IMP

Process View

Homo sapiens

20 genes annotated in human

respiratory tube development

The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "respiratory tube development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "respiratory tube development" (in gray)

Name	Description	Probability	Func Analog Organism
FGFR2	fibroblast growth factor receptor 2	0.995	Mouse
FGF1	fibroblast growth factor 1 (acidic)	0.946	Human
FHL2	four and a half LIM domains 2	0.869
NRP1	neuropilin 1	0.741
SMAD3	SMAD family member 3	0.632
JAG1	jagged 1	0.446
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.444	Mouse Rat
COL1A1	collagen, type I, alpha 1	0.413
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.346
BMP2	bone morphogenetic protein 2	0.344	Human
NCOR2	nuclear receptor corepressor 2	0.296	Mouse
ENG	endoglin	0.226
CREBBP	CREB binding protein	0.225
FLNA	filamin A, alpha	0.185
CYR61	cysteine-rich, angiogenic inducer, 61	0.170
NCOA6	nuclear receptor coactivator 6	0.168
FGFR1	fibroblast growth factor receptor 1	0.152	Mouse
ESR1	estrogen receptor 1	0.150
SRSF4	serine/arginine-rich splicing factor 4	0.146	Human
BMPR1A	bone morphogenetic protein receptor, type IA	0.145	Mouse
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.144
NCOA2	nuclear receptor coactivator 2	0.144
GH1	growth hormone 1	0.142	Rat
SORBS3	sorbin and SH3 domain containing 3	0.122
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.113	Mouse
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.113
SMAD2	SMAD family member 2	0.107	Mouse
FGF10	fibroblast growth factor 10	0.091
HNF4A	hepatocyte nuclear factor 4, alpha	0.090
PDZD11	PDZ domain containing 11	0.089
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.084
STK3	serine/threonine kinase 3	0.083
RPTOR	regulatory associated protein of MTOR, complex 1	0.080
GH2	growth hormone 2	0.072	Rat
KAT2B	K(lysine) acetyltransferase 2B	0.071
POLA2	polymerase (DNA directed), alpha 2 (70kD subunit)	0.065
CSH1	chorionic somatomammotropin hormone 1 (placental lactogen)	0.064	Rat
TTR	transthyretin	0.064
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.063
NCOA1	nuclear receptor coactivator 1	0.063
TGFB1	transforming growth factor, beta 1	0.062
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.059
FSTL1	follistatin-like 1	0.058
RARA	retinoic acid receptor, alpha	0.058
BMP4	bone morphogenetic protein 4	0.056
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.055
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.055
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.055	Mouse
DMD	dystrophin	0.053
SIRT1	sirtuin 1	0.051
FGF4	fibroblast growth factor 4	0.049	Human
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.046
PDGFC	platelet derived growth factor C	0.046
FGF8	fibroblast growth factor 8 (androgen-induced)	0.045
GATA4	GATA binding protein 4	0.044	Mouse
NLRC4	NLR family, CARD domain containing 4	0.044
ATXN1L	ataxin 1-like	0.044
SREBF2	sterol regulatory element binding transcription factor 2	0.044
MAML1	mastermind-like 1 (Drosophila)	0.043
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.041
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.041	Mouse
NCOR1	nuclear receptor corepressor 1	0.041
FHL3	four and a half LIM domains 3	0.041
PAX8	paired box 8	0.040
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.038
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.038
AR	androgen receptor	0.037
FOXO1	forkhead box O1	0.037
EP300	E1A binding protein p300	0.037	Mouse
RXRA	retinoid X receptor, alpha	0.036
ACVR1	activin A receptor, type I	0.035
ATXN1	ataxin 1	0.035	Mouse
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.033
TBX5	T-box 5	0.033	Mouse
ITGB5	integrin, beta 5	0.032
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.032
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.032	Human
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.031
FGF18	fibroblast growth factor 18	0.030
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.030
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.030
ELN	elastin	0.030
BMP7	bone morphogenetic protein 7	0.029
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.029
PPARA	peroxisome proliferator-activated receptor alpha	0.029
UTRN	utrophin	0.028
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.027
PUM1	pumilio homolog 1 (Drosophila)	0.027
SRSF2	serine/arginine-rich splicing factor 2	0.027
U2AF1	U2 small nuclear RNA auxiliary factor 1	0.026
PLCG1	phospholipase C, gamma 1	0.026
CCNE1	cyclin E1	0.026
FOXF1	forkhead box F1	0.025
FGF2	fibroblast growth factor 2 (basic)	0.025	Human Mouse
CSH2	chorionic somatomammotropin hormone 2	0.025	Rat
TCF4	transcription factor 4	0.025
PAPOLA	poly(A) polymerase alpha	0.025
MYOCD	myocardin	0.025	Mouse
HSPG2	heparan sulfate proteoglycan 2	0.023
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.023
KLF13	Kruppel-like factor 13	0.023
FBN1	fibrillin 1	0.023
CREB1	cAMP responsive element binding protein 1	0.022	Mouse
PTPRC	protein tyrosine phosphatase, receptor type, C	0.022
ITGB4	integrin, beta 4	0.021
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.021
COL2A1	collagen, type II, alpha 1	0.020
VEZF1	vascular endothelial zinc finger 1	0.020
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.020
FGF7	fibroblast growth factor 7	0.020
CSHL1	chorionic somatomammotropin hormone-like 1	0.020	Rat
FOXO3	forkhead box O3	0.019
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.019
TNRC6A	trinucleotide repeat containing 6A	0.019
DCN	decorin	0.019
WNT1	wingless-type MMTV integration site family, member 1	0.019	Human
CUL1	cullin 1	0.018
FGFR3	fibroblast growth factor receptor 3	0.018	Mouse
SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)	0.018
SMAD7	SMAD family member 7	0.018
POU5F1	POU class 5 homeobox 1	0.018
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.018
SFRP1	secreted frizzled-related protein 1	0.018
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.018
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.018
MED25	mediator complex subunit 25	0.018
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.017
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.017
MKL1	megakaryoblastic leukemia (translocation) 1	0.017
COL7A1	collagen, type VII, alpha 1	0.017
CIB1	calcium and integrin binding 1 (calmyrin)	0.016
LUM	lumican	0.016
SEC24D	SEC24 family, member D (S. cerevisiae)	0.016
PGR	progesterone receptor	0.016
SP1	Sp1 transcription factor	0.016	Mouse
PDIA3	protein disulfide isomerase family A, member 3	0.016
SMAD6	SMAD family member 6	0.015
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.015	Mouse
NCOA3	nuclear receptor coactivator 3	0.015
NKX3-1	NK3 homeobox 1	0.015
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.015
MYOD1	myogenic differentiation 1	0.014
FZD1	frizzled homolog 1 (Drosophila)	0.014	Rat
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.014
TNK2	tyrosine kinase, non-receptor, 2	0.014
FADS1	fatty acid desaturase 1	0.014
QKI	quaking homolog, KH domain RNA binding (mouse)	0.014
BRD4	bromodomain containing 4	0.014
PRKG1	protein kinase, cGMP-dependent, type I	0.014
CAV1	caveolin 1, caveolae protein, 22kDa	0.014
SRI	sorcin	0.014
CCDC6	coiled-coil domain containing 6	0.014
FN1	fibronectin 1	0.013
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.013
SMAD9	SMAD family member 9	0.013
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.013
JAG2	jagged 2	0.013
HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	0.013
PRKCZ	protein kinase C, zeta	0.013
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.013
PPP4C	protein phosphatase 4, catalytic subunit	0.013
ZFYVE9	zinc finger, FYVE domain containing 9	0.013
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.013
TGFB2	transforming growth factor, beta 2	0.013
ONECUT1	one cut homeobox 1	0.013
FOXD3	forkhead box D3	0.012
FADS2	fatty acid desaturase 2	0.012
FZD7	frizzled homolog 7 (Drosophila)	0.012
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.012
ERBB2IP	erbb2 interacting protein	0.012
NRP2	neuropilin 2	0.012
TGFB3	transforming growth factor, beta 3	0.012	Mouse
TRA2B	transformer 2 beta homolog (Drosophila)	0.012
GSC	goosecoid homeobox	0.012
TRIM11	tripartite motif containing 11	0.012
PPP1R12A	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.012
PTEN	phosphatase and tensin homolog	0.012
TDGF1	teratocarcinoma-derived growth factor 1	0.012
SCD	stearoyl-CoA desaturase (delta-9-desaturase)	0.012
RIC8A	resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)	0.012
COL3A1	collagen, type III, alpha 1	0.012
PSEN1	presenilin 1	0.012
ARIH1	ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)	0.012
CTGF	connective tissue growth factor	0.012	Mouse Rat
CDH5	cadherin 5, type 2 (vascular endothelium)	0.011
ARL4D	ADP-ribosylation factor-like 4D	0.011
SFTPB	surfactant protein B	0.011
ZEB2	zinc finger E-box binding homeobox 2	0.011
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.011
SFTPC	surfactant protein C	0.011
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.011
LRP1	low density lipoprotein receptor-related protein 1	0.011
WNT5A	wingless-type MMTV integration site family, member 5A	0.011	Mouse Rat
STC1	stanniocalcin 1	0.011
PDZK1	PDZ domain containing 1	0.011
ALX4	ALX homeobox 4	0.011
SETD2	SET domain containing 2	0.011
TNRC6B	trinucleotide repeat containing 6B	0.011
RB1	retinoblastoma 1	0.010
ZNF512B	zinc finger protein 512B	0.010
SEC24A	SEC24 family, member A (S. cerevisiae)	0.010
FGF3	fibroblast growth factor 3	0.010	Human
ARNT	aryl hydrocarbon receptor nuclear translocator	0.010
WNT11	wingless-type MMTV integration site family, member 11	0.010
FOXM1	forkhead box M1	0.010	Human
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.010	Mouse
PDGFA	platelet-derived growth factor alpha polypeptide	0.010	Mouse
BCAR1	breast cancer anti-estrogen resistance 1	0.010
PLEC	plectin	0.010
FLT4	fms-related tyrosine kinase 4	0.010