IMP

Process View

Mus musculus

2 genes annotated in mouse

stem cell fate determination

The process in which a cell becomes capable of differentiating autonomously into a stem cell regardless of its environment; upon determination, the cell fate cannot be reversed.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "stem cell fate determination"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "stem cell fate determination" (in gray)

Name	Description	Probability	Func Analog Organism
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.964
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.920
Phox2a	paired-like homeobox 2a	0.900
Nrg1	neuregulin 1	0.884
Otx1	orthodenticle homolog 1 (Drosophila)	0.878
Otx2	orthodenticle homolog 2 (Drosophila)	0.797
Dll1	delta-like 1 (Drosophila)	0.795
En1	engrailed 1	0.753	Fly
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.730
Hes1	hairy and enhancer of split 1 (Drosophila)	0.698
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.669
Msx2	homeobox, msh-like 2	0.658
Jag1	jagged 1	0.570
Shh	sonic hedgehog	0.557
Ret	ret proto-oncogene	0.474
Emx1	empty spiracles homolog 1 (Drosophila)	0.445
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.439
Neurog2	neurogenin 2	0.403
Ptf1a	pancreas specific transcription factor, 1a	0.398
Pax2	paired box gene 2	0.380
Neurod1	neurogenic differentiation 1	0.336
Lmx1b	LIM homeobox transcription factor 1 beta	0.311
Fgf8	fibroblast growth factor 8	0.308
Cdk2	cyclin-dependent kinase 2	0.270
Braf	Braf transforming gene	0.245
Chd7	chromodomain helicase DNA binding protein 7	0.228
Zfp423	zinc finger protein 423	0.226
Ntf5	neurotrophin 5	0.220
Pax6	paired box gene 6	0.207
Fgf17	fibroblast growth factor 17	0.201
Foxg1	forkhead box G1	0.194
Dsg4	desmoglein 4	0.192
En2	engrailed 2	0.186	Fly
Dll4	delta-like 4 (Drosophila)	0.179
Psen2	presenilin 2	0.171
Pten	phosphatase and tensin homolog	0.153
Vti1a	vesicle transport through interaction with t-SNAREs homolog 1A (yeast)	0.153
Neurod4	neurogenic differentiation 4	0.141
Gbx2	gastrulation brain homeobox 2	0.140
Egfl7	EGF-like domain 7	0.138
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.136
Dst	dystonin	0.132
Foxc1	forkhead box C1	0.121
Sox2	SRY-box containing gene 2	0.110
Hoxa1	homeobox A1	0.107
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.100
Efnb2	ephrin B2	0.095
Lmx1a	LIM homeobox transcription factor 1 alpha	0.089
Isl1	ISL1 transcription factor, LIM/homeodomain	0.077
Lama5	laminin, alpha 5	0.074
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.070
Gata3	GATA binding protein 3	0.069
Hes3	hairy and enhancer of split 3 (Drosophila)	0.064
Egfr	epidermal growth factor receptor	0.062
Gabrb3	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	0.060
Phox2b	paired-like homeobox 2b	0.057
Hr	hairless	0.056
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.055
Dmbx1	diencephalon/mesencephalon homeobox 1	0.054
Tcra	T-cell receptor alpha chain	0.053
Fgfr1	fibroblast growth factor receptor 1	0.051
Wnt3	wingless-related MMTV integration site 3	0.049
Mid1	midline 1	0.048
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.046
Wnt1	wingless-related MMTV integration site 1	0.044
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.041
Sp6	trans-acting transcription factor 6	0.040
Foxp3	forkhead box P3	0.039
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.039
Foxo1	forkhead box O1	0.038
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.038
Notch1	Notch gene homolog 1 (Drosophila)	0.037	Fly
Tbx10	T-box 10	0.036
Sox11	SRY-box containing gene 11	0.036
Egr3	early growth response 3	0.035
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.035
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.035
Wnt9a	wingless-type MMTV integration site 9A	0.034
Gli2	GLI-Kruppel family member GLI2	0.032
Fgf4	fibroblast growth factor 4	0.032
Mixl1	Mix1 homeobox-like 1 (Xenopus laevis)	0.032
Bdnf	brain derived neurotrophic factor	0.031	Mouse
Htra3	HtrA serine peptidase 3	0.031
Pitx3	paired-like homeodomain transcription factor 3	0.031
Vti1b	vesicle transport through interaction with t-SNAREs 1B homolog	0.031
Sim2	single-minded homolog 2 (Drosophila)	0.030
Ikbkap	inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein	0.030
Selp	selectin, platelet	0.029
Klk4	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	0.029
Ikzf1	IKAROS family zinc finger 1	0.028
Btbd17	BTB (POZ) domain containing 17	0.028
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.027
Lhx5	LIM homeobox protein 5	0.027
Hoxb13	homeobox B13	0.027
Gdnf	glial cell line derived neurotrophic factor	0.027
Jag2	jagged 2	0.027
Zic1	zinc finger protein of the cerebellum 1	0.027
Sox3	SRY-box containing gene 3	0.025
Ntf3	neurotrophin 3	0.024	Mouse
Ptk7	PTK7 protein tyrosine kinase 7	0.024
Zic2	zinc finger protein of the cerebellum 2	0.024
Tcfap2c	transcription factor AP-2, gamma	0.024
4930504O13Rik	RIKEN cDNA 4930504O13 gene	0.024
Neurog3	neurogenin 3	0.023
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.023
Insm1	insulinoma-associated 1	0.023
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.023
Dmrt3	doublesex and mab-3 related transcription factor 3	0.022
Dlx4	distal-less homeobox 4	0.022
Gli1	GLI-Kruppel family member GLI1	0.022
Tcf15	transcription factor 15	0.022
Ccne1	cyclin E1	0.022	Fly
Pou2f3	POU domain, class 2, transcription factor 3	0.022
Hoxd11	homeobox D11	0.022
Lef1	lymphoid enhancer binding factor 1	0.022
Ntrk1	neurotrophic tyrosine kinase, receptor, type 1	0.021
Efnb1	ephrin B1	0.021
Socs1	suppressor of cytokine signaling 1	0.021
Gli3	GLI-Kruppel family member GLI3	0.021
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.021
Wdhd1	WD repeat and HMG-box DNA binding protein 1	0.020
Srsf3	serine/arginine-rich splicing factor 3	0.020
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.020
Fgf15	fibroblast growth factor 15	0.020
Trp73	transformation related protein 73	0.020
Lif	leukemia inhibitory factor	0.020
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.020
Ier5l	immediate early response 5-like	0.019
Cxcr7	chemokine (C-X-C motif) receptor 7	0.019
Hoxb2	homeobox B2	0.019
Hmga2	high mobility group AT-hook 2	0.019
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.019
Nrtn	neurturin	0.019
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.018
Pou4f3	POU domain, class 4, transcription factor 3	0.018
Tcf3	transcription factor 3	0.018
Nhlh1	nescient helix loop helix 1	0.018
Foxb1	forkhead box B1	0.018
Abl2	v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)	0.018
Ebf3	early B-cell factor 3	0.018
Neurog1	neurogenin 1	0.018
Foxd3	forkhead box D3	0.018
Gal	galanin	0.018
Prr12	proline rich 12	0.018
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.018
Grik3	glutamate receptor, ionotropic, kainate 3	0.018
Ccnf	cyclin F	0.018
Foxn1	forkhead box N1	0.018	Fly
Id4	inhibitor of DNA binding 4	0.018
Pou3f1	POU domain, class 3, transcription factor 1	0.017
Sgol1	shugoshin-like 1 (S. pombe)	0.017
Pvrl1	poliovirus receptor-related 1	0.017
Gja3	gap junction protein, alpha 3	0.017
Rb1	retinoblastoma 1	0.017
Phldb1	pleckstrin homology-like domain, family B, member 1	0.017
Krt14	keratin 14	0.017
Htr1b	5-hydroxytryptamine (serotonin) receptor 1B	0.017
Prox1	prospero-related homeobox 1	0.017
Hoxd13	homeobox D13	0.017
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.016
Nkx6-1	NK6 homeobox 1	0.016
Pou4f2	POU domain, class 4, transcription factor 2	0.016
Lin9	lin-9 homolog (C. elegans)	0.016
Pou4f1	POU domain, class 4, transcription factor 1	0.016
Snai1	snail homolog 1 (Drosophila)	0.016
Lyzl4	lysozyme-like 4	0.016
Foxd2	forkhead box D2	0.016
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.016
Bcl2	B-cell leukemia/lymphoma 2	0.016
Scube3	signal peptide, CUB domain, EGF-like 3	0.016
Sall4	sal-like 4 (Drosophila)	0.016
Irx4	Iroquois related homeobox 4 (Drosophila)	0.016
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.016
Krt15	keratin 15	0.016
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.016
Wnt6	wingless-related MMTV integration site 6	0.016
Plxnb3	plexin B3	0.016
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.016
Rag2	recombination activating gene 2	0.016
Caskin2	CASK-interacting protein 2	0.016
Lhx2	LIM homeobox protein 2	0.015
Dyrk1a	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	0.015
Pofut1	protein O-fucosyltransferase 1	0.015
BC024139	cDNA sequence BC024139	0.015
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.015
Hoxa4	homeobox A4	0.015
Emx2	empty spiracles homolog 2 (Drosophila)	0.015
Zbtb7c	zinc finger and BTB domain containing 7C	0.015
BC057022	cDNA sequence BC057022	0.015
Adamts7	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7	0.015
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.015
Zp3	zona pellucida glycoprotein 3	0.015
Tssk3	testis-specific serine kinase 3	0.015
Foxa3	forkhead box A3	0.015
Cdx1	caudal type homeobox 1	0.015
Cdk6	cyclin-dependent kinase 6	0.014
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.014
Htr6	5-hydroxytryptamine (serotonin) receptor 6	0.014
Onecut1	one cut domain, family member 1	0.014
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.014
Pthlh	parathyroid hormone-like peptide	0.014
Obsl1	obscurin-like 1	0.014
Wnt7a	wingless-related MMTV integration site 7A	0.014
Calca	calcitonin/calcitonin-related polypeptide, alpha	0.014
Sac3d1	SAC3 domain containing 1	0.014
Uncx	UNC homeobox	0.014
Pou5f1	POU domain, class 5, transcription factor 1	0.014
Ski	ski sarcoma viral oncogene homolog (avian)	0.014
Cenpq	centromere protein Q	0.014
5730559C18Rik	RIKEN cDNA 5730559C18 gene	0.014
Foxl2	forkhead box L2	0.014
Tbx2	T-box 2	0.014
2010317E24Rik	RIKEN cDNA 2010317E24 gene	0.014
Myod1	myogenic differentiation 1	0.014
Hes5	hairy and enhancer of split 5 (Drosophila)	0.013
Trp53	transformation related protein 53	0.013
Twist1	twist homolog 1 (Drosophila)	0.013
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.013
Il11	interleukin 11	0.013
Irx1	Iroquois related homeobox 1 (Drosophila)	0.013
Ddx4	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	0.013
Tex19.2	testis expressed gene 19.2	0.013
Sox8	SRY-box containing gene 8	0.013
Gata4	GATA binding protein 4	0.013
Cxcr4	chemokine (C-X-C motif) receptor 4	0.013
Rax	retina and anterior neural fold homeobox	0.013
Gas1	growth arrest specific 1	0.013
Ushbp1	Usher syndrome 1C binding protein 1	0.013
Asb16	ankyrin repeat and SOCS box-containing 16	0.013
Usp43	ubiquitin specific peptidase 43	0.013
Nos3	nitric oxide synthase 3, endothelial cell	0.013
Nppc	natriuretic peptide type C	0.013
Runx1	runt related transcription factor 1	0.013
Arl6ip6	ADP-ribosylation factor-like 6 interacting protein 6	0.013
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.013
Tctex1d4	Tctex1 domain containing 4	0.013
Tnxb	tenascin XB	0.013
Tbx18	T-box18	0.013
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.013
Cd70	CD70 antigen	0.012
Gsc	goosecoid homeobox	0.012
Foxd1	forkhead box D1	0.012
Tfdp1	transcription factor Dp 1	0.012
Ptch2	patched homolog 2	0.012
Bcl6b	B-cell CLL/lymphoma 6, member B	0.012
Tll2	tolloid-like 2	0.012
Tert	telomerase reverse transcriptase	0.012
Gigyf1	GRB10 interacting GYF protein 1	0.012
Mybl2	myeloblastosis oncogene-like 2	0.012
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.012
Sox1	SRY-box containing gene 1	0.012
Arsi	arylsulfatase i	0.012
Bard1	BRCA1 associated RING domain 1	0.012
Dock1	dedicator of cytokinesis 1	0.012
Amh	anti-Mullerian hormone	0.012
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.012
Evpl	envoplakin	0.012
Efna1	ephrin A1	0.012
Barhl2	BarH-like 2 (Drosophila)	0.012
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.012
Hoxd1	homeobox D1	0.012
Nes	nestin	0.012
Gdf15	growth differentiation factor 15	0.012
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.012
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.012
Hcrt	hypocretin	0.012
Brpf1	bromodomain and PHD finger containing, 1	0.012
Adcyap1	adenylate cyclase activating polypeptide 1	0.012
Notch3	Notch gene homolog 3 (Drosophila)	0.012	Fly
Cnpy1	canopy 1 homolog (zebrafish)	0.012
Muc5ac	mucin 5, subtypes A and C, tracheobronchial/gastric	0.012
Dck	deoxycytidine kinase	0.012
Tlx2	T-cell leukemia, homeobox 2	0.011
Galr1	galanin receptor 1	0.011
Treml1	triggering receptor expressed on myeloid cells-like 1	0.011
Gipc3	GIPC PDZ domain containing family, member 3	0.011
Slc22a13	solute carrier family 22 (organic cation transporter), member 13	0.011
Dkc1	dyskeratosis congenita 1, dyskerin homolog (human)	0.011
Bhlha15	basic helix-loop-helix family, member a15	0.011
Bhlha9	basic helix-loop-helix family, member a9	0.011
Arvcf	armadillo repeat gene deleted in velo-cardio-facial syndrome	0.011
Il23a	interleukin 23, alpha subunit p19	0.011
BC020535	cDNA sequence BC020535	0.011
Foxa2	forkhead box A2	0.011
Alx4	aristaless-like homeobox 4	0.011
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.011
Tal1	T-cell acute lymphocytic leukemia 1	0.011
Tal2	T-cell acute lymphocytic leukemia 2	0.011
Glis1	GLIS family zinc finger 1	0.011
Lhx9	LIM homeobox protein 9	0.011
Fndc7	fibronectin type III domain containing 7	0.011
Sall3	sal-like 3 (Drosophila)	0.011
Mxd3	Max dimerization protein 3	0.011
Fign	fidgetin	0.011
Krt82	keratin 82	0.011
Shank3	SH3/ankyrin domain gene 3	0.011
Sox7	SRY-box containing gene 7	0.011
Bbc3	BCL2 binding component 3	0.011
She	src homology 2 domain-containing transforming protein E	0.011
Col8a1	collagen, type VIII, alpha 1	0.011
Loxl3	lysyl oxidase-like 3	0.011
Samd4b	sterile alpha motif domain containing 4B	0.011
Adra2b	adrenergic receptor, alpha 2b	0.011
Ncor2	nuclear receptor co-repressor 2	0.011
Hdac1	histone deacetylase 1	0.011
Gm7325	predicted gene 7325	0.011
Zfhx3	zinc finger homeobox 3	0.011
Id2	inhibitor of DNA binding 2	0.011
Bhlhe23	basic helix-loop-helix family, member e23	0.011
Tmem217	transmembrane protein 217	0.011
Lig4	ligase IV, DNA, ATP-dependent	0.011
Tcl1	T-cell lymphoma breakpoint 1	0.011
Rcor2	REST corepressor 2	0.011
Kif26a	kinesin family member 26A	0.011
Etv1	ets variant gene 1	0.011
Lbx2	ladybird homeobox homolog 2 (Drosophila)	0.011
Robo4	roundabout homolog 4 (Drosophila)	0.010
Hoxb1	homeobox B1	0.010
Krtap9-3	keratin associated protein 9-3	0.010
Slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.010
Ccdc96	coiled-coil domain containing 96	0.010
Heyl	hairy/enhancer-of-split related with YRPW motif-like	0.010
Atp4a	ATPase, H+/K+ exchanging, gastric, alpha polypeptide	0.010
Nfib	nuclear factor I/B	0.010
Skor1	SKI family transcriptional corepressor 1	0.010
Cabp2	calcium binding protein 2	0.010
Asgr2	asialoglycoprotein receptor 2	0.010
Grk1	G protein-coupled receptor kinase 1	0.010
Fgd5	FYVE, RhoGEF and PH domain containing 5	0.010
Fst	follistatin	0.010
Il17a	interleukin 17A	0.010
Cyp27b1	cytochrome P450, family 27, subfamily b, polypeptide 1	0.010
Unc5c	unc-5 homolog C (C. elegans)	0.010
Rfwd2	ring finger and WD repeat domain 2	0.010
Xpa	xeroderma pigmentosum, complementation group A	0.010
Trim62	tripartite motif-containing 62	0.010
Plekha4	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	0.010
Nkx2-1	NK2 homeobox 1	0.010