The network for 'negative regulation of response to wounding' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of response to wounding

Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding.

Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 0.992
VEGFA vascular endothelial growth factor A 0.978
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.972
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.875
C1QA complement component 1, q subcomponent, A chain 0.850
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.786
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.732
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.682
TBXA2R thromboxane A2 receptor 0.662
TAL1 T-cell acute lymphocytic leukemia 1 0.656
NRP1 neuropilin 1 0.645
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.610
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.564
TNF tumor necrosis factor 0.553
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.534
PLG plasminogen 0.513
PYCARD PYD and CARD domain containing 0.501
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.482
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.456
SYK spleen tyrosine kinase 0.418
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.414
GHR growth hormone receptor 0.402
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.392
PTPRB protein tyrosine phosphatase, receptor type, B 0.380
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.365
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.364
PLAU plasminogen activator, urokinase 0.354
PGF placental growth factor 0.336
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.335
EPOR erythropoietin receptor 0.311
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.309
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.298
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.258
RUNX1 runt-related transcription factor 1 0.245
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 0.244
KNG1 kininogen 1 0.228
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.220
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.219
INADL InaD-like (Drosophila) 0.208
DERL1 Der1-like domain family, member 1 0.201
PLAT plasminogen activator, tissue 0.200
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.195
DRD2 dopamine receptor D2 0.195
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.192
APOE apolipoprotein E 0.190
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.189
FN1 fibronectin 1 0.187
FADD Fas (TNFRSF6)-associated via death domain 0.180
C3 complement component 3 0.176
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.176
PELP1 proline, glutamate and leucine rich protein 1 0.169
C1QC complement component 1, q subcomponent, C chain 0.165
DCN decorin 0.162
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.161
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.156
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.153
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.151
POMP proteasome maturation protein 0.151
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.150
ZNF496 zinc finger protein 496 0.148
PLAUR plasminogen activator, urokinase receptor 0.144
ALB albumin 0.141
C1QB complement component 1, q subcomponent, B chain 0.137
HLA-DMA major histocompatibility complex, class II, DM alpha 0.136
CXCL12 chemokine (C-X-C motif) ligand 12 0.132
C19orf50 chromosome 19 open reading frame 50 0.132
A2M alpha-2-macroglobulin 0.128
RXRA retinoid X receptor, alpha 0.125
SUMO3 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) 0.123
COL4A1 collagen, type IV, alpha 1 0.123
HLA-DMB major histocompatibility complex, class II, DM beta 0.120
PDGFC platelet derived growth factor C 0.120
BHLHE40 basic helix-loop-helix family, member e40 0.115
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.113
ENG endoglin 0.113
FGF2 fibroblast growth factor 2 (basic) 0.113
MASP2 mannan-binding lectin serine peptidase 2 0.112
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.109
APOC1 apolipoprotein C-I 0.107
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 0.105
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.102
HLA-DRA major histocompatibility complex, class II, DR alpha 0.101
C1S complement component 1, s subcomponent 0.098
VCP valosin containing protein 0.098
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.095
COL4A2 collagen, type IV, alpha 2 0.095
C1R complement component 1, r subcomponent 0.094
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 0.093
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.093
HSPG2 heparan sulfate proteoglycan 2 0.092
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 0.088
PDGFA platelet-derived growth factor alpha polypeptide 0.082
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.082
VWF von Willebrand factor 0.079
APOH apolipoprotein H (beta-2-glycoprotein I) 0.076
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 0.076
HNF4A hepatocyte nuclear factor 4, alpha 0.076
EDF1 endothelial differentiation-related factor 1 0.075
CFLAR CASP8 and FADD-like apoptosis regulator 0.075
HRG histidine-rich glycoprotein 0.074
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Smad1 MAD homolog 1 (Drosophila) 0.936
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.804
Smad4 MAD homolog 4 (Drosophila) 0.766
Egr1 early growth response 1 0.754
Apoe apolipoprotein E 0.738
Ptgs2 prostaglandin-endoperoxide synthase 2 0.738
Cd44 CD44 antigen 0.672
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.638
Lyz2 lysozyme 2 0.611
Jun Jun oncogene 0.566
Plau plasminogen activator, urokinase 0.553
Foxn1 forkhead box N1 0.514
Gdnf glial cell line derived neurotrophic factor 0.500
Cd80 CD80 antigen 0.492
Serpina10 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 0.469
Stat3 signal transducer and activator of transcription 3 0.441
Lepr leptin receptor 0.433
Junb Jun-B oncogene 0.429
Fos FBJ osteosarcoma oncogene 0.429
Tnf tumor necrosis factor 0.428
Socs1 suppressor of cytokine signaling 1 0.426
Traf6 TNF receptor-associated factor 6 0.414
Il10 interleukin 10 0.413
Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha 0.402
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.402
Smad3 MAD homolog 3 (Drosophila) 0.401
Dysf dysferlin 0.401
Gdf15 growth differentiation factor 15 0.397
Arrb2 arrestin, beta 2 0.386
C1qa complement component 1, q subcomponent, alpha polypeptide 0.384
F12 coagulation factor XII (Hageman factor) 0.369
Sebox SEBOX homeobox 0.331
Klk1b5 kallikrein 1-related peptidase b5 0.327
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.325
Cav1 caveolin 1, caveolae protein 0.320
C1qc complement component 1, q subcomponent, C chain 0.320
Ctla2b cytotoxic T lymphocyte-associated protein 2 beta 0.318
Krt17 keratin 17 0.317
Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 0.304
Ptgir prostaglandin I receptor (IP) 0.303
Zfp36 zinc finger protein 36 0.299
Klk1b1 kallikrein 1-related peptidase b1 0.288
Fut7 fucosyltransferase 7 0.287
Nos1 nitric oxide synthase 1, neuronal 0.282
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.269
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.258
Lta lymphotoxin A 0.258
Pdcd1 programmed cell death 1 0.252
Fas Fas (TNF receptor superfamily member 6) 0.250
Egfr epidermal growth factor receptor 0.248
C1qb complement component 1, q subcomponent, beta polypeptide 0.243
Ceacam2 carcinoembryonic antigen-related cell adhesion molecule 2 0.243
Fasl Fas ligand (TNF superfamily, member 6) 0.240
Masp1 mannan-binding lectin serine peptidase 1 0.239
Ephb2 Eph receptor B2 0.238
Gcgr glucagon receptor 0.238
Cd40 CD40 antigen 0.232
Atf3 activating transcription factor 3 0.229
Il10ra interleukin 10 receptor, alpha 0.224
Ikbkg inhibitor of kappaB kinase gamma 0.224
Cmklr1 chemokine-like receptor 1 0.223
Cyr61 cysteine rich protein 61 0.219
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.216
Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 0.215
Apoa1 apolipoprotein A-I 0.210
Prg3 proteoglycan 3 0.207
Krt85 keratin 85 0.207
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.206
Adra2b adrenergic receptor, alpha 2b 0.205
S1pr2 sphingosine-1-phosphate receptor 2 0.205
Nphs2 nephrosis 2 homolog, podocin (human) 0.203
Pcdh12 protocadherin 12 0.202
Ephb3 Eph receptor B3 0.202
Gp9 glycoprotein 9 (platelet) 0.200
Epha2 Eph receptor A2 0.199
Spp1 secreted phosphoprotein 1 0.198
Il11 interleukin 11 0.198
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.198
C3ar1 complement component 3a receptor 1 0.190
Bmp7 bone morphogenetic protein 7 0.189
Mertk c-mer proto-oncogene tyrosine kinase 0.189
Mafb v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.188
Ins2 insulin II 0.187
F7 coagulation factor VII 0.187
Prodh2 proline dehydrogenase (oxidase) 2 0.184
Trpv1 transient receptor potential cation channel, subfamily V, member 1 0.183
Fgg fibrinogen gamma chain 0.182
Klk1 kallikrein 1 0.180
Htra3 HtrA serine peptidase 3 0.180
Klk1b3 kallikrein 1-related peptidase b3 0.179
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.176
Itgb3 integrin beta 3 0.174
Klk1b26 kallikrein 1-related petidase b26 0.173
Serpinf2 serine (or cysteine) peptidase inhibitor, clade F, member 2 0.171
Fzd1 frizzled homolog 1 (Drosophila) 0.169
Pax8 paired box gene 8 0.168
Fosl2 fos-like antigen 2 0.165
Krt6a keratin 6A 0.164
Lgals7 lectin, galactose binding, soluble 7 0.164
Axl AXL receptor tyrosine kinase 0.159
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Rattus norvegicus
Name Description Probability Func Analog Organism
Anxa5 annexin A5 0.690
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.379
Pzp pregnancy-zone protein 0.367
Anxa2 annexin A2 0.353
Iapp islet amyloid polypeptide 0.236
Lgals3 lectin, galactoside-binding, soluble, 3 0.173
Aspg asparaginase homolog (S. cerevisiae) 0.154
Arpc1b actin related protein 2/3 complex, subunit 1B 0.123
Synpo synaptopodin 0.121
Ppy pancreatic polypeptide 0.117
Syt8 synaptotagmin VIII 0.110
Adora1 adenosine A1 receptor 0.102
Cd4 Cd4 molecule 0.101
Itgb1 integrin, beta 1 0.095
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.094
Anxa1 annexin A1 0.093
S100a6 S100 calcium binding protein A6 0.092
Ahsg alpha-2-HS-glycoprotein 0.091
Apoa5 apolipoprotein A-V 0.084
Il8ra interleukin 8 receptor, alpha 0.083
Vim vimentin 0.082
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.078
Cntn3 contactin 3 (plasmacytoma associated) 0.077
Neurog1 neurogenin 1 0.076
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.076
Gucy2d guanylate cyclase 2d 0.075
Gja1 gap junction protein, alpha 1 0.074
Grm6 glutamate receptor, metabotropic 6 0.072
Foxa3 forkhead box A3 0.071
Pspn persephin 0.069
Ctsh cathepsin H 0.068
Faslg Fas ligand (TNF superfamily, member 6) 0.066
Oprd1 opioid receptor, delta 1 0.066
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.063
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.062
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.062
Btc betacellulin 0.061
C1s complement component 1, s subcomponent 0.061
Ctsl1 cathepsin L1 0.061
Timp1 TIMP metallopeptidase inhibitor 1 0.059
Cxcr5 chemokine (C-X-C motif) receptor 5 0.058
Olr837 olfactory receptor 837 0.057
Gna15 guanine nucleotide binding protein, alpha 15 0.056
Plau plasminogen activator, urokinase 0.055
Scn10a sodium channel, voltage-gated, type X, alpha subunit 0.054
Ramp1 receptor (G protein-coupled) activity modifying protein 1 0.054
Ppyr1 pancreatic polypeptide receptor 1 0.051
Pdyn prodynorphin 0.050
Cpb2 carboxypeptidase B2 (plasma) 0.050
Cnn3 calponin 3, acidic 0.049
Hmox1 heme oxygenase (decycling) 1 0.049
Slc9a4 solute carrier family 9 (sodium/hydrogen exchanger), member 4 0.048
Cd5 Cd5 molecule 0.048
Cxcl2 chemokine (C-X-C motif) ligand 2 0.047
Acrv1 acrosomal vesicle protein 1 0.047
Acan aggrecan 0.046
Nkx2-1 NK2 homeobox 1 0.045
Olr1496 olfactory receptor 1496 0.045
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.045
Fgf7 fibroblast growth factor 7 0.044
Csn2 casein beta 0.044
Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.044
Itih4 inter alpha-trypsin inhibitor, heavy chain 4 0.043
Mbl1 mannose-binding lectin (protein A) 1 0.042
Tlr4 toll-like receptor 4 0.041
Adam7 ADAM metallopeptidase domain 7 0.041
Adam1a a disintegrin and metallopeptidase domain 1a 0.041
Cd44 Cd44 molecule 0.040
Cd40lg CD40 ligand 0.040
Cpb1 carboxypeptidase B1 (tissue) 0.040
Bcan brevican 0.040
Twist2 twist homolog 2 (Drosophila) 0.039
Ush1c Usher syndrome 1C homolog (human) 0.039
Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 0.038
Tff1 trefoil factor 1 0.038
LOC60591 calcium-activated potassium channel beta subunit 0.037
Mef2d myocyte enhancer factor 2D 0.037
Gpr176 G protein-coupled receptor 176 0.036
Ctsb cathepsin B 0.036
Abcb11 ATP-binding cassette, subfamily B (MDR/TAP), member 11 0.036
Csrp1 cysteine and glycine-rich protein 1 0.035
G6pc glucose-6-phosphatase, catalytic subunit 0.035
Serpinf2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.035
Cpn1 carboxypeptidase N, polypeptide 1 0.034
Adora3 adenosine A3 receptor 0.033
Bok BCL2-related ovarian killer 0.033
Haao 3-hydroxyanthranilate 3,4-dioxygenase 0.033
Uhmk1 U2AF homology motif (UHM) kinase 1 0.032
Sell selectin L 0.032
Ifitm3 interferon induced transmembrane protein 3 0.032
Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 0.032
Fat3 FAT tumor suppressor homolog 3 (Drosophila) 0.032
Aqp9 aquaporin 9 0.031
Gzmk granzyme K 0.031
Olr1493 olfactory receptor gene Olr1493 0.031
Cacng5 calcium channel, voltage-dependent, gamma subunit 5 0.031
Mfrp membrane frizzled-related protein 0.031
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.030
Adarb2 adenosine deaminase, RNA-specific, B2 0.030
S100a10 S100 calcium binding protein A10 0.029
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism