The network for 'positive regulation of interleukin 6 production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of interleukin 6 production

Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.

Homo sapiens
Name Description Probability Func Analog Organism
RIPK2 receptor-interacting serine-threonine kinase 2 0.782
IL1R1 interleukin 1 receptor, type I 0.701
MAP2K4 mitogen-activated protein kinase kinase 4 0.646
TLR4 toll-like receptor 4 0.632
TICAM2 toll-like receptor adaptor molecule 2 0.534
MYD88 myeloid differentiation primary response gene (88) 0.494
IRAK1 interleukin-1 receptor-associated kinase 1 0.474
NLRC4 NLR family, CARD domain containing 4 0.440
BIRC3 baculoviral IAP repeat containing 3 0.339
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.273
IRAK2 interleukin-1 receptor-associated kinase 2 0.204
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.167
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.157
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.153
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.110
TRAF2 TNF receptor-associated factor 2 0.108
TRAF3 TNF receptor-associated factor 3 0.088
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.083
ATF2 activating transcription factor 2 0.071
NOD2 nucleotide-binding oligomerization domain containing 2 0.068
IL6 interleukin 6 (interferon, beta 2) 0.064
SYK spleen tyrosine kinase 0.063
MARK2 MAP/microtubule affinity-regulating kinase 2 0.062
TLR2 toll-like receptor 2 0.059
IL6R interleukin 6 receptor 0.057
JUN jun proto-oncogene 0.057
SETD8 SET domain containing (lysine methyltransferase) 8 0.057
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.044
MEFV Mediterranean fever 0.044
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.043
SOCS3 suppressor of cytokine signaling 3 0.040
CPNE6 copine VI (neuronal) 0.039
TRAF1 TNF receptor-associated factor 1 0.039
PYDC2 pyrin domain containing 2 0.038
JAK1 Janus kinase 1 0.037
BIRC2 baculoviral IAP repeat containing 2 0.036
GATA2 GATA binding protein 2 0.035
TXN thioredoxin 0.034
IL8 interleukin 8 0.033
HSPH1 heat shock 105kDa/110kDa protein 1 0.031
ARRB1 arrestin, beta 1 0.030
RUNX1 runt-related transcription factor 1 0.029
FZD1 frizzled homolog 1 (Drosophila) 0.029
MAPK14 mitogen-activated protein kinase 14 0.028
SMAD3 SMAD family member 3 0.027
NOD1 nucleotide-binding oligomerization domain containing 1 0.027
CCR1 chemokine (C-C motif) receptor 1 0.025
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.024
LY96 lymphocyte antigen 96 0.023
BTK Bruton agammaglobulinemia tyrosine kinase 0.023
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.021
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.021
TLR1 toll-like receptor 1 0.021
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.020
IRAK3 interleukin-1 receptor-associated kinase 3 0.019
IL1RAP interleukin 1 receptor accessory protein 0.019
IRAK4 interleukin-1 receptor-associated kinase 4 0.019
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.019
VNN2 vanin 2 0.018
LY86 lymphocyte antigen 86 0.016
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.015
KIAA1712 KIAA1712 0.015
MAPK15 mitogen-activated protein kinase 15 0.014
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 0.013
SPOP speckle-type POZ protein 0.013
FGF3 fibroblast growth factor 3 0.013
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.013
TLR7 toll-like receptor 7 0.013
CCL20 chemokine (C-C motif) ligand 20 0.013
ARAF v-raf murine sarcoma 3611 viral oncogene homolog 0.012
SAMHD1 SAM domain and HD domain 1 0.011
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.011
XPO7 exportin 7 0.011
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.011
GTF2I general transcription factor IIi 0.011
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.011
ELF4 E74-like factor 4 (ets domain transcription factor) 0.011
IL1B interleukin 1, beta 0.010
IRF7 interferon regulatory factor 7 0.010
PKN1 protein kinase N1 0.010
FOSL1 FOS-like antigen 1 0.010
ANG angiogenin, ribonuclease, RNase A family, 5 0.010
STAP2 signal transducing adaptor family member 2 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Tlr4 toll-like receptor 4 1.000
Tnf tumor necrosis factor 0.970
Myd88 myeloid differentiation primary response gene 88 0.952
Lyz2 lysozyme 2 0.948
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.938
Il1r1 interleukin 1 receptor, type I 0.927
Il4 interleukin 4 0.904
Lhx1 LIM homeobox protein 1 0.854
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.849
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.831
Cd44 CD44 antigen 0.798
Pax2 paired box gene 2 0.702
Ccl2 chemokine (C-C motif) ligand 2 0.689
Cd40 CD40 antigen 0.674
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.594
Ikzf1 IKAROS family zinc finger 1 0.489
Il10 interleukin 10 0.471
Casp1 caspase 1 0.444
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.424
Igh immunoglobulin heavy chain complex 0.400
Emx2 empty spiracles homolog 2 (Drosophila) 0.391
Ticam1 toll-like receptor adaptor molecule 1 0.388
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.371
Il1rl1 interleukin 1 receptor-like 1 0.362
Birc3 baculoviral IAP repeat-containing 3 0.354
Nlrp3 NLR family, pyrin domain containing 3 0.351
Fas Fas (TNF receptor superfamily member 6) 0.283
Lta lymphotoxin A 0.281
Pitx2 paired-like homeodomain transcription factor 2 0.273
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.253
Il1b interleukin 1 beta 0.253
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.241
Irak4 interleukin-1 receptor-associated kinase 4 0.212
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.198
Lif leukemia inhibitory factor 0.184
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.183
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.177
Otx2 orthodenticle homolog 2 (Drosophila) 0.176
Rarg retinoic acid receptor, gamma 0.173
Mmp9 matrix metallopeptidase 9 0.168
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.163
Tcra T-cell receptor alpha chain 0.159
Wnt4 wingless-related MMTV integration site 4 0.158
Il6 interleukin 6 0.157
Ccr1 chemokine (C-C motif) receptor 1 0.153
Gdnf glial cell line derived neurotrophic factor 0.139
Lck lymphocyte protein tyrosine kinase 0.137
Cd14 CD14 antigen 0.133
Fgf8 fibroblast growth factor 8 0.131
Btk Bruton agammaglobulinemia tyrosine kinase 0.130
Ifnar1 interferon (alpha and beta) receptor 1 0.122
Il2rg interleukin 2 receptor, gamma chain 0.122
Il7 interleukin 7 0.121
C3 complement component 3 0.119
Spp1 secreted phosphoprotein 1 0.115
Aim2 absent in melanoma 2 0.113
Ikbkg inhibitor of kappaB kinase gamma 0.110
Mavs mitochondrial antiviral signaling protein 0.102
Asprv1 aspartic peptidase, retroviral-like 1 0.101
Wt1 Wilms tumor 1 homolog 0.095
Rel reticuloendotheliosis oncogene 0.093
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.093
Otx1 orthodenticle homolog 1 (Drosophila) 0.091
Ptgs2 prostaglandin-endoperoxide synthase 2 0.090
Il15 interleukin 15 0.087
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.085
C78513 EST C78513 0.084
Tlr2 toll-like receptor 2 0.078
Ccr2 chemokine (C-C motif) receptor 2 0.077
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.073
Il2rb interleukin 2 receptor, beta chain 0.073
Cd80 CD80 antigen 0.071
Foxn1 forkhead box N1 0.070
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.070
Fadd Fas (TNFRSF6)-associated via death domain 0.069
Emx1 empty spiracles homolog 1 (Drosophila) 0.067
Casp8 caspase 8 0.066
Pou3f1 POU domain, class 3, transcription factor 1 0.066
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.064
Socs1 suppressor of cytokine signaling 1 0.061
Wnt3a wingless-related MMTV integration site 3A 0.058
Hspa9 heat shock protein 9 0.057
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.057
Gbx2 gastrulation brain homeobox 2 0.056
Ldb2 LIM domain binding 2 0.054
Hoxa13 homeobox A13 0.053
Tnfsf9 tumor necrosis factor (ligand) superfamily, member 9 0.051
Traf6 TNF receptor-associated factor 6 0.051
Ooep oocyte expressed protein homolog (dog) 0.049
Clec4n C-type lectin domain family 4, member n 0.048
S1pr2 sphingosine-1-phosphate receptor 2 0.048
Wnt10b wingless related MMTV integration site 10b 0.047
Tcf3 transcription factor 3 0.047
Il18rap interleukin 18 receptor accessory protein 0.046
Slpi secretory leukocyte peptidase inhibitor 0.046
Cxcl2 chemokine (C-X-C motif) ligand 2 0.046
Lmx1a LIM homeobox transcription factor 1 alpha 0.045
Batf basic leucine zipper transcription factor, ATF-like 0.045
Mefv Mediterranean fever 0.045
Ccl4 chemokine (C-C motif) ligand 4 0.045
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ccl4 chemokine (C-C motif) ligand 4 0.288
Hspe1 heat shock protein 1 (chaperonin 10) 0.179
Lpl lipoprotein lipase 0.139
Csf1 colony stimulating factor 1 (macrophage) 0.067
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.054
Ccl3 chemokine (C-C motif) ligand 3 0.050
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.040
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.038
Faslg Fas ligand (TNF superfamily, member 6) 0.038
Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.033
C5ar1 complement component 5a receptor 1 0.033
Ciita class II, major histocompatibility complex, transactivator 0.031
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.031
RT1-Ba RT1 class II, locus Ba 0.030
Axl Axl receptor tyrosine kinase 0.029
Ghr growth hormone receptor 0.028
Casp12 caspase 12 0.027
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.027
Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 0.027
Gzmk granzyme K 0.026
Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.025
Cxcr3 chemokine (C-X-C motif) receptor 3 0.023
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.023
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.022
Itgam integrin, alpha M 0.019
Adora2a adenosine A2a receptor 0.019
Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 0.019
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.019
Cxcl2 chemokine (C-X-C motif) ligand 2 0.019
Hspa8 heat shock protein 8 0.018
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.018
Psp parotid secretory protein 0.017
Nrarp Notch-regulated ankyrin repeat protein 0.017
Gnb4 guanine nucleotide binding protein (G protein), beta polypeptide 4 0.017
Socs3 suppressor of cytokine signaling 3 0.017
Acsl1 acyl-CoA synthetase long-chain family member 1 0.016
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.015
Crhbp corticotropin releasing hormone binding protein 0.015
Srpr signal recognition particle receptor ('docking protein') 0.015
Ralgds ral guanine nucleotide dissociation stimulator 0.015
Sh2b3 SH2B adaptor protein 3 0.015
Ednra endothelin receptor type A 0.015
Amelx amelogenin X chromosome 0.015
Vip vasoactive intestinal peptide 0.015
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.014
RT1-A3 RT1 class I, locus A3 0.014
Uhmk1 U2AF homology motif (UHM) kinase 1 0.014
Utrn utrophin 0.014
Edn1 endothelin 1 0.014
Mep1a meprin 1 alpha 0.014
Il9r interleukin 9 receptor 0.014
Crhr2 corticotropin releasing hormone receptor 2 0.014
Avp arginine vasopressin 0.014
Tlr4 toll-like receptor 4 0.014
Mamdc4 MAM domain containing 4 0.013
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.013
Dock8 dedicator of cytokinesis 8 0.013
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.013
Il1b interleukin 1 beta 0.013
Slc24a6 solute carrier family 24 (sodium/potassium/calcium exchanger), member 6 0.013
Xdh xanthine dehydrogenase 0.013
Creb1 cAMP responsive element binding protein 1 0.012
RGD1305793 similar to hypothetical protein FLJ20154 0.012
LOC363060 similar to RIKEN cDNA 1600029D21 0.012
Gja4 gap junction protein, alpha 4 0.012
Mmp12 matrix metallopeptidase 12 0.012
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.012
Mrgprf MAS-related GPR, member F 0.012
Cacng5 calcium channel, voltage-dependent, gamma subunit 5 0.011
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.011
Psg19 pregnancy specific glycoprotein 19 0.011
Grin2c glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.011
Gja5 gap junction protein, alpha 5 0.011
Lims1 LIM and senescent cell antigen-like domains 1 0.011
Neurl3 neuralized homolog 3 (Drosophila) 0.011
Chrnb3 cholinergic receptor, nicotinic, beta 3 0.010
Yy1 YY1 transcription factor 0.010
Jak1 Janus kinase 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism