IMP

Process View

Homo sapiens

29 genes annotated in human

response to transition metal nanoparticle

GO:1990267

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to transition metal nanoparticle"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to transition metal nanoparticle" (in gray)

Name	Description	Probability	Func Analog Organism
MT1E	metallothionein 1E	0.999
MT1F	metallothionein 1F	0.999	Human
MT1X	metallothionein 1X	0.999
MT2A	metallothionein 2A	0.995
MT1H	metallothionein 1H	0.990
MT1G	metallothionein 1G	0.910
ABI2	abl-interactor 2	0.664
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.589
TP53	tumor protein p53	0.569	Zebrafish
CDK2	cyclin-dependent kinase 2	0.565
APP	amyloid beta (A4) precursor protein	0.530
BCL2	B-cell CLL/lymphoma 2	0.453
BCL2L1	BCL2-like 1	0.368	Human
DLG4	discs, large homolog 4 (Drosophila)	0.280
IL1R1	interleukin 1 receptor, type I	0.273
IL1B	interleukin 1, beta	0.247	Human
PDZD11	PDZ domain containing 11	0.227
NAMPT	nicotinamide phosphoribosyltransferase	0.224
CD300LD	CD300 molecule-like family member d	0.207
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.179
LRP1	low density lipoprotein receptor-related protein 1	0.158
APOA1	apolipoprotein A-I	0.152
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.143	Rat
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.130
IL8	interleukin 8	0.129
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.126	Rat
CAV1	caveolin 1, caveolae protein, 22kDa	0.121
CCNE1	cyclin E1	0.119	Rat
BAD	BCL2-associated agonist of cell death	0.116
MAPK14	mitogen-activated protein kinase 14	0.113
TICAM2	toll-like receptor adaptor molecule 2	0.113
KATNAL1	katanin p60 subunit A-like 1	0.112
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.108
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.098
DLG1	discs, large homolog 1 (Drosophila)	0.098
SPRY4	sprouty homolog 4 (Drosophila)	0.085
CXCL3	chemokine (C-X-C motif) ligand 3	0.082
BAK1	BCL2-antagonist/killer 1	0.081
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.079
GPR50	G protein-coupled receptor 50	0.078
BCL2A1	BCL2-related protein A1	0.070
MAPT	microtubule-associated protein tau	0.070
PDLIM7	PDZ and LIM domain 7 (enigma)	0.069
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.069
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.068
ACVR1B	activin A receptor, type IB	0.067
CDK6	cyclin-dependent kinase 6	0.065
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.062
DRD2	dopamine receptor D2	0.062	Rat
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.062
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.061
RB1	retinoblastoma 1	0.060
SKP2	S-phase kinase-associated protein 2 (p45)	0.058
FBLN5	fibulin 5	0.056
IL1RAP	interleukin 1 receptor accessory protein	0.054
IL1RN	interleukin 1 receptor antagonist	0.054
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.053
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.053
MT1M	metallothionein 1M	0.050	Human
BAX	BCL2-associated X protein	0.050	Human Zebrafish Rat
BRCA2	breast cancer 2, early onset	0.049
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.046
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.046
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.045
IRS2	insulin receptor substrate 2	0.044
DUSP1	dual specificity phosphatase 1	0.043
ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	0.041
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.040
ICAM1	intercellular adhesion molecule 1	0.039
PFN1	profilin 1	0.039
SSR1	signal sequence receptor, alpha	0.038
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.038	Rat
ADORA2A	adenosine A2a receptor	0.037
MT1A	metallothionein 1A	0.037
ADM	adrenomedullin	0.037
SRGN	serglycin	0.037
CCL20	chemokine (C-C motif) ligand 20	0.033
SH3D19	SH3 domain containing 19	0.033
MYD88	myeloid differentiation primary response gene (88)	0.033
FANCD2	Fanconi anemia, complementation group D2	0.032
MAP2K6	mitogen-activated protein kinase kinase 6	0.032
EGFR	epidermal growth factor receptor	0.032
HIPK3	homeodomain interacting protein kinase 3	0.032
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.031	Human
RIPK2	receptor-interacting serine-threonine kinase 2	0.030
PLAUR	plasminogen activator, urokinase receptor	0.030
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.030
CFL1	cofilin 1 (non-muscle)	0.030
BID	BH3 interacting domain death agonist	0.029
GSK3B	glycogen synthase kinase 3 beta	0.029
CCNA2	cyclin A2	0.029
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.029
KCNJ11	potassium inwardly-rectifying channel, subfamily J, member 11	0.028
AGXT2	alanine--glyoxylate aminotransferase 2	0.028
TAGLN2	transgelin 2	0.028
NCOA1	nuclear receptor coactivator 1	0.028
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.027
USP50	ubiquitin specific peptidase 50	0.026
IL1R2	interleukin 1 receptor, type II	0.025
RNF144B	ring finger protein 144B	0.025
KCTD1	potassium channel tetramerisation domain containing 1	0.025
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.024
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.024
MT1B	metallothionein 1B	0.024
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.024
TLR2	toll-like receptor 2	0.024
CXCL2	chemokine (C-X-C motif) ligand 2	0.024
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.024	Fly
PRODH2	proline dehydrogenase (oxidase) 2	0.024
JUNB	jun B proto-oncogene	0.024
APOE	apolipoprotein E	0.023
IGF1R	insulin-like growth factor 1 receptor	0.023
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.023
EHHADH	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.022
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.022
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.022	Rat
CCNB2	cyclin B2	0.022
THBS1	thrombospondin 1	0.022
S100A8	S100 calcium binding protein A8	0.022	Rat
BBS1	Bardet-Biedl syndrome 1	0.022
ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	0.022
HSD17B4	hydroxysteroid (17-beta) dehydrogenase 4	0.022
TMF1	TATA element modulatory factor 1	0.021
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.021
S100A12	S100 calcium binding protein A12	0.021
SH3BP4	SH3-domain binding protein 4	0.021
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.020
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.020
TGFBR1	transforming growth factor, beta receptor 1	0.020
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.020
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.020
FRS2	fibroblast growth factor receptor substrate 2	0.020
IRS1	insulin receptor substrate 1	0.019
PRDX6	peroxiredoxin 6	0.019
CALCA	calcitonin-related polypeptide alpha	0.019
MYOD1	myogenic differentiation 1	0.018
IGFBP3	insulin-like growth factor binding protein 3	0.018
NCF2	neutrophil cytosolic factor 2	0.018
EP300	E1A binding protein p300	0.018
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.018
ADAMTSL4	ADAMTS-like 4	0.018
SAT1	spermidine/spermine N1-acetyltransferase 1	0.018
LY96	lymphocyte antigen 96	0.017
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.017
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.017
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.017
A2M	alpha-2-macroglobulin	0.017
CCND3	cyclin D3	0.017
APLP2	amyloid beta (A4) precursor-like protein 2	0.016
CCL2	chemokine (C-C motif) ligand 2	0.016
CAMK2B	calcium/calmodulin-dependent protein kinase II beta	0.016
PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.016
PBK	PDZ binding kinase	0.016
SOD2	superoxide dismutase 2, mitochondrial	0.016	Zebrafish
CCNB1	cyclin B1	0.016	Rat
HSPB1	heat shock 27kDa protein 1	0.016
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.016
GHRHR	growth hormone releasing hormone receptor	0.016
TNIP1	TNFAIP3 interacting protein 1	0.016
FGA	fibrinogen alpha chain	0.015
MSN	moesin	0.015
MYL4	myosin, light chain 4, alkali; atrial, embryonic	0.015
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.015
SCP2	sterol carrier protein 2	0.015
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.015
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.015
SGK1	serum/glucocorticoid regulated kinase 1	0.015
CCND1	cyclin D1	0.015	Rat
CST4	cystatin S	0.015	Rat
WDYHV1	WDYHV motif containing 1	0.015
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.014
PTAFR	platelet-activating factor receptor	0.014
C14orf1	chromosome 14 open reading frame 1	0.014
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.014
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.014
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.014
TAGLN	transgelin	0.014
MAP1B	microtubule-associated protein 1B	0.014
GUCA2B	guanylate cyclase activator 2B (uroguanylin)	0.014
SP1	Sp1 transcription factor	0.014
SYK	spleen tyrosine kinase	0.014
BHLHE40	basic helix-loop-helix family, member e40	0.014
BIRC3	baculoviral IAP repeat containing 3	0.014
RFWD2	ring finger and WD repeat domain 2	0.014
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.013
FTH1	ferritin, heavy polypeptide 1	0.013
GADD45GIP1	growth arrest and DNA-damage-inducible, gamma interacting protein 1	0.013
GCH1	GTP cyclohydrolase 1	0.013
CAPNS1	calpain, small subunit 1	0.013
RNR2	l-rRNA	0.013
LRP6	low density lipoprotein receptor-related protein 6	0.013
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.013	Rat
OXT	oxytocin, prepropeptide	0.013
CRIP1	cysteine-rich protein 1 (intestinal)	0.013
GRIN3B	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	0.013
IER3	immediate early response 3	0.013
RANBP3	RAN binding protein 3	0.013
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.013	Rat
FABP4	fatty acid binding protein 4, adipocyte	0.013
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.013
MAP3K4	mitogen-activated protein kinase kinase kinase 4	0.013
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.013
PGLYRP1	peptidoglycan recognition protein 1	0.013
ZHX1	zinc fingers and homeoboxes 1	0.012
FERMT3	fermitin family member 3	0.012
IL6	interleukin 6 (interferon, beta 2)	0.012
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.012
CREBBP	CREB binding protein	0.012
PCNA	proliferating cell nuclear antigen	0.012
COL6A1	collagen, type VI, alpha 1	0.012
AVPR1B	arginine vasopressin receptor 1B	0.012
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.012
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.012
NR6A1	nuclear receptor subfamily 6, group A, member 1	0.012
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.012
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.012
ACTL6B	actin-like 6B	0.012
MLN	motilin	0.012
KAT2B	K(lysine) acetyltransferase 2B	0.012
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.012
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.012
TREM1	triggering receptor expressed on myeloid cells 1	0.012
KRT5	keratin 5	0.012
SLC17A1	solute carrier family 17 (sodium phosphate), member 1	0.011
JAK1	Janus kinase 1	0.011
MAST1	microtubule associated serine/threonine kinase 1	0.011
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.011
AGXT	alanine-glyoxylate aminotransferase	0.011
SNCAIP	synuclein, alpha interacting protein	0.011
LTF	lactotransferrin	0.011
VNN1	vanin 1	0.011
KCTD17	potassium channel tetramerisation domain containing 17	0.011
RAD52	RAD52 homolog (S. cerevisiae)	0.011
CREB3	cAMP responsive element binding protein 3	0.011
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.011
CCL7	chemokine (C-C motif) ligand 7	0.011
NLGN1	neuroligin 1	0.011
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.011
HNF1B	HNF1 homeobox B	0.011
GK	glycerol kinase	0.011
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	0.011
TPPP	tubulin polymerization promoting protein	0.011
TNNI1	troponin I type 1 (skeletal, slow)	0.011
PDIA3	protein disulfide isomerase family A, member 3	0.011
CTSL1	cathepsin L1	0.011
C19orf39	chromosome 19 open reading frame 39	0.011
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.011
FTL	ferritin, light polypeptide	0.011
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.011
REN	renin	0.011
TFRC	transferrin receptor (p90, CD71)	0.010
MADCAM1	mucosal vascular addressin cell adhesion molecule 1	0.010
HSPD1	heat shock 60kDa protein 1 (chaperonin)	0.010
HRH3	histamine receptor H3	0.010
SGMS1	sphingomyelin synthase 1	0.010
AGL	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	0.010
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.010
CITED1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	0.010
OMP	olfactory marker protein	0.010
CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.010
DOCK7	dedicator of cytokinesis 7	0.010
VCL	vinculin	0.010
RHO	rhodopsin	0.010
S100A9	S100 calcium binding protein A9	0.010	Rat
PRKCDBP	protein kinase C, delta binding protein	0.010
USP42	ubiquitin specific peptidase 42	0.010
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.010
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.010
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.010