IMP

Process View

Homo sapiens

8 genes annotated in human

cell fate specification

The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cell fate specification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cell fate specification" (in gray)

Name	Description	Probability	Func Analog Organism
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.998	Worm
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.998	Mouse Worm Fly
FGFR2	fibroblast growth factor receptor 2	0.872	Fly
TP53	tumor protein p53	0.827
JAG1	jagged 1	0.681
PBX1	pre-B-cell leukemia homeobox 1	0.634	Worm Fly
AR	androgen receptor	0.596	Mouse
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.558
BBS10	Bardet-Biedl syndrome 10	0.514
TAL1	T-cell acute lymphocytic leukemia 1	0.440
POU3F2	POU class 3 homeobox 2	0.432	Human
BMP2	bone morphogenetic protein 2	0.417	Zebrafish Fly
SMAD4	SMAD family member 4	0.396
DAXX	death-domain associated protein	0.340
FOXD3	forkhead box D3	0.327
PDX1	pancreatic and duodenal homeobox 1	0.281
PAX3	paired box 3	0.256
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.237	Worm
SMAD1	SMAD family member 1	0.223	Fly
HDAC1	histone deacetylase 1	0.211
FGF1	fibroblast growth factor 1 (acidic)	0.193	Human
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.193
EP300	E1A binding protein p300	0.192
PSEN1	presenilin 1	0.189	Mouse
HDAC4	histone deacetylase 4	0.182
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.181
FGFR1	fibroblast growth factor receptor 1	0.156	Zebrafish Mouse Fly
PBK	PDZ binding kinase	0.152
SP1	Sp1 transcription factor	0.141
BMPR1A	bone morphogenetic protein receptor, type IA	0.134	Mouse Fly
NOTCH1	notch 1	0.133	Zebrafish Mouse Worm Fly
FOXA2	forkhead box A2	0.131	Mouse
POU5F1	POU class 5 homeobox 1	0.109
HDAC2	histone deacetylase 2	0.104
LRP6	low density lipoprotein receptor-related protein 6	0.098
HOXB9	homeobox B9	0.092
HCFC1	host cell factor C1 (VP16-accessory protein)	0.085
CREBBP	CREB binding protein	0.079
RAX	retina and anterior neural fold homeobox	0.075
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.072
PLCG1	phospholipase C, gamma 1	0.070
CSNK1E	casein kinase 1, epsilon	0.070
SOX2	SRY (sex determining region Y)-box 2	0.069
HOXA10	homeobox A10	0.066
AHR	aryl hydrocarbon receptor	0.064
TP73	tumor protein p73	0.059
MSX1	msh homeobox 1	0.058	Fly
MAP2K1	mitogen-activated protein kinase kinase 1	0.057
E2F4	E2F transcription factor 4, p107/p130-binding	0.056
SMAD7	SMAD family member 7	0.055
C2orf65	chromosome 2 open reading frame 65	0.054
RB1	retinoblastoma 1	0.054
CDK2	cyclin-dependent kinase 2	0.053
GDA	guanine deaminase	0.052
MYOD1	myogenic differentiation 1	0.051
BTBD2	BTB (POZ) domain containing 2	0.049
MEIS1	Meis homeobox 1	0.047	Worm
BMP7	bone morphogenetic protein 7	0.047	Zebrafish
HOXC11	homeobox C11	0.044
MEIS2	Meis homeobox 2	0.042	Worm
HOXA11	homeobox A11	0.041	Mouse
YAP1	Yes-associated protein 1	0.041	Fly
MDFI	MyoD family inhibitor	0.039
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.038	Worm
KDM1A	lysine (K)-specific demethylase 1A	0.037
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.036	Worm Fly
RBBP4	retinoblastoma binding protein 4	0.035	Worm
E2F6	E2F transcription factor 6	0.035
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.034	Worm Fly
PTCH1	patched 1	0.034
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.032
AXIN1	axin 1	0.031
RBL1	retinoblastoma-like 1 (p107)	0.031
CDX2	caudal type homeobox 2	0.030
HNF1A	HNF1 homeobox A	0.028
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.028
FGF3	fibroblast growth factor 3	0.028
NOTCH3	notch 3	0.027	Worm Fly
HIC1	hypermethylated in cancer 1	0.027
RUNX1	runt-related transcription factor 1	0.026
LBX1	ladybird homeobox 1	0.026	Mouse Fly
SETD8	SET domain containing (lysine methyltransferase) 8	0.026
TCF4	transcription factor 4	0.026	Worm
HOXD9	homeobox D9	0.025
SYK	spleen tyrosine kinase	0.024
APC	adenomatous polyposis coli	0.024	Worm
HOXD13	homeobox D13	0.023
FGF10	fibroblast growth factor 10	0.023	Human
SOX21	SRY (sex determining region Y)-box 21	0.022
NEUROG3	neurogenin 3	0.022
ZFPM1	zinc finger protein, multitype 1	0.022
ARID1A	AT rich interactive domain 1A (SWI-like)	0.021
HOXB13	homeobox B13	0.021
SIM2	single-minded homolog 2 (Drosophila)	0.021
GLI1	GLI family zinc finger 1	0.021	Zebrafish
OTP	orthopedia homeobox	0.021
LDB1	LIM domain binding 1	0.021
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.021	Fly
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.020	Worm
RBBP7	retinoblastoma binding protein 7	0.020	Worm
SUFU	suppressor of fused homolog (Drosophila)	0.020	Mouse
MAPK8	mitogen-activated protein kinase 8	0.020
FGF8	fibroblast growth factor 8 (androgen-induced)	0.020
GBX2	gastrulation brain homeobox 2	0.019
LHX5	LIM homeobox 5	0.019	Worm
LMX1A	LIM homeobox transcription factor 1, alpha	0.019
HOXC8	homeobox C8	0.019
CTNNBIP1	catenin, beta interacting protein 1	0.018
SOX4	SRY (sex determining region Y)-box 4	0.018	Human
BARX1	BARX homeobox 1	0.018
SFN	stratifin	0.018
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.018	Worm
WT1	Wilms tumor 1	0.017
GATA5	GATA binding protein 5	0.017
BTRC	beta-transducin repeat containing	0.017
INHBB	inhibin, beta B	0.017
KLHL12	kelch-like 12 (Drosophila)	0.017
MNX1	motor neuron and pancreas homeobox 1	0.017	Zebrafish Mouse
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.017	Worm
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.017
CDK9	cyclin-dependent kinase 9	0.017
SOX10	SRY (sex determining region Y)-box 10	0.016	Human
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.016
FGF2	fibroblast growth factor 2 (basic)	0.016
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.016
TLX2	T-cell leukemia homeobox 2	0.016
SIX1	SIX homeobox 1	0.015	Mouse
SH3BP4	SH3-domain binding protein 4	0.015
FOXB1	forkhead box B1	0.015
BHLHE23	basic helix-loop-helix family, member e23	0.015
NPAS1	neuronal PAS domain protein 1	0.015
PAX2	paired box 2	0.015	Mouse Fly
GATA2	GATA binding protein 2	0.014
SMAD2	SMAD family member 2	0.014
HPRT1	hypoxanthine phosphoribosyltransferase 1	0.014
SIX3	SIX homeobox 3	0.014
NOG	noggin	0.014	Zebrafish
FOXC1	forkhead box C1	0.014
HOXA9	homeobox A9	0.014
FOXL1	forkhead box L1	0.014
TWIST1	twist homolog 1 (Drosophila)	0.014	Worm
HES2	hairy and enhancer of split 2 (Drosophila)	0.014
POU3F3	POU class 3 homeobox 3	0.014	Human
NEUROG1	neurogenin 1	0.014
WNT5A	wingless-type MMTV integration site family, member 5A	0.013	Human Worm
FZD8	frizzled homolog 8 (Drosophila)	0.013	Human
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.013
MTA3	metastasis associated 1 family, member 3	0.013
STK36	serine/threonine kinase 36	0.013
FYN	FYN oncogene related to SRC, FGR, YES	0.013	Worm
BMP4	bone morphogenetic protein 4	0.013	Zebrafish Fly
ASCL1	achaete-scute complex homolog 1 (Drosophila)	0.013	Mouse Worm
UBQLN1	ubiquilin 1	0.012
HOXB6	homeobox B6	0.012
NKX6-1	NK6 homeobox 1	0.012	Mouse
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.012	Worm
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.012
LHX1	LIM homeobox 1	0.012	Worm
FOXF2	forkhead box F2	0.012
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.012
SOX1	SRY (sex determining region Y)-box 1	0.012	Human
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.012
EN1	engrailed homeobox 1	0.012	Worm
HOXD11	homeobox D11	0.012
SIX6	SIX homeobox 6	0.012
SFRP5	secreted frizzled-related protein 5	0.012
FOXF1	forkhead box F1	0.011
SFRP1	secreted frizzled-related protein 1	0.011
SOX11	SRY (sex determining region Y)-box 11	0.011	Human
HOXD12	homeobox D12	0.011	Fly
SIX5	SIX homeobox 5	0.011	Worm
NKX3-2	NK3 homeobox 2	0.011
POU4F1	POU class 4 homeobox 1	0.011	Human Mouse
DLX4	distal-less homeobox 4	0.011	Zebrafish
GATA4	GATA binding protein 4	0.011
TWIST2	twist homolog 2 (Drosophila)	0.011
PSEN2	presenilin 2 (Alzheimer disease 4)	0.011	Mouse
TBX1	T-box 1	0.011
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.011
NKX2-1	NK2 homeobox 1	0.010
LMX1B	LIM homeobox transcription factor 1, beta	0.010
ADAM17	ADAM metallopeptidase domain 17	0.010