IMP

Process View

Mus musculus

17 genes annotated in mouse

organ maturation

A developmental process, independent of morphogenetic (shape) change, that is required for an organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "organ maturation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "organ maturation" (in gray)

Name	Description	Probability	Func Analog Organism
Rarg	retinoic acid receptor, gamma	0.899
Fgfr2	fibroblast growth factor receptor 2	0.800	Mouse
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.758
Shh	sonic hedgehog	0.756
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.729	Mouse
Arhgef11	Rho guanine nucleotide exchange factor (GEF) 11	0.704
Fgfr3	fibroblast growth factor receptor 3	0.592
Tbx1	T-box 1	0.522
Rxra	retinoid X receptor alpha	0.513
Pax3	paired box gene 3	0.441
Ednra	endothelin receptor type A	0.438
Fgfr1	fibroblast growth factor receptor 1	0.423	Mouse
Pthlh	parathyroid hormone-like peptide	0.420
Hand1	heart and neural crest derivatives expressed transcript 1	0.287
Pax2	paired box gene 2	0.264
Nrp1	neuropilin 1	0.261
Rara	retinoic acid receptor, alpha	0.256
Prrx1	paired related homeobox 1	0.246
Nf1	neurofibromatosis 1	0.238
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.222
Dchs1	dachsous 1 (Drosophila)	0.215
Dll1	delta-like 1 (Drosophila)	0.208
Eya1	eyes absent 1 homolog (Drosophila)	0.196
Hand2	heart and neural crest derivatives expressed transcript 2	0.180
Smad3	MAD homolog 3 (Drosophila)	0.177
Bmp4	bone morphogenetic protein 4	0.173
Sox9	SRY-box containing gene 9	0.166
Sox4	SRY-box containing gene 4	0.154
Rarb	retinoic acid receptor, beta	0.149
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.141
Mesp1	mesoderm posterior 1	0.137
Hoxa1	homeobox A1	0.120
Fat4	FAT tumor suppressor homolog 4 (Drosophila)	0.118
Foxc2	forkhead box C2	0.109
Scn5a	sodium channel, voltage-gated, type V, alpha	0.101
Dlx5	distal-less homeobox 5	0.101
Fgf10	fibroblast growth factor 10	0.073
Vegfa	vascular endothelial growth factor A	0.072
Wnt9b	wingless-type MMTV integration site 9B	0.068
Jag1	jagged 1	0.064
Bcl2	B-cell leukemia/lymphoma 2	0.063
Epha4	Eph receptor A4	0.060
Hoxa11	homeobox A11	0.059
Cacna1s	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.056
Hr	hairless	0.056
Timp1	tissue inhibitor of metalloproteinase 1	0.054
Zfpm2	zinc finger protein, multitype 2	0.054
Nos3	nitric oxide synthase 3, endothelial cell	0.053
Hoxa3	homeobox A3	0.052
Pbx1	pre B-cell leukemia transcription factor 1	0.050
Chd7	chromodomain helicase DNA binding protein 7	0.050
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.048
Notch1	Notch gene homolog 1 (Drosophila)	0.048
Plxna4	plexin A4	0.047	Mouse
Hoxd11	homeobox D11	0.046
Chrd	chordin	0.043
Idua	iduronidase, alpha-L-	0.042
Bmp5	bone morphogenetic protein 5	0.042
Smad4	MAD homolog 4 (Drosophila)	0.040
Sdc3	syndecan 3	0.039
Tbx3	T-box 3	0.039
Ece1	endothelin converting enzyme 1	0.038
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.037
Lef1	lymphoid enhancer binding factor 1	0.036
Fgf8	fibroblast growth factor 8	0.036
Sulf1	sulfatase 1	0.036
Pkdcc	protein kinase domain containing, cytoplasmic	0.036
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.035
Gata6	GATA binding protein 6	0.035	Mouse
Rgnef	Rho-guanine nucleotide exchange factor	0.035
Myadm	myeloid-associated differentiation marker	0.035
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.035
Emx2	empty spiracles homolog 2 (Drosophila)	0.034
Arhgef12	Rho guanine nucleotide exchange factor (GEF) 12	0.033
Hrc	histidine rich calcium binding protein	0.033
Lama5	laminin, alpha 5	0.031
Acvr1	activin A receptor, type 1	0.031
Axin2	axin2	0.031
Bmp7	bone morphogenetic protein 7	0.031
Vangl2	vang-like 2 (van gogh, Drosophila)	0.030
Tbx5	T-box 5	0.029
Edn3	endothelin 3	0.029
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.028
Vdr	vitamin D receptor	0.028
Thrb	thyroid hormone receptor beta	0.028
Clip2	CAP-GLY domain containing linker protein 2	0.027
Gdf11	growth differentiation factor 11	0.026
Fgf3	fibroblast growth factor 3	0.026
Ret	ret proto-oncogene	0.026
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.026
Gja1	gap junction protein, alpha 1	0.026
Tnni1	troponin I, skeletal, slow 1	0.026
Hoxb3	homeobox B3	0.026
Bmp2	bone morphogenetic protein 2	0.026	Human
Gata4	GATA binding protein 4	0.025	Mouse
Tgfb2	transforming growth factor, beta 2	0.025
Fgfrl1	fibroblast growth factor receptor-like 1	0.025
Guca2a	guanylate cyclase activator 2a (guanylin)	0.024
Lmx1a	LIM homeobox transcription factor 1 alpha	0.024
Pitx2	paired-like homeodomain transcription factor 2	0.023
Fbn2	fibrillin 2	0.023
Mdm2	transformed mouse 3T3 cell double minute 2	0.023
Npr2	natriuretic peptide receptor 2	0.023
Epha1	Eph receptor A1	0.023
Tgfbr2	transforming growth factor, beta receptor II	0.022
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.022
Tal1	T-cell acute lymphocytic leukemia 1	0.022
Npr1	natriuretic peptide receptor 1	0.021
Foxc1	forkhead box C1	0.021
Mgat3	mannoside acetylglucosaminyltransferase 3	0.020
Wnt5a	wingless-related MMTV integration site 5A	0.020
Duox2	dual oxidase 2	0.020
Stra6	stimulated by retinoic acid gene 6	0.020
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.020
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.020
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.020
Ltbp1	latent transforming growth factor beta binding protein 1	0.020
Srgap1	SLIT-ROBO Rho GTPase activating protein 1	0.019
Runx1	runt related transcription factor 1	0.019
Igl	immunoglobulin lambda chain complex	0.019
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.018
Lhx1	LIM homeobox protein 1	0.018
Mrc2	mannose receptor, C type 2	0.018
Ednrb	endothelin receptor type B	0.018
Casq2	calsequestrin 2	0.017
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.017
Kif27	kinesin family member 27	0.017
Dll4	delta-like 4 (Drosophila)	0.017
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.016
Hoxc9	homeobox C9	0.016
Mafb	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.016
Gli3	GLI-Kruppel family member GLI3	0.016
Nes	nestin	0.015
Msx1	homeobox, msh-like 1	0.015
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.015
Axl	AXL receptor tyrosine kinase	0.014
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.014
Apoa1	apolipoprotein A-I	0.014
Tcf21	transcription factor 21	0.014
Eln	elastin	0.014
Myb	myeloblastosis oncogene	0.014
Il6st	interleukin 6 signal transducer	0.014
Klf6	Kruppel-like factor 6	0.014
Rgs5	regulator of G-protein signaling 5	0.013
Prlr	prolactin receptor	0.013
Cxadr	coxsackie virus and adenovirus receptor	0.013
Pde3a	phosphodiesterase 3A, cGMP inhibited	0.013
Fbn1	fibrillin 1	0.013
Wdr1	WD repeat domain 1	0.013
Des	desmin	0.013
Vasp	vasodilator-stimulated phosphoprotein	0.013
Traf4	TNF receptor associated factor 4	0.013
Tcf7	transcription factor 7, T-cell specific	0.013
Fscn1	fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)	0.013
Gli2	GLI-Kruppel family member GLI2	0.013
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.013
Sim1	single-minded homolog 1 (Drosophila)	0.013
Ppara	peroxisome proliferator activated receptor alpha	0.013
Alx3	aristaless-like homeobox 3	0.012
Trp63	transformation related protein 63	0.012
Hoxd3	homeobox D3	0.012
Flt1	FMS-like tyrosine kinase 1	0.012
Slc17a8	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8	0.012
Ctsk	cathepsin K	0.012
Nkx2-1	NK2 homeobox 1	0.012
Ntf3	neurotrophin 3	0.012
Smad1	MAD homolog 1 (Drosophila)	0.012
Dbn1	drebrin 1	0.011
Bmp1	bone morphogenetic protein 1	0.011
Isl1	ISL1 transcription factor, LIM/homeodomain	0.011
Prrx2	paired related homeobox 2	0.011
Sstr4	somatostatin receptor 4	0.011
Jag2	jagged 2	0.011
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.011
Dlx2	distal-less homeobox 2	0.011
Nynrin	NYN domain and retroviral integrase containing	0.011
Mmp16	matrix metallopeptidase 16	0.011
Upk2	uroplakin 2	0.011
Egfr	epidermal growth factor receptor	0.011
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.011
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.011
Atoh8	atonal homolog 8 (Drosophila)	0.011
Sorbs3	sorbin and SH3 domain containing 3	0.011
Gpr56	G protein-coupled receptor 56	0.011
Sfrp4	secreted frizzled-related protein 4	0.011
Grb10	growth factor receptor bound protein 10	0.010
Lamc1	laminin, gamma 1	0.010
Mmp15	matrix metallopeptidase 15	0.010
Fzd1	frizzled homolog 1 (Drosophila)	0.010
Lasp1	LIM and SH3 protein 1	0.010
Tgfa	transforming growth factor alpha	0.010
Klf3	Kruppel-like factor 3 (basic)	0.010