IMP

Process View

Mus musculus

10 genes annotated in mouse

mitotic spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mitotic spindle organization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "mitotic spindle organization" (in gray)

Name	Description	Probability	Func Analog Organism
Ctnnb1	catenin (cadherin associated protein), beta 1	0.959	Worm
Ccna2	cyclin A2	0.610
Ccnb1	cyclin B1	0.536	Human Yeast
Cct7	chaperonin containing Tcp1, subunit 7 (eta)	0.488	Fly
Hspa8	heat shock protein 8	0.476
Mis18bp1	MIS18 binding protein 1	0.407
Plk4	polo-like kinase 4 (Drosophila)	0.398	Fly
Nde1	nuclear distribution gene E homolog 1 (A nidulans)	0.391	Fly
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.389
Cdk1	cyclin-dependent kinase 1	0.349
Trp53	transformation related protein 53	0.347
Rrm1	ribonucleotide reductase M1	0.346
Kif20a	kinesin family member 20A	0.328	Worm
Kif2c	kinesin family member 2C	0.319	Fly
Psmd4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.319
Kif11	kinesin family member 11	0.312	Human Worm Fly
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.281
Apc	adenomatosis polyposis coli	0.269	Worm
Kif4	kinesin family member 4	0.258	Worm Fly
Tgfb1	transforming growth factor, beta 1	0.256
Rpgrip1l	Rpgrip1-like	0.239
Axin1	axin 1	0.235	Worm
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.235
Smc4	structural maintenance of chromosomes 4	0.225
Ckap2	cytoskeleton associated protein 2	0.220
Lef1	lymphoid enhancer binding factor 1	0.214	Worm
Cct6a	chaperonin containing Tcp1, subunit 6a (zeta)	0.210
Smu1	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	0.206
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.201
Tmpo	thymopoietin	0.197
Prc1	protein regulator of cytokinesis 1	0.190	Worm Fly
Mcm7	minichromosome maintenance deficient 7 (S. cerevisiae)	0.184
Cct5	chaperonin containing Tcp1, subunit 5 (epsilon)	0.179	Fly
Aurkb	aurora kinase B	0.178	Human Fly
Pten	phosphatase and tensin homolog	0.176
Plk1	polo-like kinase 1 (Drosophila)	0.167	Worm Fly
Gsk3b	glycogen synthase kinase 3 beta	0.139	Worm
Spag5	sperm associated antigen 5	0.138
Racgap1	Rac GTPase-activating protein 1	0.132	Human Fly
Ran	RAN, member RAS oncogene family	0.131
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.122
Lmnb1	lamin B1	0.120
Ezh2	enhancer of zeste homolog 2 (Drosophila)	0.117
Ncaph	non-SMC condensin I complex, subunit H	0.116	Fly
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.107	Fly
Meox2	mesenchyme homeobox 2	0.102
Anln	anillin, actin binding protein	0.102
Smc1a	structural maintenance of chromosomes 1A	0.101
Top2a	topoisomerase (DNA) II alpha	0.098
Psmc3	proteasome (prosome, macropain) 26S subunit, ATPase 3	0.098
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.098
Kif22	kinesin family member 22	0.098
Pkd1	polycystic kidney disease 1 homolog	0.095
Cct3	chaperonin containing Tcp1, subunit 3 (gamma)	0.094	Fly
Stag1	stromal antigen 1	0.092
Pafah1b1	platelet-activating factor acetylhydrolase, isoform 1b, subunit 1	0.082	Worm
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.080	Fly
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.077
Nf1	neurofibromatosis 1	0.076
Fgfr1	fibroblast growth factor receptor 1	0.074
Vangl2	vang-like 2 (van gogh, Drosophila)	0.073
Msh2	mutS homolog 2 (E. coli)	0.070
Csf1	colony stimulating factor 1 (macrophage)	0.070
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.067
Kif23	kinesin family member 23	0.067	Human Worm Fly
Ppp1ca	protein phosphatase 1, catalytic subunit, alpha isoform	0.067
Hnrnpab	heterogeneous nuclear ribonucleoprotein A/B	0.067
Mybl2	myeloblastosis oncogene-like 2	0.065
Vangl1	vang-like 1 (van gogh, Drosophila)	0.064
D2Ertd750e	DNA segment, Chr 2, ERATO Doi 750, expressed	0.061
Cdk4	cyclin-dependent kinase 4	0.060
Brca1	breast cancer 1	0.060
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.059
Ccnb2	cyclin B2	0.059	Yeast
Stip1	stress-induced phosphoprotein 1	0.059
Tcp1	t-complex protein 1	0.059	Fly
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.057
Rad21	RAD21 homolog (S. pombe)	0.055
Hsp90aa1	heat shock protein 90, alpha (cytosolic), class A member 1	0.055	Fly
Rb1	retinoblastoma 1	0.051
Kdr	kinase insert domain protein receptor	0.051	Fly
Plcg2	phospholipase C, gamma 2	0.051
Usp9x	ubiquitin specific peptidase 9, X chromosome	0.050
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.048
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.048
Rad51ap1	RAD51 associated protein 1	0.045
Tacc3	transforming, acidic coiled-coil containing protein 3	0.044
Kif3a	kinesin family member 3A	0.043
Nuf2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.043
Eif3a	eukaryotic translation initiation factor 3, subunit A	0.042	Fly
Cenpn	centromere protein N	0.039
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.039
Anp32e	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	0.038
Ccnf	cyclin F	0.037
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.037
Ttk	Ttk protein kinase	0.037
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.036
Psmc2	proteasome (prosome, macropain) 26S subunit, ATPase 2	0.036
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.035
Ect2	ect2 oncogene	0.034
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.033	Fly
Foxm1	forkhead box M1	0.033
Tubb5	tubulin, beta 5	0.033
Eif4g1	eukaryotic translation initiation factor 4, gamma 1	0.033
Cdca5	cell division cycle associated 5	0.032
Ranbp1	RAN binding protein 1	0.032
Sae1	SUMO1 activating enzyme subunit 1	0.032
Rrm2	ribonucleotide reductase M2	0.032
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.031
Stil	Scl/Tal1 interrupting locus	0.031	Human Zebrafish
Zeb1	zinc finger E-box binding homeobox 1	0.031
Eif3b	eukaryotic translation initiation factor 3, subunit B	0.031
Pbk	PDZ binding kinase	0.031
Birc5	baculoviral IAP repeat-containing 5	0.031
Ccdc99	coiled-coil domain containing 99	0.030
Notch1	Notch gene homolog 1 (Drosophila)	0.030
Psen1	presenilin 1	0.029
Psmc5	protease (prosome, macropain) 26S subunit, ATPase 5	0.029
Smad7	MAD homolog 7 (Drosophila)	0.028
Tcf7	transcription factor 7, T-cell specific	0.028	Worm
Invs	inversin	0.028
Fam54a	family with sequence similarity 54, member A	0.027
Rpl7a	ribosomal protein L7A	0.027
Ube2c	ubiquitin-conjugating enzyme E2C	0.027
Psmd14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.027
Ptk2	PTK2 protein tyrosine kinase 2	0.026
Rac1	RAS-related C3 botulinum substrate 1	0.026
Cenpe	centromere protein E	0.026
1110004F10Rik	RIKEN cDNA 1110004F10 gene	0.026
Ptch1	patched homolog 1	0.026
Rpl11	ribosomal protein L11	0.025
Ptprq	protein tyrosine phosphatase, receptor type, Q	0.025
Ccnd1	cyclin D1	0.024
Skp1a	S-phase kinase-associated protein 1A	0.024
Pcna	proliferating cell nuclear antigen	0.024	Fly
Psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.024
Cenph	centromere protein H	0.023
Myh9	myosin, heavy polypeptide 9, non-muscle	0.023
Notch2	Notch gene homolog 2 (Drosophila)	0.023
Cacybp	calcyclin binding protein	0.023
Fam64a	family with sequence similarity 64, member A	0.023
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.023	Fly
Nop58	NOP58 ribonucleoprotein homolog (yeast)	0.023
Eif3d	eukaryotic translation initiation factor 3, subunit D	0.022
Macf1	microtubule-actin crosslinking factor 1	0.022
Psmb6	proteasome (prosome, macropain) subunit, beta type 6	0.022
Iqgap3	IQ motif containing GTPase activating protein 3	0.022
Ppih	peptidyl prolyl isomerase H	0.021
Gltscr2	glioma tumor suppressor candidate region gene 2	0.021
Rbm8a	RNA binding motif protein 8a	0.021
Chordc1	cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1	0.020
Diap3	diaphanous homolog 3 (Drosophila)	0.020
Stat6	signal transducer and activator of transcription 6	0.020
Mcm3	minichromosome maintenance deficient 3 (S. cerevisiae)	0.020
Strn3	striatin, calmodulin binding protein 3	0.020
Nap1l1	nucleosome assembly protein 1-like 1	0.020
Melk	maternal embryonic leucine zipper kinase	0.020
Ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.020	Human
Tra2b	transformer 2 beta homolog (Drosophila)	0.019
Syncrip	synaptotagmin binding, cytoplasmic RNA interacting protein	0.019
Cep55	centrosomal protein 55	0.019
Hif1a	hypoxia inducible factor 1, alpha subunit	0.019
Mgea5	meningioma expressed antigen 5 (hyaluronidase)	0.019
Smc2	structural maintenance of chromosomes 2	0.018	Fly
Smad3	MAD homolog 3 (Drosophila)	0.018
Cdkn3	cyclin-dependent kinase inhibitor 3	0.018
Ndel1	nuclear distribution gene E-like homolog 1 (A. nidulans)	0.018
Hsph1	heat shock 105kDa/110kDa protein 1	0.018
Srsf1	serine/arginine-rich splicing factor 1	0.018
Ooep	oocyte expressed protein homolog (dog)	0.018
Nup93	nucleoporin 93	0.017
Psmb7	proteasome (prosome, macropain) subunit, beta type 7	0.017
Psmc4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.017
Cbl	Casitas B-lineage lymphoma	0.017
Vhl	von Hippel-Lindau tumor suppressor	0.017	Fly
2810417H13Rik	RIKEN cDNA 2810417H13 gene	0.017
Flii	flightless I homolog (Drosophila)	0.017
Ctcf	CCCTC-binding factor	0.016
Usp1	ubiquitin specific peptidase 1	0.016
Stk11	serine/threonine kinase 11	0.016	Fly
Lbr	lamin B receptor	0.016
Rad18	RAD18 homolog (S. cerevisiae)	0.016
Ncapg	non-SMC condensin I complex, subunit G	0.016
Cct2	chaperonin containing Tcp1, subunit 2 (beta)	0.016	Fly
Psmb4	proteasome (prosome, macropain) subunit, beta type 4	0.016
Runx2	runt related transcription factor 2	0.016
Sfpq	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.015
Psmd12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	0.015
Kif5b	kinesin family member 5B	0.015
Spnb2	spectrin beta 2	0.015
Psma1	proteasome (prosome, macropain) subunit, alpha type 1	0.015
Mki67	antigen identified by monoclonal antibody Ki 67	0.015
Mns1	meiosis-specific nuclear structural protein 1	0.015
C330027C09Rik	RIKEN cDNA C330027C09 gene	0.015
Mastl	microtubule associated serine/threonine kinase-like	0.015
Ikzf1	IKAROS family zinc finger 1	0.015
Il6st	interleukin 6 signal transducer	0.015
Nf2	neurofibromatosis 2	0.015
Fmr1	fragile X mental retardation syndrome 1 homolog	0.015
Psma6	proteasome (prosome, macropain) subunit, alpha type 6	0.015
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.015
Ckap5	cytoskeleton associated protein 5	0.015
Bicc1	bicaudal C homolog 1 (Drosophila)	0.015
Col1a1	collagen, type I, alpha 1	0.014
Nsfl1c	NSFL1 (p97) cofactor (p47)	0.014
Prim2	DNA primase, p58 subunit	0.014
Foxp3	forkhead box P3	0.014
Ssrp1	structure specific recognition protein 1	0.014
Gtse1	G two S phase expressed protein 1	0.014
Msn	moesin	0.014	Fly
Rcc2	regulator of chromosome condensation 2	0.014
U2af1	U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1	0.014	Fly
Prkce	protein kinase C, epsilon	0.014
Vegfc	vascular endothelial growth factor C	0.014
Cbx5	chromobox homolog 5 (Drosophila HP1a)	0.014
Hars	histidyl-tRNA synthetase	0.014
Ska1	spindle and kinetochore associated complex subunit 1	0.014
Usp33	ubiquitin specific peptidase 33	0.014
Nup43	nucleoporin 43	0.014
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.014
Spna2	spectrin alpha 2	0.014
Hnrnpf	heterogeneous nuclear ribonucleoprotein F	0.014
Magoh	mago-nashi homolog, proliferation-associated (Drosophila)	0.014
Cenpf	centromere protein F	0.013
Sass6	spindle assembly 6 homolog (C. elegans)	0.013	Fly
Chek1	checkpoint kinase 1 homolog (S. pombe)	0.013
Epas1	endothelial PAS domain protein 1	0.013
Cdk2	cyclin-dependent kinase 2	0.013
Exo1	exonuclease 1	0.013
Ddx1	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	0.013
Ruvbl2	RuvB-like protein 2	0.013
Dtl	denticleless homolog (Drosophila)	0.013
Map3k3	mitogen-activated protein kinase kinase kinase 3	0.012
Cpsf2	cleavage and polyadenylation specific factor 2	0.012
Sox9	SRY-box containing gene 9	0.012
Myef2	myelin basic protein expression factor 2, repressor	0.012
Tcf19	transcription factor 19	0.012
Sgol1	shugoshin-like 1 (S. pombe)	0.012
Pole2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.012
Caprin1	cell cycle associated protein 1	0.012
Raf1	v-raf-leukemia viral oncogene 1	0.012
Xpo1	exportin 1, CRM1 homolog (yeast)	0.012
Depdc1a	DEP domain containing 1a	0.012
Psma7	proteasome (prosome, macropain) subunit, alpha type 7	0.012
H2afx	H2A histone family, member X	0.012
Tmem48	transmembrane protein 48	0.012
Tpx2	TPX2, microtubule-associated protein homolog (Xenopus laevis)	0.012
Rbl1	retinoblastoma-like 1 (p107)	0.012
Enah	enabled homolog (Drosophila)	0.011
Cdc5l	cell division cycle 5-like (S. pombe)	0.011
Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	0.011
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.011
Cdc7	cell division cycle 7 (S. cerevisiae)	0.011
Flt4	FMS-like tyrosine kinase 4	0.011	Fly
Hnrnph1	heterogeneous nuclear ribonucleoprotein H1	0.011
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.011
Hnrnpr	heterogeneous nuclear ribonucleoprotein R	0.011
Ncapd2	non-SMC condensin I complex, subunit D2	0.011
Fam83d	family with sequence similarity 83, member D	0.011
Wdr1	WD repeat domain 1	0.011
Psmc3ip	proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein	0.011
Gsg2	germ cell-specific gene 2	0.011
Cse1l	chromosome segregation 1-like (S. cerevisiae)	0.011
Smarca5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.011
Srsf3	serine/arginine-rich splicing factor 3	0.011
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.011
Ubap2	ubiquitin-associated protein 2	0.011
Rpl6	ribosomal protein L6	0.011
Cct8	chaperonin containing Tcp1, subunit 8 (theta)	0.010
Trip13	thyroid hormone receptor interactor 13	0.010
Kars	lysyl-tRNA synthetase	0.010
Srrt	serrate RNA effector molecule homolog (Arabidopsis)	0.010
Vasp	vasodilator-stimulated phosphoprotein	0.010
Hnrnpu	heterogeneous nuclear ribonucleoprotein U	0.010
Cdca2	cell division cycle associated 2	0.010
Tcerg1	transcription elongation regulator 1 (CA150)	0.010
Lat	linker for activation of T cells	0.010
Epb4.1l2	erythrocyte protein band 4.1-like 2	0.010
Rbbp8	retinoblastoma binding protein 8	0.010
Eme1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.010