IMP

Process View

Mus musculus

2 genes annotated in mouse

nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry

GO:1900164

A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, which contributes to the establishment of lateral mesoderm with respect to the left and right halves.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry" (in gray)

Name	Description	Probability	Func Analog Organism
Bmp4	bone morphogenetic protein 4	1.000
Shh	sonic hedgehog	1.000
Foxc1	forkhead box C1	1.000
Fgfr2	fibroblast growth factor receptor 2	1.000
Msx1	homeobox, msh-like 1	1.000
Smo	smoothened homolog (Drosophila)	1.000
Gli3	GLI-Kruppel family member GLI3	1.000
Fgf8	fibroblast growth factor 8	1.000
Pitx2	paired-like homeodomain transcription factor 2	1.000
Hand1	heart and neural crest derivatives expressed transcript 1	1.000
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	1.000
Hand2	heart and neural crest derivatives expressed transcript 2	1.000
Prrx1	paired related homeobox 1	1.000
Otx2	orthodenticle homolog 2 (Drosophila)	1.000
Tcfap2a	transcription factor AP-2, alpha	1.000
Tbx1	T-box 1	1.000
Chrd	chordin	1.000
Tgfb2	transforming growth factor, beta 2	1.000
Sox9	SRY-box containing gene 9	1.000
Foxc2	forkhead box C2	1.000
Fgfr1	fibroblast growth factor receptor 1	0.999
Msx2	homeobox, msh-like 2	0.999
Pax3	paired box gene 3	0.999
Dlx5	distal-less homeobox 5	0.999
Bmp7	bone morphogenetic protein 7	0.998	Mouse
Gli2	GLI-Kruppel family member GLI2	0.998
Eya1	eyes absent 1 homolog (Drosophila)	0.997
Ctnnb1	catenin (cadherin associated protein), beta 1	0.996
Fgfr3	fibroblast growth factor receptor 3	0.996
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.994
Prrx2	paired related homeobox 2	0.990
Pax2	paired box gene 2	0.989
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.988
Zeb1	zinc finger E-box binding homeobox 1	0.988
Foxh1	forkhead box H1	0.988
Gata4	GATA binding protein 4	0.987
Ednra	endothelin receptor type A	0.985
Gsc	goosecoid homeobox	0.984
Rarb	retinoic acid receptor, beta	0.982
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.980
Runx2	runt related transcription factor 2	0.955
Acvr1	activin A receptor, type 1	0.954
Zic3	zinc finger protein of the cerebellum 3	0.952
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.950
Meox2	mesenchyme homeobox 2	0.946
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.940
Ptch1	patched homolog 1	0.934
Rarg	retinoic acid receptor, gamma	0.930
Bmp2	bone morphogenetic protein 2	0.908
Jag1	jagged 1	0.906
Smad3	MAD homolog 3 (Drosophila)	0.902
Apc	adenomatosis polyposis coli	0.896
Smad4	MAD homolog 4 (Drosophila)	0.881
Alx4	aristaless-like homeobox 4	0.876
Nodal	nodal	0.865
Alx1	ALX homeobox 1	0.831
Pbx1	pre B-cell leukemia transcription factor 1	0.796
Nog	noggin	0.792
Vegfa	vascular endothelial growth factor A	0.786
Isl1	ISL1 transcription factor, LIM/homeodomain	0.772
Lhx1	LIM homeobox protein 1	0.771
Lrp6	low density lipoprotein receptor-related protein 6	0.753
Gdf1	growth differentiation factor 1	0.747
Tgfbr2	transforming growth factor, beta receptor II	0.740
Hoxa1	homeobox A1	0.714
Bmper	BMP-binding endothelial regulator	0.702
Gas1	growth arrest specific 1	0.605
Gbx2	gastrulation brain homeobox 2	0.554
Tbx15	T-box 15	0.553
Pax9	paired box gene 9	0.551
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.535
Vangl2	vang-like 2 (van gogh, Drosophila)	0.529
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.484
Hoxd13	homeobox D13	0.483
Bmp5	bone morphogenetic protein 5	0.442	Mouse
Mn1	meningioma 1	0.437
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.437
Gata6	GATA binding protein 6	0.435
Lmx1b	LIM homeobox transcription factor 1 beta	0.394
Col2a1	collagen, type II, alpha 1	0.358
Ntf3	neurotrophin 3	0.334
Gdf6	growth differentiation factor 6	0.325	Mouse
Gdf5	growth differentiation factor 5	0.317	Mouse
Mks1	Meckel syndrome, type 1	0.317
Hoxa13	homeobox A13	0.313
Rxra	retinoid X receptor alpha	0.297
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.271
Foxg1	forkhead box G1	0.268
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.267
Alx3	aristaless-like homeobox 3	0.254
Acvr2b	activin receptor IIB	0.251
Rara	retinoic acid receptor, alpha	0.250
En1	engrailed 1	0.212
Gpc3	glypican 3	0.199
Tbx3	T-box 3	0.197
Gdf3	growth differentiation factor 3	0.192
Mesp1	mesoderm posterior 1	0.187
Fgf15	fibroblast growth factor 15	0.178
Lef1	lymphoid enhancer binding factor 1	0.161
Smad6	MAD homolog 6 (Drosophila)	0.154
Wnt3a	wingless-related MMTV integration site 3A	0.154
Chd7	chromodomain helicase DNA binding protein 7	0.148
Megf8	multiple EGF-like-domains 8	0.147
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.147
Otx1	orthodenticle homolog 1 (Drosophila)	0.146
Hoxa2	homeobox A2	0.146
Lrp2	low density lipoprotein receptor-related protein 2	0.141
Tdgf1	teratocarcinoma-derived growth factor 1	0.139
Fgf10	fibroblast growth factor 10	0.137
Gdf7	growth differentiation factor 7	0.125	Mouse
Psen1	presenilin 1	0.125
Hoxa3	homeobox A3	0.122
Hoxb3	homeobox B3	0.122
Cfc1	cripto, FRL-1, cryptic family 1	0.118
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.116
Dlx6	distal-less homeobox 6	0.112
Fgfrl1	fibroblast growth factor receptor-like 1	0.111
Disp1	dispatched homolog 1 (Drosophila)	0.110
Crebbp	CREB binding protein	0.107
Efnb2	ephrin B2	0.105
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.098
Foxi3	forkhead box I3	0.097
Pitx1	paired-like homeodomain transcription factor 1	0.096
Sox11	SRY-box containing gene 11	0.093
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.092
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.092
Emid2	EMI domain containing 2	0.087
Gja1	gap junction protein, alpha 1	0.085
Itga3	integrin alpha 3	0.084
Wnt6	wingless-related MMTV integration site 6	0.082
Sall4	sal-like 4 (Drosophila)	0.081
Bmpr1b	bone morphogenetic protein receptor, type 1B	0.080
Ret	ret proto-oncogene	0.077
Fgf3	fibroblast growth factor 3	0.076
Dlx2	distal-less homeobox 2	0.075
Rdh10	retinol dehydrogenase 10 (all-trans)	0.074
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.074
Eomes	eomesodermin homolog (Xenopus laevis)	0.070
Tcf21	transcription factor 21	0.070
Efna4	ephrin A4	0.068
Kif3a	kinesin family member 3A	0.068
Wnt3	wingless-related MMTV integration site 3	0.068
Tcfap2c	transcription factor AP-2, gamma	0.067
Htt	huntingtin	0.065
Wt1	Wilms tumor 1 homolog	0.064
Wnt5a	wingless-related MMTV integration site 5A	0.063
Emx2	empty spiracles homolog 2 (Drosophila)	0.062
Nkx3-2	NK3 homeobox 2	0.062
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.060
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.060
Foxa2	forkhead box A2	0.059
Pcsk6	proprotein convertase subtilisin/kexin type 6	0.058
Npr2	natriuretic peptide receptor 2	0.058
Pthlh	parathyroid hormone-like peptide	0.056
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.054
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.053
Pten	phosphatase and tensin homolog	0.053
Fuz	fuzzy homolog (Drosophila)	0.052
Lefty1	left right determination factor 1	0.052
Ltbp1	latent transforming growth factor beta binding protein 1	0.049
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.049
Slc22a6	solute carrier family 22 (organic anion transporter), member 6	0.048
Hoxd11	homeobox D11	0.046
Ece1	endothelin converting enzyme 1	0.044
Acvr2a	activin receptor IIA	0.041
Fgf9	fibroblast growth factor 9	0.040
Hoxd3	homeobox D3	0.040
Tcf15	transcription factor 15	0.039
Mecom	MDS1 and EVI1 complex locus	0.039
Wnt1	wingless-related MMTV integration site 1	0.038
Pax6	paired box gene 6	0.038
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.038
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.038
Cldn6	claudin 6	0.038
Sox3	SRY-box containing gene 3	0.038
Ptk2	PTK2 protein tyrosine kinase 2	0.036
Fgf18	fibroblast growth factor 18	0.035
Trp63	transformation related protein 63	0.035
Hes1	hairy and enhancer of split 1 (Drosophila)	0.035
Dnahc11	dynein, axonemal, heavy chain 11	0.035
Foxf1a	forkhead box F1a	0.035
Esx1	extraembryonic, spermatogenesis, homeobox 1	0.034
En2	engrailed 2	0.034
Zfpm2	zinc finger protein, multitype 2	0.033
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.033
Ihh	Indian hedgehog	0.033
Tbx2	T-box 2	0.032
Foxf2	forkhead box F2	0.031
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.031
Mgrn1	mahogunin, ring finger 1	0.030
Npr3	natriuretic peptide receptor 3	0.030
Sox4	SRY-box containing gene 4	0.030
Rhox6	reproductive homeobox 6	0.030
Smad2	MAD homolog 2 (Drosophila)	0.029	Human
Hhex	hematopoietically expressed homeobox	0.029
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.029
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.029
Cilp2	cartilage intermediate layer protein 2	0.029
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.027
Fbln1	fibulin 1	0.027
Gli1	GLI-Kruppel family member GLI1	0.027
Efna2	ephrin A2	0.026
Axin1	axin 1	0.026
Cdx2	caudal type homeobox 2	0.026
Hoxa11	homeobox A11	0.025
Zfp503	zinc finger protein 503	0.025
Notch2	Notch gene homolog 2 (Drosophila)	0.025
Sox2	SRY-box containing gene 2	0.025
Yap1	yes-associated protein 1	0.024
Tead4	TEA domain family member 4	0.024
Nf1	neurofibromatosis 1	0.024
Fzd7	frizzled homolog 7 (Drosophila)	0.024
Rnf44	ring finger protein 44	0.024
Prop1	paired like homeodomain factor 1	0.023
Ybx2	Y box protein 2	0.023
She	src homology 2 domain-containing transforming protein E	0.023
Cer1	cerberus 1 homolog (Xenopus laevis)	0.023
Cdkn1c	cyclin-dependent kinase inhibitor 1C (P57)	0.023
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.022
T	brachyury	0.022
Hesx1	homeobox gene expressed in ES cells	0.022
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.022
Itga8	integrin alpha 8	0.022
Nrk	Nik related kinase	0.022
Tgfbr3	transforming growth factor, beta receptor III	0.021
Irs3	insulin receptor substrate 3	0.021
Axin2	axin2	0.020
Otp	orthopedia homolog (Drosophila)	0.020
Edn3	endothelin 3	0.020
Twist1	twist homolog 1 (Drosophila)	0.020
Acvr1b	activin A receptor, type 1B	0.020
Krt72-ps	keratin 72, pseudogene	0.019
Neurog1	neurogenin 1	0.019
Fmn1	formin 1	0.019
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.019
Ppap2b	phosphatidic acid phosphatase type 2B	0.019
Sox17	SRY-box containing gene 17	0.019
Pgap1	post-GPI attachment to proteins 1	0.019
Tulp1	tubby like protein 1	0.019
Rnf111	ring finger 111	0.018
Twist2	twist homolog 2 (Drosophila)	0.018
Trp53	transformation related protein 53	0.018
Apaf1	apoptotic peptidase activating factor 1	0.018
Hoxb6	homeobox B6	0.018
Utf1	undifferentiated embryonic cell transcription factor 1	0.018
Fgf5	fibroblast growth factor 5	0.018
Gabrr1	gamma-aminobutyric acid (GABA) C receptor, subunit rho 1	0.018
Uncx	UNC homeobox	0.018
Crhr2	corticotropin releasing hormone receptor 2	0.017
Barx1	BarH-like homeobox 1	0.017
Krt27	keratin 27	0.017
Sct	secretin	0.017
Crxos1	Crx opposite strand transcript 1	0.017
Sox7	SRY-box containing gene 7	0.017
Sfrp2	secreted frizzled-related protein 2	0.017
Osta	organic solute transporter alpha	0.017
Hoxd9	homeobox D9	0.017
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.017
Tecta	tectorin alpha	0.017
Phlda2	pleckstrin homology-like domain, family A, member 2	0.016
Lmx1a	LIM homeobox transcription factor 1 alpha	0.016
Pnliprp2	pancreatic lipase-related protein 2	0.016
Sfn	stratifin	0.016
Hoxa5	homeobox A5	0.016
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.016
Evx1	even skipped homeotic gene 1 homolog	0.016
Igfbp3	insulin-like growth factor binding protein 3	0.016
Nrtn	neurturin	0.015
Tal2	T-cell acute lymphocytic leukemia 2	0.015
Pth1r	parathyroid hormone 1 receptor	0.015
Fzd8	frizzled homolog 8 (Drosophila)	0.015
Stra8	stimulated by retinoic acid gene 8	0.015
Phox2b	paired-like homeobox 2b	0.014
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.014
Hoxa9	homeobox A9	0.014
Pax4	paired box gene 4	0.014
Adra2b	adrenergic receptor, alpha 2b	0.014
Pkd1	polycystic kidney disease 1 homolog	0.014
Scn7a	sodium channel, voltage-gated, type VII, alpha	0.014
Sox15	SRY-box containing gene 15	0.014
Gata5	GATA binding protein 5	0.014
Angpt1	angiopoietin 1	0.014
Gja3	gap junction protein, alpha 3	0.014
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.014
Amhr2	anti-Mullerian hormone type 2 receptor	0.014
Smad1	MAD homolog 1 (Drosophila)	0.014
Rac1	RAS-related C3 botulinum substrate 1	0.014
Gjb5	gap junction protein, beta 5	0.013
Lhx5	LIM homeobox protein 5	0.013
Tek	endothelial-specific receptor tyrosine kinase	0.013
Cdx1	caudal type homeobox 1	0.013
Dlg1	discs, large homolog 1 (Drosophila)	0.013
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.013
Capn9	calpain 9	0.013
Gcm1	glial cells missing homolog 1 (Drosophila)	0.013
Ptk7	PTK7 protein tyrosine kinase 7	0.013
Lama1	laminin, alpha 1	0.013
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.013
Btbd17	BTB (POZ) domain containing 17	0.013
Wnt4	wingless-related MMTV integration site 4	0.013
Tead2	TEA domain family member 2	0.013
Dlk1	delta-like 1 homolog (Drosophila)	0.013
Clcnka	chloride channel Ka	0.013
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.013
Fam171a1	family with sequence similarity 171, member A1	0.012
Esr2	estrogen receptor 2 (beta)	0.012
Dnahc5	dynein, axonemal, heavy chain 5	0.012
Wnt8a	wingless-related MMTV integration site 8A	0.012
Pkdcc	protein kinase domain containing, cytoplasmic	0.012
Drd4	dopamine receptor D4	0.012
Nr6a1	nuclear receptor subfamily 6, group A, member 1	0.012
Tshz1	teashirt zinc finger family member 1	0.012
Hoxb4	homeobox B4	0.012
Nos3	nitric oxide synthase 3, endothelial cell	0.012
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.012
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.012
Moxd2	monooxygenase, DBH-like 2	0.012
Irs1	insulin receptor substrate 1	0.012
Per3	period homolog 3 (Drosophila)	0.012
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.012
Invs	inversin	0.011
Ext1	exostoses (multiple) 1	0.011
Wnt11	wingless-related MMTV integration site 11	0.011
Hoxa10	homeobox A10	0.011
Dkk2	dickkopf homolog 2 (Xenopus laevis)	0.011
Ccdc85c	coiled-coil domain containing 85C	0.011
Pou5f1	POU domain, class 5, transcription factor 1	0.011
Col10a1	collagen, type X, alpha 1	0.011
Cited1	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	0.011	Mouse
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.011
Gast	gastrin	0.011
Igfbp5	insulin-like growth factor binding protein 5	0.011
Hoxc4	homeobox C4	0.011
Dppa3	developmental pluripotency-associated 3	0.011
Tcfap2b	transcription factor AP-2 beta	0.011
Osr1	odd-skipped related 1 (Drosophila)	0.011
Cnga3	cyclic nucleotide gated channel alpha 3	0.011
Chrdl2	chordin-like 2	0.011
Kremen2	kringle containing transmembrane protein 2	0.011
Bdkrb2	bradykinin receptor, beta 2	0.011
Cubn	cubilin (intrinsic factor-cobalamin receptor)	0.011
Lalba	lactalbumin, alpha	0.011
Cdh3	cadherin 3	0.011
Bglap-rs1	bone gamma-carboxyglutamate protein, related sequence 1	0.011
Smad7	MAD homolog 7 (Drosophila)	0.011
Klk6	kallikrein related-peptidase 6	0.011
Sox18	SRY-box containing gene 18	0.011
Hoxb13	homeobox B13	0.010
Fgf17	fibroblast growth factor 17	0.010
Hoxb9	homeobox B9	0.010
Hoxd12	homeobox D12	0.010
Col13a1	collagen, type XIII, alpha 1	0.010
Dpep3	dipeptidase 3	0.010
Hbb-bh1	hemoglobin Z, beta-like embryonic chain	0.010
Rem1	rad and gem related GTP binding protein 1	0.010
Peg10	paternally expressed 10	0.010
Prl4a1	prolactin family 4, subfamily a, member 1	0.010