IMP

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Mus musculus

0 genes annotated in mouse

dilated cardiomyopathy

DOID:12930

An intrinsic cardiomyopathy that results in damage to the myocardium causing the heart to pump blood inefficiently and characterized by an enlarged heart.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "dilated cardiomyopathy" (in gray)

Name	Description	Probability	Func Analog Organism
Notch1	Notch gene homolog 1 (Drosophila)	0.962
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.909
Actn2	actinin alpha 2	0.871
Actc1	actin, alpha, cardiac muscle 1	0.671
Cav3	caveolin 3	0.501
Hrc	histidine rich calcium binding protein	0.500
Ncstn	nicastrin	0.463
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.460
Sgcg	sarcoglycan, gamma (dystrophin-associated glycoprotein)	0.400
Pgam2	phosphoglycerate mutase 2	0.359
Ldb3	LIM domain binding 3	0.351	Human
Myl1	myosin, light polypeptide 1	0.346
Cox6a2	cytochrome c oxidase, subunit VI a, polypeptide 2	0.343
Ttn	titin	0.255
Tnnc1	troponin C, cardiac/slow skeletal	0.250	Human
Myh7	myosin, heavy polypeptide 7, cardiac muscle, beta	0.224	Human
Hspb8	heat shock protein 8	0.220
Sgca	sarcoglycan, alpha (dystrophin-associated glycoprotein)	0.219
Des	desmin	0.191	Human
Myom1	myomesin 1	0.179
Vegfa	vascular endothelial growth factor A	0.170
Prkce	protein kinase C, epsilon	0.168
Lama2	laminin, alpha 2	0.163
Myl3	myosin, light polypeptide 3	0.159
Casq2	calsequestrin 2	0.155
Csrp3	cysteine and glycine-rich protein 3	0.150	Human
Ankrd1	ankyrin repeat domain 1 (cardiac muscle)	0.147
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.121
Art1	ADP-ribosyltransferase 1	0.119
Dll1	delta-like 1 (Drosophila)	0.116
Ctnna1	catenin (cadherin associated protein), alpha 1	0.114
Myom2	myomesin 2	0.111
Notch2	Notch gene homolog 2 (Drosophila)	0.109
Snta1	syntrophin, acidic 1	0.109
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.106
Popdc3	popeye domain containing 3	0.105
Dmd	dystrophin, muscular dystrophy	0.102	Human
Hspb7	heat shock protein family, member 7 (cardiovascular)	0.085
Nrap	nebulin-related anchoring protein	0.079
Hspb2	heat shock protein 2	0.072
Col6a3	collagen, type VI, alpha 3	0.071
Ckm	creatine kinase, muscle	0.069
Tnnt2	troponin T2, cardiac	0.069	Human
Pdlim3	PDZ and LIM domain 3	0.064
Egfr	epidermal growth factor receptor	0.062
Dag1	dystroglycan 1	0.061
Meox2	mesenchyme homeobox 2	0.056
Myh1	myosin, heavy polypeptide 1, skeletal muscle, adult	0.055
Cav1	caveolin 1, caveolae protein	0.054
Tnnt3	troponin T3, skeletal, fast	0.053
Scn7a	sodium channel, voltage-gated, type VII, alpha	0.053
Cdh13	cadherin 13	0.050
Srpk3	serine/arginine-rich protein specific kinase 3	0.049
Psenen	presenilin enhancer 2 homolog (C. elegans)	0.048
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.047
Mstn	myostatin	0.047
Dysf	dysferlin	0.043
Aph1a	anterior pharynx defective 1a homolog (C. elegans)	0.042
Plec	plectin	0.041
Gja1	gap junction protein, alpha 1	0.041
Plin4	perilipin 4	0.041
Tcap	titin-cap	0.040	Human
Ptprb	protein tyrosine phosphatase, receptor type, B	0.040
Tnni1	troponin I, skeletal, slow 1	0.040
Rxrg	retinoid X receptor gamma	0.038
Mybpc3	myosin binding protein C, cardiac	0.037
Tnni2	troponin I, skeletal, fast 2	0.036
Kcnj8	potassium inwardly-rectifying channel, subfamily J, member 8	0.036
Acta1	actin, alpha 1, skeletal muscle	0.034
Erlin2	ER lipid raft associated 2	0.034
Tnni3	troponin I, cardiac 3	0.033
Myoz2	myozenin 2	0.033
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.032
Cox8b	cytochrome c oxidase, subunit VIIIb	0.032
Hras1	Harvey rat sarcoma virus oncogene 1	0.031
Fgf7	fibroblast growth factor 7	0.031
Lrp6	low density lipoprotein receptor-related protein 6	0.031
Ckmt2	creatine kinase, mitochondrial 2	0.031
Eef1a2	eukaryotic translation elongation factor 1 alpha 2	0.030
Ilk	integrin linked kinase	0.030
Fxyd1	FXYD domain-containing ion transport regulator 1	0.028
Sync	syncoilin	0.028
Dtna	dystrobrevin alpha	0.028
2310046A06Rik	RIKEN cDNA 2310046A06 gene	0.026
Kdr	kinase insert domain protein receptor	0.026
Bves	blood vessel epicardial substance	0.026
Hhatl	hedgehog acyltransferase-like	0.026
Itga7	integrin alpha 7	0.026
Smn1	survival motor neuron 1	0.026
Pdlim5	PDZ and LIM domain 5	0.025
Dsp	desmoplakin	0.025
Pitx2	paired-like homeodomain transcription factor 2	0.025
Mib1	mindbomb homolog 1 (Drosophila)	0.025
Map2k3	mitogen-activated protein kinase kinase 3	0.025
Hfe2	hemochromatosis type 2 (juvenile) (human homolog)	0.025
Pygm	muscle glycogen phosphorylase	0.025
Egln1	EGL nine homolog 1 (C. elegans)	0.024
Flnc	filamin C, gamma	0.024
Fktn	fukutin	0.024
Casq1	calsequestrin 1	0.024
Fzd4	frizzled homolog 4 (Drosophila)	0.023
Cnn1	calponin 1	0.023
Fkrp	fukutin related protein	0.022
Pln	phospholamban	0.022
Tpm2	tropomyosin 2, beta	0.022
Xirp1	xin actin-binding repeat containing 1	0.022
Gata6	GATA binding protein 6	0.022
Myf5	myogenic factor 5	0.022
Tnnt1	troponin T1, skeletal, slow	0.022
Art3	ADP-ribosyltransferase 3	0.022
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.022
Hopx	HOP homeobox	0.021
Nppa	natriuretic peptide type A	0.021
Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide	0.021
Txlnb	taxilin beta	0.020
Cryab	crystallin, alpha B	0.020
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.019
Ptrf	polymerase I and transcript release factor	0.019
Atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.019
Mapk8	mitogen-activated protein kinase 8	0.019
P2ry2	purinergic receptor P2Y, G-protein coupled 2	0.018
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.018
Dusp1	dual specificity phosphatase 1	0.018
Mrgprf	MAS-related GPR, member F	0.018
Fermt2	fermitin family homolog 2 (Drosophila)	0.018
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.018
Smpx	small muscle protein, X-linked	0.018
Rai2	retinoic acid induced 2	0.017
Kcnk3	potassium channel, subfamily K, member 3	0.017
Ptch1	patched homolog 1	0.017
Lmod2	leiomodin 2 (cardiac)	0.017
Mmp2	matrix metallopeptidase 2	0.016
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.016
Synpo2	synaptopodin 2	0.016
Alpk3	alpha-kinase 3	0.016
Tenc1	tensin like C1 domain-containing phosphatase	0.016
Mapkapk2	MAP kinase-activated protein kinase 2	0.016
Prkca	protein kinase C, alpha	0.016
Large	like-glycosyltransferase	0.016
Fbxo32	F-box protein 32	0.016
Sgcb	sarcoglycan, beta (dystrophin-associated glycoprotein)	0.016
Phka1	phosphorylase kinase alpha 1	0.016
Chuk	conserved helix-loop-helix ubiquitous kinase	0.016
Scd1	stearoyl-Coenzyme A desaturase 1	0.015
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.015
Capn3	calpain 3	0.015
Nfib	nuclear factor I/B	0.015
Fhl2	four and a half LIM domains 2	0.015
Psen1	presenilin 1	0.015	Human
Esam	endothelial cell-specific adhesion molecule	0.015
Tbx3	T-box 3	0.015
Trim54	tripartite motif-containing 54	0.015
Sspn	sarcospan	0.015
Aoc3	amine oxidase, copper containing 3	0.015
Cisd2	CDGSH iron sulfur domain 2	0.015
Mfap5	microfibrillar associated protein 5	0.015
Dmpk	dystrophia myotonica-protein kinase	0.015
Phkg1	phosphorylase kinase gamma 1	0.015
Itgb1bp2	integrin beta 1 binding protein 2	0.014
Fhod3	formin homology 2 domain containing 3	0.014
Pxn	paxillin	0.014
Epas1	endothelial PAS domain protein 1	0.014
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.014
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.014
Efna5	ephrin A5	0.014
Tcea3	transcription elongation factor A (SII), 3	0.014
Myl4	myosin, light polypeptide 4	0.014
Tnxb	tenascin XB	0.014
Flt1	FMS-like tyrosine kinase 1	0.014
Apobec2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2	0.014
Tmem182	transmembrane protein 182	0.013
Pparg	peroxisome proliferator activated receptor gamma	0.013
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.013
Homer1	homer homolog 1 (Drosophila)	0.013
Zbtb16	zinc finger and BTB domain containing 16	0.013
Hspa1b	heat shock protein 1B	0.013
Nos3	nitric oxide synthase 3, endothelial cell	0.013
Inpp5a	inositol polyphosphate-5-phosphatase A	0.013
Sntb2	syntrophin, basic 2	0.013
Cap2	CAP, adenylate cyclase-associated protein, 2 (yeast)	0.013
Ccl11	chemokine (C-C motif) ligand 11	0.013
Calr	calreticulin	0.013
Eno3	enolase 3, beta muscle	0.012
Ushbp1	Usher syndrome 1C binding protein 1	0.012
Myh11	myosin, heavy polypeptide 11, smooth muscle	0.012
Ogn	osteoglycin	0.012
Idua	iduronidase, alpha-L-	0.012
Fosl2	fos-like antigen 2	0.012
Prkcb	protein kinase C, beta	0.011
Corin	corin	0.011
Map3k6	mitogen-activated protein kinase kinase kinase 6	0.011
Id1	inhibitor of DNA binding 1	0.011
Tinagl1	tubulointerstitial nephritis antigen-like 1	0.011
Mapk12	mitogen-activated protein kinase 12	0.011
Kcnj2	potassium inwardly-rectifying channel, subfamily J, member 2	0.011
Adipoq	adiponectin, C1Q and collagen domain containing	0.011
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.011
Kbtbd10	kelch repeat and BTB (POZ) domain containing 10	0.011
Murc	muscle-related coiled-coil protein	0.011
Fabp3	fatty acid binding protein 3, muscle and heart	0.011
Akap7	A kinase (PRKA) anchor protein 7	0.011
Akt1	thymoma viral proto-oncogene 1	0.011
Actg2	actin, gamma 2, smooth muscle, enteric	0.011
Thrsp	thyroid hormone responsive SPOT14 homolog (Rattus)	0.011
Popdc2	popeye domain containing 2	0.010
Perp	PERP, TP53 apoptosis effector	0.010
Synpo2l	synaptopodin 2-like	0.010
Ryr2	ryanodine receptor 2, cardiac	0.010
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.010
Tnfrsf12a	tumor necrosis factor receptor superfamily, member 12a	0.010
Ltbp1	latent transforming growth factor beta binding protein 1	0.010