IMP

Process View

Homo sapiens

16 genes annotated in human

limb morphogenesis

The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "limb morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "limb morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
ZNF43	zinc finger protein 43	0.920
JAG1	jagged 1	0.539
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.491	Human
SUFU	suppressor of fused homolog (Drosophila)	0.453
ZNF253	zinc finger protein 253	0.447
ZNF273	zinc finger protein 273	0.404	Human
ZNF675	zinc finger protein 675	0.366	Human
BMP2	bone morphogenetic protein 2	0.340
HDAC1	histone deacetylase 1	0.276	Mouse
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.246
MEIS1	Meis homeobox 1	0.198
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.172
HDAC2	histone deacetylase 2	0.160	Mouse
GATA4	GATA binding protein 4	0.151
PSEN1	presenilin 1	0.145	Mouse
SMAD2	SMAD family member 2	0.144
ZNF430	zinc finger protein 430	0.130	Human
SMAD3	SMAD family member 3	0.123
NOTCH3	notch 3	0.123
SMO	smoothened homolog (Drosophila)	0.120
ZNF93	zinc finger protein 93	0.119
ZNF708	zinc finger protein 708	0.090	Human
FKBP1A	FK506 binding protein 1A, 12kDa	0.084
ZFYVE9	zinc finger, FYVE domain containing 9	0.083
ZNF91	zinc finger protein 91	0.077
FGF18	fibroblast growth factor 18	0.074
HOXA11	homeobox A11	0.070	Mouse
SOX2	SRY (sex determining region Y)-box 2	0.067
TGFBR1	transforming growth factor, beta receptor 1	0.065	Human
HOXD9	homeobox D9	0.064	Mouse
ERBB2IP	erbb2 interacting protein	0.064
GDF5	growth differentiation factor 5	0.063	Mouse
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.059
SETD8	SET domain containing (lysine methyltransferase) 8	0.057
ZNF85	zinc finger protein 85	0.057	Human
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.056
ARRB1	arrestin, beta 1	0.056
MSX1	msh homeobox 1	0.054
TGFB3	transforming growth factor, beta 3	0.054
AFF1	AF4/FMR2 family, member 1	0.054
BMPR1B	bone morphogenetic protein receptor, type IB	0.052
APC	adenomatous polyposis coli	0.052
ZNF117	zinc finger protein 117	0.052	Human
MEIS2	Meis homeobox 2	0.051
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.050
HOXA10	homeobox A10	0.049
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.049
ZNF254	zinc finger protein 254	0.048	Human
MSX2	msh homeobox 2	0.046	Human Mouse
SMAD4	SMAD family member 4	0.046
ZNF680	zinc finger protein 680	0.045	Human
WNT1	wingless-type MMTV integration site family, member 1	0.043	Human
STK36	serine/threonine kinase 36	0.041
PBRM1	polybromo 1	0.040
HOXC6	homeobox C6	0.039
HOXD13	homeobox D13	0.038	Mouse
HMGA2	high mobility group AT-hook 2	0.036
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.036	Mouse
FGF1	fibroblast growth factor 1 (acidic)	0.035
HOXD11	homeobox D11	0.035	Mouse
FOXF2	forkhead box F2	0.035
YY1	YY1 transcription factor	0.034
TJP1	tight junction protein 1 (zona occludens 1)	0.034
CHD8	chromodomain helicase DNA binding protein 8	0.034
HOXC8	homeobox C8	0.034
PDZD11	PDZ domain containing 11	0.032
SORBS3	sorbin and SH3 domain containing 3	0.032
KRT5	keratin 5	0.032
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.031	Mouse
TRIP6	thyroid hormone receptor interactor 6	0.030
NGFR	nerve growth factor receptor	0.030
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.030	Mouse
DAXX	death-domain associated protein	0.029
FGF10	fibroblast growth factor 10	0.029
COL2A1	collagen, type II, alpha 1	0.029	Mouse
TERF2	telomeric repeat binding factor 2	0.029
BAK1	BCL2-antagonist/killer 1	0.028
DLX4	distal-less homeobox 4	0.028
BCL2L1	BCL2-like 1	0.028
HOXB13	homeobox B13	0.027
PRKG1	protein kinase, cGMP-dependent, type I	0.027
CREBBP	CREB binding protein	0.027
ACAN	aggrecan	0.027
SMAD1	SMAD family member 1	0.027
SRI	sorcin	0.026
CABLES1	Cdk5 and Abl enzyme substrate 1	0.026
BAX	BCL2-associated X protein	0.025	Mouse
HOXD10	homeobox D10	0.025	Mouse
BMP4	bone morphogenetic protein 4	0.025	Mouse
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.025
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.024
PSEN2	presenilin 2 (Alzheimer disease 4)	0.023	Mouse
AR	androgen receptor	0.023
HOXC11	homeobox C11	0.023	Mouse
DLX5	distal-less homeobox 5	0.023	Mouse
MAML1	mastermind-like 1 (Drosophila)	0.023
OTP	orthopedia homeobox	0.023
PDGFC	platelet derived growth factor C	0.023
MLLT1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	0.023
PRRX2	paired related homeobox 2	0.022	Mouse
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.022
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.022
SFRP1	secreted frizzled-related protein 1	0.022
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.021
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.021
CCNT1	cyclin T1	0.021
MAPK8	mitogen-activated protein kinase 8	0.021
BARX1	BARX homeobox 1	0.020
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.020
TBX2	T-box 2	0.020	Human
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.020
SMAD6	SMAD family member 6	0.020
ELL2	elongation factor, RNA polymerase II, 2	0.020
RBBP4	retinoblastoma binding protein 4	0.019
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.019
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.019
CAPRIN2	caprin family member 2	0.019
GCSH	glycine cleavage system protein H (aminomethyl carrier)	0.019
PML	promyelocytic leukemia	0.019
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.019
ATN1	atrophin 1	0.018
HOXB5	homeobox B5	0.018
FGF2	fibroblast growth factor 2 (basic)	0.018
NKX3-2	NK3 homeobox 2	0.018
SPECC1L	sperm antigen with calponin homology and coiled-coil domains 1-like	0.017
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.017
LRP6	low density lipoprotein receptor-related protein 6	0.017	Mouse
FGF8	fibroblast growth factor 8 (androgen-induced)	0.017
ARID1A	AT rich interactive domain 1A (SWI-like)	0.017
ZNF92	zinc finger protein 92	0.016	Human
NCSTN	nicastrin	0.016
FOXC1	forkhead box C1	0.016
GATA2	GATA binding protein 2	0.016
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.016
MYOD1	myogenic differentiation 1	0.016
PAX2	paired box 2	0.016
SMAD7	SMAD family member 7	0.016
HES2	hairy and enhancer of split 2 (Drosophila)	0.015
LBX1	ladybird homeobox 1	0.015
SATB2	SATB homeobox 2	0.015
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.015
SIX1	SIX homeobox 1	0.015
PKNOX1	PBX/knotted 1 homeobox 1	0.015
MDFI	MyoD family inhibitor	0.015
HOXA9	homeobox A9	0.015	Mouse
ZNF107	zinc finger protein 107	0.014
CDX2	caudal type homeobox 2	0.014
GDF6	growth differentiation factor 6	0.014
BIK	BCL2-interacting killer (apoptosis-inducing)	0.014
PEX26	peroxisomal biogenesis factor 26	0.014
BAD	BCL2-associated agonist of cell death	0.014
HOXB9	homeobox B9	0.014
PDX1	pancreatic and duodenal homeobox 1	0.014
SIX2	SIX homeobox 2	0.014
ATXN3	ataxin 3	0.014
ZNF682	zinc finger protein 682	0.014	Human
FGF3	fibroblast growth factor 3	0.014
FGF7	fibroblast growth factor 7	0.014
EP300	E1A binding protein p300	0.014
HOXC13	homeobox C13	0.013
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.013
HNF1B	HNF1 homeobox B	0.013
SIX6	SIX homeobox 6	0.013
KRT6C	keratin 6C	0.013
EN1	engrailed homeobox 1	0.013	Mouse
BMP7	bone morphogenetic protein 7	0.013	Mouse
KCTD1	potassium channel tetramerisation domain containing 1	0.013
SIM2	single-minded homolog 2 (Drosophila)	0.013
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.013
WNT4	wingless-type MMTV integration site family, member 4	0.013	Human
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.013
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.013
PAX8	paired box 8	0.012
NRP1	neuropilin 1	0.012
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.012
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.012
TGFB2	transforming growth factor, beta 2	0.012
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.012
SHOX2	short stature homeobox 2	0.012	Mouse
SP1	Sp1 transcription factor	0.012
HOXD3	homeobox D3	0.012
CELF1	CUGBP, Elav-like family member 1	0.012
TLX1	T-cell leukemia homeobox 1	0.012
CCNT2	cyclin T2	0.012
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.012
HOXD12	homeobox D12	0.011	Mouse
CHD4	chromodomain helicase DNA binding protein 4	0.011
GATA5	GATA binding protein 5	0.011
WNT11	wingless-type MMTV integration site family, member 11	0.011	Human
FOXF1	forkhead box F1	0.011
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.011
ROR2	receptor tyrosine kinase-like orphan receptor 2	0.011
PRPH	peripherin	0.011
TUBB8	tubulin, beta 8	0.011
COL6A1	collagen, type VI, alpha 1	0.011
KIAA1199	KIAA1199	0.011
WNT3A	wingless-type MMTV integration site family, member 3A	0.011
SIX3	SIX homeobox 3	0.011
DLL1	delta-like 1 (Drosophila)	0.011
HIPK2	homeodomain interacting protein kinase 2	0.011
PRDM8	PR domain containing 8	0.011
FZD10	frizzled homolog 10 (Drosophila)	0.011
CDK19	cyclin-dependent kinase 19	0.011
TGFB1	transforming growth factor, beta 1	0.011
TWIST1	twist homolog 1 (Drosophila)	0.011	Mouse
GLI3	GLI family zinc finger 3	0.011
HOXA5	homeobox A5	0.010
ACVR1	activin A receptor, type I	0.010	Human
SKIL	SKI-like oncogene	0.010
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.010
CRLF1	cytokine receptor-like factor 1	0.010
BTRC	beta-transducin repeat containing	0.010
JAG2	jagged 2	0.010
HCFC1	host cell factor C1 (VP16-accessory protein)	0.010
IHH	Indian hedgehog	0.010
ZNF764	zinc finger protein 764	0.010
RARG	retinoic acid receptor, gamma	0.010	Mouse
SH3BP4	SH3-domain binding protein 4	0.010