The network for 'lens development in camera type eye' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lens development in camera type eye

The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.

Mus musculus
Name Description Probability Func Analog Organism
Ntf3 neurotrophin 3 0.996
Shh sonic hedgehog 0.986
Smad4 MAD homolog 4 (Drosophila) 0.983
Bmp4 bone morphogenetic protein 4 0.982
Pax6 paired box gene 6 0.981
Pax3 paired box gene 3 0.980
Smad3 MAD homolog 3 (Drosophila) 0.976
Pbx1 pre B-cell leukemia transcription factor 1 0.968
Nodal nodal 0.964
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.958
Gata4 GATA binding protein 4 0.954
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.954
Hand2 heart and neural crest derivatives expressed transcript 2 0.942
Isl1 ISL1 transcription factor, LIM/homeodomain 0.936
Otx2 orthodenticle homolog 2 (Drosophila) 0.925
Gli3 GLI-Kruppel family member GLI3 0.921
Bmpr1a bone morphogenetic protein receptor, type 1A 0.920
Tcfap2a transcription factor AP-2, alpha 0.900
Hoxd13 homeobox D13 0.887
Fgf8 fibroblast growth factor 8 0.861
Pitx2 paired-like homeodomain transcription factor 2 0.824
Smad1 MAD homolog 1 (Drosophila) 0.789
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.786
Foxf1a forkhead box F1a 0.781
Pou3f3 POU domain, class 3, transcription factor 3 0.775
Gata6 GATA binding protein 6 0.768
Eya1 eyes absent 1 homolog (Drosophila) 0.753
Foxh1 forkhead box H1 0.752
Epha2 Eph receptor A2 0.727
Gbx2 gastrulation brain homeobox 2 0.708
Grb2 growth factor receptor bound protein 2 0.705
Atoh7 atonal homolog 7 (Drosophila) 0.705
Hand1 heart and neural crest derivatives expressed transcript 1 0.704
Dok1 docking protein 1 0.694
Sox2 SRY-box containing gene 2 0.692
Apc adenomatosis polyposis coli 0.681
Tbx3 T-box 3 0.674
Pax2 paired box gene 2 0.668
Fgfr2 fibroblast growth factor receptor 2 0.649
Zic3 zinc finger protein of the cerebellum 3 0.647
Trp53 transformation related protein 53 0.645
Pten phosphatase and tensin homolog 0.639
Foxg1 forkhead box G1 0.627
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.600
Crygd crystallin, gamma D 0.593
Fst follistatin 0.576
Smad6 MAD homolog 6 (Drosophila) 0.562
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.562
Sox9 SRY-box containing gene 9 0.558
Sox4 SRY-box containing gene 4 0.548
Krt14 keratin 14 0.530
Hmx1 H6 homeobox 1 0.527
Tgfbr2 transforming growth factor, beta receptor II 0.517
Ret ret proto-oncogene 0.480
Lgals7 lectin, galactose binding, soluble 7 0.476
Shc1 src homology 2 domain-containing transforming protein C1 0.476
Fzd7 frizzled homolog 7 (Drosophila) 0.474
Jag1 jagged 1 0.470
Ptk7 PTK7 protein tyrosine kinase 7 0.469
Ephb2 Eph receptor B2 0.466
Cryaa crystallin, alpha A 0.464
Tgfb2 transforming growth factor, beta 2 0.454
Eng endoglin 0.450
Foxc1 forkhead box C1 0.448
Msx2 homeobox, msh-like 2 0.446
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.409
Acvr1 activin A receptor, type 1 0.400
Pou4f2 POU domain, class 4, transcription factor 2 0.395
Axin1 axin 1 0.390
Nf1 neurofibromatosis 1 0.389
Hes1 hairy and enhancer of split 1 (Drosophila) 0.381
Ptk2 PTK2 protein tyrosine kinase 2 0.376
Uncx UNC homeobox 0.360
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.359
Neurod1 neurogenic differentiation 1 0.353
Snai1 snail homolog 1 (Drosophila) 0.344
Prph2 peripherin 2 0.341
Hdac1 histone deacetylase 1 0.324
Gata3 GATA binding protein 3 0.324
Fgf3 fibroblast growth factor 3 0.321
Krt7 keratin 7 0.319
Prph peripherin 0.316
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.301
Myl7 myosin, light polypeptide 7, regulatory 0.297
Klf3 Kruppel-like factor 3 (basic) 0.296
Smad2 MAD homolog 2 (Drosophila) 0.296
Sox1 SRY-box containing gene 1 0.289
Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 0.283
Efna2 ephrin A2 0.282
Arid1a AT rich interactive domain 1A (SWI-like) 0.279
Hoxb4 homeobox B4 0.274
Inpp5d inositol polyphosphate-5-phosphatase D 0.273
Yap1 yes-associated protein 1 0.270
Krt8 keratin 8 0.269
Pitx3 paired-like homeodomain transcription factor 3 0.269
Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.268
Tcfap2b transcription factor AP-2 beta 0.266
Pkp1 plakophilin 1 0.263
Tbx2 T-box 2 0.263
Sox11 SRY-box containing gene 11 0.262
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
crygmxl2 crystallin, gamma MX, like 2 0.842
dlc deltaC 0.715
foxe3 forkhead box E3 0.610
cryba4 crystallin, beta A4 0.583
pax6b paired box gene 6b 0.552
foxa2 forkhead box A2 0.552
bmp2b bone morphogenetic protein 2b 0.473
dnmt4 DNA (cytosine-5-)-methyltransferase 4 0.432
mab21l2 mab-21-like 2 0.423
col4a5 collagen, type IV, alpha 5 (Alport syndrome) 0.400
crygm3 crystallin, gamma M3 0.393
pax6a paired box gene 6a 0.380
cdh2 cadherin 2, neuronal 0.378
crygm6 crystallin, gamma M6 0.314
pxn paxillin 0.303
crygm1 crystallin, gamma M1 0.300
otx1b orthodenticle homolog 1b 0.294
scinla scinderin like a 0.279
ascl1a achaete-scute complex-like 1a (Drosophila) 0.274
crygm2f crystallin, gamma M2f 0.258
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.255
mdka midkine-related growth factor 0.253
fsta follistatin a 0.250
myod1 myogenic differentiation 1 0.234
shha sonic hedgehog a 0.212
tp63 tumor protein p63 0.211
notch1a notch homolog 1a 0.204
rx2 retinal homeobox gene 2 0.195
crygn1 crystallin, gamma N1 0.193
fgfr2 fibroblast growth factor receptor 2 0.191
gdf6a growth differentiation factor 6a 0.184
crygm2d11 crystallin, gamma M2d11 0.184
emx3 empty spiracles homeobox 3 0.183
rx1 retinal homeobox gene 1 0.182
pea3 ETS-domain transcription factor pea3 0.180
lamb1a laminin, beta 1a 0.173
unc5b unc-5 homolog B (C. elegans) 0.172
cryaa crystallin, alpha A 0.163
six2a sine oculis-related homeobox 2a 0.159
pitx2 paired-like homeodomain transcription factor 2 0.158
crygm2d2 crystallin, gamma M2d2 0.151
otx2 orthodenticle homolog 2 0.141
her6 hairy-related 6 0.137
sox2 SRY-box containing gene 2 0.136
dnmt6 DNA (cytosine-5-)-methyltransferase 6 0.135
crygm2a crystallin, gamma M2a 0.125
lama2 laminin, alpha 2 0.123
cryba2a crystallin, beta A2a 0.122
foxi3b forkhead box I3b 0.122
crygm4 crystallin, gamma M4 0.121
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.120
crygmx crystallin, gamma MX 0.115
foxi1 forkhead box I1 0.113
boc brother of CDO 0.112
vsx2 visual system homeobox 2 0.109
neurog1 neurogenin 1 0.108
fgfr4 fibroblast growth factor receptor 4 0.106
crygm2b crystallin, gamma M2b 0.106
cryaba crystallin, alpha B, a 0.103
jag1b jagged 1b 0.103
aqp10b aquaporin 10b 0.103
zgc:171792 zgc:171792 0.101
crygm7 crystallin, gamma M7 0.101
crygs1 crystallin, gamma S1 0.096
crygm2d8 crystallin, gamma M2d8 0.096
crestin crestin 0.093
mipb major intrinsic protein of lens fiber b 0.092
cx55.5 connexin 55.5 0.089
lama5 laminin, alpha 5 0.088
crygm2d10 crystallin, gamma M2d10 0.088
crabp2a cellular retinoic acid binding protein 2, a 0.088
extl3 exostoses (multiple)-like 3 0.086
notch3 notch homolog 3 0.085
edn1 endothelin 1 0.083
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.083
crygm2d16 crystallin, gamma M2d16 0.082
gata2a GATA-binding protein 2a 0.080
crygm2d7 crystallin, gamma M2d7 0.079
sema3aa semaphorin 3aa 0.077
irx1b iroquois homeobox protein 1, b 0.077
disp1 dispatched homolog 1 (Drosophila) 0.077
crygmxl1 crystallin, gamma MX, like 1 0.076
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.075
crygn2 crystallin, gamma N2 0.074
crygm2d15 crystallin, gamma M2d15 0.073
fgf3 fibroblast growth factor 3 0.071
grifin galectin related inter-fiber protein 0.070
nr2f5 nuclear receptor subfamily 2, group F, member 5 0.070
msxd muscle segment homeobox D 0.066
coe2 coe2 0.065
nr2f6b nuclear receptor subfamily 2, group F, member 6b 0.064
ebf3 early B-cell factor 3 0.064
fgfrl1a fibroblast growth factor receptor-like 1a 0.063
cryba2b crystallin, beta A2b 0.063
fgfr3 fibroblast growth factor receptor 3 0.060
dnmt8 DNA (cytosine-5-)-methyltransferase 8 0.059
atp1a1a.2 ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide 0.059
fn1 fibronectin 1 0.059
pitx3 paired-like homeodomain transcription factor 3 0.058
emx2 empty spiracles homeobox 2 0.057
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SP1 Sp1 transcription factor 0.984
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.976
SMAD2 SMAD family member 2 0.967
ENG endoglin 0.948
SMAD4 SMAD family member 4 0.936
SMAD3 SMAD family member 3 0.927
FGF1 fibroblast growth factor 1 (acidic) 0.867
EP300 E1A binding protein p300 0.790
FN1 fibronectin 1 0.759
TJP1 tight junction protein 1 (zona occludens 1) 0.738
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.674
PBX1 pre-B-cell leukemia homeobox 1 0.666
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.484
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.465
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.452
HNF4A hepatocyte nuclear factor 4, alpha 0.403
TGFB1 transforming growth factor, beta 1 0.402
CAV1 caveolin 1, caveolae protein, 22kDa 0.396
RB1 retinoblastoma 1 0.390
SCHIP1 schwannomin interacting protein 1 0.384
SKIL SKI-like oncogene 0.383
TGFBR1 transforming growth factor, beta receptor 1 0.380
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.375
FGFR1 fibroblast growth factor receptor 1 0.347
BCL9 B-cell CLL/lymphoma 9 0.337
YY1 YY1 transcription factor 0.334
CRYBB2 crystallin, beta B2 0.326
FSTL1 follistatin-like 1 0.325
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.315
TP53 tumor protein p53 0.303
EFNA1 ephrin-A1 0.273
HIPK2 homeodomain interacting protein kinase 2 0.248
TACC1 transforming, acidic coiled-coil containing protein 1 0.246
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.246
HDAC1 histone deacetylase 1 0.243
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.236
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.235
CLSPN claspin 0.227
TGFB3 transforming growth factor, beta 3 0.221
BTRC beta-transducin repeat containing 0.208
PVRL4 poliovirus receptor-related 4 0.208
ZFYVE9 zinc finger, FYVE domain containing 9 0.191
HCFC1 host cell factor C1 (VP16-accessory protein) 0.184
CTGF connective tissue growth factor 0.183
FGF10 fibroblast growth factor 10 0.182
HTT huntingtin 0.176
SREBF2 sterol regulatory element binding transcription factor 2 0.155
PVRL3 poliovirus receptor-related 3 0.154
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.151
SKI v-ski sarcoma viral oncogene homolog (avian) 0.149
PXN paxillin 0.144
NCOR1 nuclear receptor corepressor 1 0.138
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.133
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.128
SIRT2 sirtuin 2 0.123
MEIS2 Meis homeobox 2 0.123
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.120
DAXX death-domain associated protein 0.120
GAB1 GRB2-associated binding protein 1 0.118
CREBBP CREB binding protein 0.118
RUNX1 runt-related transcription factor 1 0.117
SMAD7 SMAD family member 7 0.114
MAK male germ cell-associated kinase 0.111
FLNA filamin A, alpha 0.106
RAD23A RAD23 homolog A (S. cerevisiae) 0.100
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.099
CREB1 cAMP responsive element binding protein 1 0.096
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.093
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.088
NRP1 neuropilin 1 0.086
EPAS1 endothelial PAS domain protein 1 0.086
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.084
BCR breakpoint cluster region 0.083
FKBP1A FK506 binding protein 1A, 12kDa 0.083
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.083
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.082
FBLN1 fibulin 1 0.076
PML promyelocytic leukemia 0.076
TRIM28 tripartite motif containing 28 0.074
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.074
NFYA nuclear transcription factor Y, alpha 0.074
SOX2 SRY (sex determining region Y)-box 2 0.071
CRYBB3 crystallin, beta B3 0.070
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.069
KRT8 keratin 8 0.069
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.067
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.066
SMAD1 SMAD family member 1 0.066
MAFB v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) 0.066
THBS1 thrombospondin 1 0.065
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.063
SALL2 sal-like 2 (Drosophila) 0.062
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.062
STK4 serine/threonine kinase 4 0.061
CSNK1D casein kinase 1, delta 0.061
FYN FYN oncogene related to SRC, FGR, YES 0.060
KCTD1 potassium channel tetramerisation domain containing 1 0.060
CDK6 cyclin-dependent kinase 6 0.058
POGZ pogo transposable element with ZNF domain 0.058
FGF7 fibroblast growth factor 7 0.056
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Rattus norvegicus
Name Description Probability Func Analog Organism
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.857
Tgfbr2 transforming growth factor, beta receptor II 0.175
Cast calpastatin 0.173
Crygc crystallin, gamma C 0.154
Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 0.139
Adam10 ADAM metallopeptidase domain 10 0.132
Crygb crystallin, gamma B 0.113
Cryba1 crystallin, beta A1 0.108
Lep leptin 0.107
Ptprc protein tyrosine phosphatase, receptor type, C 0.101
Anxa1 annexin A1 0.095
Mip major intrinsic protein of lens fiber 0.094
Lim2 lens intrinsic membrane protein 2 0.090
Crybb3 crystallin, beta B3 0.085
Tubb5 tubulin, beta 5 0.081
Anxa2 annexin A2 0.078
Foxe3 forkhead box E3 0.073
Bmpr1a bone morphogenetic protein receptor, type IA 0.070
Cdk2 cyclin dependent kinase 2 0.069
Mep1a meprin 1 alpha 0.067
Pax4 paired box 4 0.066
Psen1 presenilin 1 0.066
Gpr182 G protein-coupled receptor 182 0.064
Trim28 tripartite motif-containing 28 0.063
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.062
Id3 inhibitor of DNA binding 3 0.060
Bgn biglycan 0.059
Vipr1 vasoactive intestinal peptide receptor 1 0.058
Sp1 Sp1 transcription factor 0.056
Jund jun D proto-oncogene 0.053
Top2b topoisomerase (DNA) II beta 0.053
Lbr lamin B receptor 0.053
Olr1701 olfactory receptor 1701 0.052
Vim vimentin 0.052
Aanat arylalkylamine N-acetyltransferase 0.051
B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.050
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.049
Kcna5 potassium voltage-gated channel, shaker-related subfamily, member 5 0.049
Mef2d myocyte enhancer factor 2D 0.047
Dynlt1 dynein light chain Tctex-type 1 0.047
Acr acrosin 0.043
Crybb1 crystallin, beta B1 0.043
Accn3 amiloride-sensitive cation channel 3 0.043
Adam17 ADAM metallopeptidase domain 17 0.040
Lox lysyl oxidase 0.039
Vcan versican 0.039
Akr1c14 aldo-keto reductase family 1, member C14 0.038
Mpeg1 macrophage expressed 1 0.038
Arpc1b actin related protein 2/3 complex, subunit 1B 0.038
Jak1 Janus kinase 1 0.038
Msn moesin 0.038
Olr1469 olfactory receptor Olr1469 0.037
Hist1h1a histone cluster 1, H1a 0.037
Myh9 myosin, heavy chain 9, non-muscle 0.037
Zfx zinc finger protein X-linked 0.036
Myo1b myosin Ib 0.036
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.036
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.036
Nat1 N-acetyltransferase 1 0.035
Col9a1 collagen, type IX, alpha 1 0.035
Cp ceruloplasmin 0.034
Ucn urocortin 0.033
Aebp1 AE binding protein 1 0.033
Pdgfb platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.033
Cald1 caldesmon 1 0.033
Gabrr1 gamma-aminobutyric acid (GABA) receptor, rho 1 0.033
Atxn1 ataxin 1 0.031
Ubtf upstream binding transcription factor, RNA polymerase I 0.030
Tcfe2a transcription factor E2a 0.030
Myh13 myosin, heavy chain 13, skeletal muscle 0.029
Foxd3 forkhead box D3 0.029
Slc6a11 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 0.029
Tcf12 transcription factor 12 0.028
Anxa5 annexin A5 0.028
Enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 0.026
Hist1h1d histone cluster 1, H1d 0.026
Ahr aryl hydrocarbon receptor 0.026
Dab2 disabled homolog 2 (Drosophila) 0.026
Tlr4 toll-like receptor 4 0.026
Prdm2 PR domain containing 2, with ZNF domain 0.026
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.025
Rest RE1-silencing transcription factor 0.025
Pax8 paired box 8 0.025
A3galt2 alpha 1,3-galactosyltransferase 2 0.024
Srd5a2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 0.024
RGD1308958 similar to chromosome 9 open reading frame 5 0.024
Stat5b signal transducer and activator of transcription 5B 0.023
Lhx9 LIM homeobox 9 0.023
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.023
Homer3 homer homolog 3 (Drosophila) 0.023
Cdc23 CDC23 (cell division cycle 23, yeast, homolog) 0.022
Ush1c Usher syndrome 1C homolog (human) 0.022
Grifin galectin-related inter-fiber protein 0.022
Adrb1 adrenergic, beta-1-, receptor 0.022
Hmgb2 high mobility group box 2 0.021
Bmp15 bone morphogenetic protein 15 0.021
Chd4 chromodomain helicase DNA binding protein 4 0.021
Timp1 TIMP metallopeptidase inhibitor 1 0.021
Cel carboxyl ester lipase 0.020
Prim2 primase, DNA, polypeptide 2 0.020
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism