The network for 'prostate gland development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

prostate gland development

The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.

Homo sapiens
Name Description Probability Func Analog Organism
CREBBP CREB binding protein 0.872
MSN moesin 0.782
RARA retinoic acid receptor, alpha 0.780
ESR1 estrogen receptor 1 0.747
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.682
RXRA retinoid X receptor, alpha 0.667
MED25 mediator complex subunit 25 0.660
POU3F2 POU class 3 homeobox 2 0.522
JAG1 jagged 1 0.471
PAX3 paired box 3 0.454
FGF1 fibroblast growth factor 1 (acidic) 0.416
SMAD7 SMAD family member 7 0.349
NCOA1 nuclear receptor coactivator 1 0.296
FGF10 fibroblast growth factor 10 0.261
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.245
NCOA2 nuclear receptor coactivator 2 0.208
BMP7 bone morphogenetic protein 7 0.207
EGFR epidermal growth factor receptor 0.202
PPP5C protein phosphatase 5, catalytic subunit 0.169
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.166
MAML1 mastermind-like 1 (Drosophila) 0.160
FGFR1 fibroblast growth factor receptor 1 0.159
TIMP2 TIMP metallopeptidase inhibitor 2 0.158
STRADA STE20-related kinase adaptor alpha 0.148
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.144
SPDEF SAM pointed domain containing ets transcription factor 0.139
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.137
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 0.136
MYOD1 myogenic differentiation 1 0.136
FOXD3 forkhead box D3 0.134
POU5F1 POU class 5 homeobox 1 0.130
TPP1 tripeptidyl peptidase I 0.111
THBS2 thrombospondin 2 0.111
WDR83 WD repeat domain 83 0.110
CCND1 cyclin D1 0.110
KRT5 keratin 5 0.107
MEOX2 mesenchyme homeobox 2 0.105
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.101
CAV1 caveolin 1, caveolae protein, 22kDa 0.090
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.088
NRIP1 nuclear receptor interacting protein 1 0.087
IRS1 insulin receptor substrate 1 0.086
NOG noggin 0.086
CABLES1 Cdk5 and Abl enzyme substrate 1 0.083
FZD1 frizzled homolog 1 (Drosophila) 0.082
SIAH1 seven in absentia homolog 1 (Drosophila) 0.081
FGF2 fibroblast growth factor 2 (basic) 0.081
FHL2 four and a half LIM domains 2 0.077
MYLK2 myosin light chain kinase 2 0.076
PHF17 PHD finger protein 17 0.072
S100A6 S100 calcium binding protein A6 0.072
ZBED1 zinc finger, BED-type containing 1 0.070
YAP1 Yes-associated protein 1 0.066
SATB2 SATB homeobox 2 0.065
PRSS21 protease, serine, 21 (testisin) 0.065
A2M alpha-2-macroglobulin 0.065
RB1 retinoblastoma 1 0.064
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.060
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.060
PURA purine-rich element binding protein A 0.060
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.059
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.059
TIMP1 TIMP metallopeptidase inhibitor 1 0.059
SCRIB scribbled homolog (Drosophila) 0.058
STRADB STE20-related kinase adaptor beta 0.057
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.055
LAMP1 lysosomal-associated membrane protein 1 0.054
NCOA7 nuclear receptor coactivator 7 0.054
FTH1 ferritin, heavy polypeptide 1 0.053
SLC9A3R2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.053
AFTPH aftiphilin 0.053
AR androgen receptor 0.052
SALL2 sal-like 2 (Drosophila) 0.051
MARCKSL1 MARCKS-like 1 0.050
ARNT aryl hydrocarbon receptor nuclear translocator 0.050
IGF1R insulin-like growth factor 1 receptor 0.050
NCOR2 nuclear receptor corepressor 2 0.050
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.050
FOXA1 forkhead box A1 0.048
KIF5B kinesin family member 5B 0.048
CRIP2 cysteine-rich protein 2 0.048
BMPR1A bone morphogenetic protein receptor, type IA 0.047
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.047
NCOA6 nuclear receptor coactivator 6 0.046
CTSD cathepsin D 0.046
FGF7 fibroblast growth factor 7 0.045
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.045
ZFYVE9 zinc finger, FYVE domain containing 9 0.045
JAG2 jagged 2 0.045
RXRB retinoid X receptor, beta 0.043
COL1A1 collagen, type I, alpha 1 0.043
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.043
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.042
TCF4 transcription factor 4 0.042
HOXA10 homeobox A10 0.041
EPOR erythropoietin receptor 0.041
CCND3 cyclin D3 0.041
KAT2B K(lysine) acetyltransferase 2B 0.040
S100A2 S100 calcium binding protein A2 0.040
KRT6C keratin 6C 0.038
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 0.999
Fgfr2 fibroblast growth factor receptor 2 0.999
Ar androgen receptor 0.998
Pax2 paired box gene 2 0.993
Pax8 paired box gene 8 0.991
Gli3 GLI-Kruppel family member GLI3 0.983
Rarg retinoic acid receptor, gamma 0.978
Bmp4 bone morphogenetic protein 4 0.977
Fgfr1 fibroblast growth factor receptor 1 0.967
Fgfr3 fibroblast growth factor receptor 3 0.959
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.956
Gli2 GLI-Kruppel family member GLI2 0.953
Shh sonic hedgehog 0.949
Pthlh parathyroid hormone-like peptide 0.934
Dlx5 distal-less homeobox 5 0.889
Trp53 transformation related protein 53 0.881
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.879
Fgf8 fibroblast growth factor 8 0.851
Sox9 SRY-box containing gene 9 0.847
Rxra retinoid X receptor alpha 0.834
Wnt3a wingless-related MMTV integration site 3A 0.806
Pax3 paired box gene 3 0.802
Hoxa13 homeobox A13 0.800
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.778
Bmp7 bone morphogenetic protein 7 0.756
Ghr growth hormone receptor 0.736
Pax6 paired box gene 6 0.735
Dok1 docking protein 1 0.735
Ctnnb1 catenin (cadherin associated protein), beta 1 0.721
Sfrp2 secreted frizzled-related protein 2 0.699
Lmx1a LIM homeobox transcription factor 1 alpha 0.680
Trp63 transformation related protein 63 0.680
Hes1 hairy and enhancer of split 1 (Drosophila) 0.679
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.679
Foxc1 forkhead box C1 0.649
Gata4 GATA binding protein 4 0.648
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.604
Esr2 estrogen receptor 2 (beta) 0.592
Esr1 estrogen receptor 1 (alpha) 0.582
Fgf10 fibroblast growth factor 10 0.568
Lepr leptin receptor 0.566
Sox7 SRY-box containing gene 7 0.556
Fgf18 fibroblast growth factor 18 0.552
Vangl2 vang-like 2 (van gogh, Drosophila) 0.551
Grb10 growth factor receptor bound protein 10 0.551
Grb2 growth factor receptor bound protein 2 0.550
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.514
Pitx2 paired-like homeodomain transcription factor 2 0.499
Sox2 SRY-box containing gene 2 0.494
Apc adenomatosis polyposis coli 0.493
Hand2 heart and neural crest derivatives expressed transcript 2 0.487
Tcf21 transcription factor 21 0.462
Prlr prolactin receptor 0.456
Hoxd13 homeobox D13 0.452
Nkx2-1 NK2 homeobox 1 0.448
Stat5b signal transducer and activator of transcription 5B 0.438
Barx1 BarH-like homeobox 1 0.427
Hoxd11 homeobox D11 0.402
Pou3f3 POU domain, class 3, transcription factor 3 0.395
Emx2 empty spiracles homolog 2 (Drosophila) 0.389
Meox2 mesenchyme homeobox 2 0.386
Thrb thyroid hormone receptor beta 0.380
Pbx1 pre B-cell leukemia transcription factor 1 0.379
Nodal nodal 0.371
Nr2f1 nuclear receptor subfamily 2, group F, member 1 0.342
Fgf3 fibroblast growth factor 3 0.338
Cdx1 caudal type homeobox 1 0.329
Pdx1 pancreatic and duodenal homeobox 1 0.328
Sfrp1 secreted frizzled-related protein 1 0.321
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.320
Neurog3 neurogenin 3 0.319
Col1a1 collagen, type I, alpha 1 0.311
Insr insulin receptor 0.310
Fgf4 fibroblast growth factor 4 0.303
Efnb2 ephrin B2 0.299
Pgr progesterone receptor 0.298
Gas1 growth arrest specific 1 0.294
Gja3 gap junction protein, alpha 3 0.289
Tbx2 T-box 2 0.289
Notch2 Notch gene homolog 2 (Drosophila) 0.280
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.278
Kiss1 KiSS-1 metastasis-suppressor 0.269
Hoxa11 homeobox A11 0.269
Lhx3 LIM homeobox protein 3 0.268
Foxa2 forkhead box A2 0.255
Otx1 orthodenticle homolog 1 (Drosophila) 0.254
Npr3 natriuretic peptide receptor 3 0.253
Stat5a signal transducer and activator of transcription 5A 0.251
Alx4 aristaless-like homeobox 4 0.251
En1 engrailed 1 0.246
Tbx1 T-box 1 0.245
Nog noggin 0.243
Tgfb2 transforming growth factor, beta 2 0.240
Egfr epidermal growth factor receptor 0.237
Adra2b adrenergic receptor, alpha 2b 0.236
Kit kit oncogene 0.234
Otx2 orthodenticle homolog 2 (Drosophila) 0.226
Irf9 interferon regulatory factor 9 0.220
Wnt2b wingless related MMTV integration site 2b 0.218
Inpp5d inositol polyphosphate-5-phosphatase D 0.215
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Rattus norvegicus
Name Description Probability Func Analog Organism
S100a10 S100 calcium binding protein A10 0.446
S100a11 S100 calcium binding protein A11 (calizzarin) 0.172
Anxa2 annexin A2 0.153
S100a6 S100 calcium binding protein A6 0.063
Lgals3 lectin, galactoside-binding, soluble, 3 0.051
Anxa5 annexin A5 0.031
Timp1 TIMP metallopeptidase inhibitor 1 0.028
Dbp D site of albumin promoter (albumin D-box) binding protein 0.025
Cd151 CD151 molecule (Raph blood group) 0.025
Anxa1 annexin A1 0.024
Ccl2 chemokine (C-C motif) ligand 2 0.021
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.019
Stip1 stress-induced phosphoprotein 1 0.017
Vim vimentin 0.017
Krt5 keratin 5 0.016
Zfp469 zinc finger protein 469 0.015
Foxe3 forkhead box E3 0.015
Mmp13 matrix metallopeptidase 13 0.014
Serpinb1a serine (or cysteine) proteinase inhibitor, clade B, member 1a 0.014
Lmna lamin A 0.013
Myadm myeloid-associated differentiation marker 0.013
Gdf10 growth differentiation factor 10 0.012
Prkcdbp protein kinase C, delta binding protein 0.012
Itgb1 integrin, beta 1 0.011
Ctrc chymotrypsin C (caldecrin) 0.011
Ctsb cathepsin B 0.011
Nradd neurotrophin receptor associated death domain 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism