The network for 'endothelial cell migration' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endothelial cell migration

The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.

Homo sapiens
Name Description Probability Func Analog Organism
FN1 fibronectin 1 1.000
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.000
EGFR epidermal growth factor receptor 1.000
VEGFA vascular endothelial growth factor A 0.998
FGFR2 fibroblast growth factor receptor 2 0.997
TEK TEK tyrosine kinase, endothelial 0.996
SFN stratifin 0.996
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.996
YAP1 Yes-associated protein 1 0.994
JAG1 jagged 1 0.994
S100B S100 calcium binding protein B 0.986
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.984
S100A6 S100 calcium binding protein A6 0.978
NRP1 neuropilin 1 0.978
S100A11 S100 calcium binding protein A11 0.977
LAT linker for activation of T cells 0.973
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.967
JUN jun proto-oncogene 0.963
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.958
FOS FBJ murine osteosarcoma viral oncogene homolog 0.956
CAV1 caveolin 1, caveolae protein, 22kDa 0.953
FGF1 fibroblast growth factor 1 (acidic) 0.952
ZYX zyxin 0.950
RARA retinoic acid receptor, alpha 0.942
ANXA1 annexin A1 0.940
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.937
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.932
NOTCH1 notch 1 0.924
FYN FYN oncogene related to SRC, FGR, YES 0.924
THBS1 thrombospondin 1 0.922
POU5F1 POU class 5 homeobox 1 0.918
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.916
BMPR1A bone morphogenetic protein receptor, type IA 0.909
ENG endoglin 0.906
FKBP1A FK506 binding protein 1A, 12kDa 0.893
FGA fibrinogen alpha chain 0.891
KLF4 Kruppel-like factor 4 (gut) 0.888
S100A8 S100 calcium binding protein A8 0.887
FBLN1 fibulin 1 0.887
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.860
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.858
TGFB1 transforming growth factor, beta 1 0.851
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.840
EGR1 early growth response 1 0.832
HSPB8 heat shock 22kDa protein 8 0.830
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.827
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.823
FLNA filamin A, alpha 0.819
EMP3 epithelial membrane protein 3 0.813
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.813
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.797
SMAD3 SMAD family member 3 0.789
BCAR1 breast cancer anti-estrogen resistance 1 0.785
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.784
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.778
GRB7 growth factor receptor-bound protein 7 0.772
S100A14 S100 calcium binding protein A14 0.771
TPM4 tropomyosin 4 0.771
ANXA2 annexin A2 0.769
CTGF connective tissue growth factor 0.766
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.764
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.760
EGR3 early growth response 3 0.748
CYR61 cysteine-rich, angiogenic inducer, 61 0.745
CRYAB crystallin, alpha B 0.736
FGFR1 fibroblast growth factor receptor 1 0.734
S100A4 S100 calcium binding protein A4 0.732
S100A1 S100 calcium binding protein A1 0.696
TAL1 T-cell acute lymphocytic leukemia 1 0.695
PRKCA protein kinase C, alpha 0.694
TIMP1 TIMP metallopeptidase inhibitor 1 0.687
BMP2 bone morphogenetic protein 2 0.684
LMNA lamin A/C 0.676
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.675
PPL periplakin 0.671
PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.665
KLK10 kallikrein-related peptidase 10 0.651
NOTCH3 notch 3 0.648
NOSTRIN nitric oxide synthase trafficker 0.644
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.641
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.611
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.601
VIM vimentin 0.574
S100A16 S100 calcium binding protein A16 0.565
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.557
SH3KBP1 SH3-domain kinase binding protein 1 0.553
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.552
NCOR2 nuclear receptor corepressor 2 0.532
S100A9 S100 calcium binding protein A9 0.519
TIMP3 TIMP metallopeptidase inhibitor 3 0.506
PDGFC platelet derived growth factor C 0.505
KLF6 Kruppel-like factor 6 0.499
IER2 immediate early response 2 0.494
DUSP1 dual specificity phosphatase 1 0.483
FSTL1 follistatin-like 1 0.477
A2M alpha-2-macroglobulin 0.468
VEGFC vascular endothelial growth factor C 0.458
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.457
JUNB jun B proto-oncogene 0.455
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.445
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
efnb2a ephrin B2a 0.840
notch3 notch homolog 3 0.727
dlc deltaC 0.626
robo3 roundabout homolog 3 0.541
kdrl kinase insert domain receptor like 0.527
dll4 delta-like 4 (Drosophila) 0.500
tbx2b T-box 2b 0.488
vegfaa vascular endothelial growth factor Aa 0.450
pitx3 paired-like homeodomain transcription factor 3 0.435
cdh5 cadherin 5 0.360
itgb1b.2 integrin, beta 1b.2 0.336
vegfc vascular endothelial growth factor c 0.333
ccm2 cerebral cavernous malformation 2 0.308
si:ch211-212m21.5 si:ch211-212m21.5 0.294
etv2 ets variant gene 2 0.234
aox3 aldehyde oxidase 3 0.228
irx5a iroquois homeobox protein 5a 0.222
gata2a GATA-binding protein 2a 0.216
mmp2 matrix metalloproteinase 2 0.174
unc5b unc-5 homolog B (C. elegans) 0.170
wnt11r wingless-type MMTV integration site family, member 11, related 0.166
plcg1 phospholipase C, gamma 1 0.159
dlb deltaB 0.141
tal1 T-cell acute lymphocytic leukemia 1 0.138
fzd7a frizzled homolog 7a 0.136
tgfbi transforming growth factor, beta-induced 0.133
spry4 sprouty (Drosophila) homolog 4 0.131
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.131
cyp24a1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.130
cdh23 cadherin-like 23 0.123
dld deltaD 0.122
ccbe1 collagen and calcium binding EGF domains 1 0.120
fgfr3 fibroblast growth factor receptor 3 0.115
gata3 GATA-binding protein 3 0.108
pxn paxillin 0.107
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.103
eml2 echinoderm microtubule associated protein like 2 0.095
fabp11a fatty acid binding protein 11a 0.095
nrp2b neuropilin 2b 0.094
jag1a jagged 1a 0.094
ntrk3b neurotrophic tyrosine kinase, receptor, type 3b 0.094
pak2a p21 (CDKN1A)-activated kinase 2a 0.090
jag2 jagged 2 0.089
si:ch73-60e21.1 si:ch73-60e21.1 0.088
sulf1 sulfatase 1 0.088
nrarpa notch-regulated ankyrin repeat protein a 0.081
frem1a Fras1 related extracellular matrix 1a 0.077
bmp2a bone morphogenetic protein 2a 0.077
bmp2b bone morphogenetic protein 2b 0.073
myf5 myogenic factor 5 0.064
wtip Wilms tumor 1 interacting protein 0.063
alcama activated leukocyte cell adhesion molecule a 0.061
mcamb melanoma cell adhesion molecule b 0.059
itgb3b integrin beta 3b 0.059
myod1 myogenic differentiation 1 0.057
krit1 KRIT1, ankyrin repeat containing 0.057
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.057
skia nuclear oncoprotein skia 0.056
klf2a Kruppel-like factor 2a 0.054
crabp2b cellular retinoic acid binding protein 2, b 0.054
rarga retinoic acid receptor gamma a 0.054
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.053
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.053
appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.051
gyltl1b glycosyltransferase-like 1b 0.050
sox7 SRY-box containing gene 7 0.050
sox10 SRY-box containing gene 10 0.050
tie2 endothelium-specific receptor tyrosine kinase 2 0.049
met met proto-oncogene (hepatocyte growth factor receptor) 0.048
entpd3 ectonucleoside triphosphate diphosphohydrolase 3 0.045
LOC100003514 protein kinase C alpha type-like 0.044
bmper BMP binding endothelial regulator 0.044
hsp47 heat shock protein 47 0.044
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.043
ascl1a achaete-scute complex-like 1a (Drosophila) 0.043
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.043
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.043
tie1 endothelium-specific receptor tyrosine kinase 1 0.042
mapk4 mitogen-activated protein kinase 4 0.042
vcana versican a 0.041
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.041
acvrl1 activin A receptor type II-like 1 0.041
tp63 tumor protein p63 0.040
sdc2 syndecan 2 0.040
tfec transcription factor EC 0.039
tgfb1a transforming growth factor, beta 1a 0.039
ctrb1 chymotrypsinogen B1 0.038
smad9 MAD homolog 9 (Drosophila) 0.037
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.037
fbn2b fibrillin 2b 0.037
msna moesin a 0.036
ntn1a netrin 1a 0.036
tagln2 transgelin 2 0.036
sox11a SRY-box containing gene 11a 0.034
flt4 fms-related tyrosine kinase 4 0.034
pax7a paired box gene 7a 0.034
pax8 paired box gene 8 0.033
dcc deleted in colorectal carcinoma 0.033
sardh sarcosine dehydrogenase 0.032
itgb1b.1 integrin, beta 1b.1 0.032
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Efnb2 ephrin B2 0.994
Fgfr1 fibroblast growth factor receptor 1 0.957
Pax2 paired box gene 2 0.919
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.910
Vegfa vascular endothelial growth factor A 0.905
Nrp1 neuropilin 1 0.900
Flt4 FMS-like tyrosine kinase 4 0.876
Foxc1 forkhead box C1 0.870
Ptk2 PTK2 protein tyrosine kinase 2 0.864
Ephb2 Eph receptor B2 0.832
Jag1 jagged 1 0.817
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.810
Epha4 Eph receptor A4 0.735
Nos3 nitric oxide synthase 3, endothelial cell 0.727
Eng endoglin 0.711
Apoe apolipoprotein E 0.679
Kdr kinase insert domain protein receptor 0.660
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.622
Acvr1 activin A receptor, type 1 0.604
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.564
Nog noggin 0.558
Pax8 paired box gene 8 0.540
Col4a2 collagen, type IV, alpha 2 0.524
Slit3 slit homolog 3 (Drosophila) 0.491
Gab1 growth factor receptor bound protein 2-associated protein 1 0.485
Fgfr2 fibroblast growth factor receptor 2 0.467
Flt1 FMS-like tyrosine kinase 1 0.466
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.463
Tgfb2 transforming growth factor, beta 2 0.457
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.454
Itgb3 integrin beta 3 0.441
Gata6 GATA binding protein 6 0.438
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.420
Otx2 orthodenticle homolog 2 (Drosophila) 0.410
Ptprb protein tyrosine phosphatase, receptor type, B 0.404
Cxcl12 chemokine (C-X-C motif) ligand 12 0.395
Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.390
Cdh5 cadherin 5 0.386
Psen1 presenilin 1 0.369
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.361
Pax3 paired box gene 3 0.358
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.351
Col4a1 collagen, type IV, alpha 1 0.339
Rag1 recombination activating gene 1 0.333
Ephb3 Eph receptor B3 0.333
Dll1 delta-like 1 (Drosophila) 0.328
Nr2f1 nuclear receptor subfamily 2, group F, member 1 0.323
Kit kit oncogene 0.299
Grb2 growth factor receptor bound protein 2 0.289
Fgf10 fibroblast growth factor 10 0.286
Tspan9 tetraspanin 9 0.285
Tgfb1 transforming growth factor, beta 1 0.284
Dab1 disabled homolog 1 (Drosophila) 0.281
Fzd1 frizzled homolog 1 (Drosophila) 0.272
Notch1 Notch gene homolog 1 (Drosophila) 0.269
Plxna1 plexin A1 0.263
Csf1 colony stimulating factor 1 (macrophage) 0.261
Src Rous sarcoma oncogene 0.260
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.256
Notch2 Notch gene homolog 2 (Drosophila) 0.246
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.240
Sox7 SRY-box containing gene 7 0.235
Efnb1 ephrin B1 0.233
Acvrl1 activin A receptor, type II-like 1 0.231
Smad3 MAD homolog 3 (Drosophila) 0.227
Cyr61 cysteine rich protein 61 0.214
Notch3 Notch gene homolog 3 (Drosophila) 0.211
Wwtr1 WW domain containing transcription regulator 1 0.209
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.207
Irs1 insulin receptor substrate 1 0.201
Fyn Fyn proto-oncogene 0.200
Actn1 actinin, alpha 1 0.199
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.197
Ntf3 neurotrophin 3 0.193
Mmp15 matrix metallopeptidase 15 0.193
Apc adenomatosis polyposis coli 0.193
Dock1 dedicator of cytokinesis 1 0.190
Hif1a hypoxia inducible factor 1, alpha subunit 0.189
Gli3 GLI-Kruppel family member GLI3 0.185
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.185
Smad6 MAD homolog 6 (Drosophila) 0.184
Vangl2 vang-like 2 (van gogh, Drosophila) 0.176
Efs embryonal Fyn-associated substrate 0.172
Ctnnb1 catenin (cadherin associated protein), beta 1 0.170
Apoa1 apolipoprotein A-I 0.168
Npas1 neuronal PAS domain protein 1 0.168
Cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.168
Lox lysyl oxidase 0.166
Fjx1 four jointed box 1 (Drosophila) 0.166
Gdf11 growth differentiation factor 11 0.165
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.164
Tgfbr2 transforming growth factor, beta receptor II 0.164
Lrp1 low density lipoprotein receptor-related protein 1 0.163
Pou3f3 POU domain, class 3, transcription factor 3 0.158
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.155
Pten phosphatase and tensin homolog 0.154
Esam endothelial cell-specific adhesion molecule 0.152
Gli2 GLI-Kruppel family member GLI2 0.150
Rgnef Rho-guanine nucleotide exchange factor 0.148
Arhgef12 Rho guanine nucleotide exchange factor (GEF) 12 0.144
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Rattus norvegicus
Name Description Probability Func Analog Organism
Btg2 BTG family, member 2 0.014
Junb jun B proto-oncogene 0.014
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism