The network for 'regulation of immune effector process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of immune effector process

Any process that modulates the frequency, rate, or extent of an immune effector process.

Homo sapiens
Name Description Probability Func Analog Organism
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.984
TRAF6 TNF receptor-associated factor 6 0.984
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.891
UBC ubiquitin C 0.890
MYD88 myeloid differentiation primary response gene (88) 0.885
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.847
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.830
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.830
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.817
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.814
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.812
ICAM1 intercellular adhesion molecule 1 0.770
BIRC3 baculoviral IAP repeat containing 3 0.768
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.765
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.763
SYK spleen tyrosine kinase 0.762
HLA-C major histocompatibility complex, class I, C 0.761
HLA-A major histocompatibility complex, class I, A 0.749
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.747
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.737
SP110 SP110 nuclear body protein 0.716
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.708
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.703
C1S complement component 1, s subcomponent 0.684
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.682
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.680
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.676
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.667
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.666
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.644
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.620
CXCL2 chemokine (C-X-C motif) ligand 2 0.598
HLA-DMA major histocompatibility complex, class II, DM alpha 0.594
IL2RG interleukin 2 receptor, gamma 0.585
IL4R interleukin 4 receptor 0.571
CD84 CD84 molecule 0.566
IL8 interleukin 8 0.555
SH2D1A SH2 domain containing 1A 0.551
CCR5 chemokine (C-C motif) receptor 5 0.551
CXCL10 chemokine (C-X-C motif) ligand 10 0.549
SLAMF1 signaling lymphocytic activation molecule family member 1 0.513
LIN9 lin-9 homolog (C. elegans) 0.508
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.494
IFI44L interferon-induced protein 44-like 0.493
IFI44 interferon-induced protein 44 0.474
RNF11 ring finger protein 11 0.457
TLR2 toll-like receptor 2 0.450
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.445
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.444
CCL8 chemokine (C-C motif) ligand 8 0.439
CCR1 chemokine (C-C motif) receptor 1 0.426
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.426
IFIH1 interferon induced with helicase C domain 1 0.423
B2M beta-2-microglobulin 0.423
SAMD9 sterile alpha motif domain containing 9 0.421
HLA-B major histocompatibility complex, class I, B 0.413
TRAF1 TNF receptor-associated factor 1 0.409
PML promyelocytic leukemia 0.404
RIPK2 receptor-interacting serine-threonine kinase 2 0.404
HLA-F major histocompatibility complex, class I, F 0.400
IL2RB interleukin 2 receptor, beta 0.392
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.392
IGF1R insulin-like growth factor 1 receptor 0.388
C1R complement component 1, r subcomponent 0.384
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.382
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.372
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.365
NLRC4 NLR family, CARD domain containing 4 0.364
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.362
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.361
BIRC2 baculoviral IAP repeat containing 2 0.357
RXRA retinoid X receptor, alpha 0.357
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.357
MAVS mitochondrial antiviral signaling protein 0.353
CXCL3 chemokine (C-X-C motif) ligand 3 0.350
ESR1 estrogen receptor 1 0.341
CYLD cylindromatosis (turban tumor syndrome) 0.333
MICA MHC class I polypeptide-related sequence A 0.329
RARA retinoic acid receptor, alpha 0.326
CCR7 chemokine (C-C motif) receptor 7 0.324
MED15 mediator complex subunit 15 0.318
FAS Fas (TNF receptor superfamily, member 6) 0.312
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.311
OASL 2'-5'-oligoadenylate synthetase-like 0.304
ZNF746 zinc finger protein 746 0.303
C3 complement component 3 0.302
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.299
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.293
IRAK2 interleukin-1 receptor-associated kinase 2 0.291
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.290
GRAP2 GRB2-related adaptor protein 2 0.289
CCL4 chemokine (C-C motif) ligand 4 0.285
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.280
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.280
CXCL9 chemokine (C-X-C motif) ligand 9 0.279
IL10RA interleukin 10 receptor, alpha 0.274
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.274
CD14 CD14 molecule 0.272
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.264
CCR2 chemokine (C-C motif) receptor 2 0.263
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.152
gata4 GATA-binding protein 4 0.115
nod1 nucleotide-binding oligomerization domain containing 1 0.109
crip2 cysteine-rich protein 2 0.100
LOC557072 caspase recruitment domain-containing protein 11-like 0.094
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.082
gata6 GATA-binding protein 6 0.071
pglyrp6 peptidoglycan recognition protein 6 0.063
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.058
meis1 myeloid ecotropic viral integration 1 0.047
ripk2 receptor-interacting serine-threonine kinase 2 0.045
tlr9 toll-like receptor 9 0.041
irak4 interleukin-1 receptor-associated kinase 4 0.039
pycard PYD and CARD domain containing 0.037
zgc:64115 zgc:64115 0.036
nkx2.2a NK2 transcription factor related 2a 0.033
shha sonic hedgehog a 0.031
tlr3 toll-like receptor 3 0.029
stc1l stanniocalcin 1, like 0.028
lfng lunatic fringe homolog 0.026
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.026
pparg peroxisome proliferator activated receptor gamma 0.025
gabarapa GABA(A) receptor-associated protein a 0.024
dbx1a developing brain homeobox 1a 0.024
mpx myeloid-specific peroxidase 0.024
alk anaplastic lymphoma kinase (Ki-1) 0.022
crb2a crumbs homolog 2a 0.022
cpox coproporphyrinogen oxidase 0.021
nos2a nitric oxide synthase 2a, inducible 0.021
grna granulin a 0.021
fgfr3 fibroblast growth factor receptor 3 0.021
myh11a myosin, heavy polypeptide 11, smooth muscle a 0.020
ifng1-2 interferon, gamma 1-2 0.020
fli1b friend leukemia integration 1b 0.020
trim25 tripartite motif-containing 25 0.019
spi1l spleen focus forming virus (SFFV) proviral integration oncogene spi1 like 0.019
mmp9 matrix metalloproteinase 9 0.019
LOC100000934 hypothetical protein LOC100000934 0.018
ahctf1 AT hook containing transcription factor 1 0.018
gata1a GATA binding protein 1a 0.018
fxr2 fragile X mental retardation, autosomal homolog 2 0.017
osr1 odd-skipped related 1 (Drosophila) 0.017
snai1a snail homolog 1a (Drosophila) 0.016
ticam1 toll-like receptor adaptor molecule 1 0.015
caspa caspase a 0.015
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.014
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.014
epas1b endothelial PAS domain protein 1b 0.014
gfer growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae) 0.014
adora2aa adenosine A2a receptor a 0.013
ifnphi1 interferon phi 1 0.013
kcnh2l potassium voltage-gated channel, subfamily H (eag-related), member 2 like 0.013
aida axin interaction partner and dorsalization antagonist 0.013
pglyrp5 peptidoglycan recognition protein 5 0.013
rel v-rel reticuloendotheliosis viral oncogene homolog 0.013
erbb3a v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a 0.013
LOC100534776 toll-like receptor 7-like 0.013
si:ch211-195h23.3 si:ch211-195h23.3 0.012
foxb1.2 forkhead box B1.2 0.012
flt4 fms-related tyrosine kinase 4 0.012
zgc:153921 zgc:153921 0.012
mxra8a matrix-remodelling associated 8a 0.012
rbm22 RNA binding motif protein 22 0.012
LOC555739 serine/threonine-protein kinase LMTK1-like 0.011
hhex hematopoietically expressed homeobox 0.011
taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto 0.011
tmprss4b transmembrane protease, serine 4b 0.011
f2rl1.2 coagulation factor II (thrombin) receptor-like 1.2 0.011
jak1 Janus kinase 1 0.011
ptk6a PTK6 protein tyrosine kinase 6a 0.010
col7a1l collagen type VII alpha 1-like 0.010
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Tl Toll 0.998
Rel Relish 0.961
Spn27A Serpin 27A 0.848
ird5 immune response deficient 5 0.722
SPE Spatzle-Processing Enzyme 0.720
PGRP-LC Peptidoglycan recognition protein LC 0.715
Mpk2 CG5475 gene product from transcript CG5475-RB 0.702
Tak1 TGF-beta activated kinase 1 0.667
grass Gram-positive Specific Serine protease 0.620
Myd88 CG2078 gene product from transcript CG2078-RA 0.594
Mad Mothers against dpp 0.592
ac achaete 0.433
p38b CG7393 gene product from transcript CG7393-RA 0.431
nec necrotic 0.427
Toll-7 CG8595 gene product from transcript CG8595-RA 0.413
CG15917 CG15917 gene product from transcript CG15917-RA 0.393
Mekk1 CG7717 gene product from transcript CG7717-RB 0.335
Akt1 CG4006 gene product from transcript CG4006-RA 0.284
GNBP3 Gram-negative bacteria binding protein 3 0.275
imd immune deficiency 0.271
Egfr Epidermal growth factor receptor 0.270
Spn1 Serine protease inhibitor 1 0.266
ird1 immune response deficient 1 0.240
18w 18 wheeler 0.239
MED14 Mediator complex subunit 14 0.232
Dredd Death related ced-3/Nedd2-like protein 0.229
BG4 CG12297 gene product from transcript CG12297-RA 0.225
Traf4 TNF-receptor-associated factor 4 0.223
fon fondue 0.218
Lis-1 Lissencephaly-1 0.208
CG14478 CG14478 gene product from transcript CG14478-RA 0.203
Spn28D Serpin 28D 0.202
AGO1 Argonaute-1 0.200
Tab2 TAK1-associated binding protein 2 0.193
Pp2B-14D Protein phosphatase 2B at 14D 0.184
pirk poor Imd response upon knock-in 0.180
cindr CIN85 and CD2AP orthologue 0.167
key kenny 0.165
Kr-h1 Kruppel homolog 1 0.159
Atf-2 Activating transcription factor-2 0.157
upd3 unpaired 3 0.156
cdi center divider 0.156
Duox Dual oxidase 0.150
tsl torso-like 0.148
psh persephone 0.147
lace CG4162 gene product from transcript CG4162-RA 0.147
modSP modular serine protease 0.145
Sp7 Serine protease 7 0.141
krz kurtz 0.140
PGRP-SC1a CG14746 gene product from transcript CG14746-RA 0.139
AttA Attacin-A 0.136
Traf6 TNF-receptor-associated factor 6 0.132
PGRP-SA Peptidoglycan recognition protein SA 0.126
CG18594 CG18594 gene product from transcript CG18594-RA 0.125
Sema-1b CG6446 gene product from transcript CG6446-RA 0.125
Pvr PDGF- and VEGF-receptor related 0.124
B52 CG10851 gene product from transcript CG10851-RB 0.124
emc extra macrochaetae 0.120
bsk basket 0.120
drk downstream of receptor kinase 0.119
GNBP1 Gram-negative bacteria binding protein 1 0.117
th thread 0.117
CG16718 CG16718 gene product from transcript CG16718-RA 0.109
Glt Glutactin 0.109
Imp IGF-II mRNA-binding protein 0.107
CG1347 CG1347 gene product from transcript CG1347-RB 0.104
sc scute 0.103
CG9184 CG9184 gene product from transcript CG9184-RB 0.098
rpr reaper 0.097
Stam Signal transducing adaptor molecule 0.096
PGRP-SD CG7496 gene product from transcript CG7496-RA 0.094
CG6664 CG6664 gene product from transcript CG6664-RC 0.093
CG1103 CG1103 gene product from transcript CG1103-RA 0.093
grn grain 0.089
eater CG6124 gene product from transcript CG6124-RB 0.089
babo baboon 0.086
l(3)05822 lethal (3) 05822 0.084
cact cactus 0.084
CG3004 CG3004 gene product from transcript CG3004-RA 0.082
zen zerknullt 0.082
PGRP-LF Peptidoglycan recognition protein LF 0.080
Rbp6 RNA-binding protein 6 0.080
ec echinus 0.078
amos absent MD neurons and olfactory sensilla 0.078
upd2 unpaired 2 0.078
E(spl) Enhancer of split 0.078
CG5794 CG5794 gene product from transcript CG5794-RB 0.077
Ephrin CG1862 gene product from transcript CG1862-RA 0.076
psq pipsqueak 0.075
CG2924 CG2924 gene product from transcript CG2924-RA 0.074
ft fat 0.073
numb CG3779 gene product from transcript CG3779-RB 0.071
Atg13 Autophagy-specific gene 13 0.070
msn misshapen 0.066
l(3)mbn lethal (3) malignant blood neoplasm 0.066
Nrx-IV Neurexin IV 0.065
lwr lesswright 0.065
dpn deadpan 0.065
CG12766 CG12766 gene product from transcript CG12766-RA 0.064
tamo CG4057 gene product from transcript CG4057-RA 0.064
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hck hemopoietic cell kinase 0.177
Cp ceruloplasmin 0.160
Casp1 caspase 1 0.096
Neurl3 neuralized homolog 3 (Drosophila) 0.084
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.079
Fgg fibrinogen gamma chain 0.075
Icam1 intercellular adhesion molecule 1 0.068
LOC100363783 rCG53773-like 0.063
Cd247 Cd247 molecule 0.058
Cd53 Cd53 molecule 0.055
RT1-EC2 RT1 class Ib, locus EC2 0.055
Csf1 colony stimulating factor 1 (macrophage) 0.054
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.048
Ptafr platelet-activating factor receptor 0.048
Has2 hyaluronan synthase 2 0.047
Pzp pregnancy-zone protein 0.046
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.044
Aif1 allograft inflammatory factor 1 0.041
Tfec transcription factor EC 0.040
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.037
Dnase1l3 deoxyribonuclease 1-like 3 0.035
Phkg1 phosphorylase kinase, gamma 1 0.035
Hrh2 histamine receptor H 2 0.034
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.034
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.034
Cd86 CD86 molecule 0.034
Il1b interleukin 1 beta 0.033
Apcs amyloid P component, serum 0.032
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.032
Cxcr4 chemokine (C-X-C motif) receptor 4 0.032
Sult1e1 sulfotransferase family 1E, estrogen-preferring, member 1 0.031
Cxcl10 chemokine (C-X-C motif) ligand 10 0.031
Cybb cytochrome b-245, beta polypeptide 0.030
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.030
Mmp12 matrix metallopeptidase 12 0.030
Ifng interferon gamma 0.029
C1s complement component 1, s subcomponent 0.029
Ctsj cathepsin J 0.028
Adora3 adenosine A3 receptor 0.028
Sell selectin L 0.028
Ncr1 natural cytotoxicity triggering receptor 1 0.028
Arhgap4 Rho GTPase activating protein 4 0.027
Gzmk granzyme K 0.027
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.027
Hsph1 heat shock 105/110 protein 1 0.027
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.026
Cfb complement factor B 0.026
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.026
Cd4 Cd4 molecule 0.025
Rhoh ras homolog gene family, member H 0.025
Il2rg interleukin 2 receptor, gamma 0.025
Igsf6 immunoglobulin superfamily, member 6 0.025
Bgn biglycan 0.025
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.025
Lyz2 lysozyme 2 0.025
Tlr4 toll-like receptor 4 0.024
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.024
Hspb1 heat shock protein 1 0.024
Zcwpw1 zinc finger, CW-type with PWWP domain 1 0.024
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.024
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.023
Plau plasminogen activator, urokinase 0.023
Fga fibrinogen alpha chain 0.023
Pde3a phosphodiesterase 3A, cGMP inhibited 0.023
Klrb1a killer cell lectin-like receptor subfamily B, member 1A 0.023
Nkg7 natural killer cell group 7 sequence 0.023
RT1-Ba RT1 class II, locus Ba 0.022
Havcr1 hepatitis A virus cellular receptor 1 0.022
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.022
Tlr7 toll-like receptor 7 0.021
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.021
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.021
Adcy10 adenylate cyclase 10 (soluble) 0.020
Casp12 caspase 12 0.020
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.020
Cfi complement factor I 0.020
RT1-Da RT1 class II, locus Da 0.020
Fcgr3a Fc fragment of IgG, low affinity IIIa, receptor 0.020
Calcr calcitonin receptor 0.020
Apob apolipoprotein B 0.020
Gbp2 guanylate binding protein 2 0.020
Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) 0.020
Hbz hemoglobin, zeta 0.019
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.019
Ctsl1 cathepsin L1 0.018
Ccr5 chemokine (C-C motif) receptor 5 0.018
Olr1867 olfactory receptor 1867 0.018
Vcam1 vascular cell adhesion molecule 1 0.018
Fth1 ferritin, heavy polypeptide 1 0.018
Cd28 Cd28 molecule 0.018
Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 0.017
RT1-S3 RT1 class Ib, locus S3 0.017
C3ar1 complement component 3a receptor 1 0.017
Mcpt3 mast cell peptidase 3 0.017
Dock8 dedicator of cytokinesis 8 0.017
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.017
Cd38 CD38 molecule 0.017
Prlhr prolactin releasing hormone receptor 0.017
RT1-CE12 RT1 class I, locus CE12 0.017
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.017
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism