IMP

Process View

Homo sapiens

23 genes annotated in human

gene silencing by mirna

Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "gene silencing by mirna"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "gene silencing by mirna" (in gray)

Name	Description	Probability	Func Analog Organism
DICER1	dicer 1, ribonuclease type III	1.000
EIF2C2	eukaryotic translation initiation factor 2C, 2	1.000
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	1.000
TNRC6A	trinucleotide repeat containing 6A	1.000
EIF2C1	eukaryotic translation initiation factor 2C, 1	1.000
TNRC6B	trinucleotide repeat containing 6B	0.994	Human
EIF2C3	eukaryotic translation initiation factor 2C, 3	0.978
EIF2C4	eukaryotic translation initiation factor 2C, 4	0.920
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.891
IPO8	importin 8	0.774
TNRC6C	trinucleotide repeat containing 6C	0.646	Mouse
DGCR8	DiGeorge syndrome critical region gene 8	0.620
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.595
PABPC1	poly(A) binding protein, cytoplasmic 1	0.414
PAX3	paired box 3	0.367
DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.357
LIN28B	lin-28 homolog B (C. elegans)	0.353
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.343	Human Fly
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	0.343
SF1	splicing factor 1	0.304
STAT1	signal transducer and activator of transcription 1, 91kDa	0.299
DCP1A	DCP1 decapping enzyme homolog A (S. cerevisiae)	0.247
KLF6	Kruppel-like factor 6	0.242
HIPK3	homeodomain interacting protein kinase 3	0.202
FOXD3	forkhead box D3	0.199
DROSHA	drosha, ribonuclease type III	0.187
C17orf85	chromosome 17 open reading frame 85	0.177
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.169
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.163
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.157
ACTN1	actinin, alpha 1	0.146
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.126
TRIM71	tripartite motif containing 71	0.123	Mouse
IER2	immediate early response 2	0.110
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.109
POGZ	pogo transposable element with ZNF domain	0.107
PAN3	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	0.099
PARP9	poly (ADP-ribose) polymerase family, member 9	0.091
TRRAP	transformation/transcription domain-associated protein	0.084
HCFC1	host cell factor C1 (VP16-accessory protein)	0.080
G3BP1	GTPase activating protein (SH3 domain) binding protein 1	0.077
U2AF2	U2 small nuclear RNA auxiliary factor 2	0.076
FUS	fused in sarcoma	0.075
YY1	YY1 transcription factor	0.075
C20orf20	chromosome 20 open reading frame 20	0.074
SP1	Sp1 transcription factor	0.074
UPF1	UPF1 regulator of nonsense transcripts homolog (yeast)	0.073
PARP12	poly (ADP-ribose) polymerase family, member 12	0.073
TRIM25	tripartite motif containing 25	0.072
HTT	huntingtin	0.069
RUVBL1	RuvB-like 1 (E. coli)	0.068
DTX3L	deltex 3-like (Drosophila)	0.062
FTSJD2	FtsJ methyltransferase domain containing 2	0.061
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.059
CYLD	cylindromatosis (turban tumor syndrome)	0.058
DMAP1	DNA methyltransferase 1 associated protein 1	0.056
JUND	jun D proto-oncogene	0.055
DAZL	deleted in azoospermia-like	0.055
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.053
TARDBP	TAR DNA binding protein	0.051
MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)	0.051
VASP	vasodilator-stimulated phosphoprotein	0.050
EGR1	early growth response 1	0.049
JUNB	jun B proto-oncogene	0.048
ESR1	estrogen receptor 1	0.048
SOX2	SRY (sex determining region Y)-box 2	0.048
PARN	poly(A)-specific ribonuclease (deadenylation nuclease)	0.046
HOXA9	homeobox A9	0.045
PPP1R16A	protein phosphatase 1, regulatory (inhibitor) subunit 16A	0.044
SOX10	SRY (sex determining region Y)-box 10	0.039
DHX58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.036	Human
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.034
SAMD9	sterile alpha motif domain containing 9	0.034
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.033
IFIT5	interferon-induced protein with tetratricopeptide repeats 5	0.033
DPCD	deleted in primary ciliary dyskinesia homolog (mouse)	0.031
IFI44	interferon-induced protein 44	0.031
OAS3	2'-5'-oligoadenylate synthetase 3, 100kDa	0.031
FLNB	filamin B, beta	0.030
GCN1L1	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	0.029
PARP14	poly (ADP-ribose) polymerase family, member 14	0.029
SCRIB	scribbled homolog (Drosophila)	0.028
STAT2	signal transducer and activator of transcription 2, 113kDa	0.028
SNAI1	snail homolog 1 (Drosophila)	0.027
CMPK2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.027
INO80	INO80 homolog (S. cerevisiae)	0.026
MOCS3	molybdenum cofactor synthesis 3	0.025
MGEA5	meningioma expressed antigen 5 (hyaluronidase)	0.025
ISG15	ISG15 ubiquitin-like modifier	0.025
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.024
NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive	0.024
EPSTI1	epithelial stromal interaction 1 (breast)	0.024
SAMD9L	sterile alpha motif domain containing 9-like	0.023
SAFB2	scaffold attachment factor B2	0.022
NCOA3	nuclear receptor coactivator 3	0.022
PPP1R15A	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.021
VPS72	vacuolar protein sorting 72 homolog (S. cerevisiae)	0.021
DUSP1	dual specificity phosphatase 1	0.021
MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	0.021
SRRM2	serine/arginine repetitive matrix 2	0.021
CSRNP1	cysteine-serine-rich nuclear protein 1	0.020
HERC5	hect domain and RLD 5	0.020
KLF4	Kruppel-like factor 4 (gut)	0.019
GEMIN4	gem (nuclear organelle) associated protein 4	0.019
TTI1	Tel2 interacting protein 1 homolog (S. pombe)	0.018
JUN	jun proto-oncogene	0.018
MAVS	mitochondrial antiviral signaling protein	0.018
C5orf55	chromosome 5 open reading frame 55	0.018
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.017
BTG2	BTG family, member 2	0.017
SMYD1	SET and MYND domain containing 1	0.017
CTNNBL1	catenin, beta like 1	0.017
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.017
POLE	polymerase (DNA directed), epsilon	0.016
EWSR1	Ewing sarcoma breakpoint region 1	0.016
SP110	SP110 nuclear body protein	0.015
ADAR	adenosine deaminase, RNA-specific	0.015
FHL3	four and a half LIM domains 3	0.015
INO80E	INO80 complex subunit E	0.015
FOSL2	FOS-like antigen 2	0.015
SFPQ	splicing factor proline/glutamine-rich	0.014
ZFP28	zinc finger protein 28 homolog (mouse)	0.014
MAX	MYC associated factor X	0.014
FNIP1	folliculin interacting protein 1	0.014
LASP1	LIM and SH3 protein 1	0.014
FDFT1	farnesyl-diphosphate farnesyltransferase 1	0.014
VCL	vinculin	0.014
EP400	E1A binding protein p400	0.014	Fly
SFN	stratifin	0.014
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.014
RBMX	RNA binding motif protein, X-linked	0.013
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.013	Human
POU5F1	POU class 5 homeobox 1	0.013
SAFB	scaffold attachment factor B	0.013
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.013
SP100	SP100 nuclear antigen	0.012
IFIH1	interferon induced with helicase C domain 1	0.012	Human
GFI1B	growth factor independent 1B transcription repressor	0.012
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.012
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.012
AKAP8	A kinase (PRKA) anchor protein 8	0.012
RPL11	ribosomal protein L11	0.012
IFI44L	interferon-induced protein 44-like	0.012
POLR2A	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	0.012
KDM5A	lysine (K)-specific demethylase 5A	0.012
EIF3C	eukaryotic translation initiation factor 3, subunit C	0.012
KIAA1683	KIAA1683	0.012
RBM14	RNA binding motif protein 14	0.011
EDC3	enhancer of mRNA decapping 3 homolog (S. cerevisiae)	0.011
CSK	c-src tyrosine kinase	0.011
TAF4	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	0.011
SETX	senataxin	0.011
ZBTB17	zinc finger and BTB domain containing 17	0.011
NOVA2	neuro-oncological ventral antigen 2	0.011
HNRNPCL1	heterogeneous nuclear ribonucleoprotein C-like 1	0.011
DHX8	DEAH (Asp-Glu-Ala-His) box polypeptide 8	0.010
IFIT1	interferon-induced protein with tetratricopeptide repeats 1	0.010
ERCC3	excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)	0.010
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.010
BTBD7	BTB (POZ) domain containing 7	0.010
RSAD2	radical S-adenosyl methionine domain containing 2	0.010