IMP

Process View

Danio rerio

2 genes annotated in zebrafish

regulation of bone remodeling

Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of bone remodeling"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of bone remodeling" (in gray)

Name	Description	Probability	Func Analog Organism
fbp1b	fructose-1,6-bisphosphatase 1b	0.184
fgf3	fibroblast growth factor 3	0.099	Zebrafish
aldh1a3	aldehyde dehydrogenase 1 family, member A3	0.093
nf1a	neurofibromin 1a	0.090	Mouse
lef1	lymphocyte enhancer binding factor 1	0.077
hmx2	H6 family homeobox 2	0.071
fgf18a	fibroblast growth factor 18a	0.071
stmn4	stathmin-like 4	0.063
exorh	extra-ocular rhodopsin	0.055
kiss1	KiSS-1 metastasis-suppressor	0.051
lhcgr	luteinizing hormone/choriogonadotropin receptor	0.048
rad21	RAD21 homolog (S. pombe)	0.047
irf8	interferon regulatory factor 8	0.047
gle1	GLE1 RNA export mediator homolog (yeast)	0.046
itih2	inter-alpha (globulin) inhibitor H2	0.045
hapln3	hyaluronan and proteoglycan link protein 3	0.043
trim33	tripartite motif-containing 33	0.043
LOC100151531	zinc finger protein Gfi-1b-like	0.043
esr2b	estrogen receptor 2b	0.043
vcanb	versican b	0.042
kita	kit receptor a	0.040
fes	feline sarcoma oncogene	0.040
mpx	myeloid-specific peroxidase	0.039
pmela	premelanosome protein a	0.039
atp6v0ca	ATPase, H+ transporting, lysosomal, V0 subunit c, a	0.038
twist1b	twist1b	0.037
otomp	otolith matrix protein	0.037
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.036
si:dkeyp-7c9.1	si:dkeyp-7c9.1	0.036
serpinc1	serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1	0.035
gpr126	G protein-coupled receptor 126	0.035
mchr1a	melanin-concentrating hormone receptor 1a	0.035
nadl1.1	neural adhesion molecule L1.1	0.035
ltk	leukocyte tyrosine kinase	0.035
tbx22	T-box 22	0.035
mecom	MDS1 and EVI1 complex locus	0.034
slc30a7	solute carrier family 30 (zinc transporter), member 7	0.034
dlat	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	0.033
otpa	orthopedia homolog a	0.033
crygmxl2	crystallin, gamma MX, like 2	0.033
ptch2	patched 2	0.033
bmp2a	bone morphogenetic protein 2a	0.032
tectb	tectorin beta	0.032
spi1l	spleen focus forming virus (SFFV) proviral integration oncogene spi1 like	0.031
mcoln1	mucolipin 1	0.031
lhx6	LIM homeobox 6	0.030
fras1	Fraser syndrome 1	0.030
gh1	growth hormone 1	0.029
nf1b	neurofibromin 1b	0.028	Mouse
sc:d812	sc:d812	0.028
paqr7b	progestin and adipoQ receptor family member VII, b	0.028
crhbp	corticotropin releasing hormone binding protein	0.028
gng13a	guanine nucleotide binding protein (G protein), gamma 13a	0.028
ptenb	phosphatase and tensin homolog B (mutated in multiple advanced cancers 1)	0.027
atp6v0d1	ATPase, H+ transporting, V0 subunit D isoform 1	0.026
atoh1a	atonal homolog 1a	0.026
tnfsf10l3	tumor necrosis factor (ligand) superfamily, member 10 like 3	0.026
frem2a	Fras1 related extracellular matrix protein 2a	0.026
wnt8a	wingless-type MMTV integration site family, member 8a	0.026
comta	catechol-O-methyltransferase a	0.025
pea3	ETS-domain transcription factor pea3	0.025
bmp4	bone morphogenetic protein 4	0.025
fgfr1a	fibroblast growth factor receptor 1a	0.024
mitfa	microphthalmia-associated transcription factor a	0.024
hapln1a	hyaluronan and proteoglycan link protein 1a	0.024
lcp1	lymphocyte cytosolic plastin 1	0.024
wnt2	wingless-type MMTV integration site family member 2	0.023
rpz	rapunzel	0.023
lepr	leptin receptor	0.023
wnt10a	wingless-type MMTV integration site family, member 10a	0.023
si:dkeyp-50f5.1	si:dkeyp-50f5.1	0.023
nr5a2	nuclear receptor subfamily 5, group A, member 2	0.023
slc15a2	solute carrier family 15 (H+/peptide transporter), member 2	0.022
dmrt3a	doublesex and mab-3 related transcription factor 3a	0.022
runx1	runt-related transcription factor 1	0.022
pknox1.2	pbx/knotted 1 homeobox 1.2	0.021
ntrk1	neurotrophic tyrosine kinase, receptor, type 1	0.021
ar	androgen receptor	0.021
nadl1.2	neural adhesion molecule L1.2	0.021
vcana	versican a	0.021
avpl	arginine vasopressin-like	0.021
zgc:112329	zgc:112329	0.021
rxfp1	relaxin/insulin-like family peptide receptor 1	0.020
atp1a1a.4	ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide	0.020
gcm2	glial cells missing homolog 2 (Drosophila)	0.020
urod	uroporphyrinogen decarboxylase	0.020
pou1f1	POU domain, class 1, transcription factor 1	0.020
frem3	Fras1 related extracellular matrix 3	0.020
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.020
wnt7aa	wingless-type MMTV integration site family, member 7Aa	0.020
spry4	sprouty (Drosophila) homolog 4	0.020
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.020
foxi3a	forkhead box I3a	0.020
tp53	tumor protein p53	0.019
or111-5	odorant receptor, family D, subfamily 111, member 5	0.019
cacnb1	calcium channel, voltage-dependent, beta 1 subunit	0.019
osr1	odd-skipped related 1 (Drosophila)	0.019
wnt7ba	wingless-type MMTV integration site family, member 7Ba	0.019
ncf1	neutrophil cytosolic factor 1	0.019
eno2	enolase 2	0.018
gng2	guanine nucleotide binding protein (G protein), gamma 2	0.018
ldb1b	LIM-domain binding factor 1b	0.018
nr4a3	nuclear receptor subfamily 4, group A, member 3	0.018
wu:fb80a07	wu:fb80a07	0.018
fgf22	fibroblast growth factor 22	0.018
pcdh10b	protocadherin 10b	0.018
pax9	paired box gene 9	0.018
a2ml	alpha-2-macroglobulin-like	0.018
pi4kb	phosphatidylinositol 4-kinase, catalytic, beta	0.018
igfbp3	insulin-like growth factor binding protein 3	0.018
lhb	luteinizing hormone, beta polypeptide	0.018
sb:cb653	sb:cb653	0.018
pitx3	paired-like homeodomain transcription factor 3	0.018
drd2b	dopamine receptor D2b	0.018
slc6a9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	0.018
gdf6a	growth differentiation factor 6a	0.018
cdk5r1b	cyclin-dependent kinase 5, regulatory subunit 1b (p35)	0.018
ppox	protoporphyrinogen oxidase	0.018
LOC793701	growth arrest-specific protein 7-like	0.017
kcnq1	potassium voltage-gated channel, KQT-like subfamily, member 1	0.017
clint1	clathrin interactor 1	0.017
gfi1.1	growth factor independent 1.1	0.017
cpox	coproporphyrinogen oxidase	0.017
nipblb	novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)	0.017
wnt3	wingless-type MMTV integration site family, member 3	0.017
bmp7b	bone morphogenetic protein 7b	0.017
prmt8b	protein arginine methyltransferase 8b	0.017
rdh10a	retinol dehydrogenase 10a	0.017
efnb2a	ephrin B2a	0.016
cdkn1a	cyclin-dependent kinase inhibitor 1A	0.016
apoeb	apolipoprotein Eb	0.016
her11	hairy-related 11	0.016
gpd2	glycerol-3-phosphate dehydrogenase 2 (mitochondrial)	0.016
klfd	Kruppel-like factor d	0.016
eng1a	engrailed 1a	0.016
spon1a	spondin 1a	0.016
wu:fc25e12	wu:fc25e12	0.016
mesp2	mesoderm posterior 2 homolog (mouse)	0.015
kdr	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.015
dlx2b	distal-less homeobox gene 2b	0.015
zgc:172101	zgc:172101	0.015
cps1	carbamoyl-phosphate synthase 1, mitochondrial	0.015
kitlga	kit ligand a	0.015
zgc:162420	zgc:162420	0.015
im:7151712	im:7151712	0.015
ptch1	patched 1	0.015
tgfbi	transforming growth factor, beta-induced	0.015
sb:eu697	sb:eu697	0.015
kiss2	kisspeptin 2	0.015
wnt5a	wingless-type MMTV integration site family, member 5a	0.015
grhl2b	grainyhead-like 2b (Drosophila)	0.015
dacha	dachshund a	0.015
itga2b	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	0.015
her15.1	hairy and enhancer of split-related 15.1	0.015
msxa	muscle segment homeobox A	0.015
cpa5	carboxypeptidase A5	0.015
fgf18b	fibroblast growth factor 18b	0.015	Zebrafish
tie2	endothelium-specific receptor tyrosine kinase 2	0.014
alas2	aminolevulinate, delta-, synthetase 2	0.014
frzb	frizzled-related protein	0.014
phlda1	pleckstrin homology-like domain, family A, member 1	0.014
tfr1a	transferrin receptor 1a	0.014	Mouse
shox2	short stature homeobox 2	0.014
zgc:193613	zgc:193613	0.014
map2k4b	mitogen-activated protein kinase kinase 4b	0.014
hist2h2l	histone 2, H2, like	0.014
celsr1b	cadherin EGF LAG seven-pass G-type receptor 1b	0.014
smad3a	MAD homolog 3a (Drosophila)	0.014
aplnra	apelin receptor a	0.014
mc3r	melanocortin 3 receptor	0.014
ppp1r1c	protein phosphatase 1, regulatory (inhibitor) subunit 1C	0.014
pld1a	phospholipase D1a	0.014
cenph	centromere protein H	0.014
rxrgb	retinoid X receptor, gamma b	0.014
or111-7	odorant receptor, family D, subfamily 111, member 7	0.013
lmbr1l	limb region 1 like	0.013
stat1b	signal transducer and activator of transcription 1b	0.013
hint2	histidine triad nucleotide binding protein 2	0.013
hmox1	heme oxygenase (decycling) 1	0.013
stx1b	syntaxin 1B	0.013
leo1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.013
atp1a1a.5	ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide	0.013
plod2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	0.013
dusp6	dual specificity phosphatase 6	0.013
trpc1	transient receptor potential cation channel, subfamily C, member 1	0.013
gip	gastric inhibitory polypeptide	0.013
nkx3-1	NK3 homeobox 1	0.013
cxcl12a	chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)	0.013
fgf17	fibroblast growth factor 17	0.013	Zebrafish
smtlb	somatolactin beta	0.013
ncoa3	nuclear receptor coactivator 3	0.013
zgc:194131	zgc:194131	0.013
wu:fc18d04	wu:fc18d04	0.013
pcna	proliferating cell nuclear antigen	0.013
msxc	muscle segment homeobox C	0.013
si:ch211-258f14.6	si:ch211-258f14.6	0.013
a1cf	apobec1 complementation factor	0.013
bon	bonnie and clyde	0.013
gata1a	GATA binding protein 1a	0.013
LOC100007758	novel protein similar to vertebrate SLIT and NTRK-like family, member 3 (SLITRK3)	0.013
mbip	MAP3K12 binding inhibitory protein 1	0.013
fgf6a	fibroblast growth factor 6a	0.013	Zebrafish
crabp2a	cellular retinoic acid binding protein 2, a	0.013
oc90	otoconin 90	0.013
wnt16	wingless-type MMTV integration site family, member 16	0.013
sptb	spectrin, beta, erythrocytic	0.013
ncor2	nuclear receptor co-repressor 2	0.013
arf1	ADP-ribosylation factor 1	0.012
epb41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.012
fgf20b	fibroblast growth factor 20b	0.012
bmp8a	bone morphogenetic protein 8a	0.012
dfna5	deafness, autosomal dominant 5	0.012
cryaba	crystallin, alpha B, a	0.012
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.012
jak3	Janus kinase 3 (a protein tyrosine kinase, leukocyte)	0.012
lpin1	lipin 1	0.012
sst1.1	somatostatin 1, tandem duplicate 1	0.012
hormad1	HORMA domain containing 1	0.012
nr5a1b	nuclear receptor subfamily 5, group A, member 1b	0.012
sncga	synuclein, gamma a	0.012
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.012
sparc	secreted acidic cysteine rich glycoprotein	0.012
pomt2	protein-O-mannosyltransferase 2	0.012
atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.012
phox2a	paired-like homeobox 2a	0.012
serpina1l	serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like	0.012
snx3	sorting nexin 3	0.012
pde10a	phosphodiesterase 10A	0.012
rufy3	RUN and FYVE domain containing 3	0.012
git2a	G protein-coupled receptor kinase interactor 2a	0.012
lamb2l	laminin, beta 2-like	0.012
pwp2h	PWP2 periodic tryptophan protein homolog (yeast)	0.012
ndel1a	nudE nuclear distribution gene E homolog like 1 (A. nidulans) A	0.012
slc8a4b	solute carrier family 8 (sodium/calcium exchanger), member 4b	0.012
myh11a	myosin, heavy polypeptide 11, smooth muscle a	0.012
rag1	recombination activating gene 1	0.012
smc1al	structural maintenance of chromosomes 1A, like	0.012
sox9b	SRY-box containing gene 9b	0.012
kcnip3	Kv channel interacting protein 3, calsenilin	0.012
hcrtr2	hypocretin (orexin) receptor 2	0.012
dlx5a	distal-less homeobox gene 5a	0.012
tgm2	transglutaminase 2, C polypeptide	0.012
LOC567405	novel protein similar to vertebrate megakaryocyte-associated tyrosine kinase (MATK)	0.012
wu:fj84e08	wu:fj84e08	0.012
map2k7	mitogen-activated protein kinase kinase 7	0.012
sb:cb101	sb:cb101	0.012
sfrp1a	secreted frizzled-related protein 1a	0.012	Human
dhrs9	dehydrogenase/reductase (SDR family) member 9	0.012
stmn4l	stathmin-like 4, like	0.012
zgc:73226	zgc:73226	0.011
gng8	guanine nucleotide binding protein (G protein), gamma 8	0.011
lta4h	leukotriene A4 hydrolase	0.011
men1	multiple endocrine neoplasia type 1 and multiple endocrine neoplasia I	0.011
cyp19a1b	cytochrome P450, family 19, subfamily A, polypeptide 1b	0.011
tfeb	transcription factor EB	0.011
sb:cb677	sb:cb677	0.011
f2	coagulation factor II (thrombin)	0.011
sult3st2	sulfotransferase family 3, cytosolic sulfotransferase 2	0.011
ctsc	cathepsin C	0.011
smox	spermine oxidase	0.011
slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.011
arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.011
cldn15lb	claudin 15-like b	0.011
il1rapl1a	interleukin 1 receptor accessory protein-like 1a	0.011
slmapb	sarcolemma associated protein b	0.011
adcyap1a	adenylate cyclase activating polypeptide 1a	0.011
rhoub	ras homolog gene family, member Ub	0.011
tsc2	tuberous sclerosis 2	0.011
wnt1	wingless-type MMTV integration site family, member 1	0.011
musk	muscle, skeletal, receptor tyrosine kinase	0.011
cttnbp2	cortactin binding protein 2	0.011
ntn2	netrin 2	0.011
bcl2l10	BCL2-like 10 (apoptosis facilitator)	0.011
rbms3	RNA binding motif, single stranded interacting protein	0.011
nfe2l3	nuclear factor (erythroid-derived 2)-like 3	0.011
ctnnd2a	catenin (cadherin-associated protein), delta 2a	0.011
si:ch211-272f3.4	si:ch211-272f3.4	0.011
pomca	proopiomelanocortin a	0.011
cxcl12b	chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)	0.011
tdh	L-threonine dehydrogenase	0.011
LOC566708	FL cytokine receptor-like	0.011
oprk1	opioid receptor, kappa 1	0.011
sb:eu512	sb:eu512	0.011
sb:cb8	sb:cb8	0.011
rbpja	recombination signal binding protein for immunoglobulin kappa J region a	0.011
vwa2	von Willebrand factor A domain containing 2	0.011
nkd2	naked cuticle homolog 2 and naked 2a	0.011
her12	hairy-related 12	0.011
insm1a	insulinoma-associated 1a	0.011
esr1	estrogen receptor 1	0.011
fgf16	fibroblast growth factor 16	0.011	Zebrafish
zgc:103530	zgc:103530	0.011
sb:eu854	sb:eu854	0.011
zgc:110348	zgc:110348	0.011
tmem14c	transmembrane protein 14C	0.011
adra2c	adrenergic, alpha-2C-, receptor	0.011
zgc:100957	zgc:100957	0.011
arhgef11	Rho guanine nucleotide exchange factor (GEF) 11	0.011
zfpm1	zinc finger protein, multitype 1	0.011
atp1a3al	ATPase, Na+/K+ transporting, alpha 3a polypeptide, like	0.011
mapk6	mitogen-activated protein kinase 6	0.011
ugdh	UDP-glucose dehydrogenase	0.010
plag1	pleiomorphic adenoma gene 1	0.010
twist2	twist2	0.010
zgc:136359	zgc:136359	0.010
arl4ab	ADP-ribosylation factor-like 4ab	0.010
ptges3a	prostaglandin E synthase 3a (cytosolic)	0.010
LOC565106	novel protein similar to vertebrate calpain 1 (CAPN1)	0.010
dkk3	dickkopf homolog 3 (Xenopus laevis)	0.010
si:dkey-3d4.3	si:dkey-3d4.3	0.010
fetub	fetuin B	0.010
abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.010
ireb2	iron-responsive element binding protein 2	0.010
sema6dl	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like	0.010
c8a	complement component 8, alpha polypeptide	0.010
otc	ornithine carbamoyltransferase	0.010
taf3	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto	0.010
sort1a	sortilin 1a	0.010
etv5b	ets variant 5b	0.010
vipr2	vasoactive intestinal peptide receptor 2	0.010
capn1a	calpain 1, (mu/I) large subunit a	0.010
clstn2	calsyntenin 2	0.010
mxtx2	mix-type homeobox gene 2	0.010
traf4a	tnf receptor-associated factor 4a	0.010
card9	caspase recruitment domain family, member 9	0.010
sult1st7	sulfotransferase family 1, cytosolic sulfotransferase 7	0.010
acaa1	acetyl-Coenzyme A acyltransferase 1	0.010
irx2a	iroquois homeobox protein 2, a	0.010
mc5rb	melanocortin 5b receptor	0.010
rorca	RAR-related orphan receptor C a	0.010
gatsl2	GATS protein-like 2	0.010
slc3a2	solute carrier family 3, member 2	0.010
eif4ebp3	eukaryotic translation initiation factor 4E binding protein 3	0.010
skiv2l2	superkiller viralicidic activity 2-like 2	0.010
ros1	v-ros UR2 sarcoma virus oncogene homolog 1 (avian)	0.010
wnt9a	wingless-type MMTV integration site family, member 9A	0.010
sb:cb322	sb:cb322	0.010
pcdh1g3	protocadherin 1 gamma 3	0.010
zgc:110426	zgc:110426	0.010
mylkb	myosin light chain kinase b	0.010
dnajc2	DnaJ (Hsp40) homolog, subfamily C, member 2	0.010
sb:eu779	sb:eu779	0.010
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.010