The network for 'epithelial to mesenchymal transition' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

epithelial to mesenchymal transition

A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Tgfb2 transforming growth factor, beta 2 1.000
Gli3 GLI-Kruppel family member GLI3 0.999
Ctnnb1 catenin (cadherin associated protein), beta 1 0.996
Efnb2 ephrin B2 0.996
Fgfr2 fibroblast growth factor receptor 2 0.994
Sox2 SRY-box containing gene 2 0.992
Foxc1 forkhead box C1 0.988
Runx2 runt related transcription factor 2 0.987
Hand1 heart and neural crest derivatives expressed transcript 1 0.987
Otx2 orthodenticle homolog 2 (Drosophila) 0.986
Bmp4 bone morphogenetic protein 4 0.985
Pax2 paired box gene 2 0.984
Pax3 paired box gene 3 0.978
Prrx1 paired related homeobox 1 0.978
Nodal nodal 0.972
Msx1 homeobox, msh-like 1 0.966
Lef1 lymphoid enhancer binding factor 1 0.963
Rarg retinoic acid receptor, gamma 0.959
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.946
Alx4 aristaless-like homeobox 4 0.945
Tbx3 T-box 3 0.941
Notch1 Notch gene homolog 1 (Drosophila) 0.934
Msx2 homeobox, msh-like 2 0.931
Gli2 GLI-Kruppel family member GLI2 0.931
Snai1 snail homolog 1 (Drosophila) 0.922
Dlx5 distal-less homeobox 5 0.921
Jag1 jagged 1 0.918
Hoxa1 homeobox A1 0.899
Foxa2 forkhead box A2 0.894
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.893
Fgf8 fibroblast growth factor 8 0.879
Pitx2 paired-like homeodomain transcription factor 2 0.872
Gata4 GATA binding protein 4 0.870
Pax6 paired box gene 6 0.867
Fgfr1 fibroblast growth factor receptor 1 0.849
Smad6 MAD homolog 6 (Drosophila) 0.846
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.845
Nog noggin 0.827
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.801
Gdnf glial cell line derived neurotrophic factor 0.784
Crb2 crumbs homolog 2 (Drosophila) 0.779
Tcfap2a transcription factor AP-2, alpha 0.779
Hes1 hairy and enhancer of split 1 (Drosophila) 0.777
Prrx2 paired related homeobox 2 0.762
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.756
Gata6 GATA binding protein 6 0.754
Sox9 SRY-box containing gene 9 0.751
Ntf3 neurotrophin 3 0.747
Bmp7 bone morphogenetic protein 7 0.731
Col2a1 collagen, type II, alpha 1 0.729
Pitx1 paired-like homeodomain transcription factor 1 0.695
Hand2 heart and neural crest derivatives expressed transcript 2 0.672
Lhx1 LIM homeobox protein 1 0.665
Zeb1 zinc finger E-box binding homeobox 1 0.665
Smo smoothened homolog (Drosophila) 0.647
Hoxd13 homeobox D13 0.645
Tlx3 T-cell leukemia, homeobox 3 0.639
Lmx1a LIM homeobox transcription factor 1 alpha 0.635
Eya1 eyes absent 1 homolog (Drosophila) 0.624
Smad4 MAD homolog 4 (Drosophila) 0.619
Col1a1 collagen, type I, alpha 1 0.616
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.614
Emx1 empty spiracles homolog 1 (Drosophila) 0.614
Pou3f3 POU domain, class 3, transcription factor 3 0.602
Efnb1 ephrin B1 0.586
En1 engrailed 1 0.577
Apc adenomatosis polyposis coli 0.573
Lrp6 low density lipoprotein receptor-related protein 6 0.571
Fgf10 fibroblast growth factor 10 0.565
Pou5f1 POU domain, class 5, transcription factor 1 0.562
Pthlh parathyroid hormone-like peptide 0.537
Axin1 axin 1 0.533
Foxf1a forkhead box F1a 0.516
Twist2 twist homolog 2 (Drosophila) 0.512
Neurod1 neurogenic differentiation 1 0.511
Hes5 hairy and enhancer of split 5 (Drosophila) 0.505
Foxc2 forkhead box C2 0.495
Foxg1 forkhead box G1 0.489
Wnt3a wingless-related MMTV integration site 3A 0.474
Hoxb1 homeobox B1 0.471
Hif1a hypoxia inducible factor 1, alpha subunit 0.470
Otx1 orthodenticle homolog 1 (Drosophila) 0.466
Pax9 paired box gene 9 0.464
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.454
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.445
Zic3 zinc finger protein of the cerebellum 3 0.437
Ephb3 Eph receptor B3 0.432
Ephb2 Eph receptor B2 0.429
Foxh1 forkhead box H1 0.417
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.410
Dll4 delta-like 4 (Drosophila) 0.402
Gas1 growth arrest specific 1 0.400
Bmp2 bone morphogenetic protein 2 0.391
Gbx2 gastrulation brain homeobox 2 0.378
Tgfbr2 transforming growth factor, beta receptor II 0.376
Rarb retinoic acid receptor, beta 0.372
Wnt6 wingless-related MMTV integration site 6 0.365
Atoh7 atonal homolog 7 (Drosophila) 0.363
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.359
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.944
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.804
cdh2 cadherin 2, neuronal 0.763
shha sonic hedgehog a 0.707
dlc deltaC 0.653
sox10 SRY-box containing gene 10 0.642
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.623
bmp2b bone morphogenetic protein 2b 0.517
tgfb3 transforming growth factor, beta 3 0.443
dld deltaD 0.417
has2 hyaluronan synthase 2 0.410
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.388
wnt5b wingless-type MMTV integration site family, member 5b 0.346
fn1 fibronectin 1 0.344
dct dopachrome tautomerase 0.320
eya1 eyes absent homolog 1 0.319
lmo4a LIM domain only 4a 0.303
tgfbi transforming growth factor, beta-induced 0.289
fgf10a fibroblast growth factor 10a 0.274
alcama activated leukocyte cell adhesion molecule a 0.258
col1a2 collagen, type I, alpha 2 0.250
gli1 GLI-Kruppel family member 1 0.246
osr1 odd-skipped related 1 (Drosophila) 0.227
nrarpa notch-regulated ankyrin repeat protein a 0.227
rarga retinoic acid receptor gamma a 0.226
pax9 paired box gene 9 0.217
foxd3 forkhead box D3 0.217
bmp4 bone morphogenetic protein 4 0.212
msxc muscle segment homeobox C 0.191
mmp2 matrix metalloproteinase 2 0.182
igf1rb insulin-like growth factor 1b receptor 0.173
foxa3 forkhead box A3 0.160
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.157
lef1 lymphocyte enhancer binding factor 1 0.154
notch3 notch homolog 3 0.152
osr2 odd-skipped related 2 (Drosophila) 0.148
dlx2a distal-less homeobox gene 2a 0.141
hoxc8a homeo box C8a 0.136
tfap2a transcription factor AP-2 alpha 0.133
wnt11 wingless-type MMTV integration site family, member 11 0.132
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.125
her1 hairy-related 1 0.125
mitfa microphthalmia-associated transcription factor a 0.123
crabp2a cellular retinoic acid binding protein 2, a 0.121
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.118
gsc goosecoid 0.117
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.111
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.103
twist3 twist3 0.101
chd chordin 0.100
edn1 endothelin 1 0.099
robo3 roundabout homolog 3 0.098
lft2 lefty2 0.097
spry4 sprouty (Drosophila) homolog 4 0.095
gro1 groucho 1 0.086
gdf6a growth differentiation factor 6a 0.082
myl7 myosin, light polypeptide 7, regulatory 0.081
msxd muscle segment homeobox D 0.077
id3 inhibitor of DNA binding 3 0.076
dcn decorin 0.076
nkx2.5 NK2 transcription factor related 5 0.075
col5a2l collagen, type V, alpha 2-like 0.073
lhx5 LIM homeobox 5 0.072
spns2 spinster homolog 2 (Drosophila) 0.072
mib mind bomb 0.070
vcanb versican b 0.068
pcdh8 protocadherin 8 0.067
sox19a SRY-box containing gene 19a 0.067
fgf8a fibroblast growth factor 8 a 0.067
hapln1a hyaluronan and proteoglycan link protein 1a 0.067
col5a1 procollagen, type V, alpha 1 0.067
ripply1 ripply1 0.066
tbx18 T-box 18 0.066
wnt11r wingless-type MMTV integration site family, member 11, related 0.065
irx3a iroquois homeobox protein 3a 0.064
pkd2 polycystic kidney disease 2 0.064
lfng lunatic fringe homolog 0.063
ndr2 nodal-related 2 0.063
gli2a GLI-Kruppel family member GLI2a 0.062
rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.061
raraa retinoic acid receptor, alpha a 0.061
pdgfrl platelet-derived growth factor receptor-like 0.060
cxcr4a chemokine (C-X-C motif) receptor 4a 0.060
cdx4 caudal type homeo box transcription factor 4 0.059
tbx22 T-box 22 0.059
cdh1 cadherin 1, epithelial 0.059
vsx1 visual system homeobox 1 homolog, chx10-like 0.058
fzd10 frizzled homolog 10 0.058
rarab retinoic acid receptor, alpha b 0.058
shhb sonic hedgehog b 0.057
nkx3.2 NK3 homeobox 2 0.056
nog3 noggin 3 0.056
tbx6 T-box gene 6 0.056
lhx2b LIM homeobox 2b 0.054
fzd5 frizzled homolog 5 0.054
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.052
col1a1a collagen, type I, alpha 1a 0.052
sox3 SRY-box containing gene 3 0.051
tbx16 T-box gene 16 0.050
tgfb2 transforming growth factor, beta 2 0.049
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Egfr Epidermal growth factor receptor 0.026
baz bazooka 0.023
wg wingless 0.021
Mad Mothers against dpp 0.015
hh hedgehog 0.014
dsh dishevelled 0.014
stumps CG31317 gene product from transcript CG31317-RC 0.013
N Notch 0.013
bnl branchless 0.013
Cg25C Collagen type IV 0.012
ci cubitus interruptus 0.012
Axn Axin 0.012
tkv thickveins 0.012
ecd ecdysoneless 0.012
kibra kibra ortholog 0.011
ftz-f1 ftz transcription factor 1 0.011
shn schnurri 0.011
CG11347 CG11347 gene product from transcript CG11347-RE 0.011
pr-set7 CG3307 gene product from transcript CG3307-RC 0.011
pan pangolin 0.011
ash2 absent, small, or homeotic discs 2 0.011
CG9705 CG9705 gene product from transcript CG9705-RA 0.011
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.011
tll tailless 0.010
babo baboon 0.010
Rel Relish 0.010
wdb widerborst 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
SMAD3 SMAD family member 3 0.999
SMAD7 SMAD family member 7 0.987
SMAD2 SMAD family member 2 0.986
SMAD4 SMAD family member 4 0.986
SMAD1 SMAD family member 1 0.976
JAG1 jagged 1 0.948
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.931
NOTCH1 notch 1 0.915
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.898
COL1A1 collagen, type I, alpha 1 0.869
FHL2 four and a half LIM domains 2 0.861
AR androgen receptor 0.835
BMPR1A bone morphogenetic protein receptor, type IA 0.825
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.773
SKIL SKI-like oncogene 0.758
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.756
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.726
TP53 tumor protein p53 0.715
TGFB1 transforming growth factor, beta 1 0.693
FSTL1 follistatin-like 1 0.668
GSK3B glycogen synthase kinase 3 beta 0.623
TGFB3 transforming growth factor, beta 3 0.618
COL6A1 collagen, type VI, alpha 1 0.604
SMAD9 SMAD family member 9 0.536
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.527
FKBP1A FK506 binding protein 1A, 12kDa 0.526
AXIN1 axin 1 0.483
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.477
NCK2 NCK adaptor protein 2 0.463
YAP1 Yes-associated protein 1 0.450
BMP2 bone morphogenetic protein 2 0.449
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.425
TGFBR1 transforming growth factor, beta receptor 1 0.418
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.406
CREBBP CREB binding protein 0.386
CXXC5 CXXC finger protein 5 0.371
DDR2 discoidin domain receptor tyrosine kinase 2 0.367
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.322
EP300 E1A binding protein p300 0.315
FGF1 fibroblast growth factor 1 (acidic) 0.311
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.299
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.296
PTK2 PTK2 protein tyrosine kinase 2 0.288
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.287
BCAR1 breast cancer anti-estrogen resistance 1 0.286
COL4A1 collagen, type IV, alpha 1 0.282
SMAD6 SMAD family member 6 0.280
COL1A2 collagen, type I, alpha 2 0.278
TBX5 T-box 5 0.257
COL4A2 collagen, type IV, alpha 2 0.242
FN1 fibronectin 1 0.240
GATA4 GATA binding protein 4 0.236
SP1 Sp1 transcription factor 0.235
NOTCH3 notch 3 0.234
FZD1 frizzled homolog 1 (Drosophila) 0.221
HDAC1 histone deacetylase 1 0.218
SETD8 SET domain containing (lysine methyltransferase) 8 0.207
COL5A1 collagen, type V, alpha 1 0.207
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.205
SMN1 survival of motor neuron 1, telomeric 0.205
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.197
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.196
ENG endoglin 0.194
QKI quaking homolog, KH domain RNA binding (mouse) 0.191
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.179
POU5F1 POU class 5 homeobox 1 0.174
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.171
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.170
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.153
FOXF2 forkhead box F2 0.150
IMMT inner membrane protein, mitochondrial 0.143
FGF10 fibroblast growth factor 10 0.140
FGF3 fibroblast growth factor 3 0.134
MSX1 msh homeobox 1 0.133
RUNX1 runt-related transcription factor 1 0.130
PAX8 paired box 8 0.129
SIRT1 sirtuin 1 0.127
FOXA2 forkhead box A2 0.125
LOX lysyl oxidase 0.121
MAGEA2 melanoma antigen family A, 2 0.121
BGN biglycan 0.120
BMP7 bone morphogenetic protein 7 0.120
GATA2 GATA binding protein 2 0.116
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.113
WDYHV1 WDYHV motif containing 1 0.112
PML promyelocytic leukemia 0.102
LPXN leupaxin 0.099
FGF8 fibroblast growth factor 8 (androgen-induced) 0.099
CTNNBIP1 catenin, beta interacting protein 1 0.091
COL5A2 collagen, type V, alpha 2 0.088
HEY1 hairy/enhancer-of-split related with YRPW motif 1 0.088
WNT3A wingless-type MMTV integration site family, member 3A 0.087
POSTN periostin, osteoblast specific factor 0.086
FOXF1 forkhead box F1 0.085
HIPK2 homeodomain interacting protein kinase 2 0.085
PDX1 pancreatic and duodenal homeobox 1 0.084
SKI v-ski sarcoma viral oncogene homolog (avian) 0.083
HIC1 hypermethylated in cancer 1 0.082
SOX1 SRY (sex determining region Y)-box 1 0.082
WNT1 wingless-type MMTV integration site family, member 1 0.081
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism