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Mus musculus

4 genes annotated in mouse

Multi-species View

negative regulation of stem cell maintenance

GO:1902455

Any process that stops, prevents or reduces the frequency, rate or extent of stem cell maintenance.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of stem cell maintenance"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of stem cell maintenance" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	1.000
Bmp7	bone morphogenetic protein 7	0.999
Hand1	heart and neural crest derivatives expressed transcript 1	0.999
Fgfr2	fibroblast growth factor receptor 2	0.999
Msx1	homeobox, msh-like 1	0.997
Foxc1	forkhead box C1	0.995
Bmp4	bone morphogenetic protein 4	0.994
Eya1	eyes absent 1 homolog (Drosophila)	0.994
Pax3	paired box gene 3	0.988
Dlx5	distal-less homeobox 5	0.983
Tbx1	T-box 1	0.980
Prrx1	paired related homeobox 1	0.974
Zeb1	zinc finger E-box binding homeobox 1	0.960
Rarg	retinoic acid receptor, gamma	0.957
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.956
Gli3	GLI-Kruppel family member GLI3	0.941
Otx2	orthodenticle homolog 2 (Drosophila)	0.933
Fgfr3	fibroblast growth factor receptor 3	0.919
Hand2	heart and neural crest derivatives expressed transcript 2	0.914
Lhx1	LIM homeobox protein 1	0.912
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.892
Fgf8	fibroblast growth factor 8	0.889
Emx2	empty spiracles homolog 2 (Drosophila)	0.833
Smo	smoothened homolog (Drosophila)	0.816
Chrd	chordin	0.812
Foxc2	forkhead box C2	0.790
Rarb	retinoic acid receptor, beta	0.757
Fgfr1	fibroblast growth factor receptor 1	0.755
Hoxd13	homeobox D13	0.723
Gli2	GLI-Kruppel family member GLI2	0.688
Prrx2	paired related homeobox 2	0.664
Ptch1	patched homolog 1	0.654
Msx2	homeobox, msh-like 2	0.652
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.628
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.628
Runx2	runt related transcription factor 2	0.619
Sox9	SRY-box containing gene 9	0.567
Hoxa1	homeobox A1	0.520
Fgf10	fibroblast growth factor 10	0.508
Pitx2	paired-like homeodomain transcription factor 2	0.507
Gsc	goosecoid homeobox	0.490
Wnt9b	wingless-type MMTV integration site 9B	0.475
Wnt3a	wingless-related MMTV integration site 3A	0.475
Alx4	aristaless-like homeobox 4	0.404
Bmper	BMP-binding endothelial regulator	0.379
Tcfap2a	transcription factor AP-2, alpha	0.377
Jag1	jagged 1	0.352
Bmp2	bone morphogenetic protein 2	0.350
Tbx10	T-box 10	0.340
Pax2	paired box gene 2	0.323
Vangl2	vang-like 2 (van gogh, Drosophila)	0.315
Lef1	lymphoid enhancer binding factor 1	0.313
Hoxa2	homeobox A2	0.293
Tbx15	T-box 15	0.291
Lmx1a	LIM homeobox transcription factor 1 alpha	0.270
Alx1	ALX homeobox 1	0.258
Tgfb2	transforming growth factor, beta 2	0.239
Foxh1	forkhead box H1	0.237
Fgf3	fibroblast growth factor 3	0.231
Gdf6	growth differentiation factor 6	0.220	Mouse
Rara	retinoic acid receptor, alpha	0.220
Foxg1	forkhead box G1	0.210
Ret	ret proto-oncogene	0.209
Gbx2	gastrulation brain homeobox 2	0.200
Gdf5	growth differentiation factor 5	0.189	Mouse
Hoxa11	homeobox A11	0.184
Sox2	SRY-box containing gene 2	0.172
Adra2b	adrenergic receptor, alpha 2b	0.166
Nog	noggin	0.162
Igl	immunoglobulin lambda chain complex	0.160
Alx3	aristaless-like homeobox 3	0.147
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.147
Otx1	orthodenticle homolog 1 (Drosophila)	0.144
T	brachyury	0.143
Lrp6	low density lipoprotein receptor-related protein 6	0.142
Tcf21	transcription factor 21	0.133
Chd7	chromodomain helicase DNA binding protein 7	0.123
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.118
Hoxb3	homeobox B3	0.113
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.105
Gdf1	growth differentiation factor 1	0.104
Slc5a2	solute carrier family 5 (sodium/glucose cotransporter), member 2	0.092
Fgfrl1	fibroblast growth factor receptor-like 1	0.091
Gata3	GATA binding protein 3	0.090
Ednra	endothelin receptor type A	0.089
Mn1	meningioma 1	0.088
Pbx1	pre B-cell leukemia transcription factor 1	0.087
Ihh	Indian hedgehog	0.086
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.086
Hes1	hairy and enhancer of split 1 (Drosophila)	0.083
Hmx3	H6 homeobox 3	0.083
Gas1	growth arrest specific 1	0.082
Col2a1	collagen, type II, alpha 1	0.076
Hoxa3	homeobox A3	0.074
Hoxd11	homeobox D11	0.073
Foxe1	forkhead box E1	0.073
Thrb	thyroid hormone receptor beta	0.072
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.068
Gdf3	growth differentiation factor 3	0.068
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.067
Foxf1a	forkhead box F1a	0.065
Efnb2	ephrin B2	0.063
Hnf1b	HNF1 homeobox B	0.063
Foxf2	forkhead box F2	0.062
Foxa2	forkhead box A2	0.059
Wt1	Wilms tumor 1 homolog	0.058
Itga8	integrin alpha 8	0.056
Emx1	empty spiracles homolog 1 (Drosophila)	0.055
Bicc1	bicaudal C homolog 1 (Drosophila)	0.054
Bdnf	brain derived neurotrophic factor	0.051
Ece1	endothelin converting enzyme 1	0.050
Rdh10	retinol dehydrogenase 10 (all-trans)	0.047
Nkx3-2	NK3 homeobox 2	0.044
Smad6	MAD homolog 6 (Drosophila)	0.043
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.040
Il13	interleukin 13	0.039
Itga3	integrin alpha 3	0.039
Nkx2-1	NK2 homeobox 1	0.038
Tbx3	T-box 3	0.038
Cfc1	cripto, FRL-1, cryptic family 1	0.037
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.037
Pitx1	paired-like homeodomain transcription factor 1	0.037
Foxi1	forkhead box I1	0.036
Hoxa13	homeobox A13	0.036
Pax4	paired box gene 4	0.035
Zic3	zinc finger protein of the cerebellum 3	0.034
En1	engrailed 1	0.033
Wnt6	wingless-related MMTV integration site 6	0.033
Lrp2	low density lipoprotein receptor-related protein 2	0.032
Npr2	natriuretic peptide receptor 2	0.032
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.031
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.031
Lmx1b	LIM homeobox transcription factor 1 beta	0.031
Gdf7	growth differentiation factor 7	0.030	Mouse
Edn3	endothelin 3	0.030
Ar	androgen receptor	0.029
Atp7b	ATPase, Cu++ transporting, beta polypeptide	0.029
Osr1	odd-skipped related 1 (Drosophila)	0.029
Phlda2	pleckstrin homology-like domain, family A, member 2	0.028
Tgfbr2	transforming growth factor, beta receptor II	0.028
Duox2	dual oxidase 2	0.028
Gata6	GATA binding protein 6	0.027
Fut7	fucosyltransferase 7	0.027
Esx1	extraembryonic, spermatogenesis, homeobox 1	0.026
Hoxd12	homeobox D12	0.026
P2rx6	purinergic receptor P2X, ligand-gated ion channel, 6	0.026
Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	0.026
Rxra	retinoid X receptor alpha	0.025
Gata4	GATA binding protein 4	0.025
Dlx2	distal-less homeobox 2	0.025
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.025
Sox17	SRY-box containing gene 17	0.025
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.024
Wdr19	WD repeat domain 19	0.024
Mks1	Meckel syndrome, type 1	0.024
Hist1h1t	histone cluster 1, H1t	0.024
Pnliprp2	pancreatic lipase-related protein 2	0.024
Cldn6	claudin 6	0.023
Wnt4	wingless-related MMTV integration site 4	0.023
Chst3	carbohydrate (chondroitin 6/keratan) sulfotransferase 3	0.023
Wnt1	wingless-related MMTV integration site 1	0.023
Wnt5a	wingless-related MMTV integration site 5A	0.023
Btbd17	BTB (POZ) domain containing 17	0.023
Iqcd	IQ motif containing D	0.023
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.023
Ccr9	chemokine (C-C motif) receptor 9	0.023
Foxd2	forkhead box D2	0.022
Bmp5	bone morphogenetic protein 5	0.022	Mouse
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.022
Abca17	ATP-binding cassette, sub-family A (ABC1), member 17	0.022
Prop1	paired like homeodomain factor 1	0.022
Aym1	activator of yeast meiotic promoters 1	0.022
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.022
Dlx6	distal-less homeobox 6	0.021
Slc22a6	solute carrier family 22 (organic anion transporter), member 6	0.021
Sox7	SRY-box containing gene 7	0.021
Gdf11	growth differentiation factor 11	0.020
Cilp2	cartilage intermediate layer protein 2	0.020
Cnga3	cyclic nucleotide gated channel alpha 3	0.020
Mpv17	MpV17 mitochondrial inner membrane protein	0.020
Hnf1a	HNF1 homeobox A	0.020	Mouse
Bdkrb2	bradykinin receptor, beta 2	0.020
Cdx1	caudal type homeobox 1	0.020
Cxcl12	chemokine (C-X-C motif) ligand 12	0.020
Stra8	stimulated by retinoic acid gene 8	0.019
Otog	otogelin	0.019
Mecom	MDS1 and EVI1 complex locus	0.019
Fmn1	formin 1	0.019
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.019
Lamc1	laminin, gamma 1	0.019
Tex19.1	testis expressed gene 19.1	0.018
Tbx2	T-box 2	0.018
Cd96	CD96 antigen	0.018
Pcsk6	proprotein convertase subtilisin/kexin type 6	0.018
Krt16	keratin 16	0.018
Plekha7	pleckstrin homology domain containing, family A member 7	0.018
Cldn3	claudin 3	0.018
Fgf15	fibroblast growth factor 15	0.018
Gal3st1	galactose-3-O-sulfotransferase 1	0.018
Fgf4	fibroblast growth factor 4	0.018
Hnf4a	hepatic nuclear factor 4, alpha	0.017
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.017
Kremen2	kringle containing transmembrane protein 2	0.017
Elk4	ELK4, member of ETS oncogene family	0.017
Gata5	GATA binding protein 5	0.017
Dlx4	distal-less homeobox 4	0.017
Invs	inversin	0.017
Gcgr	glucagon receptor	0.017
Pcsk4	proprotein convertase subtilisin/kexin type 4	0.017
Hs6st3	heparan sulfate 6-O-sulfotransferase 3	0.017
Dppa5a	developmental pluripotency associated 5A	0.017
Bptf	bromodomain PHD finger transcription factor	0.016
Zg16	zymogen granule protein 16	0.016
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.016
Hoxd3	homeobox D3	0.016
Crb3	crumbs homolog 3 (Drosophila)	0.016
Osta	organic solute transporter alpha	0.016
Cdx2	caudal type homeobox 2	0.016
Nrtn	neurturin	0.016
Hmx2	H6 homeobox 2	0.016
Omp	olfactory marker protein	0.016
Hoxb6	homeobox B6	0.016
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.015
Twist2	twist homolog 2 (Drosophila)	0.015
Ggt1	gamma-glutamyltransferase 1	0.015
Neurog1	neurogenin 1	0.015
Mep1b	meprin 1 beta	0.015
Gip	gastric inhibitory polypeptide	0.014
Tff3	trefoil factor 3, intestinal	0.014
Gpc3	glypican 3	0.014
Padi3	peptidyl arginine deiminase, type III	0.014
B4galnt2	beta-1,4-N-acetyl-galactosaminyl transferase 2	0.014
Trp63	transformation related protein 63	0.014
Fosl2	fos-like antigen 2	0.014
Hpn	hepsin	0.014
Tmprss2	transmembrane protease, serine 2	0.014
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.014
Degs2	degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase	0.014
Ccdc85c	coiled-coil domain containing 85C	0.014
Fuz	fuzzy homolog (Drosophila)	0.014
Irs3	insulin receptor substrate 3	0.014
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.014
Il9r	interleukin 9 receptor	0.014
Slc38a8	solute carrier family 38, member 8	0.014
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.014
Apob	apolipoprotein B	0.013
Pthlh	parathyroid hormone-like peptide	0.013
Mogat2	monoacylglycerol O-acyltransferase 2	0.013
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.013
Mfsd6l	major facilitator superfamily domain containing 6-like	0.013
Capn9	calpain 9	0.013
Hoxa10	homeobox A10	0.013
Mpl	myeloproliferative leukemia virus oncogene	0.013
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.013
Mst1r	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	0.013
Igfbp1	insulin-like growth factor binding protein 1	0.013
Vax1	ventral anterior homeobox containing gene 1	0.013
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.013
Krt71	keratin 71	0.013
Msx3	homeobox, msh-like 3	0.013
Ptgdr	prostaglandin D receptor	0.013
Tcfap2c	transcription factor AP-2, gamma	0.013
Rgnef	Rho-guanine nucleotide exchange factor	0.013
Ocln	occludin	0.013
Hoxa5	homeobox A5	0.013
Nodal	nodal	0.013	Mouse
Prl4a1	prolactin family 4, subfamily a, member 1	0.012
Hrh2	histamine receptor H2	0.012
Il4	interleukin 4	0.012
Tgfbr3	transforming growth factor, beta receptor III	0.012
Klk4	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	0.012
Per3	period homolog 3 (Drosophila)	0.012
Gm10369	predicted gene 10369	0.012
Sox3	SRY-box containing gene 3	0.012
Tcf15	transcription factor 15	0.012
Kif3a	kinesin family member 3A	0.012
Tg	thyroglobulin	0.012
Ybx2	Y box protein 2	0.012
Utf1	undifferentiated embryonic cell transcription factor 1	0.012
Igh	immunoglobulin heavy chain complex	0.012
Nkx3-1	NK-3 transcription factor, locus 1 (Drosophila)	0.012
Rpgrip1l	Rpgrip1-like	0.012
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.012
Bnc1	basonuclin 1	0.012
Mafa	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)	0.012
Kap	kidney androgen regulated protein	0.012
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.012
Ptafr	platelet-activating factor receptor	0.012
A430105I19Rik	RIKEN cDNA A430105I19 gene	0.012
Wnt8a	wingless-related MMTV integration site 8A	0.012
Dhh	desert hedgehog	0.012
Isl1	ISL1 transcription factor, LIM/homeodomain	0.012
Fam92b	family with sequence similarity 92, member B	0.011
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.011
Mesp1	mesoderm posterior 1	0.011
3110079O15Rik	RIKEN cDNA 3110079O15 gene	0.011
Gm4980	predicted gene 4980	0.011
Slc7a9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.011
Evx1	even skipped homeotic gene 1 homolog	0.011
Col13a1	collagen, type XIII, alpha 1	0.011
Barx1	BarH-like homeobox 1	0.011
Gif	gastric intrinsic factor	0.011
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.011
Lrp4	low density lipoprotein receptor-related protein 4	0.011
Abp1	amiloride binding protein 1 (amine oxidase, copper-containing)	0.011
Tdgf1	teratocarcinoma-derived growth factor 1	0.011
Ncr1	natural cytotoxicity triggering receptor 1	0.011
Rbp2	retinol binding protein 2, cellular	0.011
Zbtb7b	zinc finger and BTB domain containing 7B	0.011
Pax9	paired box gene 9	0.011	Mouse
Pgap1	post-GPI attachment to proteins 1	0.011
Pou4f3	POU domain, class 4, transcription factor 3	0.011
Celsr1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	0.011
Tsx	testis specific X-linked gene	0.011
Tmem28	transmembrane protein 28	0.011
Sim1	single-minded homolog 1 (Drosophila)	0.011
Prss39	protease, serine, 39	0.011
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.011
Fmod	fibromodulin	0.011
Lefty2	left-right determination factor 2	0.010
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.010
Cd1d2	CD1d2 antigen	0.010
Gpr139	G protein-coupled receptor 139	0.010
Ubxn10	UBX domain protein 10	0.010
Ccr4	chemokine (C-C motif) receptor 4	0.010
Sult5a1	sulfotransferase family 5A, member 1	0.010
Nr6a1	nuclear receptor subfamily 6, group A, member 1	0.010
Acad10	acyl-Coenzyme A dehydrogenase family, member 10	0.010
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.010