The network for 'negative regulation of locomotion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of locomotion

Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.

Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
FN1 fibronectin 1 1.000
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.995
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.991
JAG1 jagged 1 0.990
FGFR2 fibroblast growth factor receptor 2 0.987
FLNA filamin A, alpha 0.987
RARA retinoic acid receptor, alpha 0.968
TEK TEK tyrosine kinase, endothelial 0.946
CD63 CD63 molecule 0.935
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.933
C1QA complement component 1, q subcomponent, A chain 0.914
TGFB1 transforming growth factor, beta 1 0.902
EGFR epidermal growth factor receptor 0.900
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.884
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.875
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.873
TAL1 T-cell acute lymphocytic leukemia 1 0.862
NCOA1 nuclear receptor coactivator 1 0.858
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.855
HOXB5 homeobox B5 0.843
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.832
CCR5 chemokine (C-C motif) receptor 5 0.824
NOTCH3 notch 3 0.822
FKBP1A FK506 binding protein 1A, 12kDa 0.821
KRT15 keratin 15 0.821
SP110 SP110 nuclear body protein 0.813
NOTCH1 notch 1 0.782
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.771
COL6A1 collagen, type VI, alpha 1 0.770
ENG endoglin 0.763
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.755
BMP2 bone morphogenetic protein 2 0.754
HIPK2 homeodomain interacting protein kinase 2 0.709
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.699
DMD dystrophin 0.675
PLAU plasminogen activator, urokinase 0.672
VCAM1 vascular cell adhesion molecule 1 0.662
MET met proto-oncogene (hepatocyte growth factor receptor) 0.655
PXN paxillin 0.652
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.651
CCL4 chemokine (C-C motif) ligand 4 0.640
TGFB3 transforming growth factor, beta 3 0.622
THBS1 thrombospondin 1 0.619
TIMP3 TIMP metallopeptidase inhibitor 3 0.607
NCOR2 nuclear receptor corepressor 2 0.584
SPTBN1 spectrin, beta, non-erythrocytic 1 0.578
SMAD3 SMAD family member 3 0.575
SLIT3 slit homolog 3 (Drosophila) 0.572
COL1A2 collagen, type I, alpha 2 0.572
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.568
BMP1 bone morphogenetic protein 1 0.560
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.549
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.546
IFITM3 interferon induced transmembrane protein 3 (1-8U) 0.544
RXRA retinoid X receptor, alpha 0.523
C1QC complement component 1, q subcomponent, C chain 0.518
IL1R1 interleukin 1 receptor, type I 0.514
ABI2 abl-interactor 2 0.514
DPP4 dipeptidyl-peptidase 4 0.511
HOXB6 homeobox B6 0.502
GATA4 GATA binding protein 4 0.498
FGF1 fibroblast growth factor 1 (acidic) 0.497
KRT6B keratin 6B 0.497
IGF1 insulin-like growth factor 1 (somatomedin C) 0.492
ADRB1 adrenergic, beta-1-, receptor 0.468
PTGIS prostaglandin I2 (prostacyclin) synthase 0.465
COX17 COX17 cytochrome c oxidase assembly homolog (S. cerevisiae) 0.458
GHR growth hormone receptor 0.457
SFRP1 secreted frizzled-related protein 1 0.455
BCAR1 breast cancer anti-estrogen resistance 1 0.454
KRT8 keratin 8 0.453
CAV1 caveolin 1, caveolae protein, 22kDa 0.438
COL1A1 collagen, type I, alpha 1 0.434
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.434
CTGF connective tissue growth factor 0.433
FBLN1 fibulin 1 0.423
VCAN versican 0.417
PDIA3 protein disulfide isomerase family A, member 3 0.410
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.400
RND1 Rho family GTPase 1 0.397
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.396
TFF1 trefoil factor 1 0.394
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.391
PKP1 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) 0.390
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.389
TRIM21 tripartite motif containing 21 0.387
BAIAP2 BAI1-associated protein 2 0.384
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.381
TBX5 T-box 5 0.370
BMPR1B bone morphogenetic protein receptor, type IB 0.366
APOC1 apolipoprotein C-I 0.364
MEF2C myocyte enhancer factor 2C 0.364
CCND1 cyclin D1 0.364
NAMPT nicotinamide phosphoribosyltransferase 0.358
STRN striatin, calmodulin binding protein 0.354
IFI16 interferon, gamma-inducible protein 16 0.352
PLAT plasminogen activator, tissue 0.345
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.335
TIMP1 TIMP metallopeptidase inhibitor 1 0.334
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
ser-4 Protein SER-4 0.670
egl-5 Protein EGL-5 0.277
F52C12.4 Protein F52C12.4 0.213
hlh-2 Protein HLH-2 0.155
syg-1 Protein SYG-1 0.136
egl-18 Protein EGL-18 0.132
cam-1 Protein CAM-1 0.117
unc-86 Protein UNC-86 0.112
nhr-67 Protein NHR-67 0.103
bli-1 Protein BLI-1 0.101
sax-3 Protein SAX-3 0.092
egl-13 Protein EGL-13 0.090
unc-53 Protein UNC-53 0.090
col-110 Protein COL-110 0.090
tbb-4 Protein TBB-4 0.087
unc-42 Protein UNC-42 0.083
smp-1 Protein SMP-1 0.082
eat-4 Protein EAT-4 0.073
ZC247.2 Protein ZC247.2 0.067
goa-1 Protein GOA-1 0.065
pqn-21 Protein PQN-21 0.063
pdfr-1 Protein PDFR-1 0.061
egl-36 Protein EGL-36 0.060
ptr-14 Protein PTR-14 0.060
CELE_E01G4.6 Protein E01G4.6 0.060
F21C10.7 Protein F21C10.7 0.058
ten-1 Protein TEN-1 0.057
oct-2 Protein OCT-2 0.056
R90.1 Protein R90.1 0.052
unc-7 Protein UNC-7 0.050
F14B8.6 Protein F14B8.6 0.045
pry-1 Protein PRY-1 0.044
sto-4 Protein STO-4 0.044
ttr-24 Protein TTR-24 0.043
vab-3 Protein VAB-3 0.040
col-49 Protein COL-49 0.039
K02A11.3 Protein K02A11.3 0.039
daf-1 Protein DAF-1 0.038
C11E4.6 Protein C11E4.6 0.037
pqn-47 Protein PQN-47 0.037
hlh-1 Protein HLH-1 0.037
unc-37 Protein UNC-37 0.035
csnk-1 Protein CSNK-1 0.035
col-38 Protein COL-38 0.034
egl-30 Protein EGL-30 0.034
egl-46 Protein EGL-46 0.034
sel-12 Protein SEL-12 0.034
tag-163 Protein TAG-163 0.034
sax-7 Protein SAX-7 0.034
ceh-18 Protein CEH-18 0.033
pqn-53 Protein PQN-53 0.033
ptp-3 Protein PTP-3 0.033
spp-15 Protein SPP-15 0.032
K01A12.3 Protein K01A12.3 0.032
qua-1 Protein QUA-1 0.031
unc-9 Protein UNC-9 0.031
ser-3 Protein SER-3 0.031
lin-12 Protein LIN-12 0.031
ser-1 Protein SER-1 0.030
ima-3 Protein IMA-3 0.029
bar-1 Protein BAR-1 0.029
CELE_M03D4.4 Protein M03D4.4 0.029
ttyh-1 Protein TTYH-1 0.029
col-56 Protein COL-56 0.027
srr-3 Protein SRR-3 0.027
vang-1 Protein VANG-1 0.027
ceh-48 Protein CEH-48 0.027
pat-3 Protein PAT-3 0.027
unc-36 Protein UNC-36 0.026
hum-6 Protein HUM-6 0.026
mes-3 Protein MES-3 0.026
cri-2 Protein CRI-2 0.026
let-60 Protein LET-60 0.025
unc-32 Protein UNC-32 0.025
brp-1 Protein BRP-1 0.025
kvs-4 Protein KVS-4 0.025
pde-4 Protein PDE-4 0.025
hmg-1.2 Protein HMG-1.2 0.024
zfp-1 Protein ZFP-1 0.024
mpk-1 Protein MPK-1 0.024
ngp-1 Protein NGP-1 0.024
sel-8 Protein SEL-8 0.024
lin-29 Protein LIN-29 0.024
unc-29 Protein UNC-29 0.024
elt-6 Protein ELT-6 0.024
mek-2 Protein MEK-2 0.023
mab-23 Protein MAB-23 0.023
ceh-22 Protein CEH-22 0.023
daf-12 Protein DAF-12 0.023
CELE_ZK829.7 Protein ZK829.7 0.023
rsbp-1 Protein RSBP-1 0.023
nhr-32 Protein NHR-32 0.023
cwn-1 Protein CWN-1 0.023
tsp-11 Protein TSP-11 0.023
lin-17 Protein LIN-17 0.023
ZK822.4 Protein ZK822.4 0.022
col-138 Protein COL-138 0.022
sma-6 Protein SMA-6 0.022
madf-2 Protein MADF-2 0.021
lit-1 Protein LIT-1 0.021
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Danio rerio
Name Description Probability Func Analog Organism
efnb2a ephrin B2a 0.769
cxcr4b chemokine (C-X-C motif), receptor 4b 0.626
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.381
kdrl kinase insert domain receptor like 0.345
robo3 roundabout homolog 3 0.219
itgb3b integrin beta 3b 0.198
dld deltaD 0.183
sulf1 sulfatase 1 0.172
ntn1a netrin 1a 0.162
gli2a GLI-Kruppel family member GLI2a 0.152
otpb orthopedia homolog b 0.139
epha4a eph receptor A4a 0.138
prox1 prospero-related homeobox gene 1 0.135
boc brother of CDO 0.127
ilk integrin linked kinase 0.110
cfl2l cofilin 2, like 0.096
gli1 GLI-Kruppel family member 1 0.089
robo1 roundabout homolog 1 0.089
wnt3 wingless-type MMTV integration site family, member 3 0.087
pdlim1 PDZ and LIM domain 1 (elfin) 0.086
irx2a iroquois homeobox protein 2, a 0.085
mib mind bomb 0.084
tbx1 T-box 1 0.083
shha sonic hedgehog a 0.079
irx5a iroquois homeobox protein 5a 0.078
ubiad1 UbiA prenyltransferase domain containing 1 0.076
fgf3 fibroblast growth factor 3 0.075
tbx2b T-box 2b 0.073
rorb RAR-related orphan receptor B 0.071
cntn2 contactin 2 0.071
sox2 SRY-box containing gene 2 0.069
lhx2b LIM homeobox 2b 0.064
mtp microsomal triglyceride transfer protein 0.064
nf1a neurofibromin 1a 0.063
ncam1b neural cell adhesion molecule 1b 0.060
bmp2b bone morphogenetic protein 2b 0.060
dtng dystrobrevin, gamma and dystrobrevin, gamma-like 0.060
sox3 SRY-box containing gene 3 0.059
fgfr2 fibroblast growth factor receptor 2 0.059
wnt11r wingless-type MMTV integration site family, member 11, related 0.058
fzd7b frizzled homolog 7b 0.058
robo2 roundabout homolog 2 0.058
hcrt hypocretin (orexin) neuropeptide precursor 0.053
dlb deltaB 0.052
dla deltaA 0.052
crh corticotropin releasing hormone 0.049
irx3a iroquois homeobox protein 3a 0.048
mbtps1 membrane-bound transcription factor protease, site 1 0.048
zgc:153063 zgc:153063 0.047
srf serum response factor 0.046
appa amyloid beta (A4) precursor protein a 0.045
fgf8b fibroblast growth factor 8 b 0.044
met met proto-oncogene (hepatocyte growth factor receptor) 0.043
spry4 sprouty (Drosophila) homolog 4 0.043
foxd3 forkhead box D3 0.042
ucn3l urocortin 3, like 0.042
sox11a SRY-box containing gene 11a 0.042
drd2a dopamine receptor D2a 0.041
esrrga estrogen-related receptor gamma a 0.041
ptmab prothymosin, alpha b 0.041
prkci protein kinase C, iota 0.041
dab1a disabled homolog 1a (Drosophila) 0.040
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.040
vegfc vascular endothelial growth factor c 0.040
LOC100006361 galanin-like 0.039
gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a 0.039
itgb1b integrin, beta 1b 0.039
neo1 neogenin 1 0.039
wnt10a wingless-type MMTV integration site family, member 10a 0.036
fabp11a fatty acid binding protein 11a 0.036
axin2 axin 2 (conductin, axil) 0.035
plxna4 plexin A4 0.034
axin1 axin 1 0.034
notch3 notch homolog 3 0.034
insm1a insulinoma-associated 1a 0.034
sulf2l sulfatase 2, like 0.034
sh3gl1b SH3-domain GRB2-like 1b 0.034
lfng lunatic fringe homolog 0.033
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.033
zgc:77714 zgc:77714 0.033
kctd12.1 potassium channel tetramerisation domain containing 12.1 0.033
tmem2 transmembrane protein 2 0.033
slit2 slit (Drosophila) homolog 2 0.032
rtn1a reticulon 1a 0.032
midn midnolin 0.032
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.032
slit1a slit homolog 1a (Drosophila) 0.031
hspb6 heat shock protein, alpha-crystallin-related, b6 0.030
pdx1 pancreatic and duodenal homeobox 1 0.030
adipoql adiponectin, C1Q and collagen domain containing, like 0.030
igf1ra insulin-like growth factor 1a receptor 0.030
unc5b unc-5 homolog B (C. elegans) 0.030
sox4a SRY-box containing gene 4a 0.030
slit3 slit (Drosophila) homolog 3 0.029
si:dkey-228g21.4 si:dkey-228g21.4 0.029
chat choline acetyltransferase 0.028
apc adenomatosis polyposis coli 0.028
rxfp1 relaxin/insulin-like family peptide receptor 1 0.028
nrp1a neuropilin 1a 0.027
nsa2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 0.027
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ifitm3 interferon induced transmembrane protein 3 0.033
Fgfr2 fibroblast growth factor receptor 2 0.019
C1s complement component 1, s subcomponent 0.018
Adora2a adenosine A2a receptor 0.017
Il4 interleukin 4 0.016
Nlgn3 neuroligin 3 0.016
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.015
Ifitm2 interferon induced transmembrane protein 2 0.015
Acta2 smooth muscle alpha-actin 0.015
Mgp matrix Gla protein 0.015
Ptafr platelet-activating factor receptor 0.015
Msn moesin 0.015
Kcnq2 potassium voltage-gated channel, KQT-like subfamily, member 2 0.014
Cntn3 contactin 3 (plasmacytoma associated) 0.014
Sstr1 somatostatin receptor 1 0.014
A3galt2 alpha 1,3-galactosyltransferase 2 0.013
Cd4 Cd4 molecule 0.013
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.013
Lims1 LIM and senescent cell antigen-like domains 1 0.013
Itga6 integrin, alpha 6 0.013
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.012
Hbe1 hemoglobin, epsilon 1 0.012
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.012
Fgf2 fibroblast growth factor 2 0.012
Tagln transgelin 0.012
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.012
Flt1 FMS-related tyrosine kinase 1 0.012
Avpr2 arginine vasopressin receptor 2 0.012
Grasp GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.012
Capn9 calpain 9 0.012
Gja5 gap junction protein, alpha 5 0.012
Sdc3 syndecan 3 0.012
Galr3 galanin receptor 3 0.012
Cd37 CD37 molecule 0.012
Syt11 synaptotagmin XI 0.012
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.012
Ece1 endothelin converting enzyme 1 0.012
A2m alpha-2-macroglobulin 0.011
Trib1 tribbles homolog 1 (Drosophila) 0.011
Lnpep leucyl/cystinyl aminopeptidase 0.011
Socs3 suppressor of cytokine signaling 3 0.011
Cd38 CD38 molecule 0.011
Uox urate oxidase 0.011
Sox17 SRY (sex determining region Y)-box 17 0.011
Slc6a7 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 0.011
Grid1 glutamate receptor, ionotropic, delta 1 0.011
Tp63 tumor protein p63 0.011
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.011
Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.011
Shisa5 shisa homolog 5 (Xenopus laevis) 0.011
Gria1 glutamate receptor, ionotropic, AMPA 1 0.011
Kcnt1 potassium channel, subfamily T, member 1 0.011
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.011
Rasgrp1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.011
Masp2 mannan-binding lectin serine peptidase 2 0.011
Cd14 CD14 molecule 0.011
Actb actin, beta 0.010
Sept9 septin 9 0.010
Slit3 slit homolog 3 (Drosophila) 0.010
Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.010
Fgf14 fibroblast growth factor 14 0.010
Cd5 Cd5 molecule 0.010
Rhoc ras homolog gene family, member C 0.010
Gnb4 guanine nucleotide binding protein (G protein), beta polypeptide 4 0.010
Pspn persephin 0.010
Epas1 endothelial PAS domain protein 1 0.010
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.010
Ltbp4 latent transforming growth factor beta binding protein 4 0.010
Impg2 interphotoreceptor matrix proteoglycan 2 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism