The network for 'respiratory tube development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

respiratory tube development

The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Pten phosphatase and tensin homolog 1.000
Gli2 GLI-Kruppel family member GLI2 0.997
Fgf8 fibroblast growth factor 8 0.996
Jag1 jagged 1 0.991
Vangl2 vang-like 2 (van gogh, Drosophila) 0.989
Rarg retinoic acid receptor, gamma 0.985
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.984
Tcf21 transcription factor 21 0.984
Bmp4 bone morphogenetic protein 4 0.982
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.980
Pitx2 paired-like homeodomain transcription factor 2 0.976
Pthlh parathyroid hormone-like peptide 0.976
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.972
Tbx3 T-box 3 0.971
Nkx2-1 NK2 homeobox 1 0.970
Nodal nodal 0.967
Fgfr2 fibroblast growth factor receptor 2 0.967
Foxa2 forkhead box A2 0.966
Meox2 mesenchyme homeobox 2 0.961
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.953
Gli3 GLI-Kruppel family member GLI3 0.947
Fgfr1 fibroblast growth factor receptor 1 0.947
Fgfr3 fibroblast growth factor receptor 3 0.938
Sox2 SRY-box containing gene 2 0.937
Nfib nuclear factor I/B 0.933
Pax2 paired box gene 2 0.928
Tgfb2 transforming growth factor, beta 2 0.919
Col1a1 collagen, type I, alpha 1 0.917
Sall4 sal-like 4 (Drosophila) 0.911
Hand2 heart and neural crest derivatives expressed transcript 2 0.904
Smad4 MAD homolog 4 (Drosophila) 0.902
Hoxa5 homeobox A5 0.900
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.897
Pax3 paired box gene 3 0.896
Tgfbr2 transforming growth factor, beta receptor II 0.890
Fgf10 fibroblast growth factor 10 0.882
Wt1 Wilms tumor 1 homolog 0.879
Acvr1 activin A receptor, type 1 0.879
Smad6 MAD homolog 6 (Drosophila) 0.874
Gata6 GATA binding protein 6 0.858
Apoe apolipoprotein E 0.838
Hand1 heart and neural crest derivatives expressed transcript 1 0.830
Gdf1 growth differentiation factor 1 0.825
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.824
Lhx1 LIM homeobox protein 1 0.817
Foxc1 forkhead box C1 0.815
Tbx1 T-box 1 0.812
Flt4 FMS-like tyrosine kinase 4 0.810
Nos3 nitric oxide synthase 3, endothelial cell 0.802
Fbn1 fibrillin 1 0.801
Emx1 empty spiracles homolog 1 (Drosophila) 0.800
Tbx2 T-box 2 0.798
Fstl1 follistatin-like 1 0.797
Vegfa vascular endothelial growth factor A 0.797
Pbx1 pre B-cell leukemia transcription factor 1 0.789
Smad3 MAD homolog 3 (Drosophila) 0.788
Tgfbr1 transforming growth factor, beta receptor I 0.783
Gata3 GATA binding protein 3 0.777
Prrx1 paired related homeobox 1 0.773
Foxc2 forkhead box C2 0.770
Hoxa13 homeobox A13 0.762
Nog noggin 0.736
Pou5f1 POU domain, class 5, transcription factor 1 0.735
Eln elastin 0.728
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.721
Bnc1 basonuclin 1 0.721
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.720
Lox lysyl oxidase 0.708
Notch1 Notch gene homolog 1 (Drosophila) 0.707
Pax8 paired box gene 8 0.703
Zeb1 zinc finger E-box binding homeobox 1 0.698
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.697
Myod1 myogenic differentiation 1 0.695
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.695
Hif1a hypoxia inducible factor 1, alpha subunit 0.691
Wnt11 wingless-related MMTV integration site 11 0.689
Ctgf connective tissue growth factor 0.675
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.672
Tlx2 T-cell leukemia, homeobox 2 0.669
Mapk8 mitogen-activated protein kinase 8 0.668
Wnt6 wingless-related MMTV integration site 6 0.660
Eya1 eyes absent 1 homolog (Drosophila) 0.659
Otx2 orthodenticle homolog 2 (Drosophila) 0.654
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.652
Efnb1 ephrin B1 0.649
Fzd8 frizzled homolog 8 (Drosophila) 0.645
Wnt3a wingless-related MMTV integration site 3A 0.642
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.627
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.626
Foxp1 forkhead box P1 0.616
Prrx2 paired related homeobox 2 0.614
Gata4 GATA binding protein 4 0.609
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.605
Foxh1 forkhead box H1 0.599
Nf1 neurofibromatosis 1 0.595
Lmx1a LIM homeobox transcription factor 1 alpha 0.589
Sox9 SRY-box containing gene 9 0.584
Pkd1 polycystic kidney disease 1 homolog 0.582
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.581
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 0.995
FGF1 fibroblast growth factor 1 (acidic) 0.946
FHL2 four and a half LIM domains 2 0.869
NRP1 neuropilin 1 0.741
SMAD3 SMAD family member 3 0.632
JAG1 jagged 1 0.446
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.444
COL1A1 collagen, type I, alpha 1 0.413
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.346
BMP2 bone morphogenetic protein 2 0.344
NCOR2 nuclear receptor corepressor 2 0.296
ENG endoglin 0.226
CREBBP CREB binding protein 0.225
FLNA filamin A, alpha 0.185
CYR61 cysteine-rich, angiogenic inducer, 61 0.170
NCOA6 nuclear receptor coactivator 6 0.168
FGFR1 fibroblast growth factor receptor 1 0.152
ESR1 estrogen receptor 1 0.150
SRSF4 serine/arginine-rich splicing factor 4 0.146
BMPR1A bone morphogenetic protein receptor, type IA 0.145
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.144
NCOA2 nuclear receptor coactivator 2 0.144
GH1 growth hormone 1 0.142
SORBS3 sorbin and SH3 domain containing 3 0.122
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.113
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.113
SMAD2 SMAD family member 2 0.107
FGF10 fibroblast growth factor 10 0.091
HNF4A hepatocyte nuclear factor 4, alpha 0.090
PDZD11 PDZ domain containing 11 0.089
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.084
STK3 serine/threonine kinase 3 0.083
RPTOR regulatory associated protein of MTOR, complex 1 0.080
GH2 growth hormone 2 0.072
KAT2B K(lysine) acetyltransferase 2B 0.071
POLA2 polymerase (DNA directed), alpha 2 (70kD subunit) 0.065
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.064
TTR transthyretin 0.064
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.063
NCOA1 nuclear receptor coactivator 1 0.063
TGFB1 transforming growth factor, beta 1 0.062
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.059
FSTL1 follistatin-like 1 0.058
RARA retinoic acid receptor, alpha 0.058
BMP4 bone morphogenetic protein 4 0.056
SPEN spen homolog, transcriptional regulator (Drosophila) 0.055
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.055
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.055
DMD dystrophin 0.053
SIRT1 sirtuin 1 0.051
FGF4 fibroblast growth factor 4 0.049
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.046
PDGFC platelet derived growth factor C 0.046
FGF8 fibroblast growth factor 8 (androgen-induced) 0.045
GATA4 GATA binding protein 4 0.044
NLRC4 NLR family, CARD domain containing 4 0.044
ATXN1L ataxin 1-like 0.044
SREBF2 sterol regulatory element binding transcription factor 2 0.044
MAML1 mastermind-like 1 (Drosophila) 0.043
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.041
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.041
NCOR1 nuclear receptor corepressor 1 0.041
FHL3 four and a half LIM domains 3 0.041
PAX8 paired box 8 0.040
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.038
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.038
AR androgen receptor 0.037
FOXO1 forkhead box O1 0.037
EP300 E1A binding protein p300 0.037
RXRA retinoid X receptor, alpha 0.036
ACVR1 activin A receptor, type I 0.035
ATXN1 ataxin 1 0.035
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.033
TBX5 T-box 5 0.033
ITGB5 integrin, beta 5 0.032
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.032
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.032
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.031
FGF18 fibroblast growth factor 18 0.030
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.030
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.030
ELN elastin 0.030
BMP7 bone morphogenetic protein 7 0.029
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.029
PPARA peroxisome proliferator-activated receptor alpha 0.029
UTRN utrophin 0.028
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.027
PUM1 pumilio homolog 1 (Drosophila) 0.027
SRSF2 serine/arginine-rich splicing factor 2 0.027
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.026
PLCG1 phospholipase C, gamma 1 0.026
CCNE1 cyclin E1 0.026
FOXF1 forkhead box F1 0.025
FGF2 fibroblast growth factor 2 (basic) 0.025
CSH2 chorionic somatomammotropin hormone 2 0.025
TCF4 transcription factor 4 0.025
PAPOLA poly(A) polymerase alpha 0.025
MYOCD myocardin 0.025
HSPG2 heparan sulfate proteoglycan 2 0.023
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.023
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Rattus norvegicus
Name Description Probability Func Analog Organism
Lyz2 lysozyme 2 0.076
Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 0.049
Dbp D site of albumin promoter (albumin D-box) binding protein 0.047
Id3 inhibitor of DNA binding 3 0.045
Aebp1 AE binding protein 1 0.034
Sox17 SRY (sex determining region Y)-box 17 0.033
Ednra endothelin receptor type A 0.032
Kitlg KIT ligand 0.028
Pip prolactin induced protein 0.027
Timp2 TIMP metallopeptidase inhibitor 2 0.026
Foxs1 forkhead box S1 0.026
Col8a1 collagen, type VIII, alpha 1 0.025
Psgb1 pregnancy-specific beta 1-glycoprotein 0.024
Cd40lg CD40 ligand 0.023
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.023
Colec12 collectin sub-family member 12 0.023
Sc4mol sterol-C4-methyl oxidase-like 0.022
Pawr PRKC, apoptosis, WT1, regulator 0.022
Lox lysyl oxidase 0.022
Chrnb3 cholinergic receptor, nicotinic, beta 3 0.022
Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.021
Mfrp membrane frizzled-related protein 0.021
Synpo synaptopodin 0.021
Fn1 fibronectin 1 0.021
Sod3 superoxide dismutase 3, extracellular 0.020
Lamc1 laminin, gamma 1 0.020
Fgf16 fibroblast growth factor 16 0.020
Prl7a4 prolactin family 7, subfamily a, member 4 0.020
Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 0.020
Gpr116 G protein-coupled receptor 116 0.020
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.019
Sox13 SRY (sex determining region Y)-box 13 0.019
S100a3 S100 calcium binding protein A3 0.019
Casp2 caspase 2 0.019
Lepr leptin receptor 0.019
A3galt2 alpha 1,3-galactosyltransferase 2 0.019
Casp1 caspase 1 0.018
Hist1h1d histone cluster 1, H1d 0.018
Sulf1 sulfatase 1 0.018
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.018
Ctsc cathepsin C 0.018
Crtap cartilage associated protein 0.018
Ednrb endothelin receptor type B 0.018
Map3k3 mitogen activated protein kinase kinase kinase 3 0.018
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.018
Serpini2 serine (or cysteine) peptidase inhibitor, clade I, member 2 0.017
Lgals7 lectin, galactoside-binding, soluble, 7 0.017
Pou1f1 POU class 1 homeobox 1 0.017
Tgfb2 transforming growth factor, beta 2 0.017
Sc65 synaptonemal complex protein SC65 0.017
Stx2 syntaxin 2 0.017
Cacng5 calcium channel, voltage-dependent, gamma subunit 5 0.017
Pla1a phospholipase A1 member A 0.017
Agtr1b angiotensin II receptor, type 1b 0.017
Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 0.017
Casp3 caspase 3 0.016
Wisp1 WNT1 inducible signaling pathway protein 1 0.016
Sult1a1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.016
Hyal2 hyaluronoglucosaminidase 2 0.016
Fgf10 fibroblast growth factor 10 0.016
Cfh complement factor H 0.016
Fcgrt Fc fragment of IgG, receptor, transporter, alpha 0.016
Gja5 gap junction protein, alpha 5 0.016
Omd osteomodulin 0.016
Fdps farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) 0.016
Boc biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein 0.016
Cdk2 cyclin dependent kinase 2 0.016
Ctsk cathepsin K 0.016
Smad7 SMAD family member 7 0.016
Zfx zinc finger protein X-linked 0.016
Scpep1 serine carboxypeptidase 1 0.016
Svs1 seminal vesicle secretory protein 1 0.015
Gpc3 glypican 3 0.015
Mrc1 mannose receptor, C type 1 0.015
Postn periostin, osteoblast specific factor 0.015
Lpcat3 lysophosphatidylcholine acyltransferase 3 0.015
Acacb acetyl-Coenzyme A carboxylase beta 0.015
Tgfb1 transforming growth factor, beta 1 0.015
Ptgfrn prostaglandin F2 receptor negative regulator 0.015
Smcp sperm mitochondria-associated cysteine-rich protein 0.015
Olr837 olfactory receptor 837 0.015
Hoxb8 homeo box B8 0.015
Il17f interleukin 17F 0.015
Ltbp1 latent transforming growth factor beta binding protein 1 0.015
Xdh xanthine dehydrogenase 0.015
Rnase4 ribonuclease, RNase A family 4 0.015
Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.015
Megf6 multiple EGF-like-domains 6 0.015
Nos3 nitric oxide synthase 3, endothelial cell 0.014
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.014
Chrna10 cholinergic receptor, nicotinic, alpha 10 0.014
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.014
Arnt aryl hydrocarbon receptor nuclear translocator 0.014
Ccr1 chemokine (C-C motif) receptor 1 0.014
Rgs4 regulator of G-protein signaling 4 0.014
Loxl1 lysyl oxidase-like 1 0.014
Col4a5 collagen, type IV, alpha 5 0.014
Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.014
Adam17 ADAM metallopeptidase domain 17 0.014
Fam38b family with sequence similarity 38, member B 0.014
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism