IMP
Process View
The network for 'thymic t cell selection' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
thymic t cell selection
The process of T cell selection that occurs in the thymus.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CD247 | CD247 molecule | 1.000 | |
| LCK | lymphocyte-specific protein tyrosine kinase | 0.998 | |
| NOTCH1 | notch 1 | 0.913 | |
| NOTCH3 | notch 3 | 0.767 | |
| SYK | spleen tyrosine kinase | 0.748 | |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 | 0.465 | |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.446 | |
| LAT | linker for activation of T cells | 0.434 | |
| MKL1 | megakaryoblastic leukemia (translocation) 1 | 0.290 | |
| GHR | growth hormone receptor | 0.267 | |
| PTPN22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.171 | |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | 0.165 | |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.136 | |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 0.130 | |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.112 | |
| MYOCD | myocardin | 0.109 | |
| GRAP2 | GRB2-related adaptor protein 2 | 0.104 | |
| STRADA | STE20-related kinase adaptor alpha | 0.103 | |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 0.103 | |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 0.102 | |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 0.090 | |
| GFI1B | growth factor independent 1B transcription repressor | 0.083 | |
| NOTCH2 | notch 2 | 0.077 | |
| CD3G | CD3g molecule, gamma (CD3-TCR complex) | 0.076 | |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.076 | |
| SH3BP2 | SH3-domain binding protein 2 | 0.071 | |
| ZAP70 | zeta-chain (TCR) associated protein kinase 70kDa | 0.062 | |
| CD8A | CD8a molecule | 0.062 | |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.059 | |
| CD2 | CD2 molecule | 0.057 | |
| STRADB | STE20-related kinase adaptor beta | 0.056 | |
| MALT1 | mucosa associated lymphoid tissue lymphoma translocation gene 1 | 0.055 | |
| CD7 | CD7 molecule | 0.055 | |
| BCL10 | B-cell CLL/lymphoma 10 | 0.054 | |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 0.051 | |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.050 | |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.048 | |
| FADD | Fas (TNFRSF6)-associated via death domain | 0.048 | |
| DAXX | death-domain associated protein | 0.043 | |
| ITGAL | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | 0.043 | |
| PRKCQ | protein kinase C, theta | 0.035 | |
| TNIP2 | TNFAIP3 interacting protein 2 | 0.034 | |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 0.034 | |
| CD22 | CD22 molecule | 0.034 | |
| MAP4K1 | mitogen-activated protein kinase kinase kinase kinase 1 | 0.032 | |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.031 | |
| CD52 | CD52 molecule | 0.030 | |
| BID | BH3 interacting domain death agonist | 0.029 | |
| PDPK1 | 3-phosphoinositide dependent protein kinase-1 | 0.029 | |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | 0.029 | |
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.029 | |
| FGR | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 0.029 | |
| HCLS1 | hematopoietic cell-specific Lyn substrate 1 | 0.028 | |
| STK36 | serine/threonine kinase 36 | 0.028 | |
| MYOG | myogenin (myogenic factor 4) | 0.027 | |
| JAG2 | jagged 2 | 0.027 | |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.025 | |
| CTLA4 | cytotoxic T-lymphocyte-associated protein 4 | 0.025 | |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 0.024 | |
| SH2D2A | SH2 domain containing 2A | 0.023 | |
| ITGA1 | integrin, alpha 1 | 0.022 | |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | 0.022 | |
| LYN | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.022 | |
| MARK4 | MAP/microtubule affinity-regulating kinase 4 | 0.021 | |
| MYOD1 | myogenic differentiation 1 | 0.020 | |
| MKL2 | MKL/myocardin-like 2 | 0.020 | |
| CD80 | CD80 molecule | 0.019 | |
| CD6 | CD6 molecule | 0.019 | |
| CD5 | CD5 molecule | 0.019 | |
| HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 | 0.018 | |
| INSR | insulin receptor | 0.018 | |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.017 | |
| P2RY10 | purinergic receptor P2Y, G-protein coupled, 10 | 0.016 | |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.016 | |
| EPS8L1 | EPS8-like 1 | 0.016 | |
| SPOCK2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | 0.016 | |
| PTPN3 | protein tyrosine phosphatase, non-receptor type 3 | 0.015 | |
| TRAT1 | T cell receptor associated transmembrane adaptor 1 | 0.015 | |
| CCR7 | chemokine (C-C motif) receptor 7 | 0.014 | |
| JAG1 | jagged 1 | 0.014 | |
| BLNK | B-cell linker | 0.014 | |
| MAML1 | mastermind-like 1 (Drosophila) | 0.014 | |
| TARP | TCR gamma alternate reading frame protein | 0.013 | |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.013 | |
| EFNB2 | ephrin-B2 | 0.013 | |
| EGFL7 | EGF-like-domain, multiple 7 | 0.013 | |
| ACAP3 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 | 0.013 | |
| AGRN | agrin | 0.012 | |
| IL2RA | interleukin 2 receptor, alpha | 0.012 | |
| ETS1 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | 0.012 | |
| PRKCB | protein kinase C, beta | 0.012 | |
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 | 0.012 | |
| PML | promyelocytic leukemia | 0.012 | |
| SH2D1A | SH2 domain containing 1A | 0.012 | |
| FAIM3 | Fas apoptotic inhibitory molecule 3 | 0.012 | |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.012 | |
| IL21R | interleukin 21 receptor | 0.012 | |
| DOCK2 | dedicator of cytokinesis 2 | 0.012 | |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 0.012 | |
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | 0.012 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Igh | immunoglobulin heavy chain complex | 0.972 | |
| Cd19 | CD19 antigen | 0.967 | |
| Foxp3 | forkhead box P3 | 0.966 | |
| Lat | linker for activation of T cells | 0.952 | |
| Cd74 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | 0.930 | |
| Ikzf1 | IKAROS family zinc finger 1 | 0.913 | |
| Lck | lymphocyte protein tyrosine kinase | 0.868 | |
| Cd247 | CD247 antigen | 0.852 | |
| Cd22 | CD22 antigen | 0.848 | |
| Fyn | Fyn proto-oncogene | 0.842 | |
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.827 | |
| H2-Eb1 | histocompatibility 2, class II antigen E beta | 0.755 | |
| Sox9 | SRY-box containing gene 9 | 0.693 | |
| Gli3 | GLI-Kruppel family member GLI3 | 0.680 | |
| H2-Ab1 | histocompatibility 2, class II antigen A, beta 1 | 0.663 | |
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.627 | |
| Tnf | tumor necrosis factor | 0.602 | |
| Il27ra | interleukin 27 receptor, alpha | 0.569 | |
| Efnb2 | ephrin B2 | 0.534 | |
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.533 | |
| Itk | IL2-inducible T-cell kinase | 0.525 | |
| Ifng | interferon gamma | 0.515 | |
| Cxcr3 | chemokine (C-X-C motif) receptor 3 | 0.463 | |
| Cd7 | CD7 antigen | 0.429 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.419 | |
| Sh2d1a | SH2 domain protein 1A | 0.413 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.413 | |
| Igk | immunoglobulin kappa chain complex | 0.402 | |
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.395 | |
| Cd4 | CD4 antigen | 0.394 | |
| Ccr6 | chemokine (C-C motif) receptor 6 | 0.377 | |
| Itgax | integrin alpha X | 0.375 | |
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.364 | |
| Il2rb | interleukin 2 receptor, beta chain | 0.350 | |
| Cxcr4 | chemokine (C-X-C motif) receptor 4 | 0.342 | |
| Ltb | lymphotoxin B | 0.342 | |
| H2-DMb2 | histocompatibility 2, class II, locus Mb2 | 0.338 | |
| Cd79a | CD79A antigen (immunoglobulin-associated alpha) | 0.337 | |
| Tcra | T-cell receptor alpha chain | 0.306 | |
| Zap70 | zeta-chain (TCR) associated protein kinase | 0.298 | |
| Cd28 | CD28 antigen | 0.292 | |
| Cd6 | CD6 antigen | 0.289 | |
| Cd3g | CD3 antigen, gamma polypeptide | 0.266 | |
| Cd96 | CD96 antigen | 0.258 | |
| Xcr1 | chemokine (C motif) receptor 1 | 0.234 | |
| S1pr4 | sphingosine-1-phosphate receptor 4 | 0.230 | |
| Cd8a | CD8 antigen, alpha chain | 0.230 | |
| Cd5 | CD5 antigen | 0.227 | |
| H2-Aa | histocompatibility 2, class II antigen A, alpha | 0.197 | |
| Pou2af1 | POU domain, class 2, associating factor 1 | 0.195 | |
| Blk | B lymphoid kinase | 0.192 | |
| Gata4 | GATA binding protein 4 | 0.189 | |
| Cd2 | CD2 antigen | 0.185 | |
| Efna1 | ephrin A1 | 0.179 | |
| Vav1 | vav 1 oncogene | 0.178 | |
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.162 | |
| Il4 | interleukin 4 | 0.161 | |
| Lta | lymphotoxin A | 0.159 | |
| Cd3e | CD3 antigen, epsilon polypeptide | 0.153 | |
| Ccr9 | chemokine (C-C motif) receptor 9 | 0.152 | |
| H2-DMa | histocompatibility 2, class II, locus DMa | 0.150 | |
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.148 | |
| Fgfr3 | fibroblast growth factor receptor 3 | 0.147 | |
| Ctsw | cathepsin W | 0.146 | |
| Dll1 | delta-like 1 (Drosophila) | 0.143 | |
| Prf1 | perforin 1 (pore forming protein) | 0.142 | |
| Ccr7 | chemokine (C-C motif) receptor 7 | 0.142 | |
| Clec4n | C-type lectin domain family 4, member n | 0.139 | |
| Ptpn22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.136 | |
| Lyz2 | lysozyme 2 | 0.129 | |
| Runx1 | runt related transcription factor 1 | 0.126 | |
| Socs1 | suppressor of cytokine signaling 1 | 0.124 | |
| Gata6 | GATA binding protein 6 | 0.124 | |
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.120 | |
| Cd8b1 | CD8 antigen, beta chain 1 | 0.119 | |
| Tnfsf14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.119 | |
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.111 | |
| Tgfb2 | transforming growth factor, beta 2 | 0.111 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.105 | |
| Foxn1 | forkhead box N1 | 0.103 | |
| Spib | Spi-B transcription factor (Spi-1/PU.1 related) | 0.097 | |
| Gimap7 | GTPase, IMAP family member 7 | 0.094 | |
| Bnc1 | basonuclin 1 | 0.093 | |
| Lef1 | lymphoid enhancer binding factor 1 | 0.092 | |
| Cxcl13 | chemokine (C-X-C motif) ligand 13 | 0.091 | |
| Six5 | sine oculis-related homeobox 5 homolog (Drosophila) | 0.090 | |
| Hr | hairless | 0.089 | |
| Ar | androgen receptor | 0.088 | |
| Cxcr6 | chemokine (C-X-C motif) receptor 6 | 0.088 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.086 | |
| Zfpm2 | zinc finger protein, multitype 2 | 0.085 | |
| Hey2 | hairy/enhancer-of-split related with YRPW motif 2 | 0.084 | |
| Ccl3 | chemokine (C-C motif) ligand 3 | 0.080 | |
| Ciita | class II transactivator | 0.079 | |
| Klra9 | killer cell lectin-like receptor subfamily A, member 9 | 0.077 | |
| Fcer2a | Fc receptor, IgE, low affinity II, alpha polypeptide | 0.076 | |
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.073 | |
| Il7r | interleukin 7 receptor | 0.073 | |
| Spn | sialophorin | 0.072 | |
| Sh2d2a | SH2 domain protein 2A | 0.069 |