IMP

Process View

Mus musculus

3 genes annotated in mouse

connective tissue replacement involved in inflammatory response wound healing

The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "connective tissue replacement involved in inflammatory response wound healing"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "connective tissue replacement involved in inflammatory response wound healing" (in gray)

Name	Description	Probability	Func Analog Organism
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.861
Vhl	von Hippel-Lindau tumor suppressor	0.593
Cxcl2	chemokine (C-X-C motif) ligand 2	0.485
Otp	orthopedia homolog (Drosophila)	0.434
Egln1	EGL nine homolog 1 (C. elegans)	0.428
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.366
Nos3	nitric oxide synthase 3, endothelial cell	0.328
Il1b	interleukin 1 beta	0.272	Mouse
Il1r1	interleukin 1 receptor, type I	0.253
Hif1a	hypoxia inducible factor 1, alpha subunit	0.238
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.199
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.197
Cxcl1	chemokine (C-X-C motif) ligand 1	0.193
Foxa2	forkhead box A2	0.183
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.147
F12	coagulation factor XII (Hageman factor)	0.133
Vegfa	vascular endothelial growth factor A	0.119
Fstl1	follistatin-like 1	0.117
Casp1	caspase 1	0.113
Lepr	leptin receptor	0.101
Lhx6	LIM homeobox protein 6	0.093
Ccl2	chemokine (C-C motif) ligand 2	0.085
Lyz2	lysozyme 2	0.079
Ptgs2	prostaglandin-endoperoxide synthase 2	0.074
Pitx1	paired-like homeodomain transcription factor 1	0.073
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.070
Slurp1	secreted Ly6/Plaur domain containing 1	0.068
Braf	Braf transforming gene	0.063
Gdnf	glial cell line derived neurotrophic factor	0.063
Egfr	epidermal growth factor receptor	0.059
Thbs1	thrombospondin 1	0.059
Phldb2	pleckstrin homology-like domain, family B, member 2	0.058
Il1a	interleukin 1 alpha	0.055
Rdh10	retinol dehydrogenase 10 (all-trans)	0.054
Epor	erythropoietin receptor	0.053
Arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.053
Wnk2	WNK lysine deficient protein kinase 2	0.051
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.051
Ccl7	chemokine (C-C motif) ligand 7	0.050
Asprv1	aspartic peptidase, retroviral-like 1	0.050
P4htm	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	0.049
Irg1	immunoresponsive gene 1	0.048
Gpr35	G protein-coupled receptor 35	0.047
Fpr1	formyl peptide receptor 1	0.047
Rb1	retinoblastoma 1	0.047
Selp	selectin, platelet	0.047
Efnb2	ephrin B2	0.047
Saa3	serum amyloid A 3	0.043
Clec4d	C-type lectin domain family 4, member d	0.042
Fgf8	fibroblast growth factor 8	0.042
Agxt	alanine-glyoxylate aminotransferase	0.041
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.041
Klf1	Kruppel-like factor 1 (erythroid)	0.041
Hbb-b1	hemoglobin, beta adult major chain	0.040
Kcnj12	potassium inwardly-rectifying channel, subfamily J, member 12	0.039
Flt1	FMS-like tyrosine kinase 1	0.039
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.038
Tpm4	tropomyosin 4	0.038
Slc27a1	solute carrier family 27 (fatty acid transporter), member 1	0.038
Slc7a11	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	0.038
Arnt	aryl hydrocarbon receptor nuclear translocator	0.037
Sftpc	surfactant associated protein C	0.035
Pls3	plastin 3 (T-isoform)	0.035
Btbd17	BTB (POZ) domain containing 17	0.035
Ctnnb1	catenin (cadherin associated protein), beta 1	0.034
Niacr1	niacin receptor 1	0.034
Tnfaip2	tumor necrosis factor, alpha-induced protein 2	0.034
Avp	arginine vasopressin	0.034
Tead4	TEA domain family member 4	0.033
Barx2	BarH-like homeobox 2	0.032
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.032
Ch25h	cholesterol 25-hydroxylase	0.032
Clps	colipase, pancreatic	0.031
Gck	glucokinase	0.031
Sumo1	SMT3 suppressor of mif two 3 homolog 1 (yeast)	0.031
Stat1	signal transducer and activator of transcription 1	0.031
Gdf15	growth differentiation factor 15	0.030
Kif12	kinesin family member 12	0.030
Chi3l1	chitinase 3-like 1	0.030
Plaur	plasminogen activator, urokinase receptor	0.030
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.030
Hbb-b2	hemoglobin, beta adult minor chain	0.030
Cxcl5	chemokine (C-X-C motif) ligand 5	0.030
Acsl4	acyl-CoA synthetase long-chain family member 4	0.029
Slpi	secretory leukocyte peptidase inhibitor	0.029
Proc	protein C	0.029
Pigr	polymeric immunoglobulin receptor	0.029
Sult5a1	sulfotransferase family 5A, member 1	0.029
Pkd2	polycystic kidney disease 2	0.028
Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	0.028
Wasf1	WASP family 1	0.028
Ank1	ankyrin 1, erythroid	0.028
Cd14	CD14 antigen	0.028
Adora2b	adenosine A2b receptor	0.027
Vax1	ventral anterior homeobox containing gene 1	0.027
Osmr	oncostatin M receptor	0.027
Tgm2	transglutaminase 2, C polypeptide	0.027
Adam17	a disintegrin and metallopeptidase domain 17	0.027
Insr	insulin receptor	0.027
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.026
2310002J15Rik	RIKEN cDNA 2310002J15 gene	0.026
Tgfa	transforming growth factor alpha	0.026
Adam9	a disintegrin and metallopeptidase domain 9 (meltrin gamma)	0.025
Cav1	caveolin 1, caveolae protein	0.025
Fpr2	formyl peptide receptor 2	0.025
Nhlh1	nescient helix loop helix 1	0.024
Foxd4	forkhead box D4	0.024
Ptprb	protein tyrosine phosphatase, receptor type, B	0.024
Tbx15	T-box 15	0.023
Tlr4	toll-like receptor 4	0.023
Kcns1	K+ voltage-gated channel, subfamily S, 1	0.023
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.023
Pou3f1	POU domain, class 3, transcription factor 1	0.023
Ccr1	chemokine (C-C motif) receptor 1	0.023
Grb10	growth factor receptor bound protein 10	0.023
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.022
Il6	interleukin 6	0.022
Itih1	inter-alpha trypsin inhibitor, heavy chain 1	0.022
Ghr	growth hormone receptor	0.022
1100001G20Rik	RIKEN cDNA 1100001G20 gene	0.021
Wt1	Wilms tumor 1 homolog	0.021
Clec4f	C-type lectin domain family 4, member f	0.021
Kcne1l	potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene	0.021
Msr1	macrophage scavenger receptor 1	0.020
Stat3	signal transducer and activator of transcription 3	0.020
Nrg3	neuregulin 3	0.020
Onecut1	one cut domain, family member 1	0.020
BC024139	cDNA sequence BC024139	0.020
Mdfic	MyoD family inhibitor domain containing	0.020
Col4a3	collagen, type IV, alpha 3	0.020
Cnn3	calponin 3, acidic	0.020
Nlrp3	NLR family, pyrin domain containing 3	0.020
Has1	hyaluronan synthase1	0.020
Krt25	keratin 25	0.020
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.020
Apom	apolipoprotein M	0.020
Sox17	SRY-box containing gene 17	0.020
Tnf	tumor necrosis factor	0.019
Foxf1a	forkhead box F1a	0.019
Fosl2	fos-like antigen 2	0.019
Slc22a1	solute carrier family 22 (organic cation transporter), member 1	0.019
Sall3	sal-like 3 (Drosophila)	0.019
Elovl3	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	0.019
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.019
Il12b	interleukin 12b	0.018
Fermt2	fermitin family homolog 2 (Drosophila)	0.018
Il1rn	interleukin 1 receptor antagonist	0.018	Mouse
Slc26a1	solute carrier family 26 (sulfate transporter), member 1	0.018
Aadat	aminoadipate aminotransferase	0.018
Il1r2	interleukin 1 receptor, type II	0.018
Tinagl1	tubulointerstitial nephritis antigen-like 1	0.018
Ugdh	UDP-glucose dehydrogenase	0.018
Rdh7	retinol dehydrogenase 7	0.018
Cxcl10	chemokine (C-X-C motif) ligand 10	0.018
Wnt9a	wingless-type MMTV integration site 9A	0.018
Ccl12	chemokine (C-C motif) ligand 12	0.018
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.018
Socs3	suppressor of cytokine signaling 3	0.018
Slc10a6	solute carrier family 10 (sodium/bile acid cotransporter family), member 6	0.018
Fgfr3	fibroblast growth factor receptor 3	0.018
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.018
Nkx6-1	NK6 homeobox 1	0.018
Asgr2	asialoglycoprotein receptor 2	0.017	Mouse
Adam10	a disintegrin and metallopeptidase domain 10	0.017
Tat	tyrosine aminotransferase	0.017
Adra2b	adrenergic receptor, alpha 2b	0.017
Fas	Fas (TNF receptor superfamily member 6)	0.017
AI118078	expressed sequence AI118078	0.017
Efna2	ephrin A2	0.017
Tgfbr1	transforming growth factor, beta receptor I	0.016
Tcfap2c	transcription factor AP-2, gamma	0.016
Vcam1	vascular cell adhesion molecule 1	0.016
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.016
Wwtr1	WW domain containing transcription regulator 1	0.016
Krt13	keratin 13	0.016
Slc4a3	solute carrier family 4 (anion exchanger), member 3	0.016
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.016
Krt16	keratin 16	0.016
Efna5	ephrin A5	0.015
Cdh4	cadherin 4	0.015
Ptk6	PTK6 protein tyrosine kinase 6	0.015
Cux2	cut-like homeobox 2	0.015
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.015
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.015
Pax3	paired box gene 3	0.015
Hpn	hepsin	0.015
BC021891	cDNA sequence BC021891	0.015
Cyp24a1	cytochrome P450, family 24, subfamily a, polypeptide 1	0.015
Cdh10	cadherin 10	0.015
Ephb2	Eph receptor B2	0.015
Col22a1	collagen, type XXII, alpha 1	0.015
Atoh8	atonal homolog 8 (Drosophila)	0.015
F10	coagulation factor X	0.015
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.015
Ereg	epiregulin	0.015
Areg	amphiregulin	0.015
Tlr2	toll-like receptor 2	0.014
Il1f9	interleukin 1 family, member 9	0.014
Mal	myelin and lymphocyte protein, T-cell differentiation protein	0.014
Socs1	suppressor of cytokine signaling 1	0.014
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.014
Irx1	Iroquois related homeobox 1 (Drosophila)	0.014
Wap	whey acidic protein	0.014
Irak4	interleukin-1 receptor-associated kinase 4	0.014
Sele	selectin, endothelial cell	0.014
Vnn3	vanin 3	0.014
Anxa10	annexin A10	0.014
Aldob	aldolase B, fructose-bisphosphate	0.014
Prss23	protease, serine, 23	0.014
Krt4	keratin 4	0.014
Rbms1	RNA binding motif, single stranded interacting protein 1	0.014
Ptp4a1	protein tyrosine phosphatase 4a1	0.014
Nfia	nuclear factor I/A	0.014
Zfr2	zinc finger RNA binding protein 2	0.014
Skil	SKI-like	0.014
Efnb1	ephrin B1	0.014
Pitx3	paired-like homeodomain transcription factor 3	0.014
Apoe	apolipoprotein E	0.014
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.014
Mas1	MAS1 oncogene	0.013
Rax	retina and anterior neural fold homeobox	0.013
Ptprg	protein tyrosine phosphatase, receptor type, G	0.013
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.013
Pten	phosphatase and tensin homolog	0.013
Nphs2	nephrosis 2 homolog, podocin (human)	0.013
Clic4	chloride intracellular channel 4 (mitochondrial)	0.013
Pou3f2	POU domain, class 3, transcription factor 2	0.013
Dab1	disabled homolog 1 (Drosophila)	0.013
Atp2c2	ATPase, Ca++ transporting, type 2C, member 2	0.013
Clic3	chloride intracellular channel 3	0.013
Lypd5	Ly6/Plaur domain containing 5	0.013
Adam11	a disintegrin and metallopeptidase domain 11	0.013
Gnmt	glycine N-methyltransferase	0.013
Myod1	myogenic differentiation 1	0.013
Hp	haptoglobin	0.013
Inhbe	inhibin beta E	0.013
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.013
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.013
Serpina3m	serine (or cysteine) peptidase inhibitor, clade A, member 3M	0.013
Neurog1	neurogenin 1	0.013
Mdfi	MyoD family inhibitor	0.013
Prkd1	protein kinase D1	0.012
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.012
Klf6	Kruppel-like factor 6	0.012
Ppara	peroxisome proliferator activated receptor alpha	0.012
Hmx1	H6 homeobox 1	0.012
Fzd9	frizzled homolog 9 (Drosophila)	0.012
Defb1	defensin beta 1	0.012
Adcy8	adenylate cyclase 8	0.012
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.012
Lcn13	lipocalin 13	0.012
Gabrd	gamma-aminobutyric acid (GABA) A receptor, subunit delta	0.012
Plscr1	phospholipid scramblase 1	0.012
Serpinb6c	serine (or cysteine) peptidase inhibitor, clade B, member 6c	0.012
Tns1	tensin 1	0.012
Trhde	TRH-degrading enzyme	0.012
Fitm1	fat storage-inducing transmembrane protein 1	0.012
Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide	0.012
Ccdc96	coiled-coil domain containing 96	0.012
Il11	interleukin 11	0.012
Mst1	macrophage stimulating 1 (hepatocyte growth factor-like)	0.012
Lhx1	LIM homeobox protein 1	0.012
Rptn	repetin	0.012
S100a14	S100 calcium binding protein A14	0.012
Ppl	periplakin	0.012
Fgfr2	fibroblast growth factor receptor 2	0.012
Ccl4	chemokine (C-C motif) ligand 4	0.012
Cyr61	cysteine rich protein 61	0.012
Sim2	single-minded homolog 2 (Drosophila)	0.011	Mouse
Alppl2	alkaline phosphatase, placental-like 2	0.011
Sost	sclerostin	0.011
Hmx3	H6 homeobox 3	0.011
Prss29	protease, serine, 29	0.011
Shd	src homology 2 domain-containing transforming protein D	0.011
Notch2	Notch gene homolog 2 (Drosophila)	0.011
Gsdma	gasdermin A	0.011
Sox7	SRY-box containing gene 7	0.011
Irx2	Iroquois related homeobox 2 (Drosophila)	0.011
Igf2	insulin-like growth factor 2	0.011
Tsks	testis-specific serine kinase substrate	0.011
Drd3	dopamine receptor D3	0.011
Cdh5	cadherin 5	0.011
Xirp1	xin actin-binding repeat containing 1	0.011
Csf3	colony stimulating factor 3 (granulocyte)	0.011
Mat1a	methionine adenosyltransferase I, alpha	0.011
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.011
Gsx1	GS homeobox 1	0.011
Lcn2	lipocalin 2	0.011
Marco	macrophage receptor with collagenous structure	0.011
Wnt3	wingless-related MMTV integration site 3	0.011
Rdh16	retinol dehydrogenase 16	0.011
Gbp5	guanylate binding protein 5	0.011
Tbx20	T-box 20	0.011
Fos	FBJ osteosarcoma oncogene	0.011
Gata6	GATA binding protein 6	0.011
Ptprm	protein tyrosine phosphatase, receptor type, M	0.011
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.011
Bai3	brain-specific angiogenesis inhibitor 3	0.010
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.010
Eya4	eyes absent 4 homolog (Drosophila)	0.010
F8	coagulation factor VIII	0.010
Obfc2a	oligonucleotide/oligosaccharide-binding fold containing 2A	0.010
Serpinb2	serine (or cysteine) peptidase inhibitor, clade B, member 2	0.010
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.010
Pax7	paired box gene 7	0.010
Hnf4a	hepatic nuclear factor 4, alpha	0.010
Crct1	cysteine-rich C-terminal 1	0.010
Gata2	GATA binding protein 2	0.010
Hbegf	heparin-binding EGF-like growth factor	0.010
Tcfec	transcription factor EC	0.010