Zebrafish
flh	floating head	0.199
gdf6a	growth differentiation factor 6a	0.187
wnt10a	wingless-type MMTV integration site family, member 10a	0.186	Zebrafish
kdrl	kinase insert domain receptor like	0.186
zgc:113210	zgc:113210	0.182
sox2	SRY-box containing gene 2	0.178	Human Mouse
ndr2	nodal-related 2	0.172
spry2	sprouty homolog 2	0.165
zbtb4	zinc finger and BTB domain containing 4	0.163
pea3	ETS-domain transcription factor pea3	0.163
wnt3a	wingless-type MMTV integration site family, member 3A	0.160	Zebrafish
six1b	sine oculis homeobox homolog 1b	0.150
sox9b	SRY-box containing gene 9b	0.147
pcdh18b	protocadherin 18b	0.145
vsx1	visual system homeobox 1 homolog, chx10-like	0.132
fgf17	fibroblast growth factor 17	0.131
axin2	axin 2 (conductin, axil)	0.126	Human Zebrafish
aplnrb	apelin receptor b	0.120
mapk1	mitogen-activated protein kinase 1	0.119
map2k4a	mitogen-activated protein kinase kinase 4a	0.107
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.105
hmgcrb	3-hydroxy-3-methylglutaryl-Coenzyme A reductase b	0.103
notch3	notch homolog 3	0.102
foxa2	forkhead box A2	0.101
has2	hyaluronan synthase 2	0.101
tgfbi	transforming growth factor, beta-induced	0.098
LOC100331502	melanopsin-B-like	0.098
wnt11	wingless-type MMTV integration site family, member 11	0.093
dkk1b	dickkopf 1b	0.088
rarga	retinoic acid receptor gamma a	0.087
dld	deltaD	0.084
lrp2	low density lipoprotein-related protein 2	0.083
admp	anti-dorsalizing morphogenic protein	0.081
amotl2a	angiomotin like 2a	0.079
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.073
osr2	odd-skipped related 2 (Drosophila)	0.073
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.069
rest	RE1-silencing transcription factor	0.068
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.067
hnf1ba	HNF1 homeobox Ba	0.066
notum3	notum 3	0.065
gsc	goosecoid	0.061
zic3	zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)	0.060
ptch2	patched 2	0.058
sp5l	Sp5 transcription factor-like	0.058
epb41l5	erythrocyte membrane protein band 4.1 like 5	0.058
otx1b	orthodenticle homolog 1b	0.056
mespa	mesoderm posterior a	0.053	Mouse
ppp4cb	protein phosphatase 4 (formerly X), catalytic subunit b	0.053
tpbgl	trophoblast glycoprotein-like	0.053
kctd12.1	potassium channel tetramerisation domain containing 12.1	0.053
fzd7b	frizzled homolog 7b	0.053	Zebrafish
wnt9a	wingless-type MMTV integration site family, member 9A	0.052	Zebrafish
nog2	noggin 2	0.052
sfrp1a	secreted frizzled-related protein 1a	0.051	Human Mouse
nhsl1b	NHS-like 1b	0.050
tp63	tumor protein p63	0.050
hoxb5a	homeo box B5a	0.050
zgc:171495	zgc:171495	0.049
nkx2.2a	NK2 transcription factor related 2a	0.048
wnt16	wingless-type MMTV integration site family, member 16	0.046
si:dkeyp-7c9.1	si:dkeyp-7c9.1	0.045
tcf7l1a	transcription factor 7-like 1a (T-cell specific, HMG-box)	0.045
mib	mind bomb	0.043
wnt7bb	wingless-type MMTV integration site family, member 7Bb	0.043
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.043
bcl2	B-cell leukemia/lymphoma 2	0.042
nrarpa	notch-regulated ankyrin repeat protein a	0.042
gbx1	gastrulation brain homeobox 1	0.041
nog1	noggin 1	0.041	Human
aplnra	apelin receptor a	0.041
LOC567452	G protein-coupled receptor kinase 5-like	0.041
sulf1	sulfatase 1	0.040
tbx16	T-box gene 16	0.039
pcdh8	protocadherin 8	0.037
her1	hairy-related 1	0.037
wls	wntless homolog (Drosophila)	0.037
lef1	lymphocyte enhancer binding factor 1	0.037	Human
etv2	ets variant gene 2	0.036
wnt9b	wingless-type MMTV integration site family, member 9B	0.036	Zebrafish
wnt8b	wingless-type MMTV integration site family, member 8b	0.036	Zebrafish
crb2b	crumbs homolog 2b	0.035	Zebrafish
wnt7aa	wingless-type MMTV integration site family, member 7Aa	0.035	Zebrafish
ndr1	nodal-related 1	0.035
spon2a	spondin 2a, extracellular matrix protein	0.034
nanos3	nanos homolog 3	0.034
neurod	neurogenic differentiation	0.033
map2k4b	mitogen-activated protein kinase kinase 4b	0.033
dlc	deltaC	0.032
sox19a	SRY-box containing gene 19a	0.032
id1	inhibitor of DNA binding 1	0.032
robo2	roundabout homolog 2	0.032
pomca	proopiomelanocortin a	0.032
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.032
col2a1a	collagen type II, alpha-1a	0.031
igf1rb	insulin-like growth factor 1b receptor	0.031
foxa3	forkhead box A3	0.031
nkx3.2	NK3 homeobox 2	0.031
mapk6	mitogen-activated protein kinase 6	0.031
myl9l	myosin, light polypeptide 9, like	0.031
wnt10b	wingless-type MMTV integration site family, member 10b	0.031	Zebrafish
wif1	wnt inhibitory factor 1	0.031
fzd10	frizzled homolog 10	0.030	Zebrafish
runx2b	runt-related transcription factor 2b	0.028
ism1	isthmin 1	0.028
mapk7	mitogen-activated protein kinase 7	0.028
map2k7	mitogen-activated protein kinase kinase 7	0.027
klf4	Kruppel-like factor 4	0.027
wnt7ba	wingless-type MMTV integration site family, member 7Ba	0.027	Zebrafish
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.027
fyna	FYN oncogene related to SRC, FGR, YES a	0.027
gro2	groucho 2	0.027	Fly
inhbb	inhibin, beta B	0.027
runx1	runt-related transcription factor 1	0.026
zfyve26	zinc finger, FYVE domain containing 26	0.026
myf5	myogenic factor 5	0.026
spry4	sprouty (Drosophila) homolog 4	0.026
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.026
zgc:172136	zgc:172136	0.026
bon	bonnie and clyde	0.026
hapln1a	hyaluronan and proteoglycan link protein 1a	0.025
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.025	Human
fbln1	fibulin 1	0.025
crb3a	crumbs homolog 3a	0.025
ripply2	ripply2	0.025
fgf3	fibroblast growth factor 3	0.024
matn1	matrilin 1	0.024
bmpr1ab	bone morphogenetic protein receptor, type 1ab	0.024
wnt3	wingless-type MMTV integration site family, member 3	0.024	Zebrafish
sb:cb81	sb:cb81	0.024
si:dkey-273o13.1	si:dkey-273o13.1	0.023
dkk3	dickkopf homolog 3 (Xenopus laevis)	0.023
buc	bucky ball	0.023
axin1	axin 1	0.023
inka1a	induced in neural crest by AP2, 1a	0.023
wnt5a	wingless-type MMTV integration site family, member 5a	0.022	Zebrafish
hoxd4a	homeo box D4a	0.022
arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.022
mga	MAX gene associated	0.022
fli1a	friend leukemia integration 1a	0.021
kal1a	Kallmann syndrome 1a sequence	0.021
otx2	orthodenticle homolog 2	0.021
bmp7a	bone morphogenetic protein 7a	0.021
crb1	crumbs homolog 1 (Drosophila)	0.021	Zebrafish
gnb1b	guanine nucleotide binding protein (G protein), beta polypeptide 1b	0.020
twist3	twist3	0.020
glcci1	glucocorticoid induced transcript 1	0.020
irx5a	iroquois homeobox protein 5a	0.020
nog3	noggin 3	0.020
si:ch211-173o4.2	si:ch211-173o4.2	0.020
brd4	bromodomain containing 4	0.020
cacnb4a	calcium channel, voltage-dependent, beta 4a subunit	0.020
col10a1	collagen, type X, alpha 1	0.020
cd81	CD81 antigen	0.020
dharma	dharma	0.020
pob	partial optokinetic response b	0.019
prdm14	PR domain containing 14	0.019
shhb	sonic hedgehog b	0.019	Mouse
sox19b	SRY-box containing gene 19b	0.019
col11a2	collagen type XI alpha-2	0.019
og9x	OG9 homeobox gene	0.019
tll1	tolloid-like 1	0.019
per3	period homolog 3 (Drosophila)	0.018
cxcl12a	chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)	0.018
snai1b	snail homolog 1b (Drosophila)	0.018
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.018
grk7a	G-protein-coupled receptor kinase 7a	0.018
adcyap1a	adenylate cyclase activating polypeptide 1a	0.018
tal1	T-cell acute lymphocytic leukemia 1	0.018
ptpra	protein tyrosine phosphatase, receptor type, A	0.018
ldb2b	LIM-domain binding factor 2b	0.018
ext1a	exostoses (multiple) 1a	0.018
smad3b	MAD, mothers against decapentaplegic homolog 3b (Drosophila)	0.018
znf503	zinc finger protein 503	0.018
lamc1	laminin, gamma 1	0.017
pkd2	polycystic kidney disease 2	0.017
sox11b	SRY-box containing gene 11b	0.017
grhl2b	grainyhead-like 2b (Drosophila)	0.017
mtmr8	myotubularin related protein 8	0.017
mapk3	mitogen-activated protein kinase 3	0.017
fgfr1a	fibroblast growth factor receptor 1a	0.017
daam1a	dishevelled associated activator of morphogenesis 1a	0.017
lingo1b	leucine rich repeat and Ig domain containing 1b	0.017
ano2	anoctamin 2	0.017
sema3d	semaphorin 3d	0.017
ncor1	nuclear receptor co-repressor 1	0.017
ripply1	ripply1	0.017
chst11	carbohydrate (chondroitin 4) sulfotransferase 11	0.016
hoxb1a	homeo box B1a	0.016
chd	chordin	0.016
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.016
fgfrl1b	fibroblast growth factor receptor-like 1b	0.016
dlat	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	0.016
vgll4l	vestigial like 4 like	0.016
mesp2	mesoderm posterior 2 homolog (mouse)	0.016
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.016
sesn1	sestrin 1	0.016
igfbp3	insulin-like growth factor binding protein 3	0.016
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.015
appl2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	0.015
fgf10a	fibroblast growth factor 10a	0.015
pnx	posterior neuron-specific homeobox	0.015
lfng	lunatic fringe homolog	0.015
cdh5	cadherin 5	0.015
dbx1a	developing brain homeobox 1a	0.015
six4b	sine oculis homeobox homolog 4b	0.015
guca1c	guanylate cyclase activator 1C	0.015
rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.015
boc	brother of CDO	0.015
sox1a	SRY-box containing gene 1a	0.014
ptenb	phosphatase and tensin homolog B (mutated in multiple advanced cancers 1)	0.014
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.014
mapk12	mitogen-activated protein kinase 12	0.014
myl9	myosin, light polypeptide 9, regulatory	0.014
si:ch211-173b8.2	si:ch211-173b8.2	0.014
rargb	retinoic acid receptor, gamma b	0.014
fzd8b	frizzled homolog 8b	0.014	Zebrafish
epha4b	eph receptor A4b	0.014
zgc:64114	zgc:64114	0.014
zgc:163064	zgc:163064	0.014
zic6	zic family member 6	0.014
hmx1	H6 homeo box 1	0.014
oep	one-eyed pinhead	0.014
vent	ventral expressed homeobox	0.014
LOC795916	mucolipin-1-like	0.014
twist2	twist2	0.014
dynlrb1	dynein, light chain, roadblock-type 1	0.014
dynlt3	dynein, light chain, Tctex-type 3	0.014
lhx1a	LIM homeobox 1a	0.013
cacnb4b	calcium channel, voltage-dependent, beta 4b subunit	0.013
hoxb6b	homeo box B6b	0.013
inka1b	induced in neural crest by AP2, 1b	0.013
eya1	eyes absent homolog 1	0.013
hoxb1b	homeo box B1b	0.013
wnt2	wingless-type MMTV integration site family member 2	0.013	Zebrafish
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.013
lrp5	low density lipoprotein receptor-related protein 5	0.013
dnmt6	DNA (cytosine-5-)-methyltransferase 6	0.013
gnl2	guanine nucleotide binding protein-like 2 (nucleolar)	0.013
fkbp1aa	FK506 binding protein 1Aa	0.013
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.013	Mouse
ptmab	prothymosin, alpha b	0.013
rxrbb	retinoid x receptor, beta b	0.013
rarab	retinoic acid receptor, alpha b	0.013
si:ch211-14a17.11	si:ch211-14a17.11	0.013
pax3a	paired box gene 3a	0.013
ube2i	ubiquitin-conjugating enzyme E2I	0.013
spast	spastin	0.013
robo3	roundabout homolog 3	0.013
gpc4	glypican 4	0.012
wu:fj62d01	wu:fj62d01	0.012
cplx4a	complexin 4a	0.012
si:dkeyp-68f6.1	si:dkeyp-68f6.1	0.012
hmgb1a	high-mobility group box 1a	0.012
nin	ninein (GSK3B interacting protein)	0.012
si:dkey-24h22.4	si:dkey-24h22.4	0.012
hmx3	homeo box (H6 family) 3	0.012
neurod6b	neurogenic differentiation 6b	0.012
foxb1.2	forkhead box B1.2	0.012
unc5db	unc-5 homolog Db (C. elegans)	0.012
rfng	radical fringe homolog (Drosophila)	0.012
nrarpb	notch-regulated ankyrin repeat protein b	0.012
ca10a	carbonic anhydrase Xa	0.012
barx2	BarH-like homeobox 2	0.012
gngt2b	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2b	0.012
cnn3a	calponin 3, acidic a	0.012
si:ch1073-204j4.2	si:ch1073-204j4.2	0.012
LOC566708	FL cytokine receptor-like	0.012
pdcd5	programmed cell death 5	0.012
zgc:122977	zgc:122977	0.012
fas	Fas (TNF receptor superfamily, member 6)	0.012
prnprs1	prion protein, related sequence 1	0.012
fam84b	family with sequence similarity 84, member B	0.012
hs3st1l1	heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like1	0.011
ssrp1a	structure specific recognition protein 1a	0.011
pax6a	paired box gene 6a	0.011
arpc3	actin related protein 2/3 complex, subunit 3	0.011
grk1b	G protein-coupled receptor kinase 1 b	0.011
kop	askopos	0.011
ihha	Indian hedgehog homolog a	0.011
dao.2	D-amino-acid oxidase 2	0.011
lft1	lefty1	0.011
ctnnd2a	catenin (cadherin-associated protein), delta 2a	0.011
vegfab	vascular endothelial growth factor Ab	0.011
frem3	Fras1 related extracellular matrix 3	0.011
c1ql4l	complement component 1, q subcomponent-like 4 like	0.011
cdh2	cadherin 2, neuronal	0.011	Mouse
LOC556647	GDNF family receptor alpha-4-like	0.011
kctd8	potassium channel tetramerisation domain containing 8	0.011	Zebrafish
prtga	protogenin homolog a (Gallus gallus)	0.011
spry1	sprouty homolog 1 (Drosophila)	0.011
irx2a	iroquois homeobox protein 2, a	0.010
hoxa13b	homeo box A13b	0.010
rbpja	recombination signal binding protein for immunoglobulin kappa J region a	0.010
efnb2a	ephrin B2a	0.010
tnw	tenascin W	0.010
oprd1b	opioid receptor, delta 1b	0.010
nrg2a	neuregulin 2a	0.010
her7	hairy and enhancer of split related-7	0.010
sept2	septin 2	0.010
vasa	vasa homolog	0.010
phc2	polyhomeotic-like 2 (Drosophila)	0.010
olfm2	olfactomedin 2	0.010
clec14a	C-type lectin domain family 14, member A	0.010