The network for 'peptidyl tyrosine dephosphorylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

peptidyl tyrosine dephosphorylation

The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.

Homo sapiens
Name Description Probability Func Analog Organism
MAPK1 mitogen-activated protein kinase 1 1.000
MAPK14 mitogen-activated protein kinase 14 1.000
GHR growth hormone receptor 0.999
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.999
DUSP1 dual specificity phosphatase 1 0.977
DUSP7 dual specificity phosphatase 7 0.958
MAP2K1 mitogen-activated protein kinase kinase 1 0.915
LCK lymphocyte-specific protein tyrosine kinase 0.902
YAP1 Yes-associated protein 1 0.774
PTPRB protein tyrosine phosphatase, receptor type, B 0.749
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.747
MAPK3 mitogen-activated protein kinase 3 0.730
PTPRR protein tyrosine phosphatase, receptor type, R 0.707
DUSP5 dual specificity phosphatase 5 0.702
DUSP3 dual specificity phosphatase 3 0.671
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.655
SYK spleen tyrosine kinase 0.632
PEA15 phosphoprotein enriched in astrocytes 15 0.518
PTPRJ protein tyrosine phosphatase, receptor type, J 0.482
DUSP6 dual specificity phosphatase 6 0.431
RB1 retinoblastoma 1 0.429
CCNB2 cyclin B2 0.423
CCNE1 cyclin E1 0.387
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.376
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.371
ARHGAP9 Rho GTPase activating protein 9 0.367
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.350
CD247 CD247 molecule 0.342
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.316
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.298
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.275
PTK2 PTK2 protein tyrosine kinase 2 0.244
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.234
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.229
CHMP4B chromatin modifying protein 4B 0.178
PTPN7 protein tyrosine phosphatase, non-receptor type 7 0.173
CAV2 caveolin 2 0.166
DPYSL4 dihydropyrimidinase-like 4 0.142
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.133
MBP myelin basic protein 0.122
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.116
CTNND1 catenin (cadherin-associated protein), delta 1 0.110
MTPN myotrophin 0.109
IQGAP1 IQ motif containing GTPase activating protein 1 0.105
MTMR9 myotubularin related protein 9 0.105
CDK2 cyclin-dependent kinase 2 0.102
MET met proto-oncogene (hepatocyte growth factor receptor) 0.101
ADAM15 ADAM metallopeptidase domain 15 0.091
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.086
PKN2 protein kinase N2 0.084
SOCS2 suppressor of cytokine signaling 2 0.082
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 0.082
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.077
SIRT2 sirtuin 2 0.077
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.075
SRCIN1 SRC kinase signaling inhibitor 1 0.072
MAP2K4 mitogen-activated protein kinase kinase 4 0.070
KIAA1377 KIAA1377 0.069
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.065
IER3 immediate early response 3 0.064
DPPA4 developmental pluripotency associated 4 0.064
SH3GL3 SH3-domain GRB2-like 3 0.059
ALK anaplastic lymphoma receptor tyrosine kinase 0.057
ZFP36L1 zinc finger protein 36, C3H type-like 1 0.053
CDC25A cell division cycle 25 homolog A (S. pombe) 0.052
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.049
DNM1 dynamin 1 0.047
CKS1B CDC28 protein kinase regulatory subunit 1B 0.047
CDC25B cell division cycle 25 homolog B (S. pombe) 0.045
NEK2 NIMA (never in mitosis gene a)-related kinase 2 0.044
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.043
WEE1 WEE1 homolog (S. pombe) 0.042
TSC22D4 TSC22 domain family, member 4 0.042
CSK c-src tyrosine kinase 0.041
CSDA cold shock domain protein A 0.041
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.039
PTPN9 protein tyrosine phosphatase, non-receptor type 9 0.039
PTK2B PTK2B protein tyrosine kinase 2 beta 0.038
ARHGAP29 Rho GTPase activating protein 29 0.037
CKS2 CDC28 protein kinase regulatory subunit 2 0.037
CDT1 chromatin licensing and DNA replication factor 1 0.036
THAP2 THAP domain containing, apoptosis associated protein 2 0.034
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.034
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.034
ATF3 activating transcription factor 3 0.032
SH3GL2 SH3-domain GRB2-like 2 0.032
MKNK1 MAP kinase interacting serine/threonine kinase 1 0.031
MAP2K6 mitogen-activated protein kinase kinase 6 0.031
FOXM1 forkhead box M1 0.030
ANAPC1 anaphase promoting complex subunit 1 0.029
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.028
DUSP9 dual specificity phosphatase 9 0.028
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.028
GAB1 GRB2-associated binding protein 1 0.027
PXN paxillin 0.026
RNF6 ring finger protein (C3H2C3 type) 6 0.026
SIX1 SIX homeobox 1 0.026
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.026
EGR3 early growth response 3 0.025
ZNF512B zinc finger protein 512B 0.025
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ptpra protein tyrosine phosphatase, receptor type, A 0.100
six1b sine oculis homeobox homolog 1b 0.038
fgf3 fibroblast growth factor 3 0.036
fzd8a frizzled homolog 8a 0.030
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.029
pigu phosphatidylinositol glycan anchor biosynthesis, class U 0.027
smad5 MAD homolog 5 (Drosophila) 0.026
smad1 MAD homolog 1 (Drosophila) 0.022
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.021
sh3gl1b SH3-domain GRB2-like 1b 0.020
jag1b jagged 1b 0.020
amotl2a angiomotin like 2a 0.019
appl2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 0.019
ptprea protein tyrosine phosphatase, receptor type, E, a 0.019
unc45a unc-45 homolog A (C. elegans) 0.019
homez homeodomain leucine zipper gene 0.019
ptpreb protein tyrosine phosphatase, receptor type, E, b 0.018
sec24c SEC24 family, member C (S. cerevisiae) 0.018
hmx2 H6 family homeobox 2 0.017
csk c-src tyrosine kinase 0.017
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.017
csnk1g2a casein kinase 1, gamma 2a 0.016
zgc:92014 zgc:92014 0.016
spns2 spinster homolog 2 (Drosophila) 0.015
LOC100151531 zinc finger protein Gfi-1b-like 0.015
pdgfaa platelet-derived growth factor alpha a 0.015
zgc:101614 zgc:101614 0.015
mapk3 mitogen-activated protein kinase 3 0.015
mbtps1 membrane-bound transcription factor protease, site 1 0.015
npepps aminopeptidase puromycin sensitive 0.015
robo3 roundabout homolog 3 0.015
zgc:63947 zgc:63947 0.015
zdhhc8b zinc finger, DHHC-type containing 8b 0.015
brd2a bromodomain-containing 2a 0.014
slc35e1 solute carrier family 35, member E1 0.014
huwe1 HECT, UBA and WWE domain containing 1 0.014
foxo3b forkhead box O3b 0.013
si:dkeyp-104h9.6 si:dkeyp-104h9.6 0.013
axin1 axin 1 0.013
notch3 notch homolog 3 0.013
ptprf protein tyrosine phosphatase, receptor type, F 0.013
traf4a tnf receptor-associated factor 4a 0.013
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.012
crfb5 cytokine receptor family member b5 0.012
zgc:122977 zgc:122977 0.012
scn4ba sodium channel, voltage-gated, type IV, beta a 0.012
pld1a phospholipase D1a 0.012
tfe3b transcription factor binding to IGHM enhancer 3b 0.012
zgc:165373 zgc:165373 0.012
pald paladin 0.012
mfn2 mitofusin 2 0.012
copb2 coatomer protein complex, subunit beta 2 0.012
calub calumenin b 0.012
scn1ba sodium channel, voltage-gated, type I, beta a 0.012
capn2b calpain 2, (m/II) large subunit b 0.012
jak1 Janus kinase 1 0.012
zgc:55392 zgc:55392 0.012
cxcr3.2 chemokine (C-X-C motif) receptor 3.2 0.012
ass1 argininosuccinate synthetase 1 0.011
zgc:162965 zgc:162965 0.011
pdcd10a programmed cell death 10a 0.011
f2rl1.1 coagulation factor II (thrombin) receptor-like 1.1 0.011
fmr1 fragile X mental retardation 1 0.011
ube4b ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) 0.011
polr2a polymerase (RNA) II (DNA directed) polypeptide A 0.011
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.011
plekha7 pleckstrin homology domain containing, family A member 7 0.011
cdc14b CDC14 cell division cycle 14 homolog B 0.011
slc16a9a solute carrier family 16 (monocarboxylic acid transporters), member 9a 0.011
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.011
rps6ka1 ribosomal protein S6 kinase a, polypeptide 1 0.011
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.011
zgc:112211 zgc:112211 0.011
midn midnolin 0.011
cnpy2 canopy 2 0.011
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.011
g2e3 G2/M-phase specific E3 ubiquitin ligase 0.011
itpr1a inositol 1,4,5-triphosphate receptor, type 1a 0.011
plk1 polo-like kinase 1 (Drosophila) 0.011
ggps1 geranylgeranyl diphosphate synthase 1 0.011
sox1a SRY-box containing gene 1a 0.010
xpo6 exportin 6 0.010
spna2 spectrin alpha 2 0.010
dzip1 DAZ interacting protein 1 0.010
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.010
zgc:111944 zgc:111944 0.010
mapkapk2a mitogen-activated protein kinase-activated protein kinase 2a 0.010
csrnp1a cysteine-serine-rich nuclear protein 1a 0.010
srpr signal recognition particle receptor (docking protein) 0.010
lycat lysocardiolipin acyltransferase 0.010
hs2st1a heparan sulfate 2-O-sulfotransferase 1a 0.010
atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.010
uba3 ubiquitin-like modifier activating enzyme 3 0.010
sox3 SRY-box containing gene 3 0.010
golim4b golgi integral membrane protein 4b 0.010
dpf3 D4, zinc and double PHD fingers, family 3 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Fyn Fyn proto-oncogene 0.537
Cdc25c cell division cycle 25 homolog C (S. pombe) 0.471
Ush1c Usher syndrome 1C homolog (human) 0.165
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.148
Igh immunoglobulin heavy chain complex 0.139
Vav1 vav 1 oncogene 0.093
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.065
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.061
Mapk1 mitogen-activated protein kinase 1 0.060
Prkcd protein kinase C, delta 0.058
Ptprf protein tyrosine phosphatase, receptor type, F 0.055
Cdh5 cadherin 5 0.052
Sykb spleen tyrosine kinase 0.048
Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 0.047
Ikzf1 IKAROS family zinc finger 1 0.044
Sharpin SHANK-associated RH domain interacting protein 0.037
Jak1 Janus kinase 1 0.036
Plcg2 phospholipase C, gamma 2 0.035
Cdc25b cell division cycle 25 homolog B (S. pombe) 0.035
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.035
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.035
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.034
Grb2 growth factor receptor bound protein 2 0.031
Nsf N-ethylmaleimide sensitive fusion protein 0.030
Flt1 FMS-like tyrosine kinase 1 0.030
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.030
Il1rapl1 interleukin 1 receptor accessory protein-like 1 0.028
Tcrb T-cell receptor beta chain 0.028
Ptk2b PTK2 protein tyrosine kinase 2 beta 0.028
Myo6 myosin VI 0.027
Grxcr1 glutaredoxin, cysteine rich 1 0.026
Plk1 polo-like kinase 1 (Drosophila) 0.026
Shc1 src homology 2 domain-containing transforming protein C1 0.026
Cdc25a cell division cycle 25 homolog A (S. pombe) 0.025
Inpp5d inositol polyphosphate-5-phosphatase D 0.025
Ptprn protein tyrosine phosphatase, receptor type, N 0.025
Chl1 cell adhesion molecule with homology to L1CAM 0.023
Map2k2 mitogen-activated protein kinase kinase 2 0.022
Cd22 CD22 antigen 0.022
Src Rous sarcoma oncogene 0.022
Foxc1 forkhead box C1 0.021
Amotl2 angiomotin-like 2 0.021
Fcgr2b Fc receptor, IgG, low affinity IIb 0.021
Ctnnb1 catenin (cadherin associated protein), beta 1 0.021
Tcrd T-cell receptor delta chain 0.021
Rap1b RAS related protein 1b 0.020
LOC100503041 PDZ domain-containing protein 7-like 0.019
Kit kit oncogene 0.018
Ptprs protein tyrosine phosphatase, receptor type, S 0.018
Plxna1 plexin A1 0.018
Itga3 integrin alpha 3 0.017
Tnfrsf19 tumor necrosis factor receptor superfamily, member 19 0.017
Efnb2 ephrin B2 0.017
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.017
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.017
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.017
Homer1 homer homolog 1 (Drosophila) 0.017
Cd72 CD72 antigen 0.017
Rps6ka3 ribosomal protein S6 kinase polypeptide 3 0.017
Slc16a2 solute carrier family 16 (monocarboxylic acid transporters), member 2 0.017
Cdh2 cadherin 2 0.016
Ifrd1 interferon-related developmental regulator 1 0.016
Jak2 Janus kinase 2 0.016
Fgfr2 fibroblast growth factor receptor 2 0.016
Sema4d sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.016
Efnb1 ephrin B1 0.016
Pcdh15 protocadherin 15 0.016
Cd19 CD19 antigen 0.016
Prkcb protein kinase C, beta 0.015
Grm1 glutamate receptor, metabotropic 1 0.015
Kdr kinase insert domain protein receptor 0.015
Pag1 phosphoprotein associated with glycosphingolipid microdomains 1 0.015
Traf3ip2 TRAF3 interacting protein 2 0.015
Cntn6 contactin 6 0.015
Actn1 actinin, alpha 1 0.015
Rgs12 regulator of G-protein signaling 12 0.015
Cit citron 0.015
Grid2 glutamate receptor, ionotropic, delta 2 0.014
Ptprm protein tyrosine phosphatase, receptor type, M 0.014
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.014
Wwc2 WW, C2 and coiled-coil domain containing 2 0.014
Bdnf brain derived neurotrophic factor 0.014
Cd79b CD79B antigen 0.014
Irf8 interferon regulatory factor 8 0.014
Kif4 kinesin family member 4 0.014
Ctnnd1 catenin (cadherin associated protein), delta 1 0.013
Fam64a family with sequence similarity 64, member A 0.013
Dlx2 distal-less homeobox 2 0.013
Ptpn21 protein tyrosine phosphatase, non-receptor type 21 0.013
Dsg1a desmoglein 1 alpha 0.013
Rgnef Rho-guanine nucleotide exchange factor 0.012
Prkar1b protein kinase, cAMP dependent regulatory, type I beta 0.012
Shank2 SH3/ankyrin domain gene 2 0.012
Fermt2 fermitin family homolog 2 (Drosophila) 0.012
Hras1 Harvey rat sarcoma virus oncogene 1 0.012
Gata3 GATA binding protein 3 0.012
Dlg2 discs, large homolog 2 (Drosophila) 0.012
Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.012
Rora RAR-related orphan receptor alpha 0.012
Sh3rf1 SH3 domain containing ring finger 1 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism