The network for 'proteoglycan biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

proteoglycan biosynthetic process

The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.

Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 0.903
Ins1 insulin I 0.642
Adam17 a disintegrin and metallopeptidase domain 17 0.521
Egfr epidermal growth factor receptor 0.504
Smad4 MAD homolog 4 (Drosophila) 0.356
Npc1 Niemann Pick type C1 0.350
Ghr growth hormone receptor 0.303
Fgfr1 fibroblast growth factor receptor 1 0.280
Igf1r insulin-like growth factor I receptor 0.274
Bmpr1a bone morphogenetic protein receptor, type 1A 0.254
Grb10 growth factor receptor bound protein 10 0.228
Ins2 insulin II 0.226
Twsg1 twisted gastrulation homolog 1 (Drosophila) 0.222
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.221
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.213
Ahr aryl-hydrocarbon receptor 0.200
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.194
Foxc1 forkhead box C1 0.189
Apc adenomatosis polyposis coli 0.188
Pgr progesterone receptor 0.186
Sox9 SRY-box containing gene 9 0.171
Kit kit oncogene 0.146
Pitx2 paired-like homeodomain transcription factor 2 0.143
Cabp7 calcium binding protein 7 0.140
Rps6kl1 ribosomal protein S6 kinase-like 1 0.140
Chst2 carbohydrate sulfotransferase 2 0.138
Col11a1 collagen, type XI, alpha 1 0.133
Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) 0.130
Foxf2 forkhead box F2 0.118
Lepr leptin receptor 0.112
Ctnna1 catenin (cadherin associated protein), alpha 1 0.110
Tgfbr2 transforming growth factor, beta receptor II 0.089
Rarb retinoic acid receptor, beta 0.088
Foxo3 forkhead box O3 0.082
Ikbip IKBKB interacting protein 0.082
Twist2 twist homolog 2 (Drosophila) 0.081
Numb numb gene homolog (Drosophila) 0.080
Trp53 transformation related protein 53 0.079
Ccdc24 coiled-coil domain containing 24 0.075
Meox2 mesenchyme homeobox 2 0.073
Fgfr2 fibroblast growth factor receptor 2 0.072
Cav1 caveolin 1, caveolae protein 0.066
Cdx2 caudal type homeobox 2 0.065
Glp1r glucagon-like peptide 1 receptor 0.065
Apaf1 apoptotic peptidase activating factor 1 0.064
Bmp4 bone morphogenetic protein 4 0.061
Itgav integrin alpha V 0.061
Tyro3 TYRO3 protein tyrosine kinase 3 0.059
Hif1a hypoxia inducible factor 1, alpha subunit 0.059
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.057
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.055
Cdk14 cyclin-dependent kinase 14 0.054
Nckap5l NCK-associated protein 5-like 0.054
Cldn11 claudin 11 0.052
B4galt2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 0.051
Rdh10 retinol dehydrogenase 10 (all-trans) 0.051
Akt1 thymoma viral proto-oncogene 1 0.050
Kif3a kinesin family member 3A 0.050
Xylt2 xylosyltransferase II 0.049
Gna11 guanine nucleotide binding protein, alpha 11 0.049
Ptk2 PTK2 protein tyrosine kinase 2 0.049
Foxf1a forkhead box F1a 0.047
Kcnk12 potassium channel, subfamily K, member 12 0.047
Tmem132e transmembrane protein 132E 0.047
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.047
Cbfb core binding factor beta 0.046
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.045
Adra1b adrenergic receptor, alpha 1b 0.044
Numbl numb-like 0.044
Shroom1 shroom family member 1 0.044
Psen1 presenilin 1 0.043
Abca3 ATP-binding cassette, sub-family A (ABC1), member 3 0.043
Dgcr2 DiGeorge syndrome critical region gene 2 0.041
Colec12 collectin sub-family member 12 0.040
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.040
Crlf1 cytokine receptor-like factor 1 0.040
Kl klotho 0.039
Tgfbr1 transforming growth factor, beta receptor I 0.039
Ext1 exostoses (multiple) 1 0.038
Col2a1 collagen, type II, alpha 1 0.038
Gjc3 gap junction protein, gamma 3 0.038
Tcf7l2 transcription factor 7-like 2, T-cell specific, HMG-box 0.037
Col1a1 collagen, type I, alpha 1 0.037
Epha4 Eph receptor A4 0.037
Fgfr4 fibroblast growth factor receptor 4 0.036
Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 0.036
Esr1 estrogen receptor 1 (alpha) 0.036
Rpusd1 RNA pseudouridylate synthase domain containing 1 0.034
Kitl kit ligand 0.034
Abca2 ATP-binding cassette, sub-family A (ABC1), member 2 0.034
Fgf18 fibroblast growth factor 18 0.034
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.034
Edil3 EGF-like repeats and discoidin I-like domains 3 0.033
Fubp3 far upstream element (FUSE) binding protein 3 0.033
Olig2 oligodendrocyte transcription factor 2 0.033
Tmem121 transmembrane protein 121 0.033
Nrk Nik related kinase 0.033
Matn4 matrilin 4 0.032
Ptf1a pancreas specific transcription factor, 1a 0.032
Adam18 a disintegrin and metallopeptidase domain 18 0.032
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
smo smoothened homolog (Drosophila) 0.942
sec24d SEC24 family, member D (S. cerevisiae) 0.857
extl3 exostoses (multiple)-like 3 0.736
zgc:158603 zgc:158603 0.700
uxs1 UDP-glucuronic acid decarboxylase 1 0.662
xylt1 xylosyltransferase 1 0.606
plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.411
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.319
hs6st1b heparan sulfate 6-O-sulfotransferase 1b 0.245
hs6st1a heparan sulfate 6-O-sulfotransferase 1a 0.214
hs6st3 heparan sulfate 6-O-sulfotransferase 3 0.209
ext2 exostoses (multiple) 2 0.204
hs6st2 heparan sulfate 6-O-sulfotransferase 2 0.202
ihha Indian hedgehog homolog a 0.189
fam20b family with sequence similarity 20, member B (H. sapiens) 0.159
csnk1a1 casein kinase 1, alpha 1 0.145
bmp1a bone morphogenetic protein 1a 0.139
slc35b2 solute carrier family 35, member B2 0.118
wu:fj34h01 wu:fj34h01 0.103
sox9a SRY-box containing gene 9a 0.080
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.064
furina furin (paired basic amino acid cleaving enzyme) a 0.061
disp1 dispatched homolog 1 (Drosophila) 0.051
b3gat3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) and beta3-glucuronyltransferase 0.043
atp7a ATPase, Cu++ transporting, alpha polypeptide 0.039
tjp1 tight junction protein 1 (zona occludens 1) 0.035
sufu suppressor of fused homolog (Drosophila) 0.030
gle1 GLE1 RNA export mediator homolog (yeast) 0.030
grifin galectin related inter-fiber protein 0.029
lhx2b LIM homeobox 2b 0.028
ephb4b eph receptor B4b 0.026
nkd1 naked cuticle homolog 1 (Drosophila) 0.024
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.023
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.022
hs2st1a heparan sulfate 2-O-sulfotransferase 1a 0.022
chd7 chromodomain helicase DNA binding protein 7 0.020
sec23a Sec23 homolog A (S. cerevisiae) 0.019
smad3b MAD, mothers against decapentaplegic homolog 3b (Drosophila) 0.018
efnb3b ephrin B3b 0.018
spry2 sprouty homolog 2 0.018
ptpra protein tyrosine phosphatase, receptor type, A 0.017
prdm5 PR domain containing 5 0.015
brpf1 bromodomain and PHD finger containing, 1 0.015
tfe3b transcription factor binding to IGHM enhancer 3b 0.015
enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.013
rpz rapunzel 0.013
wnt3a wingless-type MMTV integration site family, member 3A 0.012
usp9 ubiquitin specific peptidase 9 0.011
pigu phosphatidylinositol glycan anchor biosynthesis, class U 0.011
LOC100334210 growth/differentiation factor 5-like 0.011
fzd5 frizzled homolog 5 0.011
odz4 odd Oz/ten-m homolog 4 0.011
prickle2 prickle-like 2 (Drosophila) 0.010
acvr1b activin A receptor, type IB 0.010
scospondin subcommissural organ spondin 0.010
vasp vasodilator-stimulated phosphoprotein 0.010
si:dkeyp-117b8.1 si:dkeyp-117b8.1 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Ext2 CG8433 gene product from transcript CG8433-RA 0.882
rasp CG11495 gene product from transcript CG11495-RA 0.660
sfl sulfateless 0.645
botv brother of tout-velu 0.557
sgl sugarless 0.539
CG14837 CG14837 gene product from transcript CG14837-RC 0.403
por porcupine 0.362
sll slalom 0.285
smo smoothened 0.216
CG3194 CG3194 gene product from transcript CG3194-RB 0.187
ci cubitus interruptus 0.179
cg combgap 0.164
Bre1 CG10542 gene product from transcript CG10542-RA 0.150
Pgant35A Polypeptide N-acetylgalactosaminyltransferase 35A 0.134
ttv tout-velu 0.087
heix heixuedian 0.080
CG14506 CG14506 gene product from transcript CG14506-RA 0.078
Jon99Ci Jonah 99Ci 0.068
LvpH Larval visceral protein H 0.066
rumi CG31152 gene product from transcript CG31152-RA 0.060
CG13160 CG13160 gene product from transcript CG13160-RA 0.058
CG6283 CG6283 gene product from transcript CG6283-RA 0.057
Dok Downstream of kinase 0.055
Jon65Aiv Jonah 65Aiv 0.055
CG6277 CG6277 gene product from transcript CG6277-RA 0.054
CG18180 CG18180 gene product from transcript CG18180-RA 0.054
EloA Elongin A 0.046
DmsR-2 Dromyosuppressin receptor 2 0.043
CG12883 CG12883 gene product from transcript CG12883-RA 0.041
CG12746 CG12746 gene product from transcript CG12746-RD 0.039
amx almondex 0.038
ric8a CG15797 gene product from transcript CG15797-RA 0.038
LysB Lysozyme B 0.037
CG6295 CG6295 gene product from transcript CG6295-RA 0.036
CG9053 CG9053 gene product from transcript CG9053-RA 0.035
arr arrow 0.035
Mo25 CG4083 gene product from transcript CG4083-RA 0.032
Cyp4d21 CG6730 gene product from transcript CG6730-RA 0.030
vari varicose 0.029
mib1 mind bomb 1 0.029
CG7916 CG7916 gene product from transcript CG7916-RA 0.026
CG10222 CG10222 gene product from transcript CG10222-RA 0.025
CG10555 CG10555 gene product from transcript CG10555-RA 0.025
Hs6st Heparan sulfate 6-O-sulfotransferase 0.025
CG1887 CG1887 gene product from transcript CG1887-RD 0.023
Sp1 CG1343 gene product from transcript CG1343-RB 0.023
Vhl von Hippel-Lindau 0.023
CG10444 CG10444 gene product from transcript CG10444-RA 0.022
CG17189 CG17189 gene product from transcript CG17189-RA 0.022
CG12483 CG12483 gene product from transcript CG12483-RA 0.022
ash2 absent, small, or homeotic discs 2 0.021
yellow-f2 CG8063 gene product from transcript CG8063-RA 0.021
Papss PAPS synthetase 0.020
CG10361 CG10361 gene product from transcript CG10361-RA 0.020
CG12374 CG12374 gene product from transcript CG12374-RA 0.020
CG15549 CG15549 gene product from transcript CG15549-RA 0.020
CG18745 CG18745 gene product from transcript CG18745-RA 0.020
CG2837 CG2837 gene product from transcript CG2837-RB 0.020
Kul Kuzbanian-like 0.019
CG4293 CG4293 gene product from transcript CG4293-RD 0.019
CG8176 CG8176 gene product from transcript CG8176-RD 0.019
CG18616 CG18616 gene product from transcript CG18616-RA 0.018
CG6996 CG6996 gene product from transcript CG6996-RB 0.017
Pxd Peroxidase 0.017
disp dispatched 0.017
Spn77Bb Serpin 77Bb 0.017
ImpE1 Ecdysone-inducible gene E1 0.016
CG9672 CG9672 gene product from transcript CG9672-RA 0.015
sinu sinuous 0.015
CG1105 CG1105 gene product from transcript CG1105-RA 0.014
HLH106 Helix loop helix protein 106 0.014
CG11103 CG11103 gene product from transcript CG11103-RB 0.014
otk off-track 0.014
CG5945 CG5945 gene product from transcript CG5945-RA 0.014
CG8690 CG8690 gene product from transcript CG8690-RA 0.014
CG3631 CG3631 gene product from transcript CG3631-RD 0.014
Pp2B-14D Protein phosphatase 2B at 14D 0.013
CG15650 CG15650 gene product from transcript CG15650-RA 0.013
Cyp18a1 Cytochrome P450-18a1 0.013
alpha-Est10 alpha-Esterase-10 0.012
CG14196 CG14196 gene product from transcript CG14196-RA 0.012
CG7213 CG7213 gene product from transcript CG7213-RA 0.012
CG31559 CG31559 gene product from transcript CG31559-RA 0.012
CG11029 CG11029 gene product from transcript CG11029-RA 0.012
Jon25Bi Jonah 25Bi 0.011
CG6462 CG6462 gene product from transcript CG6462-RA 0.011
Cyp4d20 CG16761 gene product from transcript CG16761-RA 0.011
CG14820 CG14820 gene product from transcript CG14820-RA 0.011
CG11127 CG11127 gene product from transcript CG11127-RA 0.011
CG14119 CG14119 gene product from transcript CG14119-RA 0.011
CG11816 CG11816 gene product from transcript CG11816-RA 0.011
CG18135 CG18135 gene product from transcript CG18135-RC 0.010
l(2)01810 lethal (2) 01810 0.010
CG15555 CG15555 gene product from transcript CG15555-RA 0.010
CG11391 CG11391 gene product from transcript CG11391-RA 0.010
CG14470 CG14470 gene product from transcript CG14470-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.962
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.717
CTNNBIP1 catenin, beta interacting protein 1 0.635
APC adenomatous polyposis coli 0.471
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.300
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.297
TCF4 transcription factor 4 0.239
GLIS2 GLIS family zinc finger 2 0.205
CTNND1 catenin (cadherin-associated protein), delta 1 0.140
PSEN1 presenilin 1 0.120
ITGB1BP3 integrin beta 1 binding protein 3 0.108
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.060
BTRC beta-transducin repeat containing 0.056
PKP4 plakophilin 4 0.042
CNTF ciliary neurotrophic factor 0.035
AR androgen receptor 0.034
FAF1 Fas (TNFRSF6) associated factor 1 0.033
GSK3B glycogen synthase kinase 3 beta 0.030
AXIN1 axin 1 0.030
HIC1 hypermethylated in cancer 1 0.028
EMD emerin 0.027
ERBB2IP erbb2 interacting protein 0.026
JUP junction plakoglobin 0.024
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.022
WDYHV1 WDYHV motif containing 1 0.022
ACSL4 acyl-CoA synthetase long-chain family member 4 0.019
TNIK TRAF2 and NCK interacting kinase 0.018
VCAN versican 0.018
KLF10 Kruppel-like factor 10 0.018
NCOA2 nuclear receptor coactivator 2 0.018
DSP desmoplakin 0.017
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.016
HYOU1 hypoxia up-regulated 1 0.016
FNDC3B fibronectin type III domain containing 3B 0.016
PTK7 PTK7 protein tyrosine kinase 7 0.014
LEF1 lymphoid enhancer-binding factor 1 0.014
BMP1 bone morphogenetic protein 1 0.014
RUNX3 runt-related transcription factor 3 0.014
MFSD5 major facilitator superfamily domain containing 5 0.013
CDH5 cadherin 5, type 2 (vascular endothelium) 0.013
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.013
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.013
CREBBP CREB binding protein 0.012
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 0.012
PFDN1 prefoldin subunit 1 0.010
HSPA13 heat shock protein 70kDa family, member 13 0.010
FGFR1 fibroblast growth factor receptor 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism