The network for 'protein k48 linked ubiquitination' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein k48 linked ubiquitination

A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.

Homo sapiens
Name Description Probability Func Analog Organism
UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 1.000
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 1.000
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 1.000
RNF11 ring finger protein 11 1.000
XIAP X-linked inhibitor of apoptosis 1.000
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 1.000
RNF5 ring finger protein 5 1.000
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 1.000
ZNRF1 zinc and ring finger 1 0.997
RNF111 ring finger protein 111 0.991
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.991
RNF14 ring finger protein 14 0.985
TRIM39 tripartite motif containing 39 0.984
FBXW11 F-box and WD repeat domain containing 11 0.980
BIRC2 baculoviral IAP repeat containing 2 0.979
DZIP3 DAZ interacting protein 3, zinc finger 0.974
UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) 0.973
TRAF6 TNF receptor-associated factor 6 0.955
UBE3A ubiquitin protein ligase E3A 0.916
UBE2W ubiquitin-conjugating enzyme E2W (putative) 0.911
RNF4 ring finger protein 4 0.903
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.894
ARIH2 ariadne homolog 2 (Drosophila) 0.874
MARCH7 membrane-associated ring finger (C3HC4) 7 0.870
CUL3 cullin 3 0.837
CUL1 cullin 1 0.824
MARCH5 membrane-associated ring finger (C3HC4) 5 0.820
UBE2E3 ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast) 0.803
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.803
UBE2E2 ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast) 0.775
RNF114 ring finger protein 114 0.762
UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog) 0.743
OPTN optineurin 0.740
UBA1 ubiquitin-like modifier activating enzyme 1 0.739
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.724
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.722
UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog) 0.714
RNF38 ring finger protein 38 0.706
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.629
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.628
TRIM43 tripartite motif containing 43 0.616
SKP1 S-phase kinase-associated protein 1 0.611
SIAH1 seven in absentia homolog 1 (Drosophila) 0.589
TRIM23 tripartite motif containing 23 0.587
BTRC beta-transducin repeat containing 0.582
BIRC3 baculoviral IAP repeat containing 3 0.567
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.558
KLHL12 kelch-like 12 (Drosophila) 0.535
UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) 0.526
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.489
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.480
CHFR checkpoint with forkhead and ring finger domains 0.467
ZNF746 zinc finger protein 746 0.462
RNF26 ring finger protein 26 0.452
RNF168 ring finger protein 168 0.425
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) 0.403
RNF2 ring finger protein 2 0.396
PJA2 praja ring finger 2 0.391
RNF10 ring finger protein 10 0.364
UBC ubiquitin C 0.364
TRIM32 tripartite motif containing 32 0.363
MIB1 mindbomb homolog 1 (Drosophila) 0.347
DTX3L deltex 3-like (Drosophila) 0.340
RNF130 ring finger protein 130 0.331
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.328
AMFR autocrine motility factor receptor 0.327
ANKRD13A ankyrin repeat domain 13A 0.308
RNF185 ring finger protein 185 0.286
ZFAND5 zinc finger, AN1-type domain 5 0.282
UBQLN2 ubiquilin 2 0.282
WNK4 WNK lysine deficient protein kinase 4 0.278
KLHL2 kelch-like 2, Mayven (Drosophila) 0.278
TRIM27 tripartite motif containing 27 0.238
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.233
RNF146 ring finger protein 146 0.220
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.214
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.213
RLIM ring finger protein, LIM domain interacting 0.211
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.205
DAPK1 death-associated protein kinase 1 0.192
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.184
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.172
UBOX5 U-box domain containing 5 0.162
BFAR bifunctional apoptosis regulator 0.161
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.158
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.155
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.155
TRIM8 tripartite motif containing 8 0.152
PCGF2 polycomb group ring finger 2 0.143
TRAF1 TNF receptor-associated factor 1 0.142
RNF103 ring finger protein 103 0.140
BIRC8 baculoviral IAP repeat containing 8 0.136
UBE2G1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.134
SCAMP1 secretory carrier membrane protein 1 0.131
ZMYND11 zinc finger, MYND-type containing 11 0.131
USP15 ubiquitin specific peptidase 15 0.123
SQSTM1 sequestosome 1 0.120
PTTG1 pituitary tumor-transforming 1 0.118
MED28 mediator complex subunit 28 0.116
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.115
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
chic2 cysteine-rich hydrophobic domain 2 0.164
vps28 vacuolar protein sorting 28 (yeast) 0.121
si:ch211-239j15.4 si:ch211-239j15.4 0.117
crsp6 cofactor required for Sp1 transcriptional activation, subunit 6 0.096
tceb1b transcription elongation factor B (SIII), polypeptide 1b 0.086
h3f3c H3 histone, family 3C 0.075
rab5aa RAB5A, member RAS oncogene family, a 0.070
lsr lipolysis stimulated lipoprotein receptor 0.069
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.069
cnpy1 canopy1 0.067
zgc:77849 zgc:77849 0.065
zgc:55573 zgc:55573 0.062
elof1 elongation factor 1 homolog (S. cerevisiae) 0.055
golga7 golgi autoantigen, golgin subfamily a, 7 0.055
smndc1 survival motor neuron domain containing 1 0.055
zgc:55671 zgc:55671 0.055
tmed4 transmembrane emp24 protein transport domain containing 4 0.050
oaz2a ornithine decarboxylase antizyme 2a 0.050
tpd52l2a tumor protein D52-like 2a 0.050
fbxw11b F-box and WD-40 domain protein 11b 0.049
nipblb novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila) 0.049
bnip3lb BCL2/adenovirus E1B interacting protein 3-like b 0.048
sfswap splicing factor, suppressor of white-apricot homolog (Drosophila) 0.047
march6 membrane-associated ring finger (C3HC4) 6 0.047
zgc:103670 zgc:103670 0.045
gtf2b general transcription factor IIB 0.044
ranbp9 RAN binding protein 9 0.041
fzr1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.040
cdc34a cell division cycle 34 homolog (S. cerevisiae) a 0.040
yy1b YY1 transcription factor b 0.038
pdzd11 PDZ domain containing 11 0.038
akap8l A kinase (PRKA) anchor protein 8-like 0.037
clasp2 cytoplasmic linker associated protein 2 0.037
ppp6c protein phosphatase 6, catalytic subunit 0.037
zgc:55512 zgc:55512 0.037
tial1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.037
zgc:101121 zgc:101121 0.037
aktip akt interacting protein 0.036
maea macrophage erythroblast attacher 0.035
wdr45l wdr45 like 0.035
mapkapk2a mitogen-activated protein kinase-activated protein kinase 2a 0.035
ube2d1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.034
rab5ab RAB5A, member RAS oncogene family, b 0.034
zgc:56706 zgc:56706 0.034
st14a suppression of tumorigenicity 14 (colon carcinoma) a 0.033
rab1a RAB1A, member RAS oncogene family 0.033
zgc:100869 zgc:100869 0.033
tmem50a transmembrane protein 50A 0.033
ube2d2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 0.033
zgc:77304 zgc:77304 0.033
klhl20 kelch-like 20 (Drosophila) 0.031
zgc:73311 zgc:73311 0.030
tmem199 transmembrane protein 199 0.030
vps26b vacuolar protein sorting 26 homolog B 0.030
zgc:92606 zgc:92606 0.029
timm17a translocase of inner mitochondrial membrane 17 homolog A (yeast) 0.028
exoc7 exocyst complex component 7 0.028
snx6 sorting nexin 6 0.028
ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.028
taf8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.028
mmgt1 membrane magnesium transporter 1 0.028
cdc34b cell division cycle 34 homolog (S. cerevisiae) b 0.028
fbxw11a F-box and WD-40 domain protein 11a 0.027
rmnd5b required for meiotic nuclear division 5 homolog B (S. cerevisiae) 0.027
zgc:114169 zgc:114169 0.027
zgc:112356 zgc:112356 0.027
zgc:63992 zgc:63992 0.027
ubb ubiquitin B 0.027
zgc:56223 zgc:56223 0.026
slc7a6os solute carrier family 7, member 6 opposite strand 0.026
tuba1l2 tubulin, alpha 1, like 2 0.026
zgc:86598 zgc:86598 0.026
rab11ba RAB11B, member RAS oncogene family, a 0.026
ubc ubiquitin C 0.025
zgc:55886 zgc:55886 0.025
wipi2 WD repeat domain, phosphoinositide interacting 2 0.025
ankha ankylosis, progressive homolog a 0.025
zfand2a zinc finger, AN1-type domain 2A 0.024
ccni cyclin I 0.024
cnot6 CCR4-NOT transcription complex, subunit 6 0.023
fbxo42 F-box protein 42 0.023
dnaja2l DnaJ (Hsp40) homolog, subfamily A, member 2, like 0.023
sirt1 sirtuin (silent mating type information regulation 2 homolog) 1 0.023
mospd1 motile sperm domain containing 1 0.023
mobkl1aa MOB1, Mps One Binder kinase activator-like 1A (yeast), genome duplicate a 0.023
parn poly(A)-specific ribonuclease (deadenylation nuclease) 0.023
arglu1a arginine and glutamate rich 1a 0.023
eif1b eukaryotic translation initiation factor 1B 0.023
zgc:56525 zgc:56525 0.022
zgc:92624 zgc:92624 0.022
bmpr1ab bone morphogenetic protein receptor, type 1ab 0.022
zc3h14 zinc finger CCCH-type containing 14 0.022
zgc:55448 zgc:55448 0.022
ing3 inhibitor of growth family, member 3 0.022
zgc:77880 zgc:77880 0.022
zgc:101080 zgc:101080 0.022
ing4 inhibitor of growth family, member 4 0.022
dcun1d2 DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae) 0.022
LOC100536647 disintegrin and metalloproteinase domain-containing protein 10-like 0.021
pbx2 pre-B-cell leukemia transcription factor 2 0.021
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CG32581 CG32581 gene product from transcript CG32581-RB 0.845
trp transient receptor potential 0.564
endos endosulfine 0.204
l(3)05822 lethal (3) 05822 0.203
Nc Nedd2-like caspase 0.194
CG8974 CG8974 gene product from transcript CG8974-RD 0.193
th thread 0.163
Sap30 SIN3-associated polypeptide 30 0.144
CG32486 CG32486 gene product from transcript CG32486-RD 0.111
Rpn6 Proteasome p44.5 subunit 0.110
CG4495 CG4495 gene product from transcript CG4495-RA 0.110
Miro Mitochondrial Rho 0.088
Rab14 Rab-protein 14 0.080
loqs loquacious 0.074
CG15098 CG15098 gene product from transcript CG15098-RA 0.068
RhoBTB CG5701 gene product from transcript CG5701-RA 0.061
Stam Signal transducing adaptor molecule 0.060
UbcD2 Ubiquitin conjugating enzyme 2 0.059
CG2924 CG2924 gene product from transcript CG2924-RA 0.059
inaC inactivation no afterpotential C 0.056
CG3305 CG3305 gene product from transcript CG3305-RA 0.054
Rad23 CG1836 gene product from transcript CG1836-RB 0.052
CG11984 CG11984 gene product from transcript CG11984-RD 0.050
CG7967 CG7967 gene product from transcript CG7967-RA 0.050
mts microtubule star 0.045
drongo CG3365 gene product from transcript CG3365-RH 0.043
CG7220 CG7220 gene product from transcript CG7220-RD 0.042
CG1943 CG1943 gene product from transcript CG1943-RA 0.042
Snx6 CG8282 gene product from transcript CG8282-RA 0.041
HIP-R Hsc/Hsp70-interacting protein related 0.041
CG42557 CG42557 gene product from transcript CG42557-RA 0.040
Arr2 Arrestin 2 0.040
CG9855 CG9855 gene product from transcript CG9855-RA 0.040
Ef1alpha48D Elongation factor 1alpha48D 0.040
Lasp CG3849 gene product from transcript CG3849-RB 0.038
Hsp27 Heat shock protein 27 0.036
CG11009 CG11009 gene product from transcript CG11009-RB 0.036
Uev1A CG10640 gene product from transcript CG10640-RA 0.036
Dlc90F Dynein light chain 90F 0.036
Vps26 Vacuolar protein sorting 26 0.035
Mkrn1 Makorin 1 0.034
CG12299 CG12299 gene product from transcript CG12299-RA 0.032
Uch-L3 Ubiquitin C-terminal hydrolase 0.032
SmG Small ribonucleoprotein particle protein SmG 0.032
CG3678 CG3678 gene product from transcript CG3678-RA 0.032
Ark Apaf-1-related-killer 0.032
ninaC neither inactivation nor afterpotential C 0.032
CG6961 CG6961 gene product from transcript CG6961-RA 0.031
trpl trp-like 0.030
UbcD10 Ubiquitin conjugating enzyme 10 0.030
CG9866 CG9866 gene product from transcript CG9866-RA 0.030
UbcD4 Ubiquitin conjugating enzyme 4 0.030
MSBP membrane steroid binding protein 0.029
CG8116 CG8116 gene product from transcript CG8116-RB 0.029
Nca Neurocalcin 0.028
CG5555 CG5555 gene product from transcript CG5555-RA 0.028
phol pleiohomeotic like 0.028
Fer1HCH Ferritin 1 heavy chain homologue 0.028
wmd wing morphogenesis defect 0.027
Tango9 Transport and Golgi organization 9 0.027
CG5059 CG5059 gene product from transcript CG5059-RD 0.027
mub mushroom-body expressed 0.026
CG4502 CG4502 gene product from transcript CG4502-RB 0.026
Unr Upstream of N-ras 0.026
squ squash 0.026
CG3016 CG3016 gene product from transcript CG3016-RA 0.026
galectin CG11372 gene product from transcript CG11372-RA 0.026
CG5978 CG5978 gene product from transcript CG5978-RA 0.026
CG7656 CG7656 gene product from transcript CG7656-RA 0.025
Ice CG7788 gene product from transcript CG7788-RA 0.025
Cpr Cytochrome P450 reductase 0.025
CG13366 CG13366 gene product from transcript CG13366-RA 0.025
CG4165 CG4165 gene product from transcript CG4165-RD 0.024
l(3)L1231 lethal (3) L1231 0.024
r2d2 CG7138 gene product from transcript CG7138-RB 0.024
f-cup flyers-cup 0.024
CG10267 CG10267 gene product from transcript CG10267-RB 0.024
CG8481 CG8481 gene product from transcript CG8481-RB 0.023
CG10158 CG10158 gene product from transcript CG10158-RA 0.023
Syx13 Syntaxin 13 0.022
Gprk2 G protein-coupled receptor kinase 2 0.022
h hairy 0.022
CG31919 CG31919 gene product from transcript CG31919-RC 0.022
rux roughex 0.021
CG4996 CG4996 gene product from transcript CG4996-RA 0.021
tef teflon 0.021
Sgt1 CG9617 gene product from transcript CG9617-RA 0.021
t tan 0.021
Syx7 Syntaxin 7 0.021
kermit CG11546 gene product from transcript CG11546-RB 0.020
Lac Lachesin 0.020
granny-smith granny smith 0.020
CG30344 CG30344 gene product from transcript CG30344-RA 0.020
jar jaguar 0.020
Cam Calmodulin 0.020
l(1)G0269 lethal (1) G0269 0.020
Trn Transportin 0.020
CG12162 CG12162 gene product from transcript CG12162-RA 0.019
CG12404 CG12404 gene product from transcript CG12404-RA 0.019
CG4603 CG4603 gene product from transcript CG4603-RA 0.019
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Mus musculus
Name Description Probability Func Analog Organism
Trim30d tripartite motif-containing 30D 0.113
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.085
Trim30a tripartite motif-containing 30A 0.070
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.070
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.053
Rnf11 ring finger protein 11 0.049
Ythdf3 YTH domain family 3 0.046
Rmnd5a required for meiotic nuclear division 5 homolog A (S. cerevisiae) 0.046
Traf6 TNF receptor-associated factor 6 0.027
Mgea5 meningioma expressed antigen 5 (hyaluronidase) 0.022
Zmynd11 zinc finger, MYND domain containing 11 0.021
Cyld cylindromatosis (turban tumor syndrome) 0.019
Msl1 male-specific lethal 1 homolog (Drosophila) 0.017
Rac1 RAS-related C3 botulinum substrate 1 0.017
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.015
Grb10 growth factor receptor bound protein 10 0.015
Paip2 polyadenylate-binding protein-interacting protein 2 0.014
Spast spastin 0.014
Csnk2b casein kinase 2, beta polypeptide 0.014
Fzr1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.013
Birc5 baculoviral IAP repeat-containing 5 0.013
Trim12a tripartite motif-containing 12A 0.012
Atl2 atlastin GTPase 2 0.012
Ulk2 Unc-51 like kinase 2 (C. elegans) 0.012
Ndfip1 Nedd4 family interacting protein 1 0.011
Zfand6 zinc finger, AN1-type domain 6 0.011
Zfand5 zinc finger, AN1-type domain 5 0.011
Trp53bp1 transformation related protein 53 binding protein 1 0.010
Ccnb2 cyclin B2 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism