The network for 'positive regulation of cell size' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of cell size

Any process that increases cell size.

Homo sapiens
Name Description Probability Func Analog Organism
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.000
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.977
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.743
RICTOR RPTOR independent companion of MTOR, complex 2 0.678
MAPK14 mitogen-activated protein kinase 14 0.673
RPTOR regulatory associated protein of MTOR, complex 1 0.664
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.457
PRR5 proline rich 5 (renal) 0.433
RHEB Ras homolog enriched in brain 0.407
RB1 retinoblastoma 1 0.402
SIRT1 sirtuin 1 0.400
AKT1S1 AKT1 substrate 1 (proline-rich) 0.337
COASY CoA synthase 0.254
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.230
PRKCZ protein kinase C, zeta 0.226
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.211
DEPTOR DEP domain containing MTOR-interacting protein 0.198
HSF1 heat shock transcription factor 1 0.197
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.188
SOCS3 suppressor of cytokine signaling 3 0.171
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 0.169
CPNE6 copine VI (neuronal) 0.160
E2F2 E2F transcription factor 2 0.138
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.113
DUSP9 dual specificity phosphatase 9 0.110
MAPK3 mitogen-activated protein kinase 3 0.108
MAPK11 mitogen-activated protein kinase 11 0.104
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.094
SH3KBP1 SH3-domain kinase binding protein 1 0.092
TELO2 TEL2, telomere maintenance 2, homolog (S. cerevisiae) 0.085
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.082
MAP2K6 mitogen-activated protein kinase kinase 6 0.082
PEBP4 phosphatidylethanolamine-binding protein 4 0.076
YAP1 Yes-associated protein 1 0.073
FGFR1 fibroblast growth factor receptor 1 0.072
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.069
CARD11 caspase recruitment domain family, member 11 0.067
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.067
PDPK1 3-phosphoinositide dependent protein kinase-1 0.067
ZFP36L1 zinc finger protein 36, C3H type-like 1 0.066
RPL39 ribosomal protein L39 0.066
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.066
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.061
WWOX WW domain containing oxidoreductase 0.057
MKNK1 MAP kinase interacting serine/threonine kinase 1 0.053
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.052
USP46 ubiquitin specific peptidase 46 0.051
ATF2 activating transcription factor 2 0.050
HPS6 Hermansky-Pudlak syndrome 6 0.045
IGSF21 immunoglobin superfamily, member 21 0.045
MBNL1 muscleblind-like (Drosophila) 0.045
ATG16L1 ATG16 autophagy related 16-like 1 (S. cerevisiae) 0.044
ABI1 abl-interactor 1 0.042
TRAF2 TNF receptor-associated factor 2 0.041
PRR5L proline rich 5 like 0.041
PHC2 polyhomeotic homolog 2 (Drosophila) 0.041
SH3RF1 SH3 domain containing ring finger 1 0.040
SPRY2 sprouty homolog 2 (Drosophila) 0.040
E2F1 E2F transcription factor 1 0.038
ASXL1 additional sex combs like 1 (Drosophila) 0.038
DUSP7 dual specificity phosphatase 7 0.037
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.037
MAPT microtubule-associated protein tau 0.036
NCOA7 nuclear receptor coactivator 7 0.035
NCOA6 nuclear receptor coactivator 6 0.034
PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.034
LIMK1 LIM domain kinase 1 0.034
ALAS1 aminolevulinate, delta-, synthase 1 0.034
BAG1 BCL2-associated athanogene 0.033
SBF1 SET binding factor 1 0.033
VHL von Hippel-Lindau tumor suppressor 0.033
CCL14 chemokine (C-C motif) ligand 14 0.033
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.032
CMIP c-Maf-inducing protein 0.032
PKN1 protein kinase N1 0.032
SH3BP2 SH3-domain binding protein 2 0.031
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 0.031
STK4 serine/threonine kinase 4 0.031
NCOA3 nuclear receptor coactivator 3 0.030
C1orf93 chromosome 1 open reading frame 93 0.030
MBD1 methyl-CpG binding domain protein 1 0.029
SKI v-ski sarcoma viral oncogene homolog (avian) 0.029
MBD3 methyl-CpG binding domain protein 3 0.029
SOS1 son of sevenless homolog 1 (Drosophila) 0.029
RPL41 ribosomal protein L41 0.029
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.028
ARL6IP4 ADP-ribosylation-like factor 6 interacting protein 4 0.028
LRRK2 leucine-rich repeat kinase 2 0.028
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.027
PDK1 pyruvate dehydrogenase kinase, isozyme 1 0.027
EGLN1 egl nine homolog 1 (C. elegans) 0.027
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.027
EEF2K eukaryotic elongation factor-2 kinase 0.027
PDCD6IP programmed cell death 6 interacting protein 0.027
MAPK1 mitogen-activated protein kinase 1 0.026
MTA1 metastasis associated 1 0.026
MAP2K3 mitogen-activated protein kinase kinase 3 0.025
NRIP1 nuclear receptor interacting protein 1 0.025
RPLP1 ribosomal protein, large, P1 0.025
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.025
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
S6k RPS6-p70-protein kinase 0.592
Akt1 CG4006 gene product from transcript CG4006-RA 0.411
Hcf Host cell factor 0.379
l(2)gl lethal (2) giant larvae 0.353
Lnk CG17367 gene product from transcript CG17367-RC 0.292
rl rolled 0.277
Pk61C Protein kinase 61C 0.274
Pkn Protein kinase related to protein kinase N 0.258
chico CG5686 gene product from transcript CG5686-RB 0.241
p38b CG7393 gene product from transcript CG7393-RA 0.237
dm diminutive 0.208
foxo forkhead box, sub-group O 0.206
Pten CG5671 gene product from transcript CG5671-RB 0.190
Rheb CG1081 gene product from transcript CG1081-RA 0.167
Mekk1 CG7717 gene product from transcript CG7717-RB 0.158
Atg1 Autophagy-specific gene 1 0.148
hppy happyhour 0.147
RagA CG11968 gene product from transcript CG11968-RA 0.119
Mad Mothers against dpp 0.106
InR Insulin-like receptor 0.106
E(var)3-9 Enhancer of variegation 3-9 0.095
Thor CG8846 gene product from transcript CG8846-RA 0.090
Mpk2 CG5475 gene product from transcript CG5475-RB 0.089
Lis-1 Lissencephaly-1 0.084
MTF-1 Metal response element-binding Transcription Factor-1 0.082
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.077
Rac1 CG2248 gene product from transcript CG2248-RA 0.075
Mnt CG13316 gene product from transcript CG13316-RD 0.070
Rab7 Rab-protein 7 0.059
raptor CG4320 gene product from transcript CG4320-RA 0.053
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.052
Atg18 Autophagy-specific gene 18 0.052
crb crumbs 0.051
RhoL rho-like 0.048
Hr96 Hormone receptor-like in 96 0.046
Gp150 CG5820 gene product from transcript CG5820-RA 0.046
Rab11 Rab-protein 11 0.043
Clic Chloride intracellular channel 0.040
tub tube 0.040
Tl Toll 0.040
Arf79F ADP ribosylation factor 79F 0.039
Tak1 TGF-beta activated kinase 1 0.036
Pvr PDGF- and VEGF-receptor related 0.036
Pi3K21B CG2699 gene product from transcript CG2699-RA 0.035
Parp Poly-(ADP-ribose) polymerase 0.035
cert ceramide transfer protein 0.034
Traf6 TNF-receptor-associated factor 6 0.033
hep hemipterous 0.032
mys myospheroid 0.031
Rala Ras-related protein 0.030
Ric Ras which interacts with Calmodulin 0.030
Hph HIF prolyl hydroxylase 0.029
Arf51F ADP ribosylation factor 51F 0.029
klar klarsicht 0.028
klu klumpfuss 0.028
Mt2 Methyltransferase 2 0.027
Rab2 Rab-protein 2 0.026
Lk6 CG17342 gene product from transcript CG17342-RA 0.026
slif slimfast 0.025
CG5794 CG5794 gene product from transcript CG5794-RB 0.025
ImpL2 Ecdysone-inducible gene L2 0.025
scb scab 0.024
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.024
egl egalitarian 0.024
wnd wallenda 0.024
ex expanded 0.023
Tsc1 CG6147 gene product from transcript CG6147-RA 0.022
edl ETS-domain lacking 0.022
Gyc76C Guanylyl cyclase at 76C 0.022
mbt mushroom bodies tiny 0.022
sxc super sex combs 0.021
Dcr-2 Dicer-2 0.021
hth homothorax 0.021
kibra kibra ortholog 0.020
CG8155 CG8155 gene product from transcript CG8155-RA 0.020
Atf-2 Activating transcription factor-2 0.020
PRL-1 CG4993 gene product from transcript CG4993-RB 0.020
Eip63E Ecdysone-induced protein 63E 0.020
Ilp6 Insulin-like peptide 6 0.020
Ef1gamma CG11901 gene product from transcript CG11901-RC 0.020
Traf4 TNF-receptor-associated factor 4 0.020
skpA CG16983 gene product from transcript CG16983-RD 0.019
Mio Mlx interactor 0.019
rg rugose 0.019
sNPF-R short neuropeptide F receptor 0.018
Trx-2 thioredoxin-2 0.018
put punt 0.018
path pathetic 0.018
CG3004 CG3004 gene product from transcript CG3004-RA 0.018
B-H1 BarH1 0.017
HLH106 Helix loop helix protein 106 0.017
Ilp2 Insulin-like peptide 2 0.017
nuf nuclear fallout 0.017
sw short wing 0.017
Hnf4 Hepatocyte nuclear factor 4 0.017
mus309 mutagen-sensitive 309 0.017
CG32528 CG32528 gene product from transcript CG32528-RA 0.017
CG16718 CG16718 gene product from transcript CG16718-RA 0.016
CalpB Calpain-B 0.016
whd withered 0.016
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Mus musculus
Name Description Probability Func Analog Organism
Mapk14 mitogen-activated protein kinase 14 0.558
Pten phosphatase and tensin homolog 0.388
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.294
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.051
Trp53 transformation related protein 53 0.046
Rictor RPTOR independent companion of MTOR, complex 2 0.043
Mapkap1 mitogen-activated protein kinase associated protein 1 0.034
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.028
Akt1 thymoma viral proto-oncogene 1 0.021
Apc adenomatosis polyposis coli 0.019
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.017
Raf1 v-raf-leukemia viral oncogene 1 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hsph1 heat shock 105/110 protein 1 0.323
Hspd1 heat shock protein 1 (chaperonin) 0.113
Hspa8 heat shock protein 8 0.048
Stip1 stress-induced phosphoprotein 1 0.022
Eef2 eukaryotic translation elongation factor 2 0.021
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism