The network for 'heat generation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

heat generation

Any homeostatic process in which an organism produces heat, thereby raising its internal temperature.

Name Description Probability Func Analog Organism
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.991
Tnf tumor necrosis factor 0.990
Lta lymphotoxin A 0.927
Ptgs2 prostaglandin-endoperoxide synthase 2 0.755
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.703
Pnpla2 patatin-like phospholipase domain containing 2 0.688
ND6 NADH dehydrogenase subunit 6 0.626
Nos2 nitric oxide synthase 2, inducible 0.620
Cd40 CD40 antigen 0.611
Adrb3 adrenergic receptor, beta 3 0.602
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.566
LOC100048884 novel member of the major urinary protein (Mup) gene family 0.407
Il10 interleukin 10 0.362
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.312
Mup10 major urinary protein 10 0.292
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.267
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.258
Il6 interleukin 6 0.255
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.238
Mup19 major urinary protein 19 0.218
Mup9 major urinary protein 9 0.208
Mup1 major urinary protein 1 0.199
Kl klotho 0.193
Mup12 major urinary protein 12 0.192
Pparg peroxisome proliferator activated receptor gamma 0.191
Adrb1 adrenergic receptor, beta 1 0.182
Ltb lymphotoxin B 0.167
Cxcl13 chemokine (C-X-C motif) ligand 13 0.167
Il1r1 interleukin 1 receptor, type I 0.153
Mup15 major urinary protein 15 0.147
Il1b interleukin 1 beta 0.146
Mup13 major urinary protein 13 0.145
Mup8 major urinary protein 8 0.137
Mup17 major urinary protein 17 0.133
Npy1r neuropeptide Y receptor Y1 0.132
Mup14 major urinary protein 14 0.132
Ren1 renin 1 structural 0.128
Mup7 major urinary protein 7 0.124
S1pr2 sphingosine-1-phosphate receptor 2 0.116
Cd40lg CD40 ligand 0.103
Mup2 major urinary protein 2 0.102
Mup11 major urinary protein 11 0.096
Tlr4 toll-like receptor 4 0.092
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.092
LOC100048885 major urinary protein LOC100048885 0.085
Plat plasminogen activator, tissue 0.085
Il12b interleukin 12b 0.083
Il4 interleukin 4 0.082
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.072
Esr2 estrogen receptor 2 (beta) 0.072
Il1a interleukin 1 alpha 0.070
Htr4 5 hydroxytryptamine (serotonin) receptor 4 0.069
Mup5 major urinary protein 5 0.060
Ifng interferon gamma 0.059
Oprm1 opioid receptor, mu 1 0.054
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.054
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.051
Mup4 major urinary protein 4 0.050
Acvrl1 activin A receptor, type II-like 1 0.045
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.045
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.044
Kcnk3 potassium channel, subfamily K, member 3 0.044
Sstr3 somatostatin receptor 3 0.040
Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 0.040
Nhedc2 Na+/H+ exchanger domain containing 2 0.039
Grm2 glutamate receptor, metabotropic 2 0.039
Cldn16 claudin 16 0.036
Il22 interleukin 22 0.036
Clec4d C-type lectin domain family 4, member d 0.035
Adora2a adenosine A2a receptor 0.035
Cd160 CD160 antigen 0.034
Lepr leptin receptor 0.034
Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) 0.033
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.033
Apoe apolipoprotein E 0.032
Sstr1 somatostatin receptor 1 0.031
Glycam1 glycosylation dependent cell adhesion molecule 1 0.031
Bcl6 B-cell leukemia/lymphoma 6 0.029
Nos3 nitric oxide synthase 3, endothelial cell 0.027
Spp1 secreted phosphoprotein 1 0.027
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.027
Ccl2 chemokine (C-C motif) ligand 2 0.026
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.026
Tlr6 toll-like receptor 6 0.026
Pdcd1 programmed cell death 1 0.026
Gpr132 G protein-coupled receptor 132 0.026
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.026
Col4a3 collagen, type IV, alpha 3 0.025
Edn1 endothelin 1 0.025
Htra3 HtrA serine peptidase 3 0.024
Itga2 integrin alpha 2 0.024
Hamp hepcidin antimicrobial peptide 0.024
Npy5r neuropeptide Y receptor Y5 0.024
Clcnka chloride channel Ka 0.024
Fpr2 formyl peptide receptor 2 0.023
Cd70 CD70 antigen 0.023
Dmbx1 diencephalon/mesencephalon homeobox 1 0.022
Traf2 TNF receptor-associated factor 2 0.022
Adrb2 adrenergic receptor, beta 2 0.022
Fndc7 fibronectin type III domain containing 7 0.022
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Il1a interleukin 1 alpha 0.234
Ccl2 chemokine (C-C motif) ligand 2 0.115
Cd14 CD14 molecule 0.067
Il6 interleukin 6 0.066
Cxcl2 chemokine (C-X-C motif) ligand 2 0.062
Gzmk granzyme K 0.048
Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.043
Ccl4 chemokine (C-C motif) ligand 4 0.042
RT1-Ba RT1 class II, locus Ba 0.041
Serpinb2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.033
Cxcl10 chemokine (C-X-C motif) ligand 10 0.028
F13a1 coagulation factor XIII, A1 polypeptide 0.020
Il1rn interleukin 1 receptor antagonist 0.020
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.019
Tgm1 transglutaminase 1, K polypeptide 0.018
Cdh6 cadherin 6 0.018
LOC685020 similar to paired immunoglobin-like type 2 receptor alpha 0.017
Calcrl calcitonin receptor-like 0.017
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.016
Ccl3 chemokine (C-C motif) ligand 3 0.015
Nkg7 natural killer cell group 7 sequence 0.015
Clcn5 chloride channel 5 0.014
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.014
RT1-Bb RT1 class II, locus Bb 0.014
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.013
Aqp4 aquaporin 4 0.013
Grxcr1 glutaredoxin, cysteine rich 1 0.013
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.013
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.012
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.012
Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.012
Casp1 caspase 1 0.012
Neurl3 neuralized homolog 3 (Drosophila) 0.011
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.011
Rab32 RAB32, member RAS oncogene family 0.011
Fosl1 fos-like antigen 1 0.011
Nlgn1 neuroligin 1 0.011
Gzmb granzyme B 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism