IMP

Process View

Homo sapiens

24 genes annotated in human

regulation of gene silencing

Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of gene silencing"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of gene silencing" (in gray)

Name	Description	Probability	Func Analog Organism
CBX5	chromobox homolog 5	0.992	Fly
SP1	Sp1 transcription factor	0.986	Fly
HIST2H2BE	histone cluster 2, H2be	0.912
MBD1	methyl-CpG binding domain protein 1	0.874
HIST1H3D	histone cluster 1, H3d	0.770
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.760
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.753
HIST1H3B	histone cluster 1, H3b	0.707
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.654
MCM3	minichromosome maintenance complex component 3	0.491
HIST1H3A	histone cluster 1, H3a	0.470
DICER1	dicer 1, ribonuclease type III	0.425	Worm
HIST1H2AJ	histone cluster 1, H2aj	0.376	Human
CBX3	chromobox homolog 3	0.367	Fly
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.360
HIST1H2AI	histone cluster 1, H2ai	0.357	Human
HIST1H2BG	histone cluster 1, H2bg	0.302
ORC1	origin recognition complex, subunit 1	0.294
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.282
MCM2	minichromosome maintenance complex component 2	0.252
EP300	E1A binding protein p300	0.252
HDAC1	histone deacetylase 1	0.236
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.207
SMAD4	SMAD family member 4	0.201
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.191
HIST1H4D	histone cluster 1, H4d	0.189
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.188
HIPK3	homeodomain interacting protein kinase 3	0.187
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.182
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.169
E2F1	E2F transcription factor 1	0.160
MCM4	minichromosome maintenance complex component 4	0.159
TNRC6B	trinucleotide repeat containing 6B	0.157
HIST1H2AE	histone cluster 1, H2ae	0.151	Human
HIST1H2AM	histone cluster 1, H2am	0.146
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.144
PAX3	paired box 3	0.135
SKP2	S-phase kinase-associated protein 2 (p45)	0.133
ADNP	activity-dependent neuroprotector homeobox	0.130
CBX1	chromobox homolog 1	0.130	Fly
MCM6	minichromosome maintenance complex component 6	0.127
HIST1H1C	histone cluster 1, H1c	0.112
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.111
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.109
HIST1H4A	histone cluster 1, H4a	0.106	Human
HIST1H4B	histone cluster 1, H4b	0.103
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.103
CDT1	chromatin licensing and DNA replication factor 1	0.100
FMR1	fragile X mental retardation 1	0.098
PUM2	pumilio homolog 2 (Drosophila)	0.092
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.091
ORC2	origin recognition complex, subunit 2	0.089
SIRT1	sirtuin 1	0.089
HTT	huntingtin	0.087
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.086
SOX10	SRY (sex determining region Y)-box 10	0.086
SMAD3	SMAD family member 3	0.083
TRRAP	transformation/transcription domain-associated protein	0.083
HIST1H2AB	histone cluster 1, H2ab	0.078	Human
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.077	Fly
FOXD3	forkhead box D3	0.075
ORC6	origin recognition complex, subunit 6	0.072
RUFY1	RUN and FYVE domain containing 1	0.071
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.071
POGZ	pogo transposable element with ZNF domain	0.070
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.069
HIST1H2BM	histone cluster 1, H2bm	0.066
BCOR	BCL6 corepressor	0.066
HIST1H2AL	histone cluster 1, H2al	0.062	Human
MCM10	minichromosome maintenance complex component 10	0.059
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.058
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.058
CCNA2	cyclin A2	0.057
HIST1H2BB	histone cluster 1, H2bb	0.056
PARP1	poly (ADP-ribose) polymerase 1	0.053
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.049
MCM7	minichromosome maintenance complex component 7	0.049
HIST1H2BJ	histone cluster 1, H2bj	0.049
YBX1	Y box binding protein 1	0.047
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.047
SAP30	Sin3A-associated protein, 30kDa	0.047
ACTL6A	actin-like 6A	0.046	Fly
HIST1H4H	histone cluster 1, H4h	0.045
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.045
HIST1H1E	histone cluster 1, H1e	0.043
ASF1B	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.042
RBBP4	retinoblastoma binding protein 4	0.041
HDAC2	histone deacetylase 2	0.040
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.039
HIST1H2AG	histone cluster 1, H2ag	0.039	Human
PCNA	proliferating cell nuclear antigen	0.037
HIST2H4A	histone cluster 2, H4a	0.036
HIST1H3G	histone cluster 1, H3g	0.035
VEZF1	vascular endothelial zinc finger 1	0.035
TALDO1	transaldolase 1	0.034
LMNA	lamin A/C	0.033
SMAD7	SMAD family member 7	0.033
CDYL	chromodomain protein, Y-like	0.032
SETDB1	SET domain, bifurcated 1	0.032	Fly
ZNF512B	zinc finger protein 512B	0.032
LIN28B	lin-28 homolog B (C. elegans)	0.031
SSRP1	structure specific recognition protein 1	0.031
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.031
HCFC1	host cell factor C1 (VP16-accessory protein)	0.029
NASP	nuclear autoantigenic sperm protein (histone-binding)	0.029
TNRC6A	trinucleotide repeat containing 6A	0.028
CHD3	chromodomain helicase DNA binding protein 3	0.028
HIST1H4F	histone cluster 1, H4f	0.028
SP100	SP100 nuclear antigen	0.028
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.028
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.027	Fly
SOX2	SRY (sex determining region Y)-box 2	0.027
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	0.027
HIST2H2AA3	histone cluster 2, H2aa3	0.026	Human
DAZL	deleted in azoospermia-like	0.026
HIST1H2BO	histone cluster 1, H2bo	0.026
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.025
ESR1	estrogen receptor 1	0.025
HIST1H3F	histone cluster 1, H3f	0.025
TOP2B	topoisomerase (DNA) II beta 180kDa	0.025
HIST1H3C	histone cluster 1, H3c	0.024
HIST1H2BN	histone cluster 1, H2bn	0.024
TP53	tumor protein p53	0.023
HIST1H1B	histone cluster 1, H1b	0.023
NCOR1	nuclear receptor corepressor 1	0.022
CLSPN	claspin	0.022
HIST1H1D	histone cluster 1, H1d	0.022
HIST1H4L	histone cluster 1, H4l	0.022
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.022
RB1	retinoblastoma 1	0.022
KDM4B	lysine (K)-specific demethylase 4B	0.022
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.022
SETD7	SET domain containing (lysine methyltransferase) 7	0.021
LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.021
AURKB	aurora kinase B	0.021
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.020
HIST1H4J	histone cluster 1, H4j	0.020
HOXA9	homeobox A9	0.019
RANBP2	RAN binding protein 2	0.019
PPP1R16A	protein phosphatase 1, regulatory (inhibitor) subunit 16A	0.019
RCOR1	REST corepressor 1	0.019
EXOSC10	exosome component 10	0.018
DAXX	death-domain associated protein	0.018
DBF4	DBF4 homolog (S. cerevisiae)	0.018
HIST1H2BC	histone cluster 1, H2bc	0.018
TRIM33	tripartite motif containing 33	0.018
SNAI1	snail homolog 1 (Drosophila)	0.018
SMYD3	SET and MYND domain containing 3	0.018
SRSF2	serine/arginine-rich splicing factor 2	0.017
TARBP2	TAR (HIV-1) RNA binding protein 2	0.017	Fly
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.017
MAPK14	mitogen-activated protein kinase 14	0.017
MOCS3	molybdenum cofactor synthesis 3	0.017
HIST4H4	histone cluster 4, H4	0.017
CUL1	cullin 1	0.016
HMGA1	high mobility group AT-hook 1	0.016
YY1	YY1 transcription factor	0.016
HIST1H3I	histone cluster 1, H3i	0.016
NSL1	NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.016
ZFP28	zinc finger protein 28 homolog (mouse)	0.016
ARID4B	AT rich interactive domain 4B (RBP1-like)	0.016
HIST1H4I	histone cluster 1, H4i	0.016
CDK2	cyclin-dependent kinase 2	0.015
C20orf20	chromosome 20 open reading frame 20	0.015
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.015
KDM4A	lysine (K)-specific demethylase 4A	0.015
SENP1	SUMO1/sentrin specific peptidase 1	0.015
ARID1A	AT rich interactive domain 1A (SWI-like)	0.015
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.015
BRD7	bromodomain containing 7	0.014
APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	0.014
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.014
RNF19A	ring finger protein 19A	0.014
HMGB2	high mobility group box 2	0.014
NONO	non-POU domain containing, octamer-binding	0.014
HIST2H4B	histone cluster 2, H4b	0.014
SUV420H1	suppressor of variegation 4-20 homolog 1 (Drosophila)	0.014
ORC3	origin recognition complex, subunit 3	0.013
CREB1	cAMP responsive element binding protein 1	0.013
HIST1H2AK	histone cluster 1, H2ak	0.013	Human
MSL2	male-specific lethal 2 homolog (Drosophila)	0.013
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.013
CREBBP	CREB binding protein	0.013
CHD4	chromodomain helicase DNA binding protein 4	0.013
HIST1H3J	histone cluster 1, H3j	0.013
SETMAR	SET domain and mariner transposase fusion gene	0.013
HIST1H3H	histone cluster 1, H3h	0.013
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.012
HIST1H2BD	histone cluster 1, H2bd	0.012
MMS22L	MMS22-like, DNA repair protein	0.012
G6PD	glucose-6-phosphate dehydrogenase	0.012
HIST3H3	histone cluster 3, H3	0.012	Human
ATF7IP	activating transcription factor 7 interacting protein	0.012
TICAM2	toll-like receptor adaptor molecule 2	0.012
HIST1H4E	histone cluster 1, H4e	0.012
TRIM28	tripartite motif containing 28	0.012
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.012
LASP1	LIM and SH3 protein 1	0.012
PABPC1	poly(A) binding protein, cytoplasmic 1	0.012
NQO1	NAD(P)H dehydrogenase, quinone 1	0.012
HIST2H3C	histone cluster 2, H3c	0.011	Human
HIST1H2BL	histone cluster 1, H2bl	0.011
LBR	lamin B receptor	0.011
FAM126B	family with sequence similarity 126, member B	0.011
RSBN1	round spermatid basic protein 1	0.011
PLEKHO1	pleckstrin homology domain containing, family O member 1	0.011
PAN3	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	0.011
RHOA	ras homolog gene family, member A	0.011
USP9X	ubiquitin specific peptidase 9, X-linked	0.011
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.010
HDAC6	histone deacetylase 6	0.010
ANKRD12	ankyrin repeat domain 12	0.010
SATB1	SATB homeobox 1	0.010
PIAS3	protein inhibitor of activated STAT, 3	0.010	Yeast
SOCS1	suppressor of cytokine signaling 1	0.010