IMP

Process View

Mus musculus

10 genes annotated in mouse

type i interferon signaling pathway

A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "type i interferon signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "type i interferon signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Stat3	signal transducer and activator of transcription 3	0.999	Mouse
Irf9	interferon regulatory factor 9	0.997	Mouse
Stat1	signal transducer and activator of transcription 1	0.978
Stat5b	signal transducer and activator of transcription 5B	0.946	Mouse
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.931
Fas	Fas (TNF receptor superfamily member 6)	0.931
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.903
Myd88	myeloid differentiation primary response gene 88	0.892
Stat2	signal transducer and activator of transcription 2	0.806	Mouse
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.785
Stat5a	signal transducer and activator of transcription 5A	0.773	Mouse
Lyz2	lysozyme 2	0.763
Stat6	signal transducer and activator of transcription 6	0.610	Mouse
Il6st	interleukin 6 signal transducer	0.596
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.594
Il1r1	interleukin 1 receptor, type I	0.544
Csf1	colony stimulating factor 1 (macrophage)	0.478
Foxp3	forkhead box P3	0.473
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.326
Trim21	tripartite motif-containing 21	0.324
Batf	basic leucine zipper transcription factor, ATF-like	0.322
Uba7	ubiquitin-like modifier activating enzyme 7	0.307
Irf7	interferon regulatory factor 7	0.295
Socs3	suppressor of cytokine signaling 3	0.287
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.275
Irf1	interferon regulatory factor 1	0.250	Mouse
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.236
Lepr	leptin receptor	0.232
Pparg	peroxisome proliferator activated receptor gamma	0.231
Il4ra	interleukin 4 receptor, alpha	0.224
Ncoa3	nuclear receptor coactivator 3	0.222
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.200
Ifitm2	interferon induced transmembrane protein 2	0.197
Il6	interleukin 6	0.191
Ticam1	toll-like receptor adaptor molecule 1	0.181
Parp14	poly (ADP-ribose) polymerase family, member 14	0.153
Usp18	ubiquitin specific peptidase 18	0.143
Igtp	interferon gamma induced GTPase	0.143
Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.132
Unc93b1	unc-93 homolog B1 (C. elegans)	0.129
Il10	interleukin 10	0.123
Sfpi1	SFFV proviral integration 1	0.120
Parp12	poly (ADP-ribose) polymerase family, member 12	0.118
1810019J16Rik	RIKEN cDNA 1810019J16 gene	0.115
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.112
Bcl3	B-cell leukemia/lymphoma 3	0.105
Lep	leptin	0.105
Icam1	intercellular adhesion molecule 1	0.102
Ccl2	chemokine (C-C motif) ligand 2	0.102
Trp53	transformation related protein 53	0.099
Tnf	tumor necrosis factor	0.088
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.088
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.086
Ikzf1	IKAROS family zinc finger 1	0.085
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.083
Irgm2	immunity-related GTPase family M member 2	0.075
Irgm1	immunity-related GTPase family M member 1	0.074
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.067
Ifnar1	interferon (alpha and beta) receptor 1	0.066
Jak2	Janus kinase 2	0.064
Tapbp	TAP binding protein	0.063
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.061
Parp10	poly (ADP-ribose) polymerase family, member 10	0.061
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.055
Il17ra	interleukin 17 receptor A	0.053
Ptgs2	prostaglandin-endoperoxide synthase 2	0.053
Arid1b	AT rich interactive domain 1B (SWI-like)	0.052
Ifnar2	interferon (alpha and beta) receptor 2	0.051
Jak3	Janus kinase 3	0.051
BC006779	cDNA sequence BC006779	0.051
Ar	androgen receptor	0.050
Traf3	TNF receptor-associated factor 3	0.046
Casp8	caspase 8	0.045
Cd44	CD44 antigen	0.045
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.044
Samhd1	SAM domain and HD domain, 1	0.042
Hif1a	hypoxia inducible factor 1, alpha subunit	0.041
Ddx58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.041
Ifi35	interferon-induced protein 35	0.039
Ghr	growth hormone receptor	0.038
Mmp9	matrix metallopeptidase 9	0.038
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.038
Il27ra	interleukin 27 receptor, alpha	0.038
Znfx1	zinc finger, NFX1-type containing 1	0.037
Tor3a	torsin family 3, member A	0.036
H2-K1	histocompatibility 2, K1, K region	0.034
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.034
Tgfb1	transforming growth factor, beta 1	0.033
Junb	Jun-B oncogene	0.032
Jak1	Janus kinase 1	0.032
Ikbkb	inhibitor of kappaB kinase beta	0.032
Nckap1l	NCK associated protein 1 like	0.032
Vdr	vitamin D receptor	0.032
Itgal	integrin alpha L	0.031
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.031
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.031
Nfil3	nuclear factor, interleukin 3, regulated	0.030
Tlr4	toll-like receptor 4	0.030
Oas1a	2'-5' oligoadenylate synthetase 1A	0.028
Irf8	interferon regulatory factor 8	0.028	Mouse
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.027
Zfp36	zinc finger protein 36	0.027
Trim30a	tripartite motif-containing 30A	0.027
Ifi47	interferon gamma inducible protein 47	0.026
Mx1	myxovirus (influenza virus) resistance 1	0.025
Gbp7	guanylate binding protein 7	0.024
Pml	promyelocytic leukemia	0.024
Ikbkg	inhibitor of kappaB kinase gamma	0.023
Lgals9	lectin, galactose binding, soluble 9	0.023
Tmem173	transmembrane protein 173	0.022
Ifng	interferon gamma	0.022
Ccr2	chemokine (C-C motif) receptor 2	0.022
Adar	adenosine deaminase, RNA-specific	0.021
Sp100	nuclear antigen Sp100	0.021
Dock2	dedicator of cyto-kinesis 2	0.021
Ccl5	chemokine (C-C motif) ligand 5	0.020
Plac8	placenta-specific 8	0.020
Gbp2	guanylate binding protein 2	0.020
Igh	immunoglobulin heavy chain complex	0.020
Crebbp	CREB binding protein	0.019
Irf4	interferon regulatory factor 4	0.019	Mouse
Plcg2	phospholipase C, gamma 2	0.019
Slfn2	schlafen 2	0.019
Birc3	baculoviral IAP repeat-containing 3	0.018
Tapbpl	TAP binding protein-like	0.017
Hck	hemopoietic cell kinase	0.017
Cd274	CD274 antigen	0.017
Rsad2	radical S-adenosyl methionine domain containing 2	0.016
Oasl2	2'-5' oligoadenylate synthetase-like 2	0.016
Ifi27l2a	interferon, alpha-inducible protein 27 like 2A	0.016
Itgb2	integrin beta 2	0.016
Esr1	estrogen receptor 1 (alpha)	0.016
Cd72	CD72 antigen	0.016
Serpina3g	serine (or cysteine) peptidase inhibitor, clade A, member 3G	0.015
Rtp4	receptor transporter protein 4	0.015
Cd19	CD19 antigen	0.015
Ciita	class II transactivator	0.015
Shisa5	shisa homolog 5 (Xenopus laevis)	0.015
Apobec3	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3	0.015
Psmb10	proteasome (prosome, macropain) subunit, beta type 10	0.014
Rnf31	ring finger protein 31	0.014
Epsti1	epithelial stromal interaction 1 (breast)	0.014
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.014
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.014
C3	complement component 3	0.014
Socs1	suppressor of cytokine signaling 1	0.013
Trim26	tripartite motif-containing 26	0.013
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.013
Kit	kit oncogene	0.012
Hmha1	histocompatibility (minor) HA-1	0.012
Daxx	Fas death domain-associated protein	0.012
Traf6	TNF receptor-associated factor 6	0.012
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.012
Lef1	lymphoid enhancer binding factor 1	0.012
Dtx3l	deltex 3-like (Drosophila)	0.012
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.011
Ldlr	low density lipoprotein receptor	0.011
BC013712	cDNA sequence BC013712	0.011
Pyhin1	pyrin and HIN domain family, member 1	0.011
Pim1	proviral integration site 1	0.011
Herc6	hect domain and RLD 6	0.011
Irf5	interferon regulatory factor 5	0.011	Mouse
Cxcl10	chemokine (C-X-C motif) ligand 10	0.011
Prlr	prolactin receptor	0.011
Trim30d	tripartite motif-containing 30D	0.011
Stk10	serine/threonine kinase 10	0.011
Plagl2	pleiomorphic adenoma gene-like 2	0.011
Smad3	MAD homolog 3 (Drosophila)	0.011
Prkcd	protein kinase C, delta	0.010
Smad4	MAD homolog 4 (Drosophila)	0.010
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.010
Cmpk2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.010
Parp9	poly (ADP-ribose) polymerase family, member 9	0.010